Category: 4263-52-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4263-52-9, name is Sodium 2-bromoethanesulphonate, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 4263-52-9

A mixture of (E)-1,2-di(4-pyridyl)ethylene (91 mg, 0.5 mmol) and sodium 2-bromoethanesulfonate (317 mg, 1.5 mmol) (Aldrich) in abs. EtOH (3 mL) was refluxed with stirring for 50 h. The insoluble substance was filtered, washed with benzene, MeOH, and acetone, and re-crystallized from water-EtOH (2.8:1 (v/v), 2.7 mL) to yield 128 mg (64%) of (E)-3a as a pinkish powder.

According to the analysis of related databases, 4263-52-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Vedernikov, Artem I.; Lobova, Natalia A.; Kuz’mina, Lyudmila G.; Howard, Judith A.K.; Strelenko, Yuri A.; Alfimov, Michael V.; Gromov, Sergey P.; Journal of Molecular Structure; vol. 989; 1-3; (2011); p. 114 – 121;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 4263-52-9, These common heterocyclic compound, 4263-52-9, name is Sodium 2-bromoethanesulphonate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A reactor was charged with 54.89 g (0.186 mol) methyloleate, 9.55 g (0.093 mol) diethylenetriamine and heated under an argon atmosphere with stirring to 160 C., whereupon methanol began to reflux, enough methanol was distilled off to bring to 180 C., stirring with argon sparging was continued for 2 days to yield pure 3-(2-((z)-hepatadec-8-en- 1 -y-1 -(2-oleamido ethyl)-4,5-dihydro- 1H-imidazoline as a viscous light straw colored fluid. ?3C NMR (ppm in CDC13, 100 MHz) oe=25.8, 36.6, 38.0, 46.6, 50.2, 52.2, 167.5, 173.4. A flask was charged with 4.000 g (6.514 mmol) 3-(2-((z)-hepatadec-8-en-1-yl)-1-(2-oleamido ethyl)-4,5-dihydro-1H-imidazoline, 1.648 g (7.810 mmol) sodium 2-bromoethylsulfonate, 20 ml anhydrous N-Methyl-2-pyrrolidone (NMP), heated under an argon atmosphere with stirring at 140 C. for 2 days. Evaporated the mixture in vacuo (90 C./0.8 mmHg), poured into 30 mL sodium chloride saturated deionized water, extracted with 20 mL aliquots of chloroform until the chloroform layer had only a faint color, combined the chloroform layer and dried over anhydrous magnesium sulfate, filtered through celite, vacuum distilled. A viscous dark amber fluid comprised of about 38 wt % of 2-(2-((Z)-heptadec-8-en-1-yl)-1-(2-oleamidoethyl)-4,5-dihydro-1H-imidazol-3-ium-3-yl)ethane-1-sulfonate (z-Im-1), 48 wt % Im and 15 wt % of NMP was obtained. The product was purified using flash chromatography with MeOH-water (9:1), and yield 80 mol % of z-IM-1. 13C NMR (ppm in CDCl3, 100 MHz) delta=170.8, 46.7, 47.4, 36.0, 46.3, 174.8, 25.7, 43.4, 45.7, 362, 25.6.

Statistics shows that Sodium 2-bromoethanesulphonate is playing an increasingly important role. we look forward to future research findings about 4263-52-9.

Reference:
Patent; GPCP IP Holdings LLC; Chen, Yu; Holtman, Kevin M.; Hammes, Brian S.; Boettcher, Jeffrey J.; (31 pag.)US2018/202109; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 4263-52-9, name is Sodium 2-bromoethanesulphonate, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4263-52-9, Safety of Sodium 2-bromoethanesulphonate

EXAMPLE 2 Production of Disodium 2,2′-dithiobis Ethane Sulfonate To a mixture of 50.1 g of water with 24.4 g of thioacetic acid, 50.7 g of 25% aqueous sodium hydroxide solution were added dropwise at 10-30 C. This solution was added dropwise to a solution of 63.3 g of sodium 2-bromoethane sulfonate and 70 g of water at 50-70 C. and allowed to react at 80-90 C. for 2 hours. Thereto 54.2 g of 25% aqueous sodium hydroxide solution were added and allowed to react at refluxing temperature (about 105 C.) until the end of the reaction was confirmed by HPLC. After addition of 3.25 g of acetic acid, the reaction mixture was refluxed for 6 hours and then cooled to about 30 C. The pH of the mixture was adjusted to 7.3 with 25% sodium hydroxide solution. Oxygen was allowed to react with 260 mL of aqueous sodium 2-mercapto ethane sulfonate solution obtained above at about 30 C. and 0.5-0.6 MPa of oxygen pressure. When the end of the reaction was confirmed by HPLC, the reaction was stopped and the mixture was neutralized with acetic acid. The mixture was heated to about 70 C. and it was observed that the mixture had been dissolved. After that, the mixture was filtered with a filtering assistant agent (radiolite) and the filtering assistant agent was washed with 10 g of water. The mixture was concentrated under reduced pressure (about 10 kPa) at 70 C. When the amount of the distilled out water became 60 g, the concentration was stopped and it was observed that the mixture remained dissolved at about 75 C. Cooling the mixture, crystallization began at 60+-5 C. After aging for about 30 minutes, the mixture was cooled to 25 C. and the crystals were aged for 2 hours at 25 C. The crystals were filtered out and washed with 24 g of water being cooled to 2 C. and then 48 mL of 70% aqueous ethanol solution. Drying the crystals at about 70 C. afforded 39.1 g of substantially pure disodium 2,2′-dithiobis ethane sulfonate crystals. The yield was 77.6% after crystallization. The purity of the product was 99.4%. According to the present invention, compounds of Formula II, such as disodium 2,2′-dithiobis ethane sulfonate, can be produced by an efficient procedure from available, relatively less expensive raw compounds in good yield with high purity. The above details are not limitative of the invention, which is defined by the scope of the following claims. It will be appreciated by those skilled in the art that changes could be made to the embodiments described above without departing from the broad inventive concept thereof. It is understood, therefore, that this invention is not limited to the particular embodiments disclosed, but it is intended to cover modifications within the spirit and scope of the present invention as defined by the appended claims.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; BioNumerik Pharmaceuticals, Inc.; US2005/137419; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

4263-52-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4263-52-9 name is Sodium 2-bromoethanesulphonate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Sodium-2-bromoethane sulfonate (41 1 mg, 1.95 mmol) and powdered K2C03 (269 mg, 1.95 mmol) are suspended in 3ml_ of dry DMF under argon atmosphere. N-methyldodecylamine (298 mg, 1.50 mmol) is added and the mixture stirred at 130C overnight. The volatiies are removed on a rotary evaporator and the residue purified by preparative HPLC and dried in high vacuum to yield 342 mg (74%) of 1q as a white solid.1H-NMR (300 MHz, CDCI3): delta = 0.81 (t, J = 6.4, 3H), 1.10-1.35 (m, 18H), 1 .70 (m, 2H), 2.88 (s), 2.89 (s,? = 3H), 3.0-3.45 (m, 5H), 3.55 (m, 1 H), 8.46 (br. s, 1 H), 8.89 (br. s, 1 H).MS (ESI): 308.2 (M+H+), 325.3 (M+NH4+), 615.4 (2M+H+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Sodium 2-bromoethanesulphonate, and friends who are interested can also refer to it.

Reference:
Patent; JADO TECHNOLOGIES GMBH; TECHNISCHE UNIVERSITAeT DRESDEN; SCHLECHTINGEN, Georg; KNOeLKER, Hans-Joachim; FRIEDRICHSON, Tim; JENNINGS, Gary; BRAXMEIER, Tobias; WO2012/160187; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4263-52-9, name is Sodium 2-bromoethanesulphonate, This compound has unique chemical properties. The synthetic route is as follows., 4263-52-9

A mixture of sodium-2-bromoethanesulfonate (41 1 mg, 1.95 mmol), N-methyltetradecylamine (342 mg, 1.50 mmol), K2C03 (269 mg, 1.95 mmol) and DMF (3 mL) is stirred at 135C bath temperature under argon atmosphere overnight. The volatiies are removed on a rotary evaporator and the residue purified by preparative HPLC to yield 324 mg (64%) of 1 s.1H-NMR (300 MHz, CDCI3): delta = 0.90 (t, J = 6.4, 3H), 1.15-1.45 (m, 22H), 1.78 (m, 2H), 2.97 /2.99 (2s,? = 3H), 3.05-3.55 (m, 5H), 3.64 (m, 1 H), 7.36 (br. s, 1 H).MS (ESI): 336.3 (M+H+), 671.5 (2M+H+), 693.5 (2M+Na+), 709.5 (2M+K+).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; JADO TECHNOLOGIES GMBH; TECHNISCHE UNIVERSITAeT DRESDEN; SCHLECHTINGEN, Georg; KNOeLKER, Hans-Joachim; FRIEDRICHSON, Tim; JENNINGS, Gary; BRAXMEIER, Tobias; WO2012/160187; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 4263-52-9, name is Sodium 2-bromoethanesulphonate, molecular formula is C2H4BrNaO3S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 4263-52-9

10.5 g sodium 2-bromoethanesulfonate was added to a solution of 110 ml benzyl alcohol and 1.15 g sodium benzyloxide.Then the mixture was boiled under reflux four times. The mixture was then concentrated under vacuum to dryness and then boiled with ethyl alcohol three times. The alcohol was filtered and concentrated to dryness.The yield was 9.8 g and was confirmed by UV and IR.Pure crystals were obtained by boiling the resultant sodium 2-benzylether ethanesulfonate in ethyl alcohol, filtering, then cooling the solution to crystallize pure sodium 2-benzylether ethanesulfonate crystals out of solution.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4263-52-9, its application will become more common.

Reference:
Patent; GEISTLICH PHARMA AG; PFIRRMANN, Rolf W.; (101 pag.)WO2016/98054; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

4263-52-9, A common compound: 4263-52-9, name is Sodium 2-bromoethanesulphonate, belongs to bromides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Potassium O-ethylxanthate (3 x 95mg, O.deltaOmmol) is added portion wise every 1 .5 hours to a solution of sodium 2-bromoethanesulphonate (0.42g, 2.00mmol) in acetonitrile (15ml). The reaction mixture is heated at 850C, under a nitrogen atmosphere, for a total of 6 hours. Upon cooling the suspension is filtered, washed with acetonitrile and air-dried affording an off-white solid.1 H NMR (DMSO d6) delta (ppm) 4.67 (q, 2H), 3.40 (2H, m), 3.26 (m, 2H), 1 .39 (t, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Sodium 2-bromoethanesulphonate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UCB PHARMA S.A.; WO2009/19119; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary