Category: 4549-33-1

Reference of 4549-33-1, These common heterocyclic compound, 4549-33-1, name is 1,9-Dibromononane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of 5,6-dimethoxy-1-oxo-indan-2-carboxylic acid ethyl ester 14 (235 mg, 0.88 mmol) and NaH (79.5 mg, 2.65 mmol, 80% dispersion in mineral oil) in DMF (8 mL) was stirred at room temperature for 30 min, after which 1-chloro-3-iodo propane (0.185 mL, 1.76 mmol) was added. The reaction mixture was stirred at room temperature for 20 h and quenched by adding water (15 mL) and aqueous HCl (1 mL, 1.0 N). The mixture was extracted with dichloromethane (3 * 20 mL), and the combined organic layers were washed with brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure. The resulting residue was purified by column chromatography (silica gel, EtOAc/PE, 1/4) to generate the title compound (200 mg, 66%) as pale yellow oil.

The synthetic route of 4549-33-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hu, Yueqing; Zhang, Jun; Chandrashankra, Oormila; Ip, Fanny C.F.; Ip, Nancy Y.; Bioorganic and Medicinal Chemistry; vol. 21; 3; (2013); p. 676 – 683;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4549-33-1, name is 1,9-Dibromononane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 4549-33-1

Preparation 55 (R)-4-(Biphenyl-2-ylcarbamoyloxy)-1-(9-bromononyl)-1-azoniabicyclo[3.2.1]octane Bromide To a stirred solution of the product of Preparation 54 (1.21 g, 3.76 mmol) and triethylamine (1.05 mL, 7.52 mmol) in acetonitrile (18.8 mL) was added 1,9-dibromononane (994 muL, 4.89 mmol) and the reaction mixture was heated at 50 C. for 4 h. The reaction mixture was then cooled and the solvent was removed under reduced pressure. The residue was dissolved in dichloromethane (20 mL) and the organic layer was washed with saturated aqueous sodium bicarbonate (10 mL), dried (magnesium sulfate) and solvent removed under reduced pressure. The crude product was purified by flash chromatography (10% methanol/dichloromethane, 0.5% ammonium hydroxide) to give the title compound (1.04 g, 1.97 mmol, 52% yield).

The synthetic route of 4549-33-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Mammen, Mathai; Dunham, Sarah; US2005/113417; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4549-33-1, name is 1,9-Dibromononane, A new synthetic method of this compound is introduced below., Application In Synthesis of 1,9-Dibromononane

Under inert atmosphere, to a stirred solution of NaH (140 mg, 3.45 mmol) in 2 ml anhydrous DMF at 0C, it was added a solution of theophylline (378 mg, 2.098 mmol) in 10 ml anhydrous DMF. After 2 h at room temperature, 1,9-dibromononane (142 mu, 1.41 mmol) was slowly added to the reaction mixture. This mixture was stirred at room temperature overnight, and then solvent was completely removed. The crude was chromatographically purified over Si02 using gradient mixtures of AcOEt/MeOH as the eluant, yielding 0.108 g (32 %) of the desired product B. NMR (400 MHz, DMSO-d6): delta 8.07 (s, 2 H), 4.22 (t, J=7.0 Hz, 1 H), 3.42 (s, 6 H), 3.22 (s, 6 H), 1.69 – 1.83 (m, 4 H), 1.24 (br. s., 10 H) ppm. MS (ESI (+)): m/z = 507.2 [M+Na]+ MS (ESI (-): m/z = 483.0 [M-H]”

The synthetic route of 4549-33-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITAT DE VALENCIA; INSTITUT QUIMIC DE SARRIA CETS FUNDACIO PRIVADA; INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S.A.; ARTERO ALLEPUZ, Ruben; CASTELLS BOLIART, Josep; BORRELL BILBAO, Jose Ignacio; LLAMUSI TROISI, Beatriz; BARGIELA SCHOeNBRUNN, Ariadna; KONIECZNY, Piotr; PASCUAL GILABERT, Marta; TEIXIDO CLOSA, Jordi; ESTRADA TEJEDOR, Roger; LOPEZ GONZALEZ, Alejandro; (68 pag.)WO2016/75285; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 4549-33-1, name is 1,9-Dibromononane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4549-33-1, Product Details of 4549-33-1

General procedure: To a stirred solution of n-dibromoalkane (1 equiv.) in anhydrous THF (0.1M) under an argon atmosphere was added tert-BuOK (1.15 equiv.) in portionwise over 30 min. After being stirred under reflux for 16h, the reaction was cooled and subsequently quenched with water. The resulting mixture was then diluted with diethylether, and the layers were separated. The aqueous layer was extracted several times with diethylether, and the combined organic layers were washed with brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The resultant crude product was purified by flash column chromatography over silica gel using petroleum ether as eluent to afford the desired product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,9-Dibromononane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Saied, Essa M.; Le, Thuy Linh-Stella; Hornemann; Arenz, Christoph; Bioorganic and Medicinal Chemistry; vol. 26; 14; (2018); p. 4047 – 4057;,
Bromide – Wikipedia,
bromide – Wiktionary

4549-33-1, name is 1,9-Dibromononane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 1,9-Dibromononane

General procedure: A solution of 2 0.5 g (2 mmol) and anhydrous CH3CN (10 ml) was treated with dihalogenid (1 mmol) and heated on a bath at 70-75 C for different time from 10 to 30 h depending on dihalogenide structure. The solvent was removed at reduced pressure. The resulting precipitate was chromatographed over silica gel ((CHCl3+NH4OH)/MeOH eluent, (100:0?0:100)).

The synthetic route of 4549-33-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sokolova, Anastasiya S.; Yarovaya, Olga I.; Shernyukov, Andrey V.; Pokrovsky, Michail A.; Pokrovsky, Andrey G.; Lavrinenko, Valentina A.; Zarubaev, Vladimir V.; Tretiak, Tatiana S.; Anfimov, Pavel M.; Kiselev, Oleg I.; Beklemishev, Anatoly B.; Salakhutdinov, Nariman F.; Bioorganic and Medicinal Chemistry; vol. 21; 21; (2013); p. 6690 – 6698;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 4549-33-1,Some common heterocyclic compound, 4549-33-1, name is 1,9-Dibromononane, molecular formula is C9H18Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Compound 2a or 2b (2 mmol) and KOH (0.34 g, 6 mmol) weredissolved in acetonitrile. The solution was stirred for 1 h under argonat room temperature. Then, different dibromoalkanes(4 mmol) were added to the mixture. After stirring for 48 h, themixture was filtered and evaporated under reduced pressure. Theresidue was chromatographed on silica gel, with petroleumether/ethyl acetate, 10:1, plus 10 mL triethylamine per 1000 mLas the eluent to afford the compounds.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,9-Dibromononane, its application will become more common.

Reference:
Article; Sun, Yang; Chen, Jianwen; Chen, Xuemin; Huang, Ling; Li, Xingshu; Bioorganic and Medicinal Chemistry; vol. 21; 23; (2013); p. 7406 – 7417;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4549-33-1, name is 1,9-Dibromononane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C9H18Br2

General procedure: To a stirred solution of 2-(phenylsulfonyl)methyl-4,5-diphenyloxazole 1 (500 mg, 1.33 mmol, 1.0 equiv) in dry THF (10 mL) was added potassium tert-butoxide (1.60 mmol, 1.2 equiv) at 5 C. The resulting yellow reaction mixture was stirred under a nitrogen atmosphere (30 min). The dibromo alkane (1.60 mmol, 1.2 equiv) was then slowly added to the reaction mixture by syringe, and reaction mixture was allowed to warm to room temperature and stirring was continued (16 h). After completion of reaction, cold water (10 mL) was poured into the reaction mixture followed by extraction with dichloromethane (2 x 20 mL). The organic layers were combined, washed with brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude residue was submitted to gravity-column chromatography (hexane/ethyl acetate, 9:1) to afford the corresponding products 2a-d.

The synthetic route of 4549-33-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Patil, Pravin C.; Luzzio, Frederick A.; Tetrahedron; vol. 73; 29; (2017); p. 4206 – 4213;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 4549-33-1, The chemical industry reduces the impact on the environment during synthesis 4549-33-1, name is 1,9-Dibromononane, I believe this compound will play a more active role in future production and life.

General procedure: To a stirred solution of monovalent beta-carbolines 1-17 (2.0 mmol) in anhydrous DMF (30 ml) was added 60% NaH (0.4 g, 10 mmol). After stirring for 20 min at room temperature, the appropriate dibromoalkane (1.0 mmol) was added. And then the reaction mixture was stirred at room temperature for 8-20 h. After completion of the reaction as indicated by TLC, the solution was poured into ice-water and extracted with CH2Cl2. The combined organic layer was washed with water and brine, dried over anhydrous Na2SO4, filtered and evaporated in vacuum. The residue was purified by column chromatography with CH2Cl2/MeOH (50:1) to successfully afford the desirable target products.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,9-Dibromononane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Shi, Buxi; Cao, Rihui; Fan, Wenxi; Guo, Liang; Ma, Qin; Chen, Xuemei; Zhang, Guoxian; Qiu, Liqin; Song, Huacan; European Journal of Medicinal Chemistry; vol. 60; (2013); p. 10 – 22;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 4549-33-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4549-33-1, name is 1,9-Dibromononane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 10 N, N’-Nonane-1, 9-diyl-bis-quinolinium Dibromide (bQNB).; 1,9-Dibromononane (mmol) was added to a solution (30 mL) of dry quinoline, and the solution heated for 24 hours at 65 C. The resulting precipitate was filtered, and the product washed five times with dry diethyl ether. The resulting purple solid was isolated in a 92% yield. IH NMR (300 MHz, DMSO-D6) 6 9.68 (1H, d, C2-H), 9.34 (1H, d, C3-H), 8.67 (1H, d, C8-H), 8.55 (1H, d, C4-H), 8.27 (2H, m, C5&C7-H), 8.07 (1H, d, C6-H), 5.09 (2H, t, C’1-CH2), 1.95 (2H, m, C’2-CH2), 1.19-1. 45 (5H, m, C’3-5-CH2)

The synthetic route of 1,9-Dibromononane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION; WO2005/66129; (2005); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 4549-33-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4549-33-1, name is 1,9-Dibromononane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Intermediate 163.trans-4-[(9-bromononyl)(methyl)amino]cyclohexyl 9-methyl-9H-xanthene-9- carboxylate.318 mg (0.90 mmol) of intermediate 162 are dissolved in 12 ml THF. 0.728 ml (3.61 mmol) of 1 ,9-dibromononane and 0.19 ml (1.36 mmol) of triethylamine are added and the system is stirred at 50C for 24 hr. 0.19 additioinal ml of triethylamine are added and the stirring at 50C prosecuted overnight. After a new addition of 1 ,9- dibromononane (0.911 ml; 4.5 mmol) and 72 hr of stirring at 70C the solvents are eliminated, ethyl ether is added and the solids (triethylammonium hydrobromide) filtered. The filtrate is concentrated and purified via SP1 chromatography to give 220 mg (42% yield) of the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,9-Dibromononane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ALMIRALL, S.A.; PRAT QUINONES, Maria; FONQUERNA POU, Silvia; PUIG DURAN, Carlos; LUMERAS AMADOR, Wenceslao; AIGUADE BOSCH, Jose; CATURLA JAVALOYES, Juan Francisco; WO2011/141180; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary