Category: 452-62-0

Fuchs, Evelyn et al. published their research in Chemistry – A European Journal in 2006 | CAS: 452-62-0

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Category: bromides-buliding-blocks

Phosphabarrelenes as ligands in rhodium-catalyzed hydroformylation of internal alkenes essentially free of alkene isomerization was written by Fuchs, Evelyn;Keller, Manfred;Breit, Bernhard. And the article was included in Chemistry – A European Journal in 2006.Category: bromides-buliding-blocks This article mentions the following:

Despite significant research efforts in the past, one of the remaining problems to be solved in industrially important hydroformylation is the chemoselective low-pressure hydroformylation of internal alkenes. The authors prepare a new class of phosphabarrelenes (I, R = Ph (26%, 4a), i-Pr (35%, 4b), 2,4-xylyl (47%, 4c)) by Diels Alder reactions of benzyne with phosphabenzenes. Studies of the coordination properties of I, as well as results obtained in the Rh-catalyzed hydroformylation of cyclic and acyclic internal alkenes are reported. The rhodium/phosphabarrelene catalyst displays a very high activity towards hydroformylation with an unusually low tendency towards alkene isomerization. E.g., phosphabarrelene rhodium-catalyzed hydroformylation (4c/[Rh(CO)2acac], acac = acetylacetonate) of N-Boc-pyrroline gives exclusively the pyrroline 3-carboxaldehyde. The mol. structures of 4a and two phosphabarrelene rhodium complexes are determined by x-ray crystallog. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Category: bromides-buliding-blocks).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Anderson, Paul S. et al. published their research in Journal of Organic Chemistry in 1979 | CAS: 452-62-0

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Reference of 452-62-0

Synthesis of 9,10-dihydroanthracen-9,10-imines was written by Anderson, Paul S.;Christy, Marcia E.;Colton, C. Dylion;Halczenko, Wasyl;Ponticello, Gerald S.;Shepard, Kenneth L.. And the article was included in Journal of Organic Chemistry in 1979.Reference of 452-62-0 This article mentions the following:

The cycloaddition of benzynes with isoindoles to generate the 9,10-dihydroanthracen-9,10-imine system (I) was examined in detail. A versatile synthesis of these ring-strained heterocycles based on a detailed anal. of the 2,3-dihydro-1H-isoindol-1-one (phthalimidine) approach to the prerequisite isoindoles is presented. A variety of synthetic methods to phthalimidines were evaluated and developed including: reductive amination of o-acylbenzoic acids; amidoalkylation of benzoic acids; halogenation and amination of o-alkylbenzoic acids; and reduction of phthalimides. In addition, generation of benzynes from chlorobenzenes and Li tetramethylpiperidide greatly increase the scope of the Diels-Alder reaction to form the desired products. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Reference of 452-62-0).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Reference of 452-62-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Appler, Hubertus et al. published their research in Journal of Organometallic Chemistry in 1985 | CAS: 452-62-0

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Product Details of 452-62-0

Chemistry of heavy carbene analogs R2M, M = Si, Ge, Sn. IX. Properties and thermolysis of new 7-silabicyclo[2.2.1]heptadienes was written by Appler, Hubertus;Gross, Lutz W.;Mayer, Bernd;Neumann, Wilhelm P.. And the article was included in Journal of Organometallic Chemistry in 1985.Product Details of 452-62-0 This article mentions the following:

Factors governing the ease and mechanism of 7-silabicyclo[2.2.1]heptadienes thermolysis in order to generate free silylenes and the corresponding benzene derivatives are investigated. For this purpose, 29 new compounds, I–IV (R1 = Cl, Me, p-tolyl; R2 = Cl, Me, Ph, p-tolyl, R3, R4 = H, Me, Ph; R5 = H, CO2Me; R6, R7, R8, R9 = H, Me; R6 = R9 = H; R7R8 = benzo), have been prepared No indications for a polar mechanism or an intermediate biradical could be found. The degradation is 1st order in all cases investigated, and is enhanced by Ph groups at the bridgehead C atoms, if a conformation coplanar with the basic ring is allowed by the neighboring substituents, but is not enhanced by Ph groups at the Si. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Product Details of 452-62-0).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Product Details of 452-62-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shi, Jun et al. published their research in Journal of Medicinal Chemistry in 2018 | CAS: 452-62-0

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Electric Literature of C7H6BrF

Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists was written by Shi, Jun;Gu, Zhengxiang;Jurica, Elizabeth Anne;Wu, Ximao;Haque, Lauren E.;Williams, Kristin N.;Hernandez, Andres S.;Hong, Zhenqiu;Gao, Qi;Dabros, Marta;Davulcu, Akin H.;Mathur, Arvind;Rampulla, Richard A.;Gupta, Arun Kumar;Jayaram, Ramya;Apedo, Atsu;Moore, Douglas B.;Liu, Heng;Kunselman, Lori K.;Brady, Edward J.;Wilkes, Jason J.;Zinker, Bradley A.;Cai, Hong;Shu, Yue-Zhong;Sun, Qin;Dierks, Elizabeth A.;Foster, Kimberly A.;Xu, Carrie;Wang, Tao;Panemangalore, Reshma;Cvijic, Mary Ellen;Xie, Chunshan;Cao, Gary G.;Zhou, Min;Krupinski, John;Whaley, Jean M.;Robl, Jeffrey A.;Ewing, William R.;Ellsworth, Bruce Alan. And the article was included in Journal of Medicinal Chemistry in 2018.Electric Literature of C7H6BrF This article mentions the following:

G protein-coupled receptor 40 (GPR40) has become an attractive target for the treatment of diabetes since it was shown clin. to promote glucose-stimulated insulin secretion. Herein, we report our efforts to develop highly selective and potent GPR40 agonists with a dual mechanism of action, promoting both glucose-dependent insulin and incretin secretion. Employing strategies to increase polarity and the ratio of sp3/sp2 character of the chemotype, we identified BMS-986118 (compound I), which showed potent and selective GPR40 agonist activity in vitro. In vivo, compound I demonstrated insulinotropic efficacy and GLP-1 secretory effects resulting in improved glucose control in acute animal models. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Electric Literature of C7H6BrF).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Electric Literature of C7H6BrF

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Anchan, Kavitha et al. published their research in Synthetic Communications in 2020 | CAS: 452-62-0

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of 3-Bromo-4-fluorotoluene

One-pot synthesis of substituted dibenzoxazepinones and pyridobenzoxazepinones using octacarbonyldicobalt as an effective CO source was written by Anchan, Kavitha;Baburajan, Poongavanam;Puttappa, Nagaswarupa H.;Kumar Sarkar, Sujit. And the article was included in Synthetic Communications in 2020.Quality Control of 3-Bromo-4-fluorotoluene This article mentions the following:

A facile one-pot protocol for the synthesis of substituted dibenzoxazepinones I (R = H, 2-F, 2-Me, 3-OMe; R1 = H, 7-Me, 8-Cl, 9-Me, etc.) and pyridobenzoxazepinones II (R2 = H, 3-Me, 2-Me; R3 = H, 8,9-Cl2, 9-Me, 8-Cl, 9-Cl) from com. available aryl/heteroaryl halides 2-X-R4C6H3X1 (R4 = H, 4-F, 4-Me, 4-OMe; X = F, Cl; X1 = I, Br)/III (X2 = F, Cl; R5 = H, 5-Me, 6-Me) and amino phenols 2-NH-3-R6-4-R7-5-R8C6HOH (R6 = H, Me; R7 = H, Cl, ; R8 = H, Cl, Me) using octacarbonyldicobalt (Co2(CO)8) as an effective metal carbonyl source has been demonstrated. This method proceeds via the sequential coupling of aryl/heteroaryl halides with aminophenol by amidation and intramol. cyclization to give dibenzoxazepinones I/pyridobenzoxazepinones II. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Quality Control of 3-Bromo-4-fluorotoluene).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of 3-Bromo-4-fluorotoluene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Farina, Carlo et al. published their research in Bioorganic & Medicinal Chemistry in 2008 | CAS: 452-62-0

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: 3-Bromo-4-fluorotoluene

Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain was written by Farina, Carlo;Gagliardi, Stefania;Ghelardini, Carla;Martinelli, Marisa;Norcini, Monica;Parini, Carlo;Petrillo, Paola;Ronzoni, Silvano. And the article was included in Bioorganic & Medicinal Chemistry in 2008.Recommanded Product: 3-Bromo-4-fluorotoluene This article mentions the following:

Chem. modifications of dimiracetam (I), a bicyclic analog of the nootropic drug piracetam, afforded a small set of novel derivatives that were investigated in in vivo models of neuropathic pain. Compounds 5, 7 and 8 displayed a very promising antihyperalgesic profile in rat models of neuropathic pain induced by both chronic constriction injury of the sciatic nerve and streptozotocin. The compounds completely reverted the reduction of pain threshold evaluated by the paw pressure test. Importantly these derivatives did not induce any behavioral impairment as evaluated by the rotarod test. These results suggest that compounds 5, 7 and 8 might represent novel and well-tolerated therapeutic agents for the relief of neuropathic pain. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Recommanded Product: 3-Bromo-4-fluorotoluene).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: 3-Bromo-4-fluorotoluene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 452-62-0

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 452-62-0.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 452-62-0, name is 3-Bromo-4-fluorotoluene, This compound has unique chemical properties. The synthetic route is as follows., Formula: C7H6BrF

EXAMPLE 3 4-Methyl-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene Hydrochloride The title compound was prepared by the methods described in Examples 1 and 2 starting with 2-fluoro-5-methylbromobenzene. (data for free base) 1H NMR (400 MHz, CDCl3) delta 7.04 (d, J=7.5 Hz, 1H), 6.99 (s, 1H), 6.98 (d, J=7.5 Hz, 1H), 2.98-2.90 (m, 4H), 2.63 (m, 2H), 2.35 (m, 1H), 2.32 (s, 3H), 1.87 (d, J=11.5 Hz, 1H). APCI MS m/e 174.2 [(M+1)+]. (HCl salt) M.p. 254-255 C. Anal. Calcd. for C12H12F3N.HCl.1/3H2O: C, 53.44; H, 5.11; N. 5.19. Found C, 53.73; H, 4.82; N, 5.15.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 452-62-0.

Reference:
Patent; Pfizer Inc; US6605610; (2003); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

Analyzing the synthesis route of 452-62-0

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 452-62-0, name is 3-Bromo-4-fluorotoluene, A new synthetic method of this compound is introduced below., SDS of cas: 452-62-0

14a. (2-Fluoro-5methylphenyl)(6-(4-methylthiophenyl)(2H-benzo(d)1,3-dioxolen-5-yl))methan-1-ol To a solution of 3-bromo-4-fluorotoluene (0.7 mL, 5 mmol) in anhydrous THF (25 mL) at -78 C. under nitrogen atmosphere, a solution of t-BuLi in pentane (5.9 mL, 10 mmol) was added and the mixture stirred for 15 minutes. (color change observed). To this reaction mixture the product of Example 1b (1.34 g, 5 mmol), dissolved in anhydrous THF (20 mL), was added drop-wise and stirred at -78 C. for 15 minutes, then slowly allowed to warm to room temperature and stirred for 3 hours at room temperature. The reaction was then quenched with saturated aqueous ammonium chloride and the organic layer was separated. The organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and the filtrate was evaported under reduced pressure. Purification by flash column chromatography using 5% ethyl acetate in hexanes as the eluant gave the title compound as a white solid, (1.42 g, 74% yield), mp 110 C. 1H NMR (CDCl3, 300 MHz) delta 7.26-7.18 (m, 5H), 7.01-6.98 (m, 1H), 6.87 (s, 1H), 6.82-6.76 (s, 1H), 6.69 (s, 1H), 5.97 (s, 1H), 5.95 (s, 2H), 2.50 (s, 3H), 2.31 (s, 3H), 2.10 (s, 1H). 13C NMR (CDCl3, 75.45 MHz) delta 159.5, 156.3, 147.1, 146.8, 137.4, 137.3, 135.0, 133.4, 133.4, 130.2, 129.8, 129.3, 129.2, 128.0, 127.9, 126.2, 115.0, 114.8, 110.0, 107.5, 101.2, 67.2, 20.8, 15.8. LRMS (APIMS) m/z 782 (2M+NH4)+, 365 (M-OH)+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Khanapure, Subhash P.; Garvey, David S.; Earl, Richard A.; Ezawa, Maiko; Fang, Xinqin; Gaston, Ricky D.; US2002/119977; (2002); A1;,
Bromide – Wikipedia,
bromide – Wiktionary