Design, synthesis and insecticidal activity of novel anthranilic diamides with benzyl sulfide scaffold was written by Chen, Yin-Bo;Li, Ji-Ling;Shao, Xu-Sheng;Xu, Xiao-Yong;Li, Zhong. And the article was included in Chinese Chemical Letters in 2013.Computed Properties of C8H4BrF3O3 This article mentions the following:
A series of novel anthranilic diamides with benzyl sulfide scaffold were synthesized, in which the N-pyridylpyrazole moiety generally regarded as key pharmacophore was abandoned. Preliminary bioassays indicated that half of the title compounds were endowed with good insecticidal activities against armyworm (Mythimna separata) at 500 mg/L. Exhilaratingly, one of the synthesized compounds was also active against Tetranychus cinnabarinus at 100 mg/L. The difference in activities between the target compounds was influenced by the substituents, which provided some hints for further investigation on structure modifications. In the experiment, the researchers used many compounds, for example, 3-Bromo-5-(trifluoromethoxy)benzoic acid (cas: 453565-90-7Computed Properties of C8H4BrF3O3).
3-Bromo-5-(trifluoromethoxy)benzoic acid (cas: 453565-90-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Computed Properties of C8H4BrF3O3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary