Category: 4457-67-4

Allylboronates from Vinyl Triflates and 浼?Chloroboronates by Reductive Nickel Catalysis was written by Qiao, Jin-Bao;Zhao, Zhen-Zhen;Zhang, Ya-Qian;Yin, Kai;Tian, Zhi-Xiong;Shu, Xing-Zhong. And the article was included in Organic Letters in 2020.Related Products of 4457-67-4 This article mentions the following:

Allylboronates are unique building blocks widely used in organic synthesis, but the construction of cyclic allylboranates remains a challenging subject. The authors demonstrate here a mild and efficient access to this type of compound through the cross-electrophile coupling of vinyl triflates and 浼?chloroboronates. The reaction proceeded with a good substrate scope and good functional group compatibility. The ready availability of vinyl triflates from ketones, as well as the rich chem. of allylboranates, makes the authors’ method suitable for the divergent modification of biol. active compounds Preliminary mechanistic studies revealed that 浼?chloroboronates were activated via a radical process. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Related Products of 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Related Products of 4457-67-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-catalyzed reductive coupling of homoenolates and their higher homologues with unactivated alkyl bromides was written by Lin, Tingzhi;Gu, Yuanyun;Qian, Pengcheng;Guan, Haixing;Walsh, Patrick J.;Mao, Jianyou. And the article was included in Nature Communications in 2020.Product Details of 4457-67-4 This article mentions the following:

A nickel-catalyzed generation of homoenolates, and their higher homologues, via decarbonylation of readily available cyclic anhydrides was developed. The utility of nickel-bound homoenolates and their higher homologues was demonstrated by cross-coupling with unactivated alkyl bromides, generated a diverse array of aliphatic acids. A broad range of functional groups was tolerated. Preliminary mechanistic studies demonstrated that the oxidative addition of anhydrides by the catalyst was faster than oxidative addition of alkyl bromides. The nickel bound metallocycles were involved in this transformation. The catalyst undergoes a single electron transfer (SET) process with the alkyl bromide. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Product Details of 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Product Details of 4457-67-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Base strengths of (锠?methoxyalkyl)triphenyl- and (锠?methoxyalkyl)diphenylmethylsilanes was written by Bellama, Jon M.;Harmon, Linda A.. And the article was included in Inorganic Chemistry in 1978.Quality Control of 1-Bromo-4-methoxybutane This article mentions the following:

The basicity of MeO(CH₂)_nSiPh₃ (I) and of MeO(CH₂)_nSiMePh₂ (II), determined from the difference between their IR in Et₂O or MeOH-CCl₄, is n = 1 << n = 2 > n = 3. A combination of inductive, steric, hyperconjugative, and conjugative effects is responsible for this basicity order. The mass spectral fragmentation of I and II involved rearrangements of the O atom to Si. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Quality Control of 1-Bromo-4-methoxybutane).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Quality Control of 1-Bromo-4-methoxybutane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Iron catalysis of Grignard reductions. Mechanism of 1,3-reductive eliminations from 绾?propyl halides was written by Rollick, K. L.;Nugent, W. A.;Kochi, J. K.. And the article was included in Journal of Organometallic Chemistry in 1982.Synthetic Route of C5H11BrO This article mentions the following:

The Fe³⁺-catalyzed reduction of 3-substituted propyl bromides by Grignard reagents gives propylene (I) and cyclopropane. The reduction to I is particularly noteworthy since it formally represents a 1,2-H shift. Two key intermediates are identified in I formation, in which MeO(CH₂)₃Br is first catalytically reduced to the Mg derivative by the Grignard reagent. The Fe³⁺-catalyzed 灏?elimination of the MeO(CH₂)₃MgBr intermediate gives CH₂:CHCH₂OMe, which is then reductively cleaved to I. Extensive studies of D labeling in the reactants, as well as in both intermediates, allow the course of the H shift to be followed unequivocally. The mechanism of Fe catalysis is proposed for the first and second stages of the reduction to I. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Synthetic Route of C5H11BrO).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Synthetic Route of C5H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reductive coupling of benzyl oxalates with highly functionalized alkyl bromides by nickel catalysis was written by Yan, Xiao-Biao;Li, Chun-Ling;Jin, Wen-Jie;Guo, Peng;Shu, Xing-Zhong. And the article was included in Chemical Science in 2018.Application In Synthesis of 1-Bromo-4-methoxybutane This article mentions the following:

Coupling reactions involving non-sulfonated C-O electrophiles provide a promising method for forming C-C bonds, but the incorporation of functionalized or secondary alkyl groups remains a challenge due to the requirement for well-defined alkylmetal species. In this study, a reductive nickel-catalyzed cross-coupling of benzyl oxalates with alkyl bromides, using oxalate as a new leaving group is reported. A broad range of highly functionalized alkyl units (such as functional groups: alkyl chloride, alc., aldehyde, amine, amide, boronate ester, ether, ester, heterocycle, phosphonate, strained ring) were efficiently incorporated at the benzylic position. The utility of this synthetic method was further demonstrated by late-stage modification of complex bioactive compounds Preliminary mechanistic experiments revealed that a radical process might be involved in the reaction. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Application In Synthesis of 1-Bromo-4-methoxybutane).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application In Synthesis of 1-Bromo-4-methoxybutane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic carboxylate salt-enabled alternative synthetic routes for bio-functional cyclic carbonates and aliphatic polycarbonates was written by Watanabe, Yuya;Takaoka, Shunya;Haga, Yuta;Kishi, Kohei;Hakozaki, Shunta;Narumi, Atsushi;Kato, Takashi;Tanaka, Masaru;Fukushima, Kazuki. And the article was included in Polymer Chemistry in 2022.Quality Control of 1-Bromo-4-methoxybutane This article mentions the following:

Simple and efficient synthetic routes for functionalized cyclic carbonates are indispensable for the practical application of side-chain bio-functionalized aliphatic polycarbonates as biodegradable functional biomaterials. In this study, a six-membered cyclic carbonate with a triethylammonium carboxylate has been prepared in one step from 2,2-bis(methylol)propionic acid (bis-MPA). We have demonstrated the suitability of the organic carboxylate salt of the bis-MPA cyclic carbonate for esterification with alkyl bromides via the S_N2 mechanism, leading to the formation of functionalized cyclic carbonate monomers. The esterification of the organic carboxylate salt proceeds efficiently when alkyl bromides with 浼?carbonyl, allyl, and benzyl groups are used. This approach enables a two-step synthesis of functionalized cyclic carbonates from bis-MPA. The organocatalyzed ring-opening polymerization of the resultant functionalized cyclic carbonates is effectively controlled, indicating that the synthetic process involving the organic carboxylate salt does not influence their polymerizability. The ether-functionalized aliphatic polycarbonates obtained from the organic carboxylate salt exhibit good antiplatelet properties, comparable to those of a previously developed blood-compatible aliphatic polycarbonate. The synthetic pathways exploiting organic carboxylate salts enable alternative shortcuts to functionalized cyclic carbonates from bis-MPA. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Quality Control of 1-Bromo-4-methoxybutane).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of 1-Bromo-4-methoxybutane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands – Fluoxetine and fluvoxamine was written by Staron, Jakub;Pietrus, Wojciech;Bugno, Ryszard;Kurczab, Rafal;Satala, Grzegorz;Warszycki, Dawid;Lenda, Tomasz;Wantuch, Anna;Hogendorf, Adam S.;Hogendorf, Agata;Duszynska, Beata;Bojarski, Andrzej J.. And the article was included in European Journal of Medicinal Chemistry in 2021.Recommanded Product: 4457-67-4 This article mentions the following:

To elucidate the role of halogen atoms in the binding of SSRIs to SERT, a series of 22 fluoxetine and fluvoxamine analogs substituted with fluorine, chlorine, bromine, and iodine atoms, differently arranged on the Ph ring was designed. The obtained biol. activity data, supported by a thorough in silico binding mode anal., allowed the identification of two partners for halogen bond interactions: the backbone carbonyl oxygen atoms of E493 and T497. Addnl., compounds with heavier halogen atoms were found to bind with the SERT via a distinctly different binding mode, a result not presented elsewhere. The subsequent anal. of the prepared XSAR sets showed that E493 and T497 participated in the largest number of formed halogen bonds. The XSAR library anal. led to the synthesis of two of the most active compounds (3,4-diCl-fluoxetine, SERT K_i = 5 nM and 3,4-diCl-fluvoxamine, SERT K_i = 9 nM, fluoxetine SERT K_i = 31 nM, fluvoxamine SERT K_i = 458 nM). An example of the successful use of a rational methodol. was presented to analyze binding and design more active compounds by halogen atom introduction. ‘XSAR library anal.’, a new tool in medicinal chem., was instrumental in identifying optimal halogen atom substitution. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Recommanded Product: 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 4457-67-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of a new antidepressant, fluvoxamine maleate was written by Yu, Bing;Wu, Fanhong. And the article was included in Zhongguo Yaowu Huaxue Zazhi in 2004.SDS of cas: 4457-67-4 This article mentions the following:

Fluvoxamine maleate was synthesized using Et benzoate as the starting material via four steps: substitution reaction, aminolysis, hydrolysis and salt formation. The target compound was identified by IR and ¹H-NMR, and the overall yield was 51%. The preparative method of N-(2-bromoethyl) phthalimide was improved. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4SDS of cas: 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. SDS of cas: 4457-67-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The nickel(II)-catalyzed direct benzylation, allylation, alkylation, and methylation of C-H bonds in aromatic amides containing an 8-aminoquinoline moiety as the directing group was written by Aihara, Yoshinori;Wuelbern, Jendrik;Chatani, Naoto. And the article was included in Bulletin of the Chemical Society of Japan in 2015.Related Products of 4457-67-4 This article mentions the following:

Direct alkylation via the cleavage of the ortho C-H bonds by a nickel-catalyzed reaction of aromatic amides containing an 8-aminoquinoline moiety as the directing group with alkyl halides is reported. Various alkyl halides, including benzyl, allyl, alkyl, and Me halides (or pseudo halides) participate as electrophilic coupling partners. The reaction shows a high functional group compatibility. The reaction proceeds in a highly regioselective manner at the less hindered C-H bonds in the reaction of meta-substituted aromatic amides, irresp. of the electronic nature of the substituent. The mechanism responsible for the C-H alkylation reaction is discussed based on the results obtained in a variety of mechanistic experiments In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Related Products of 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Related Products of 4457-67-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organophosphorus compounds. 109. Synthesis of fluorescent reagents with chemically selective anchor groups was written by Horner, Leopold;Hallenbach, Werner. And the article was included in Phosphorus and Sulfur and the Related Elements in 1984.Name: 1-Bromo-4-methoxybutane This article mentions the following:

About 20 title compounds were prepared Thus acridine was alkylated with RO(CH₂)_nLi (R = Me, Et, tetrahydropyranyl; n = 3, 4, 6) to give dihydroacridines I, which were oxidized to give alkylacridines II (R¹ = OMe, OEt, OH). II (R¹ = OH; n = 2, 3, 4, 6) reacted with ClP(O)MeR² (R² = OEt, F) to give II [R¹ = OP(O)MeR²]. II [R¹ = OP(O)MeF, n = 4] and serine derivative HOCH₂CH(CO₂H)NHCO₂CMe₃ gave II [R¹ = OP(O)MeOCH₂CH(CO₂H)NHCO₂CMe₃]. Bromoalkylacridines II (R¹ = Br; n = 2, 3, 4, 6) and NaP(O)(OR³)₂ (R³ = Et, Bu) gave II [R¹ = P(O)(OR³)₂]. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Name: 1-Bromo-4-methoxybutane).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Name: 1-Bromo-4-methoxybutane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary