454-65-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 454-65-9 as follows.
To a stirred solution of 3-BROMOPHENYLSULFONYL fluoride (D1) (1 g, 4.18 MMOL) in dry THF (20 ml) at-78 C, under argon was added phenylmagnesium bromide (1 M, 1.4 ML, 4.18 MMOL) dropwise. The reaction was left to warm to room temperature overnight and then quenched with ammonium chloride (50 ml), extracted with ethyl acetate (3 X 40 mi) and the combined organic extracts dried (NA2SO4). SOLVENTS WERE EVAPORATED IN VACUO to give A colourless solid (1.09 g, 88 %). 1H NMR (CDCl3) : No. 7.40 (1H, t), 7.50-7. 55 (2H, m), 7.60 (1H, d), 7.69 (1H, d), 7. 86 (1H, d), 7.93 (2H, d), 8. 08 (1H, s).
According to the analysis of related databases, 3-Bromobenzene-1-sulfonyl fluoride, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; WO2004/80986; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary