Category: 4333-56-6

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4333-56-6 as follows. HPLC of Formula: C3H5Br

To a stirred solution of 2-bromo-5-fluorophenol (1.0 g) in DMF (15 mL) in a microwave tube was added cesium carbonate (5.0 g), potassium iodide (130 mg) and bromocyclopropane (1.82 g). The mixture was heated in a microwave oven to 180 C. for 1 h, to 200 C. for 1 h and to 220 C. for 1 h. Ethyl acetate was added and the mixture was washed with water. The organic phase was washed with saturated sodium chloride solution, dried (sodium sulfate) and the solvent was removed in vacuum. Silica gel chromatography gave 1.14 g of the title compound.1H-NMR (300 MHz, DMSO-d6): delta [ppm]=0.62-0.88 (m, 4H), 3.90-4.00 (m, 1H), 6.77 (td, 1H), 7.23 (dd, 1H), 7.48-7.63 (m, 1H)

According to the analysis of related databases, 4333-56-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Schulze, Volker; Mais, Franz-Josef; US2015/148542; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4333-56-6, name is Bromocyclopropane, A new synthetic method of this compound is introduced below., HPLC of Formula: C3H5Br

[000459j A mixture of Compound 19A (2.0 g, 10 mmol), bromocyclopropane (2.4 g, 20 mmol), Cs2CO3 (9.8 g, 30 mmol) in DMSO (40 mL) was stirred at 170 C for 2 days under high pressure. The mixture was cooled to room temperature and filtered through celite. The filtrate was diluted with ethyl acetate (100 mL), washed with brine (100 mL x 2), dried over sodium sulfate, and concentrated. The crude was purified with column chromatography on silica gel (petroleum ether, 100% v/v) to render Compound 19B. LC-MS (mlz): 247 [M+1] ?H-NMR (CDC13, 400 MHz) major characteristic peaks: 5 (ppm) 0.78-0.82 (m, 4H), 3.7 1-3.73 (m, 1H), 6.95-6.95 (m, 1H), 7.13-7.18 (m, 1H), 7.34-7.36 (m, 1H).

The synthetic route of 4333-56-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; WO2015/65937; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 4333-56-6, name is Bromocyclopropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 4333-56-6

A flame dried two-neck round bottom flask fitted with a reflux condenser and N2 outlet was charged with anhydrous THF, freshly activated Mg (120 mg, 4.95 mmol) and a catalytic amount of iodine. A small portion of cyclopropyl bromide dissolved in THF was added. Afier initiation of reflux, the reaction mixture was cooled to -20 C. and the remaining cyclopropyl bromide (500 mg, 4.13 mmol) was gradually added. Afier 30 mm a freshly distilled solution of glyoxalate 45 (549 mg, 5.37 mmol) in THF was added over a 10 mm period and the resulting solution was stirred at -20 C. for 2 h before being quenched with a small amount of watet After 10 mm the reaction mixture was thrther diluted with water (50 mL) and extracted with ethyl acetate (3×50 mL). The organic extracts were combined, dried over anhydrous Mg504, filtered, concentrated in vacuo and purifiedby column chromatography eluting with ethyl acetate/nhexane (a gradient of 10-20%) to furnish ethyl a-hydroxy132 cyclopropaneacetate (422 mg, 71%) as a viscous oil. The oil (350 mg, 2.43 mmol) was dissolved in anhydrous DCM and cooled to 0 C. Then Ph3P (2.04 gm, 7.78 mmol) was added followed by C13r4 (1.20 gm, 3.64 mmol). The reactionmixture was stirred at 0 C. for 2 h and then concentrated in vacuo. The Ph3PO was precipitated by addition of n-hexane and removed by filtration. The crude reaction mixture was purified by flash column chromatography to furnish ethyl a-bromocyclopropaneacetate (46, R=c-Pr): (311 mg, 62%yield).

The synthetic route of Bromocyclopropane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Brandeis University; University of Georgia Research Foundation, Inc.; The Brigham and Women’s Hospital, Inc.; Hedstrom, Lizbeth K.; Cuny, Gregory D.; Gollapalli, Deviprasad R.; Kirubakaran, Sivapriya; Maurya, Sushil K.; Striepen, Boris; Gorla, Suresh K.; Johnson, Corey R.; Kavitha, Mandapati; Khan, Jihan; (149 pag.)US10125116; (2018); B2;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4333-56-6, name is Bromocyclopropane, A new synthetic method of this compound is introduced below., Formula: C3H5Br

10 mg of Compound 9 was weighed into 5 mL of THF, 5 mg of NaH was added, and the mixture was stirred at room temperature for half an hour. Twenty-fiveBromide cyclopropane, 50 C reaction 6h, TLC detection reaction material almost completely disappeared, adding saturated ammonium chloride to stop the reactionAfter extraction with ethyl acetate twice, the organic layer was dried over anhydrous sodium sulfate, concentrated, and purified by silica gel column chromatography (eluent EtOAc /Petroleum ether = 20: 1 to 10: 1) to give Compound 11 (9.5 mg) in 85% yield, ESI-MS m / z: 409.2 [M + Na]Ie ^: detection purity of 96.6%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Yangzhou University; Chen Min; Yu Yue; (16 pag.)CN104710396; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 4333-56-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4333-56-6, name is Bromocyclopropane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of bromocyclopropane (Aldrich, 4.2 g, 35 mmol) in tetrahydrofuran (15 mL), magnesium turnings (Aldrich, 0.795 g, 33.1 mmol) were added in three equal portions at room temperature while the reaction was controlled with a water bath so that slight boiling of the solvent was maintained. _

The synthetic route of Bromocyclopropane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chu, Xin-Jie; Ding, Qingjie; Jiang, Nan; Kim, Kyungjin; Lovey, Allen John; McComas, Warren William; Mullin JR., John Guilfoyle; Tilley, Jefferson Wright; US2004/6058; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 4333-56-6, name is Bromocyclopropane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4333-56-6, Quality Control of Bromocyclopropane

A 5 L flask fitted with a magnetic stirrer was charged with Mg turnings (106 g, 4.34 mol, 1.58 equiv) and anhydrous THF (2.00 L) and purged with N2. Mg was activated by addition of Br2 (1 mL, 19.5 mmol) and stirring at rt for 15 min. A solution of cyclopropyl bromide (500 g, 4.13 mol, 1.5 equiv) in anhydrous THF (1.9 L) was added slowly over 2 h. The reaction was kept on ice during the addition and the rate controlled so the internal temperature was kept below 35 C. After addition the mixture was stirred at rt for 1.5 h then cooled on ice overnight. The next day the reaction was gently warmed to 22 C to redissolve most of the precipitate and used in the following step.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; CHEMOCENTRYX, INC.; FAN, Junfa; KALISIAK, Jaroslaw; LUI, Rebecca, M.; MALI, Venkat, Reddy; MCMAHON, Jeffrey, P.; POWERS, Jay, P.; TANAKA, Hiroko; ZENG, Yibin; ZHANG, Penglie; (194 pag.)WO2016/187393; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 4333-56-6, These common heterocyclic compound, 4333-56-6, name is Bromocyclopropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a microwave vial charged with Mg powder (2 equiv.) and THF was addedbromocyclopropane (2 equiv.). The resulting mixture was stirred for 30 min at rt before a solution of arylnitrile (1 equiv.) in THF was added. It was microwaved 10 min at 100 C, cooled to rt and added dropwise to a cold solution of NaBFL, (2 equiv.) in MeO at 0 C. The resulting mixture was stirred for 15 min at rt, quenched with H20, extracted with DCM and purified by Biotage Si02 column (gradient: MeOH/DCM 0-30%) to give the desired product.

The synthetic route of 4333-56-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITY HEALTH NETWORK; PAULS, Heinz W.; LAUFER, Radoslaw; LIU, Yong; LI, Sze-Wan; FORREST, Bryan T.; LANG, Yunhui; PATEL, Narendra Kumar B.; EDWARDS, Louise G.; NG, Grace; SAMPSON, Peter Brent; FEHER, Miklos; AWREY, Donald E.; WO2013/53051; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 4333-56-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4333-56-6, name is Bromocyclopropane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Tert-butyl N-ftert-butoxycarbonylamino)-N-cvclopropyl-carbamate To a stirred suspension of magnesium (1.34g, 55mmol) and catalytic iodine in tetrahydrofuran (5ml)was added 5ml of a 45ml solution of cyclopropyl bromide (4.0ml) in tetrahydrofuran (50ml). The mixture was heated to initiate Grignard formation then the remaining solution of cyclopropyl bromide was added dropwise over 30mins with heating (70C). The Grignard solution was heated at reflux for a further 30 minutes then cooled to 0C. To a stirred solution of di-tert-butyl azodicarboxylate in THF (50ml) at -78C was added the solution of cyclopropylmagnesium bromide dropwise via cannula. The resulting solution was stirred at -78C for 30mins then quenched with acetic acid. The mixture was allowed to warm to room temperature then water (150 ml) was added and the mixture extracted three times with diethyl ether. The combined organic extracts were dried, filtered and concentrated in vacuo. The crude product was purified by column chromatography on silica, eluting with ethyl acetate/hexane, to give the product as a white solid (6.68g). IH NMR (400 MHz, Chloroform) delta ppm 0.7 (4H, br s), 1.5 (18H, s), 2.9-3.0 (IH, br m), 6.1 and 6.4 (IH, br s)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Bromocyclopropane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SYNGENTA LIMITED; BHONOAH, Yunas; ELLIOTT, Alison Clare; GAULIER, Steven; LING, Kenneth; MITCHELL, Glynn; MORRIS, James Alan; RZEPA, Paula Rocha; VINER, Russell Colin; WO2013/50421; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 4333-56-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4333-56-6 name is Bromocyclopropane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation of 1.1-cyclopropyl-1hydro-naphthalene [2,3-bis]imidazole-4,9-dione: Naphthyl imidazole (396 mg, 2.0 mmol) was dissolved in dimethyl sulfoxide (10 mL). Further, sodium hydride (376 mg, 6.0 mmol) was added, and the mixture was stirred at room temperature for 30 min to give a brown-yellow liquid, and then bromocyclopropane (4.8 mL, 60 mmol) was added and stirring was continued for 24 hours. The reaction solution was poured into ice water (50 g), and the pH was adjusted to 9 with dilute hydrochloric acid (1.0M). After extracting 5 times with chloroform (20 mL/time), the organic phase was washed with saturated brine and dried over anhydrous magnesium sulfate, filtered and evaporated to remove solvent.By silica gel column chromatographyThe yellow solid was 422 mg, yield 87%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Bromocyclopropane, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Jiao Tong University; Yan Deyue; Zhang Wanbin; Zhang Zhenfeng; Liu Zhanxiong; (21 pag.)CN108794403; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

4333-56-6, name is Bromocyclopropane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 4333-56-6

Step (i) of Example W1: 4-Cyclopropylmethylpyridine A solution of 19.5 ml (200 mmol) of 4-picoline in tetrahydrofuran (120 ml) was cooled to -78C. Lithium diisopropylamide (2 M heptane, tetrahydrofuran, ethylbenzene solution) (200 ml) was added dropwise to the cooled solution over a period of 20 min. The mixture was then stirred at -40C for 20 min and was cooled to -78C. Cyclopropylbromide (16.0 ml, 200 mmol) was added dropwise to the reaction solution over a period of 25 min, and the mixture was stirred at -78C for one hr. The reaction solution was then added to 300 ml of a saturated aqueous ammonium chloride solution, and the mixture was satisfactorily washed with 100 ml of water. The solution was extracted twice with 200 ml of ethyl acetate, and the extract was dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated, and the residue was distilled under the reduced pressure (8 mmHg, 86 to 87C). The distillation residue was purified by column chromatography on silica gel (hexane : ethyl acetate = 70 : 30) to give 17.6 g (yield 66%) of the title compound. 1H-NMR (400 MHz, CDCl3) delta: 0.19-0.25 (2H, m), 0.55-0.61 (2H, m), 0.93-1.04 (1H, m), 2.54 (2H, d, J = 7.1 Hz), 7.17-7.22 (2H, m), 8.47-8.52 (2H, m). MS (FAB) m/z 134 [M+H]+.

The synthetic route of 4333-56-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Meiji Seika Kaisha Ltd.; EP2151447; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary