Aicher, Thomas D. published the artcileDiscovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ) Agonist for Use in Treating Cancer, Formula: C7H4BrF3O, the main research area is benzoxazine derivative oral RAR ROR receptor agonist preparation cancer.
Retinoic acid receptor-related orphan receptor γ (RORc, RORγ, or NR1F3) is the nuclear receptor master transcription factor that drives the function and development of IL-17-producing T helper cells (Th17), cytotoxic T cells (Tc17), and subsets of innate lymphoid cells. Activation of RORγ+ T cells in the tumor microenvironment is hypothesized to render immune infiltrates more effective at countering tumor growth. To test this hypothesis, a family of benzoxazines was optimized to provide LYC-55716 (37c), a potent, selective, and orally bioavailable small-mol. RORγ agonist. LYC-55716 decreases tumor growth and enhances survival in preclin. tumor models and was nominated as a clin. development candidate for evaluation in patients with solid tumors.
Journal of Medicinal Chemistry published new progress about Antiproliferative agents. 433939-28-7 belongs to class bromides-buliding-blocks, name is 1-Bromo-3-(difluoromethoxy)-5-fluorobenzene, and the molecular formula is C7H4BrF3O, Formula: C7H4BrF3O.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary