Category: 452-63-1

Baumgarth, Manfred published the artcileA concise and efficient synthesis of [2-methyl-5-methylsulfonyl-4-(pyrrol-1-yl)benzoyl]guanidinium methanesulfonate (eniporide), Computed Properties of 452-63-1, the main research area is eniporide preparation.

A new synthesis of the benzoylguanidine-type Na+/H+ antiporter inhibitor eniporide is described. Starting from 2-bromo-5-fluorotoluene, aromatic substituents were introduced by methanesulfonylation, Pd-catalyzed carboxylation with CO, and halogen-pyrrole exchange. Guanidine acylation was performed using Mukaiyama’s procedure.

European Journal of Organic Chemistry published new progress about eniporide preparation. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Computed Properties of 452-63-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ahemed, Jakeer published the artcileSynthesis of new Zn (II) complexes for photo decomposition of organic dye pollutants, industrial wastewater and photo-oxidation of methyl arenes under visible-light, COA of Formula: C7H6BrF, the main research area is zinc methyl arene ODP industrial wastewater photooxidation photodecomposition.

Synthesis of new Schiff′s base Zn-complexes for photo-oxidation of Me arenes and xylenes are reported under visible light irradiation conditions. All the synthesized new ligands and Zn-complexes are thoroughly characterized with various spectral analyses and confirmed as 1:1 ratio of Zn and ligand with distorted octahedral structure. The bandgap energies of the ligands are higher than its Zn-complexes. These synthesized new Zn(II) complexes are used for the photo-fragmentation of organic dye pollutants, photodegradation of food industrial wastewater and oxidation of Me arenes which are converted into its resp. aldehydes with moderate yields under visible light irradiation The photooxidation reaction dependency on the intensity of the visible light was also studied. With the increase in the dosage of photocatalyst, the Me groups are oxidized to get aldehydes and mono acid products, which are also identified from LC-MS data. Finally, [Zn(PPMHT)Cl] is with better efficiency than [Zn(PTHMT)Cl] and [Zn(MIMHPT)Cl] for oxidation of Me arenes is reported under visible-light-driven conditions.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about Band gap. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, COA of Formula: C7H6BrF.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bugday, Nesrin published the artcilePd-NHC complex catalyzed C-H bond activation reactions of caffeine and 2-isobutylthiazole, Quality Control of 452-63-1, the main research area is palladium NHC imidazolidinylidene benzimidazole caffeine complex preparation arylation catalyst; CH activation benzimidazole purine thiazole arylation palladium catalyst.

A series of new Pd-NHC complexes [(SI-Ar)PdCl2(1-BuBIm)] (4a-c, SI-Ar = 1,3-diaryl-2-imidazolidinylidene, Ar = 2,6-Me2C6H3, 2,4,6-Me3C6H2, 2,6-iPr2C6H3; 1-BuBIm = 1-butyl-5,6-dimethylbenzimidazole-κN3), [(SI-Xyl)PdCl2(Caf)] (5a, Caf = caffeine-κN7), [(SI-Mes)PdCl2(2-HOCHMeBIm)] (5b) were synthesized, characterized, and utilized as catalysts on 8-(hetero)arylation of xanthines and C-5 (hetero)arylation of 2-isobutylthiazole. All the synthesized derivatives were characterized by NMR, Q-TOF-LC/MS, FTIR, and X-ray anal. In addition, DFT calculations and computational NBO studies for Pd-NHC complexes were examined, and HOMO and LUMO energy levels and electron d. of each Pd-NHC complex were defined. Complexes 4a-c and 5a-b showed good catalytic activity in C-H bond activation reactions. DFT studies have also been conducted to examine the reaction mechanism following the CMD pathway. Complex 5a was chosen as a representative catalyst for the reaction of unsubstituted Ph with caffeine and 2-isobutylthiazole. Although the ΔE values of the complexes are so close, slight difference in the catalytic activity were observed for 4a-c and 5a-b. Since this low ΔE value facilitates the oxidative addition reaction of (hetero)aryl bromides, thanks to this catalytic system, new 8-(hetero)aryl xanthines and 5-(hetero)aryl thiazole derivatives could be synthesized with high yields and low catalyst loading.

Molecular Catalysis published new progress about Arylation. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Quality Control of 452-63-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Jingtao published the artcileEnhanced grain growth in an Al-Mg alloy with ultrafine grain size, Product Details of C7H6BrF, the main research area is aluminum magnesium alloy annealing grain growth.

A submicrometer-grained (SMG) microstructure, with an average grain size of ∼0.2 μm, was introduced into an Al-3% Mg solid solution alloy by equal-enhanced angular pressing. The SMG structure was heterogeneous with regions of equiaxed elongated grains and with grain boundaries in a non-equilibrium configuration. Samples were annealed for various times at a temperature of 473 K and then examined using transmission electron microscopy. The results show that the grain boundaries evolve with time into an equilibrium condition and some limited grain occurs primarily in the grains where recovery has taken place. The results establish that the SMG structure is reasonably stable in the Al-3% Mg alloy at a temperature of 473 K.

Materials Science & Engineering, A: Structural Materials: Properties, Microstructure and Processing published new progress about Annealing. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Product Details of C7H6BrF.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Singh, I. D. published the artcileInfrared studies of 3-fluoro-6-bromotoluene and 4-fluoro-3-bromotoluene, Synthetic Route of 452-63-1, the main research area is IR bromofluorotoluene; toluene bromo fluoro IR.

The IR absorption spectra of 3-fluoro-6-bromotoluene and 4-fluoro-3-bromotoluene in the form of thin films were investigated in the frequency range 200-4000 cm-1. Modes of vibrations were assigned to different observed vibrational frequencies in each case. Me group vibrations are discussed.

Acta Ciencia Indica, Physics published new progress about IR spectra. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Synthetic Route of 452-63-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xiang, Feifei published the artcilePlanar π-extended cycloparaphenylenes featuring an all-armchair edge topology, Recommanded Product: 1-Bromo-4-fluoro-2-methylbenzene, the main research area is armchair edge topol planar cycloparaphenylene.

The [n]cycloparaphenylenes ([n]CPPs)-npara-linked phenylenes that form a closed-loop-have attracted substantial attention due to their unique cyclic structure and highly effective para-conjugation leading to a myriad of fascinating electronic and optoelectronic properties. However, their strained topol. prevents the π-extension of CPPs to convert them either into armchair nanobelts or planarized CPP macrocycles. Here we successfully tackle this long-standing challenge and present the bottom-up synthesis and characterization of atomically precise in-plane π-extended [12]CPP on Au(111) by low-temperature scanning probe microscopy and spectroscopy combined with d. functional theory. The planar π-extended CPP is a nanographene with an all-armchair edge topol. The exclusive para-conjugation at the periphery yields delocalized electronic states and the planarization maximizes the overlap of p orbitals, which both reduce the bandgap compared to conventional CPPs. Calculations predict ring currents and global aromaticity in the doubly charged system. The intriguing planar ring topol. and unique electronic properties make planar π-extended CPPs promising quantum materials. [graphic not available: see fulltext]

Nature Chemistry published new progress about Adsorption. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Recommanded Product: 1-Bromo-4-fluoro-2-methylbenzene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Masillamani, Appan Merari published the artcileMultiscale Charge Injection and Transport Properties in Self-Assembled Monolayers of Biphenyl Thiols with Varying Torsion Angles, Application of 1-Bromo-4-fluoro-2-methylbenzene, the main research area is multiscale charge transport self assembled biphenyl thiol.

This article describes the mol. structure-function relation for biphenylthiol derivatives with varying torsional degree of freedom in their mol. backbone when self-assembled on gold electrodes. These biphenylthiol mols. chemisorbed on Au exhibit different tilt angles with respect to the surface normal and different packing densities. The charge transport through the biphenylthiol self-assembled monolayers (SAMs) showed a characteristic decay trend with the effective monolayer thickness. Based on parallel pathways model the tunneling decay factor β is 0.27 Å-1. The hole mobility of poly(3-hexylthiophene)-based thin-film transistors incorporating a biphenylthiol SAM coating the Au source and drain electrodes revealed a dependence on the injection barrier with the HOMO level of the semiconductor. The possible role of the resistivity of the SAMs on transistor electrodes on the threshold voltage shift is discussed. The control over the chem. structure, electronic properties, and packing order of the SAMs provides a versatile platform to regulate the charge injection in organic electronic devices.

Chemistry – A European Journal published new progress about Chemisorption. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Application of 1-Bromo-4-fluoro-2-methylbenzene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xiong, Rui published the artcileNovel Selective Estrogen Receptor Downregulators (SERDs) Developed against Treatment-Resistant Breast Cancer, Category: bromides-buliding-blocks, the main research area is estrogen receptor downregulator SERD antitumor breast cancer.

Resistance to the selective estrogen receptor modulator (SERM) tamoxifen and to aromatase inhibitors that lower circulating estradiol occurs in up to 50% of patients, generally leading to an endocrine-independent ER+ phenotype. Selective ER downregulators (SERDs) are able to ablate ER and thus theor. to prevent survival of both endocrine-dependent and independent ER+ tumors. The clin. SERD, fulvestrant, is hampered by i.m. administration and undesirable pharmacokinetics. Novel SERDs were designed using the 6-OH-benzothiophene (BT) scaffold common to arzoxifene and raloxifene. Treatment-resistant (TR) ER+ cell lines (MCF-7:5C and MCF-7:TAM1) were used for optimization, followed by validation in the parent endocrine-dependent cell line (MCF-7:WS8), in 2D and 3D cultures, using ERα in-cell westerns, ERE-luciferase, and cell viability assays, with GDC-0810 (ARN-810) used for comparison. Two BT SERDs with superior in vitro activity to GDC-0810 were studied for bioavailability and shown to cause regression of a TR, endocrine-independent ER+ xenograft superior to GDC-0810.

Journal of Medicinal Chemistry published new progress about Antiestrogens. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bugday, Nesrin published the artcilePalladium nanoparticle supported on nitrogen-doped porous carbon: Investigation of structural properties and catalytic activity on Suzuki-Miyaura reactions, Computed Properties of 452-63-1, the main research area is nitrogen doped porous carbon supported palladium nanoparticle preparation; phenylboronic acid halobenzene palladium catalyst Suzuki Miyaura coupling green; biphenyl preparation.

Novel palladium-doped nanoporous carbon composite material obtained via thermolysis of amorphous zeolitic imidazolate framework (aZIF) was synthesized and used as an efficient catalyst on Suzuki-Miyaura cross-coupling reactions of aryl bromides. With this developed catalytic system, the Suzuki-Miyaura cross-coupling reaction was accomplished in aqueous solutions, and biaryls were obtained in good to excellent yields in a short reaction time. The APC-750@Pd catalyst was characterized by Fourier Transform IR spectroscopy (FTIR), X-ray Diffraction (XRD), Scanning Electron Eicroscopy (SEM), XPS, Transmission Electron Microscopy (TEM), Thermal Gravimetric Anal. (TGA), DTA (DTA), Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and Brunauer-Emmett-Teller (BET) anal. tecniques. N-doped porous carbon material (NPC-1000) was synthesized by thermolysis from aZIF. Activated porous carbon material (APC-750) was fabricated via fused at 750°C with KOH from NPC-1000. The APC-750@Pd was obtained as a result of the interaction of APC-750 and PdCl2 in deionized water. The cross-coupling reaction of different aryl bromides with phenylboronic acid was investigated to show the potential of the APC-750@Pd in the Suzuki-Miyaura cross-coupling reactions. The APC-750@Pd catalyst could be recycled at least five times with a 15% loss of catalytic efficiency in this catalytic system.

Applied Organometallic Chemistry published new progress about Binding energy. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Computed Properties of 452-63-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Carson, J. R. published the artcile2-Ethynylbenzenealkanamines. A new class of calcium entry blockers, Recommanded Product: 1-Bromo-4-fluoro-2-methylbenzene, the main research area is acetylenic benzenealkanamine calcium blocker; amine araliph calcium blocker; araliph amine antihypertensive vasodilator.

A series of 2-[aryl(alkyl)ethynyl]benzenealkanamines was synthesized. The compounds exhibit antihypertensive activity in spontaneously hypertensive rats and coronary vasodilator activity with minimal neg. inotropic activity in the Langendorff guinea pig heart in vitro. They exert their activity by inhibition of Ca2+ influx across cell membranes. Optimal activity is found among the N-(arylethyl)-5-methoxy-α-methyl-2-(phenylethynyl)benzeneethanamines and -propanamines, e.g., I.

Journal of Medicinal Chemistry published new progress about Angina pectoris. 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Recommanded Product: 1-Bromo-4-fluoro-2-methylbenzene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary