Category: 41825-73-4

Reference of 41825-73-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41825-73-4 name is 2-Bromo-4,6-dimethylaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 2-iodoaniline (0.5 mmol) or 2-bromoaniline (0.5 mmol), complex 1 (0.05mmol), K2CO3 (1 mmol), (n-Bu)4NBr (0.1 mmol) and water (10 mL) were added to a sealed tube. The reaction mixture was stirred at 120oC for 30 h, then cooled to room temperature and then extracted with ethyl acetate. The organic layer was dried over anhydrous Na2SO4 and the solvent was then removed under reduced pressure. The product was finally obtained by column chromatography on silica gel.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-4,6-dimethylaniline, and friends who are interested can also refer to it.

Reference:
Short Survey; Yu, Lintao; Zhou, Xiangge; Wu, Di; Xiang, Haifeng; Journal of Organometallic Chemistry; vol. 705; (2012); p. 75 – 78;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41825-73-4, name is 2-Bromo-4,6-dimethylaniline, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Bromo-4,6-dimethylaniline

General procedure: To a homogenous solution of S7 (20 mmol) in dioxane (60 mL) was added K2CO3 (21 mmol) and anilines S2/S4/S10-S15 (21 mmol) and allowed to stir at room temperature for 36 h. Solvents were evaporated and water was added, extracted with EtOAc (3 x100 mL), organic layers were washed with NaHCO3, brine and water, dried and evaporated to get white powder.

The synthetic route of 41825-73-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Venkatraj, Muthusamy; Arin, Kevin K.; Heeres, Jan; Joossens, Jurgen; Diri, Bertrand; Lyssens, Sophie; Michiels, Johan; Cos, Paul; Lewi, Paul J.; Vanham, Guido; Maes, Louis; Van Der Veken, Pieter; Augustyns, Koen; Bioorganic and Medicinal Chemistry; vol. 22; 19; (2014); p. 5241 – 5248;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 41825-73-4, These common heterocyclic compound, 41825-73-4, name is 2-Bromo-4,6-dimethylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1: Synthesis of 3,5-dimethyl-6-phenanthridinamine Added together 2-cyanophenylboronic acid pinacol ester (13.7 g, 60 mmol), 2-bromo-4,6-dimethylaniline (10.0 g, 50 mmol), tetrakis(triphenylphosphine)palladium(0) (2.3 g, 2.0 mmol) and potassium carbonate (18.6 g, 138.21 mol) to a 125 mL of a 95/5 mixture of toluene/methanol. The solvents were degassed and the reaction mixture heated to reflux for 48 hours. After cooling, the reaction mixture was vacuum filtered and the organics evaporated and crude product was purified using silica gel column chromatography treated with triethylamine and 1:9 ethyl acetate and methylene chloride mixture as the eluants. The pure product was collected and concentrated to give 3,5-dimethyl-6-phenanthridinamine (9.1 g, 82% Yield).

The synthetic route of 41825-73-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Universal Display Corporation; Knowles, David; Lin, Chun; Mackenzie, Peter; Tsai, Jui-Yi; Walters, Robert W.; Beers, Scott; Brown, Cory S.; Yeager, Walter; (85 pag.)US9281483; (2016); B2;,
Bromide – Wikipedia,
bromide – Wiktionary