Category: 45762-41-2

Application of 45762-41-2,Some common heterocyclic compound, 45762-41-2, name is 4-Bromo-2-ethylaniline, molecular formula is C8H10BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 1: SYNTHESIS OF COMPOUNDS COMPOUND 1 : 2-(1,8-DIETHYL-6-PHENYL-1,3,4,9-TETRAHYDRO-PYRANO[3,4-B]INDOL-1- YL)-ETHANOL I. A. SYNTHESIS OF N-(4-BROMO-2-ETHYL-PHEHYL)-2-HYDROXIMINO-ACETOAMIDE To a suspension of 4-bromo-2-ethylaniline (50.0 g, 250 mmol) in water (1000 mL) was added concentrated hydrochloric acid (25 mL), sodium sulfate (220 g), and hydroxylamine hydrochloride (56.25 g), followed by addition of chloral hydrate (44.0 g). The reaction mixture was heated to 90C using an oil bath for 1 hour. After cooling down to room temperature, it was extracted with ethyl acetate. Extract was dried over magnesium sulfate and concentrated under reduced pressure to give the title compound (31.1 g, 46% YIELD). 1H NMR (DMSO-d6) 5 12.24 (s, 1H), 9.56 (s, 1H), 7. 68 (s, 1H), 7.41 (m, 3H), 2. 58 (q, 2H), 1.11 (t, 3H). 47. A. Synthesis of N-(4-Bromo-2-ethyl-phenyl)-2-hydroxyimino-acetamide Following the procedure of example 36. A. except using 4-bromo-2-ethylaniline as the aniline component afforded the title compound as a solid. ESI (-) MS m/e=269 (MH-).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-2-ethylaniline, its application will become more common.

Reference:
Patent; SALMEDIX, INC.; WO2005/33112; (2005); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 45762-41-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 45762-41-2, name is 4-Bromo-2-ethylaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A solution of 4-bromo-2-ethylaniline (1.09g) in chloroform (20ml) was stirred at room temp. then treated with potassium acetate (0.49g) followed by acetic anhydride (0. 95ml). 18-Crown-6 (0.26g) and t-butylnitrite (1. 32ml) were added after 30 min and the mixture was stirred at reflux for 18h. The reaction mixture was diluted with chloroform and washed with saturated aqueous sodium hydrogen carbonate. The organic phase was separated using a hydrophobic frit and the solvent was evaporated to give the title compound as a brown solid (l. Og). NMR : 8H [CDC13] 8.30 (1H, d), 7.79 (1H, s), 7.63 (1H, d), 2.74 (3H, s), (2.55 (3H, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2-ethylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2004/10995; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 45762-41-2, name is 4-Bromo-2-ethylaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 45762-41-2, name: 4-Bromo-2-ethylaniline

A solution of 4-bromo-2-ethylaniline (200 mg) in dichloromethane (10 mL) was treated with 1-fluoro-2-isocyanato-4-methylbenzene (151 mg), stirred at room temperature overnight, diluted with hexanes, and filtered. The filter cake provided 227 mg of the desired product. MS (ESI(+)) m/e 351,353 (M+H)+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Dai, Yujia; Davidsen, Steven K.; Ericsson, Anna M.; Hartandi, Kresna; Ji, Zhiqin; Michaelides, Michael R.; US2004/235892; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 45762-41-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 45762-41-2, name is 4-Bromo-2-ethylaniline, This compound has unique chemical properties. The synthetic route is as follows.

4-Bromo-2-ethyl-aniline (2ml_, 14 mmol) dissolved in anhydrous pyridine (35 ml) at toom temperature was treated with methylsulfonyl chloride (1.3 ml_, 16.8 mmol). The reaction was stirred at that temperature for 15 hours before it was diluted with EtOAc. The mixture was washed with H2O, brine and dried over MgSO4. The solvent was removed in vacua and the residue was purified with flash chromatography (SiO2, 5-30% EtOAc in hexanes) to afford thedesired product (3.1 g, 81% yield). 1H NMR (300 MHz, CDCI3): 6 1.25 (t, J=7.5 Hz, 3 H), 2.61-2.68 (m, 2 H), 3.02 (s, 3 H), 6.36 (s, 1 H), 7.36-7.39 (m, 3 H).

The chemical industry reduces the impact on the environment during synthesis 4-Bromo-2-ethylaniline. I believe this compound will play a more active role in future production and life.

Reference:
Patent; PFIZER INC.; WO2006/18725; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary