Category: 452-62-0

Non-steroidal aromatase inhibitors based on a biphenyl scaffold: synthesis, in vitro SAR, and molecular modelling was written by Jackson, Toby;Woo, L. W. Lawrence;Trusselle, Melanie N.;Purohit, Atul;Reed, Michael J.;Potter, Barry V. L.. And the article was included in ChemMedChem in 2008.Electric Literature of C7H6BrF This article mentions the following:

The synthesis and in vitro biol. evaluation (JEG-3 cells) of a series of novel and potent aromatase inhibitors, prepared by microwave-enhanced Suzuki cross-coupling methodol., are reported. These compounds possess a biphenyl template incorporated with the haem-ligating triazolylmethyl moiety, either on its own or in combination with other substituent(s) at various positions on the Ph rings. The most potent aromatase inhibitor reported herein has an IC₅₀ value of 0.12 nM, although seven of its congeners are also highly potent (IC₅₀ 闂?0.5 nM). They all bear the (5-triazolylmethyl-2-cyano)biphenyl structural motif. Docking of representative compounds into a homol. model of human aromatase assists in the rationalisation of the SAR derived from the in vitro biol. results and supports a crucial role for a cyano group on the “A” Ph ring, which is accessible to hydrogen bond interactions with Ser478. Further development of these compounds as potential therapeutic agents for the treatment of hormone-dependent breast cancer is warranted given the high level of potency observed for this class of aromatase inhibitor in vitro. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Electric Literature of C7H6BrF).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon闁艰京鐗梤omine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Electric Literature of C7H6BrF

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of 4-fluoro-3-phenoxytoluene was written by Zhao, Wen-xian;Wang, De-kun;Zhou, Yan-li. And the article was included in Jingxi Huagong in 2004.Application of 452-62-0 This article mentions the following:

4-Fluoro-3-phenoxytoluene (I) was synthesized by Ullmann coupling reaction of 3-bromo-4-fluorotoluene (II) and phenol. When the molar ratio of PhONa to II was 3:1 with 15% (mol) of CuO as catalyst and DMA as solvent, the reaction ran at 160 閳?165 鎺矯 for 5 h to give I in 88% yield. The structure of I was confirmed by elementary anal., ¹HNMR, IR, and MS. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Application of 452-62-0).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application of 452-62-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Phosphabarrelenes as ligands in rhodium-catalyzed hydroformylation of internal alkenes essentially free of alkene isomerization was written by Fuchs, Evelyn;Keller, Manfred;Breit, Bernhard. And the article was included in Chemistry – A European Journal in 2006.Category: bromides-buliding-blocks This article mentions the following:

Despite significant research efforts in the past, one of the remaining problems to be solved in industrially important hydroformylation is the chemoselective low-pressure hydroformylation of internal alkenes. The authors prepare a new class of phosphabarrelenes (I, R = Ph (26%, 4a), i-Pr (35%, 4b), 2,4-xylyl (47%, 4c)) by Diels Alder reactions of benzyne with phosphabenzenes. Studies of the coordination properties of I, as well as results obtained in the Rh-catalyzed hydroformylation of cyclic and acyclic internal alkenes are reported. The rhodium/phosphabarrelene catalyst displays a very high activity towards hydroformylation with an unusually low tendency towards alkene isomerization. E.g., phosphabarrelene rhodium-catalyzed hydroformylation (4c/[Rh(CO)₂acac], acac = acetylacetonate) of N-Boc-pyrroline gives exclusively the pyrroline 3-carboxaldehyde. The mol. structures of 4a and two phosphabarrelene rhodium complexes are determined by x-ray crystallog. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Category: bromides-buliding-blocks).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of 9,10-dihydroanthracen-9,10-imines was written by Anderson, Paul S.;Christy, Marcia E.;Colton, C. Dylion;Halczenko, Wasyl;Ponticello, Gerald S.;Shepard, Kenneth L.. And the article was included in Journal of Organic Chemistry in 1979.Reference of 452-62-0 This article mentions the following:

The cycloaddition of benzynes with isoindoles to generate the 9,10-dihydroanthracen-9,10-imine system (I) was examined in detail. A versatile synthesis of these ring-strained heterocycles based on a detailed anal. of the 2,3-dihydro-1H-isoindol-1-one (phthalimidine) approach to the prerequisite isoindoles is presented. A variety of synthetic methods to phthalimidines were evaluated and developed including: reductive amination of o-acylbenzoic acids; amidoalkylation of benzoic acids; halogenation and amination of o-alkylbenzoic acids; and reduction of phthalimides. In addition, generation of benzynes from chlorobenzenes and Li tetramethylpiperidide greatly increase the scope of the Diels-Alder reaction to form the desired products. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Reference of 452-62-0).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Reference of 452-62-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chemistry of heavy carbene analogs R₂M, M = Si, Ge, Sn. IX. Properties and thermolysis of new 7-silabicyclo[2.2.1]heptadienes was written by Appler, Hubertus;Gross, Lutz W.;Mayer, Bernd;Neumann, Wilhelm P.. And the article was included in Journal of Organometallic Chemistry in 1985.Product Details of 452-62-0 This article mentions the following:

Factors governing the ease and mechanism of 7-silabicyclo[2.2.1]heptadienes thermolysis in order to generate free silylenes and the corresponding benzene derivatives are investigated. For this purpose, 29 new compounds, I–IV (R¹ = Cl, Me, p-tolyl; R² = Cl, Me, Ph, p-tolyl, R³, R⁴ = H, Me, Ph; R⁵ = H, CO₂Me; R⁶, R⁷, R⁸, R⁹ = H, Me; R⁶ = R⁹ = H; R⁷R⁸ = benzo), have been prepared No indications for a polar mechanism or an intermediate biradical could be found. The degradation is 1st order in all cases investigated, and is enhanced by Ph groups at the bridgehead C atoms, if a conformation coplanar with the basic ring is allowed by the neighboring substituents, but is not enhanced by Ph groups at the Si. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Product Details of 452-62-0).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Product Details of 452-62-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists was written by Shi, Jun;Gu, Zhengxiang;Jurica, Elizabeth Anne;Wu, Ximao;Haque, Lauren E.;Williams, Kristin N.;Hernandez, Andres S.;Hong, Zhenqiu;Gao, Qi;Dabros, Marta;Davulcu, Akin H.;Mathur, Arvind;Rampulla, Richard A.;Gupta, Arun Kumar;Jayaram, Ramya;Apedo, Atsu;Moore, Douglas B.;Liu, Heng;Kunselman, Lori K.;Brady, Edward J.;Wilkes, Jason J.;Zinker, Bradley A.;Cai, Hong;Shu, Yue-Zhong;Sun, Qin;Dierks, Elizabeth A.;Foster, Kimberly A.;Xu, Carrie;Wang, Tao;Panemangalore, Reshma;Cvijic, Mary Ellen;Xie, Chunshan;Cao, Gary G.;Zhou, Min;Krupinski, John;Whaley, Jean M.;Robl, Jeffrey A.;Ewing, William R.;Ellsworth, Bruce Alan. And the article was included in Journal of Medicinal Chemistry in 2018.Electric Literature of C7H6BrF This article mentions the following:

G protein-coupled receptor 40 (GPR40) has become an attractive target for the treatment of diabetes since it was shown clin. to promote glucose-stimulated insulin secretion. Herein, we report our efforts to develop highly selective and potent GPR40 agonists with a dual mechanism of action, promoting both glucose-dependent insulin and incretin secretion. Employing strategies to increase polarity and the ratio of sp³/sp² character of the chemotype, we identified BMS-986118 (compound I), which showed potent and selective GPR40 agonist activity in vitro. In vivo, compound I demonstrated insulinotropic efficacy and GLP-1 secretory effects resulting in improved glucose control in acute animal models. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Electric Literature of C7H6BrF).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Electric Literature of C7H6BrF

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One-pot synthesis of substituted dibenzoxazepinones and pyridobenzoxazepinones using octacarbonyldicobalt as an effective CO source was written by Anchan, Kavitha;Baburajan, Poongavanam;Puttappa, Nagaswarupa H.;Kumar Sarkar, Sujit. And the article was included in Synthetic Communications in 2020.Quality Control of 3-Bromo-4-fluorotoluene This article mentions the following:

A facile one-pot protocol for the synthesis of substituted dibenzoxazepinones I (R = H, 2-F, 2-Me, 3-OMe; R¹ = H, 7-Me, 8-Cl, 9-Me, etc.) and pyridobenzoxazepinones II (R² = H, 3-Me, 2-Me; R³ = H, 8,9-Cl₂, 9-Me, 8-Cl, 9-Cl) from com. available aryl/heteroaryl halides 2-X-R⁴C₆H₃X¹ (R⁴ = H, 4-F, 4-Me, 4-OMe; X = F, Cl; X¹ = I, Br)/III (X² = F, Cl; R⁵ = H, 5-Me, 6-Me) and amino phenols 2-NH-3-R⁶-4-R⁷-5-R⁸C₆HOH (R⁶ = H, Me; R⁷ = H, Cl, ; R⁸ = H, Cl, Me) using octacarbonyldicobalt (Co₂(CO)₈) as an effective metal carbonyl source has been demonstrated. This method proceeds via the sequential coupling of aryl/heteroaryl halides with aminophenol by amidation and intramol. cyclization to give dibenzoxazepinones I/pyridobenzoxazepinones II. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Quality Control of 3-Bromo-4-fluorotoluene).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of 3-Bromo-4-fluorotoluene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain was written by Farina, Carlo;Gagliardi, Stefania;Ghelardini, Carla;Martinelli, Marisa;Norcini, Monica;Parini, Carlo;Petrillo, Paola;Ronzoni, Silvano. And the article was included in Bioorganic & Medicinal Chemistry in 2008.Recommanded Product: 3-Bromo-4-fluorotoluene This article mentions the following:

Chem. modifications of dimiracetam (I), a bicyclic analog of the nootropic drug piracetam, afforded a small set of novel derivatives that were investigated in in vivo models of neuropathic pain. Compounds 5, 7 and 8 displayed a very promising antihyperalgesic profile in rat models of neuropathic pain induced by both chronic constriction injury of the sciatic nerve and streptozotocin. The compounds completely reverted the reduction of pain threshold evaluated by the paw pressure test. Importantly these derivatives did not induce any behavioral impairment as evaluated by the rotarod test. These results suggest that compounds 5, 7 and 8 might represent novel and well-tolerated therapeutic agents for the relief of neuropathic pain. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Recommanded Product: 3-Bromo-4-fluorotoluene).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: 3-Bromo-4-fluorotoluene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Non-steroidal aromatase inhibitors based on a biphenyl scaffold: synthesis, in vitro SAR, and molecular modelling was written by Jackson, Toby;Woo, L. W. Lawrence;Trusselle, Melanie N.;Purohit, Atul;Reed, Michael J.;Potter, Barry V. L.. And the article was included in ChemMedChem in 2008.Electric Literature of C7H6BrF This article mentions the following:

The synthesis and in vitro biol. evaluation (JEG-3 cells) of a series of novel and potent aromatase inhibitors, prepared by microwave-enhanced Suzuki cross-coupling methodol., are reported. These compounds possess a biphenyl template incorporated with the haem-ligating triazolylmethyl moiety, either on its own or in combination with other substituent(s) at various positions on the Ph rings. The most potent aromatase inhibitor reported herein has an IC₅₀ value of 0.12 nM, although seven of its congeners are also highly potent (IC₅₀ 閳?0.5 nM). They all bear the (5-triazolylmethyl-2-cyano)biphenyl structural motif. Docking of representative compounds into a homol. model of human aromatase assists in the rationalisation of the SAR derived from the in vitro biol. results and supports a crucial role for a cyano group on the “A” Ph ring, which is accessible to hydrogen bond interactions with Ser478. Further development of these compounds as potential therapeutic agents for the treatment of hormone-dependent breast cancer is warranted given the high level of potency observed for this class of aromatase inhibitor in vitro. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Electric Literature of C7H6BrF).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Electric Literature of C7H6BrF

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of 4-fluoro-3-phenoxytoluene was written by Zhao, Wen-xian;Wang, De-kun;Zhou, Yan-li. And the article was included in Jingxi Huagong in 2004.Application of 452-62-0 This article mentions the following:

4-Fluoro-3-phenoxytoluene (I) was synthesized by Ullmann coupling reaction of 3-bromo-4-fluorotoluene (II) and phenol. When the molar ratio of PhONa to II was 3:1 with 15% (mol) of CuO as catalyst and DMA as solvent, the reaction ran at 160 ∼ 165 °C for 5 h to give I in 88% yield. The structure of I was confirmed by elementary anal., ¹HNMR, IR, and MS. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Application of 452-62-0).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application of 452-62-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary