Category: 43204-63-3

43204-63-3, name is Bis(2-Bromoethyl)amine hydrobromide, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: bromides-buliding-blocks

PREPARATION EXAMPLE 4 (2S)-3-{4-[2-(5-methyl-2-phenyl-1, 3-oxazol-4-yl)-ethoxy]-phenyl}-2-piperazin-1-yl-propionic acid methyl ester (Intermediate 4) Diethanolamine (100 g) and 40% HBr aqueous solution (1000 mL) were mixed and vigorously refluxed for 10 h, while water was removed continuously under reduced pressure during the reaction. The resulting solution was concentrated to give 297 g of a brown liquid. The above brown liquid (47.4 g), Intermediate 3A (4.5 g, 11.8 mmol ) and 150 mL of anhydrous ethanol were mixed with refluxing overnight. Thereafter, the mixture was cooled to room temperature, to which Na2CO3 (1.3 g, 11.8 mmol) was added before further refluxing for 10 h. After cooling to room temperature, the mixture was filtered and evaporated to remove ethanol. The residue was dissolved in CHCl3, and washed with water and saturated brine in turn, and then dried over anhydrous Na2SO4. After concentration and purification with silica gel column chromatography (using CHCl3/CH3OH (60/1) as an eluent), Intermediate 4A (1.0 g, 24% yield) as a brown solid was obtained. MS[M]+=449.4 m/e; 1H-NMR (400 MHz, DMSO-d6), delta 7.987.96 (m, 2H), 7.467.38 (m, 3H), 7.06 (d, 2H), 6.81 (d, 2H), 2.702.61 (m, 2H), 2.602.51 (m, 2H), 2.36 (s, 3H).

The synthetic route of 43204-63-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO., LTD.; US2007/259883; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 43204-63-3, name is Bis(2-Bromoethyl)amine hydrobromide, This compound has unique chemical properties. The synthetic route is as follows., name: Bis(2-Bromoethyl)amine hydrobromide

PREPARATION 5 A mixture of 6-amino-8-methyl-3,4-dihydro-2(1H)-quinolinone (19.4 g), bis(2-bromoethyl)amine hydrobromide (41 g) and methanol (140 ml) was stirred for 13 hours at 64 C. After cooling, sodium carbonate (5.83 g) was added thereto and the mixture was stirred for 9 hours at 70 C. After cooling, the resulting precipitate was collected by filtration and the residue was washed with methanol to give 3,4-dihydro-8-methyl-6-(1-piperazinyl)-2(1H)-quinolinone hydrobromide (21.6 g). mp: >250 C. IR (Nujol): 1680, 1595 cm-1

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 43204-63-3.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US4988698; (1991); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 43204-63-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 43204-63-3 as follows.

EXAMPLE 1 A mixture of 5-aminooxindol (14 g), 29 g of bis(beta-bromoethyl)amine.hydrobromide in 250 ml of ethanol was stirred under reflux for 8 hours and allowed to stand overnight at room temperature. To the mixture was added sodium carbonate (10.1 g) and the mixture was stirred further for 8 hours under reflux. After cooling to room temperature, crystals which precipitated were collected by filtration and recrystallized from a mixture of water and ethanol to give 16 g of 5-(1-piperazinyl)oxindol.hydrobromide. Pale yellow powdery crystal NMR (200 MHz, DMSO-d6) delta: 3.30 (8H, s), 3.47 (2H, s), 6.78 (1H, d, J=8.5 Hz), 6.90 (1H, dd, J=8.5 Hz, 2 Hz), 7.04 (1H, d, J=2 Hz), 8.88 (2H, brs), 10.27 (1H, s)

According to the analysis of related databases, 43204-63-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Otsuka Pharmaceutical Co., Ltd.; US4737501; (1988); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 43204-63-3, name is Bis(2-Bromoethyl)amine hydrobromide, A new synthetic method of this compound is introduced below., category: bromides-buliding-blocks

REFERENCE EXAMPLE 6 A mixture of di(2-bromoethyl)amine hydrobromide (15.6 g; 0.05 mol), 3-aminobenzotrifluoride (24.2 g; 0.15 mol) and methylethylketone (50 ml) was heated under reflux for 4 hours, and the resultant mixture was neutralized with a dilute sodium hydroxide solution and extracted with ether. The ethereal layer was washed with a saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the residue was distilled to give N-(alpha, alpha, alpha-trifluorom-tolyl)piperazine. B.P., 130-140 C./0.3 mmHg.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Sumitomo Chemical Company, Limited; US4598078; (1986); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 43204-63-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 43204-63-3 name is Bis(2-Bromoethyl)amine hydrobromide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Formula X A mixture of 0.1 mol of bis-bromoethylamine hydrobromide and 0.1 mol of 2,4-difluoroaniline in 50 ml of butan-1-ol is heated at the boil for 14 hours. The reaction mixture is then cooled and the precipitate obtained is filtered off. The crystals are taken up with water and the mixture is rendered basic in the cold with a 10% solution of sodium hydroxide. The aqueous phase is extracted with chloroform and the extract is washed with water, dried over sodium carbonate and filtered. The chloroform is evaporated off and the residue obtained is taken up with acetone. Hydrogen chloride gas is bubbled through this solution, with stirring, until the pH is acid, and the crystals formed are allowed to settle. The crystals obtained are filtered off and then washed with acetone and dried. 4-(2,4-Difluorophenyl)piperazine dihydrochloride is thus recovered in the form of crystals melting at 205 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Bis(2-Bromoethyl)amine hydrobromide, and friends who are interested can also refer to it.

Reference:
Patent; Centre D’Activite Et De Recherches Pharmaceutique Industrielle Biologique Medicale; US4886805; (1989); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 43204-63-3, A common heterocyclic compound, 43204-63-3, name is Bis(2-Bromoethyl)amine hydrobromide, molecular formula is C4H10Br3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 4: 5-Fluoro-2-(piperazin-1-yl)benzenesulfonamide A mixture of 2-amino-5-fluoro-benzenesulfonamide (950.00 mg, 4.99 mmol), 2-bromo-N-(2-bromoethyl) ethanamine hydrobromide (7.78 g, 24.95 mmol) and n-butyl alcohol (50.00 mL) was stirred at 120 C. for 24 h. The reaction mixture was allowed to cool to rt. Filtered and the filtrate was used for the next step directly. MS (EI+, m/z): 260.2 [M+H]+

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Navitor Pharmaceuticals, Inc.; O’Neill, David John; Saiah, Eddine; Kang, Seong Woo Anthony; Brearley, Andrew; Bentley, Jonathan; (519 pag.)US2018/127370; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 43204-63-3, name is Bis(2-Bromoethyl)amine hydrobromide, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 43204-63-3, Safety of Bis(2-Bromoethyl)amine hydrobromide

a Synthesis of 2-bromo-N-(2-bromoethyl)-N-carbobenzoxyethanamine (1c): Benzyl chloroformate (1.97 ml, 13.8 mmol) and 1M sodium hydroxide solution is added with vigorous stirring to an ice-cold solution of bis(2-bromoethyl)amine hydrobromide (4.5 g, 14.4 mmol) in water (25 ml) until the pH is just basic (about 24 ml). The mixture is acidified with 1M hydrochloric acid (2 ml) and extracted with ether (3*40 ml). The organic phase is washed with sodium hydrogen carbonate solution and water, dried over magnesium sulfate and concentrated, and the residue is chromatographed (hexane/ethyl acetate 5:1?4:1). Compound 1 c (4.1 g, 81%) is obtained. 1 H-NMR (300 MHz, CDCl3): delta=3.43, 3.53 ?2 m, 4H, N(CH2 –CH2 Br)2!, 3.73 ?m, 4H, N(CH2 –CH2 Br)2!, 5.17 (s, 2H, CH2 Ph), 7.36 (m, 5H, Ph).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Hoechst Aktiengesellschaft; US5739300; (1998); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 43204-63-3, name is Bis(2-Bromoethyl)amine hydrobromide, A new synthetic method of this compound is introduced below., COA of Formula: C4H10Br3N

To a mixture of 5-amino-3,4-dihydroquinolin-2(1H)-one 1(5.00 g, 30.83 mmol), bis(2-bromoethyl)amine hydrobromide(9.05 g, 33.91 mmol) and water (40 mL), a solution of potassiumhydroxide (1.90 g, 33.91 mmol,10 mL)was added dropwise at 80 C.Then the reaction mixture was stirred at 100 C for 3 h. The progressof the reaction was monitored by TLC. After the reaction wascompleted, the reaction mixture was cooled to the room temperature.The mixture was filtered and the filtrate was adjusted toPH 10 with the 10% aqueous solution of potassiumhydroxide. Theresultant solid was filtered, washed with water to afford 6.4 g of 5-(piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one 2 as a white solid.Yield 61%, m. p. 235e237 C; 1H NMR (300 MHz, DMSO-d6) d: 10.01(s, 1H, quinolin, eCONHe), 7.07 (t, J 7.9 Hz, 1H, quinolin-H7), 6.65(d, J 8.0 Hz, 1H, quinolin-H8), 6.58 (d, J 7.8 Hz, 1H, quinolin-H6),3.94 (s, 1H, NH), 2.82e2.94 (m, 4H, quinolin-H4 and eCH2-),2.67e2.84 (m, 6H, eCH2-), 2.35 (t, J 7.3 Hz, 2H, quinolin-H3); 13CNMR (75 MHz, DMSO-d6) d: 170.59, 150.18, 139.44, 127.33, 117.62,112.55, 110.18, 51.34, 46.73, 30.16, 20.38; LC-MS (ESI): m/z 232[MH].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Ji, Qinggang; Deng, Qiao; Li, Bing; Li, Baihui; Shen, Yangli; European Journal of Medicinal Chemistry; vol. 180; (2019); p. 204 – 212;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 43204-63-3, A common heterocyclic compound, 43204-63-3, name is Bis(2-Bromoethyl)amine hydrobromide, molecular formula is C4H10Br3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Add 5-amino-3,4-dihydroquinolin-2(1H)one 7 (5.00 g, 30.83 mmol) to 40 ml of water in turn, di-(2-bromoethyl)amine hydrobromide (50.57 g, 33.91 mmol), stirring to 80 C, An aqueous solution of potassium hydroxide (1.90 g, 33.91 mmol, 10 ml) was added dropwise in three portions over half an hour. After the addition is completed, the reaction is heated to 100 C. The reaction was further incubated for 3 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered, and the filtrate was adjusted to pH 10 with a 10% aqueous potassium hydroxide solution to precipitate a large white solid. Filtered, washed with a suitable amount of water, dried to give a white powdery solid 8 (6.4 g, yield 61%, Mp 235-237 C);

The synthetic route of 43204-63-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Southwest University; Ji Qinggang; Deng Qiao; (15 pag.)CN109438344; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

43204-63-3, name is Bis(2-Bromoethyl)amine hydrobromide, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 43204-63-3

PREPARATION EXAMPLE 4 (2S)-3-{4-[2-(5-methyl-2-phenyl-1, 3-oxazol-4-yl)-ethoxy]-phenyl}-2-piperazin-1-yl-propionic acid methyl ester (Intermediate 4) Diethanolamine (100 g) and 40% HBr aqueous solution (1000 mL) were mixed and vigorously refluxed for 10 h, while water was removed continuously under reduced pressure during the reaction. The resulting solution was concentrated to give 297 g of a brown liquid. The above brown liquid (47.4 g), Intermediate 3A (4.5 g, 11.8 mmol ) and 150 mL of anhydrous ethanol were mixed with refluxing overnight. Thereafter, the mixture was cooled to room temperature, to which Na2CO3 (1.3 g, 11.8 mmol) was added before further refluxing for 10 h. After cooling to room temperature, the mixture was filtered and evaporated to remove ethanol. The residue was dissolved in CHCl3, and washed with water and saturated brine in turn, and then dried over anhydrous Na2SO4. After concentration and purification with silica gel column chromatography (using CHCl3/CH3OH (60/1) as an eluent), Intermediate 4A (1.0 g, 24% yield) as a brown solid was obtained. MS[M]+=449.4 m/e; 1H-NMR (400 MHz, DMSO-d6), delta 7.987.96 (m, 2H), 7.467.38 (m, 3H), 7.06 (d, 2H), 6.81 (d, 2H), 2.702.61 (m, 2H), 2.602.51 (m, 2H), 2.36 (s, 3H).

The synthetic route of 43204-63-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO., LTD.; US2007/259883; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary