Category: 41668-13-7

Ambre, Premlata K. published the artcileMolecular modeling studies, synthesis and biological evaluation of novel Plasmodium falciparum lactate dehydrogenase (pfLDH) inhibitors, Recommanded Product: 5-Bromo-6-hydroxynicotinic acid, the main research area is lactate dehydrogenase Plasmodium inhibitor synthesis mol modeling antimalarials.

In silico methods have been used to identify five different classes of compounds as inhibitors of the essential Plasmodium falciparum enzyme lactate dehydrogenase (LDH). The mols. were assayed for in vitro antimalarial activity in both cell- and enzyme-based inhibition models. 5-Bromo-2-hydroxypyridine-3-carboxylic acid 19 is the most active with IC50 of 3.5 nM for chloroquine sensitive and 5 nM for resistant strains of Plasmodium falciparum, compared to 11 nM and 100 nM for the standard chloroquine. In LDH-enzyme inhibition assays the leading compounds are 5, 10, 18 and 19. Docking studies and the 3D-QSAR technique – CoRIA have been used to identify key binding elements between the mols. and residues in the LDH active site. A bifurcated salt bridge that associates the carboxylate group on the mols. with the guanidino group in the side chain of both Arg109 and Arg171 along with π-stack of the heterocycle with the pyridine ring of the cofactor NAD+, are the prime interactions. In silico ADME/toxicity studies also suggest these mols. have favorable pharmacokinetic and toxicity profiles.

Anti-Infective Agents published new progress about Antimalarials. 41668-13-7 belongs to class bromides-buliding-blocks, name is 5-Bromo-6-hydroxynicotinic acid, and the molecular formula is C6H4BrNO3, Recommanded Product: 5-Bromo-6-hydroxynicotinic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kuo, Gee-Hong published the artcileSynthesis and structure-activity relationships of pyrazine-pyridine biheteroaryls as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors, Computed Properties of 41668-13-7, the main research area is pyridinyltin dichloropyrazine Stille coupling; chloropyrazine pyridine preparation; pyrazine pyridine derivative preparation VEGFR2 ligand; pyridine pyrazine derivative preparation anticancer.

There is much evidence that direct inhibition of the kinase activity of vascular endothelial growth factor receptor-2 (VEGFR-2) will result in the reduction of angiogenesis and the suppression of tumor growth. Palladium-catalyzed C-C bond, C-N bond formation reactions were used to assemble various pyrazine-pyridine biheteroaryls as potent VEGFR-2 inhibitors. Among them, I [R = NH(CH2)4OH, NH(CH2)2NMe2] exhibited the highest kinase selectivity against fibroblast growth factor receptor kinase, platelet-derived growth factor receptor kinase, and glycogen synthase kinase-3. All of these compounds showed good cellular potency to inhibit VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC) but with modest effects on the unstimulated growth of HUVEC. The low inhibition of these compounds to the growth of tumor cell lines, such as HeLa, HCT-116, and A375 further confirms that these VEGFR-2 inhibitors are not cytotoxic agents. The in vivo antitumor activity of I were demonstrated in the A375 human melanoma xenograft nude mice model. Mol. modeling (QSAR anal.) was conducted in an attempt to rationalize the observed structure-activity relationship.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 41668-13-7 belongs to class bromides-buliding-blocks, name is 5-Bromo-6-hydroxynicotinic acid, and the molecular formula is C6H4BrNO3, Computed Properties of 41668-13-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rover, Stephan published the artcile6-Alkoxy-5-aryl-3-pyridinecarboxamides, a New Series of Bioavailable Cannabinoid Receptor Type 1 (CB1) Antagonists Including Peripherally Selective Compounds, Formula: C6H4BrNO3, the main research area is alkoxy arylpyridinecarboxamide preparation bioavailable cannabinoid CB1 antagonist.

The authors identified 6-alkoxy-5-aryl-3-pyridinecarboxamides as potent CB1 receptor antagonists with high selectivity over CB2 receptors. The series was optimized to reduce lipophilicity compared to rimonabant to achieve peripherally active mols. with minimal central effects. Several compounds that showed high plasma exposures in rats were evaluated in vivo to probe the contribution of central vs peripheral CB1 agonism to metabolic improvement. Both rimonabant and I, a potent brain penetrant CB1 receptor antagonist, significantly reduced the rate of body weight gain. However, II, a mol. with markedly reduced brain exposure, had no significant effect on body weight PK studies confirmed similarly high exposure of both I and II in the periphery but 10-fold lower exposure in the brain for II. On the basis of these data, which are consistent with reported effects in tissue-specific CB1 receptor KO mice, it was concluded that the metabolic benefits of CB1 receptor antagonists are primarily centrally mediated as originally believed.

Journal of Medicinal Chemistry published new progress about Antiobesity agents. 41668-13-7 belongs to class bromides-buliding-blocks, name is 5-Bromo-6-hydroxynicotinic acid, and the molecular formula is C6H4BrNO3, Formula: C6H4BrNO3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wisniewski, John A. published the artcileStructure-Based Design of 1,4-Dibenzoylpiperazines as β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction Inhibitors, Formula: C6H4BrNO3, the main research area is dibenzoylpiperazine preparation beta catenin BCL9 protein interaction inhibitor antitumor; B-cell lymphoma 9; Wnt signaling; inhibitor; protein−protein interactions; selectivity; β-Catenin.

A small-mol. inhibitor with a 1,4-dibenzoylpiperazine scaffold was designed to match the critical binding elements in the β-catenin/B-cell lymphoma 9 (BCL9) protein-protein interaction interface. Inhibitor optimization led to a potent inhibitor that can disrupt the β-catenin/BCL9 interaction and exhibit 98-fold selectivity over the β-catenin/cadherin interaction. The binding mode of new inhibitors was characterized by structure-activity relationships and site-directed mutagenesis studies. Cell-based studies demonstrated that this series of inhibitors can selectively suppress canonical Wnt signaling and inhibit growth of Wnt/β-catenin-dependent cancer cells.

ACS Medicinal Chemistry Letters published new progress about Antiproliferative agents. 41668-13-7 belongs to class bromides-buliding-blocks, name is 5-Bromo-6-hydroxynicotinic acid, and the molecular formula is C6H4BrNO3, Formula: C6H4BrNO3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Jing published the artcileIdentification and Elimination of an Unexpected Catalyst Poison in Suzuki Coupling, Safety of 5-Bromo-6-hydroxynicotinic acid, the main research area is unexpected Suzuki coupling catalyst poison sulfur free synthesis.

A Suzuki coupling reaction gave an uncharacteristically low conversion in a GMP campaign. Initial investigation revealed a palladium catalyst poison in the starting material. A temporary solution was developed along with contingency plans to enable successful material delivery. Further systematic studies led to the identification of elemental sulfur as the culprit. A “”sulfur-free”” synthesis of the starting material was developed for the next round of manufacturing

Organic Process Research & Development published new progress about Polymerization catalysts (poisons). 41668-13-7 belongs to class bromides-buliding-blocks, name is 5-Bromo-6-hydroxynicotinic acid, and the molecular formula is C6H4BrNO3, Safety of 5-Bromo-6-hydroxynicotinic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Carlson, Lars A. published the artcilePotential hypolipidemic agents. III. Heterocyclic compounds affecting free fatty acid mobilization in vivo, SDS of cas: 41668-13-7, the main research area is fatty acid mobilization fluoronicotinate blood; fluoropyridylacetate fatty acid mobilization blood; methylpyrazole fatty acid mobilization blood.

Compounds such as 3-methyl-5-isoxazolecarboxylic acid [4857-42-5], 5-fluoronicotinic acid [402-66-4], 5-fluoro-3-pyridylacetic acid [38129-24-7], and 3-methylpyrazole [1453-58-3] exhibited the highest inhibition of free fatty acid mobilization in blood among 188 heterocyclic compounds tested in dogs, while compounds such as 5-methyl-3-isoxazolecarboxylic acid [3405-77-4], 2-fluoronicotinic acid [393-55-5], and 3-aminobenzoic acid [99-05-8] had no effect on free fatty acid mobilization.

Acta Pharmaceutica Suecica published new progress about Fatty acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 41668-13-7 belongs to class bromides-buliding-blocks, name is 5-Bromo-6-hydroxynicotinic acid, and the molecular formula is C6H4BrNO3, SDS of cas: 41668-13-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Ying-Chu published the artcileC-N Coupling of DNA-Conjugated (Hetero)aryl Bromides and Chlorides for DNA-Encoded Chemical Library Synthesis, Recommanded Product: 5-Bromo-6-hydroxynicotinic acid, the main research area is DNA encoded heteroaryl amide library synthesis.

DNA-encoded chem. library (DECL) screens are a rapid and economical tool to identify chem. starting points for drug discovery. As a robust transformation for drug discovery, palladium-catalyzed C-N coupling is a valuable synthetic method for the construction of DECL chem. matter; however, currently disclosed methods have only been demonstrated on DNA-attached (hetero)aromatic iodide and bromide electrophiles. We developed conditions utilizing an N-heterocyclic carbene-palladium catalyst that extends this reaction to the coupling of DNA-conjugated (hetero)aromatic chlorides with (hetero)aromatic and select aliphatic amine nucleophiles. In addition, we evaluated steric and electronic effects within this catalyst series, carried out a large substrate scope study on two representative (hetero)aryl bromides, and applied this newly developed method within the construction of a 63 million-membered DECL.

Bioconjugate Chemistry published new progress about Anilines Role: CMB (Combinatorial Study), RCT (Reactant), RACT (Reactant or Reagent). 41668-13-7 belongs to class bromides-buliding-blocks, name is 5-Bromo-6-hydroxynicotinic acid, and the molecular formula is C6H4BrNO3, Recommanded Product: 5-Bromo-6-hydroxynicotinic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary