Category: 4117-09-3

Related Products of 4117-09-3,Some common heterocyclic compound, 4117-09-3, name is 7-Bromo-1-heptene, molecular formula is C7H13Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The alkyl bromide (1.0 equiv) was added to a solution of mercaptoaceticacid (1.0 equiv) in methanol (10.0 mL) and the resultingsolution stirred. Then a solution of NaOH (2.0 equiv) in methanol(5.0 mL)was added slowly, and the final mixturewas stirred at roomtemperature or heated to reflux until absence of the alkyl bromide(checked by TLC). The reaction mixture was concentrated in vacuo,diluted with H2O, and neutralized with 1 N HCl. Then the obtainedreaction mixture was extracted with EtOAc. The combined organicfractions were washed with brine, dried with Na2SO4, and concentratedin vacuo. Purification of the crude residue by column chromatography(petroleum ether/EtOAc) afforded the title compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7-Bromo-1-heptene, its application will become more common.

Reference:
Article; Chen, Ying; Wu, Bolin; Hao, Yameng; Liu, Yunqi; Zhang, Zhili; Tian, Chao; Ning, Xianling; Guo, Ying; Liu, Junyi; Wang, Xiaowei; European Journal of Medicinal Chemistry; vol. 171; (2019); p. 420 – 433;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4117-09-3, name is 7-Bromo-1-heptene, A new synthetic method of this compound is introduced below., Recommanded Product: 7-Bromo-1-heptene

Take N-(1-adamantane)-3-indolecarboxamide (322 mg, 1.10 mmol)In dimethylformamide (5ml),Sodium hydride (88 mg, 2.20 mmol) was slowly added under ice-water bath.After the absence of bubbles, 7-bromo-1-heptene (244 mg, 1.30 mmol) was added.After 30 min reaction, the intermediate (7-(3-((1-adamantamine) formyl))-indolyl)heptene (187 mg, 44%) was obtained.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; East China Normal University; Shanghai Bangyao Biological Technology Co., Ltd.; Zhang Hankun; Pang Xiufeng; Liu Mingyao; Jiang Beier; Liu Zhitao; Yu Weiwei; Liang Qiuwen; (41 pag.)CN109879790; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4117-09-3, name is 7-Bromo-1-heptene, A new synthetic method of this compound is introduced below., Recommanded Product: 7-Bromo-1-heptene

9-Hept-6-enyloxy-5-hydroxymethyl-2-isopropyl-l-methyl-l,4,5,6-tetrahydro- 2H-benzo[e][l,4]diazoein-3-one (3): 7-Bromo-l-heptene (44 muL, 0.29 mmol), KI (72 mg, 0.43 mmol), and K2CO3 (80 mg, 0.58 mmol) were added to a solution of compound 2 (40 mg, 0.14 mmol) in anhydrous N,iV-dimethylformamide (DMF; 2 mL), and then heated at 8O0C for 8 h. The mixture was cooled and extracted with EtOAc (50 mL), washed with H2O (30 mL) and brine (30 mL), dried over anhydrous Na2Stheta4 (sodium sulfate), concentrated, and purified by column chromatography to afford compound 3 (17 mg, 31%); [af£ -221.23 (c=0.09 in MeOH); 1H NMR (400 MHz, CDCl3): delta=6.93 (brs, 1 H), 6.92 (d, /=8.0 Hz, 1 H), 6.52 (d, /=4.0 Hz, 1 H), 6.41 (dd, /=4.0, 8.0 Hz, 1 H), 5.87-5.77 (m, 1 H), 5.03-4.94 (m, 2 H), 3.93- 3.89 (m, 3 H), 3.72-3.66 (m, 2 H), 3.50-3.48 (m, 2 H), 3.03 (dd, /=8.0, 16.0 Hz, 1 H), 2.77 (s, 3 H), 2.77-2.69 (m, 1 H), 2.45-2.37 (m, 1 H), 2.09-2.08 (m, 2 H), 1.79- 1.76 (m, 2 H), 1.47- 1.46 (m, 4 H), 1.05 (d, /=8.0 Hz, 3H), 0.87 ppm (d, /=8.0 Hz, 3H); 13C NMR (100 MHz, CDCl3): delta =174.4, 159.0, 152.8, 139.0, 132.5, 123.2, 1 14.7, 106.8, 106.6, 70.0, 68.1, 66.1 , 54.8, 36.7, 35.3, 33.9, 29.4, 28.9, 28.5, 25.8, 20.7, 20.1 ppm; ESI-HRMS calculated for [C22H34N2O3+H]”: 375.2648, found: 375.2642; HPLC purity: 95.1 %.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; KOZIKOWSKI, Alan; CHEN, Yihua; WO2010/17272; (2010); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 4117-09-3, name is 7-Bromo-1-heptene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4117-09-3, Recommanded Product: 7-Bromo-1-heptene

Production Example 9To a mixture of 0.20 g of N- (3-hydroxyphenyl) methyl-benzothiazole-6-carboxamide, 0.16 g of 7-bromo-l-heptene and 5 ml of DMF- was added 0.26 g of cesium carbonate, and the mixture was stirred at room temperature for 4 hours. To the reaction mixture was added water, and the generated solid was collected by filtration. The solid was washed sequentially with a sodium hydroxide aqueous solution, water and hexane, and 0.12 g of N- (3- ( 6-heptenyloxy) phenyl) methyl-benzothiazole-6-carboxami de (hereinafter, referred to as the compound (9) of the present invention) was obtained.The compound (9) of the present invention 1H-NMR (CDCl3) delta: 9.11 (IH, s) , 8.50 (IH, d, J = 1.7 Hz) , 8.16 (IH, d, J = 8.5 Hz) , 7.88 (IH, dd, J = 8.5, 1.7 Hz) , 7.27 (IH, t, J = 7.9 Hz) , 6.95-6.91 (2H, m) , 6.84 (IH, dd, J = 8.3, 2.4Hz) , 6.50 (IH, s) , 5.86-5.76 (IH, m) , 5.00 (IH, dq, J = 17.1,1.7 Hz) , 4.94 (IH, dd, J = 10.2, 2.0 Hz) , 4.66 (2H, d, J = 5.6Hz) , 3.95 (2H, t, J = 6.5 Hz) , 2.08 (2H, d, J = 6.8 Hz) , 1.82-1.75 (2H, m) , 1.52-1.42 (4H, m) .

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2009/157528; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 4117-09-3, These common heterocyclic compound, 4117-09-3, name is 7-Bromo-1-heptene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Grignard reagent hept-6-en-1-ylmagnesium bromide was prepared by suspending magnesium granules (0.22g, 9.05mmol) in anhydrous tetrahydrofuran (20mL) and subsequently adding 7-bromo-1-heptene (1.63g, 9.19mmol) dropwise. The mixture was refluxed for 30min. In a separate flask, copper(I) iodide (1.72g, 9.03mmol) was suspended in anhydrous tetrahydrofuran (10mL) and cooled to-78C in an isopropyl alcohol-dry ice bath. Methyllithium solution (1.6M in diethyl ether, 5.65mL, 9.04mmol) was added very slowly via syringe. The resultant mixture was stirred at-78C for 1h and then slowly allowed to warm to 0C, whereupon a brownish suspension formed, which was immediately cooled to-78C. After that, the aforementioned solution of Grignard reagent in tetrahydrofuran was added via syringe. The mixture thus obtained was stirred at-78C for 1h and then allowed to warm to 0C, whereupon a purple colouration appeared. The mixture was then cooled again to-78C and a solution of 1 (1.47g, 4.51mmol) in tetrahydrofuran (20mL) was added via syringe. That mixture was allowed to stir at-78C for 1h and at room temperature for 2h, and the reaction was quenched by adding saturated aqueous ammonium chloride (15mL). After addition of diethyl ether (50mL), two layers and a brown insoluble formed which was filtered off. The organic phase was separated and the royal blue aqueous phase was extracted with diethyl ether. The combined organic fractions were washed with brine, dried over anhydrous magnesium sulphate, filtered and concentrated under reduced pressure. Flash column chromatography of the residual brown oil with n-hexane-diethyl ether (95:5) yielded the crude ester mixture (0.56g, 42%). A 0.23g portion was separated from the by-product 3 by passing over a 10g SPE cartridge. Step gradient elution from acetonitrile-water (9:1) to pure acetonitrile yielded pure ester 2 as a white solid (0.20g, 96%) after concentration under reduced pressure. TLC (n-hexane-diethyl ether 9:1): Rf 0.43. RP-TLC (acetonitrile): Rf 0.22. 1H NMR (400MHz, CDCl3): delta 5.80 (1H, ddt, J=16.9, 10.1, 6.6Hz), 5.00-4.89 (2H, m), 3.65 (3H, s), 2.28 (2H, t, J=7.4Hz), 2.05-1.99 (2H, m), 1.60 (2H, qui, J=7.3Hz), 1.38-1.20 (24H, m). 13C NMR (100MHz, CDCl3): delta 174.4, 139.3, 114.1, 51.5, 34.2, 33.9, 29.7 (3), 29.6, 29.5, 29.3, 29.2, 29.0, 25.0. GC: tR 16.6min. EIMS (70eV): m/z (%) 296 (1), 264 (51), 222 (28), 180 (19), 111 (19), 97 (45), 87 (59), 74 (83), 55 (100), 41 (58).

The synthetic route of 4117-09-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Huber, Thimo; Firlbeck, Doris; Riepl, Herbert M.; Journal of Organometallic Chemistry; vol. 744; (2013); p. 144 – 148;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4117-09-3, name is 7-Bromo-1-heptene, A new synthetic method of this compound is introduced below., Product Details of 4117-09-3

Mg shavings (939 mg, 38.6 mmol) are suspended in Et2O (20 ml)and 1-bromohept-6-ene (3.385 g, 19.115 mmol) is added dropwise. Thereaction mixture is stirred at RT for 3 h. Then the Grignard reagent isadded to EtOSiCl3 (945 mg, 5.150 mmol), dissolved in Et2O (20 ml), at 0 C via cannula. The reaction mixture is allowed to warm to RT andthen stirred for 2 h. Subsequently, 20 ml of the solvent are removed invacuo and 20 ml of hexanes are added to precipitate the salts formedduring the Grignard reaction. The reaction mixture is ffiltered throughcelite and the solvent removed in vacuo. The crude product is purifiedby column chromatography (SiO2, hexanes : ethylacetate=8 : 1) and 2 from the first fraction. The colorless liquid 2d (510 mg, 0.778 mmol) isisolated from the second fraction as the major product in 30% yield. Tris(hept-6-enyl)ethoxysilane 21H NMR (CDCl3, 499.7 MHz): X (ppm)=5.81 (ddt,3Jtrans(1H-1H)=16.9, 3 Hz, 3Jcis(1H-1H) =10.2 Hz, 3J(1H-1H) =6.7 Hz,3H, H6), 4.99 (ddt, 3Jtrans(1H-1H) =17.1 Hz, 2J(1H-1H) =2.1 Hz, 4J(1H-1H) =1.5 Hz, 3H, H7Z), 4.93 (ddt, 3Jcis(1H-1H) =10.2 Hz, 2J(1H-1H) =2.3 Hz, 4J(1H-1H) =1.1 Hz, 3H, H7E), 3.65 (q, 3J(1H-1H)=6.9 Hz, 2H, H8), 2.00-2.07 (m, 6H, H5), 1.30-1.41 (m, 18H, overlappingH2, H3, H4), 1.17 (t, 3J(1H-1H) =6.9 Hz, 2H, H9), 0.56-0.61(m, 6H, H1); 13C{1H} NMR (CDCl3, 125.7 MHz): X (ppm)=139.21(C6), 114.11 (C7), 58.37 (C8), 33.73 (C5*), 33.11 (C3*), 28.57 (C4),23.02 (C2), 18.65 (C9), 13.59 (C1), *assignments interchangeable; 29Si{1H} NMR (CDCl3, 79.4 MHz): X (ppm)=15.36 (s).Hexakis(hept-6-enyl)disiloxane 2d.1H NMR (CDCl3, 499.7 MHz): X (ppm)=5.81 (ddt, 3Jtrans(1H-1H)=16.9 Hz, 3Jcis(1H-1H) =10.2 Hz, 3J(1H-1H) =6.7 Hz, 6H, H6), 4.99(ddt, 3Jtrans(1H-1H) =17.1 Hz, 2J(1H-1H) =2.1 Hz, 4J(1H-1H) =1.5 Hz,6H, H7Z), 4.93 (ddt, 3Jcis(1H-1H) =10.2 Hz, 2J(1H-1H) =2.2 Hz, 4J(1H-1H) =1.2 Hz, 6H, H7E), 2.04 (dt, 3J(1H-1H) =6.7 Hz, 3J(1H-1H)=6.6 Hz, 12H, H5), 1.30-1.43 (m, 36H, overlapping H2, H3, H4), 0.56-0.61 (m, 12H, H1); 13C{1H} NMR (CDCl3, 125.7 MHz): X(ppm)=139.16 (C6), 114.15 (C7), 33.69 (C5*), 33.01 (C3*), 28.57(C4), 22.91 (C2), 14.99 (C1), *assignments interchangeable

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Guenther; Reibenspies; Bluemel; Molecular catalysis; vol. 479; (2019);,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4117-09-3, name is 7-Bromo-1-heptene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 4117-09-3

To a solution of ethyl 2-oxocyclopentane-l -carboxylate (3.56 mL, 26.7 mmol, 1 equiv.) in acetone (62 mL) at r.t. was rapidly added potassium carbonate (8.43 g, 60.4 mmol, 2.25 equiv.) and potassium iodide (1.43 g, 8.55 mmol, 0.32 equiv.). After stirring for 10 min, a solution of 7-bromohept-l-ene (4.23 mL, 26.9 mmol, 1.01 equiv.) in acetone (17 ml) was added and the reaction was refluxed for 23 h. Diethyl ether (100 mL) was added, the mixture was filtered on a Celite pad and the solvent was evaporated. The residue was diluted with ether, washed with water and brine, dried over sodium sulfate, filtered and concentrated in vacuo to afford ethyl l-(hept-6-en-l-yl)-2-oxocyclopentane-l -carboxylate as an oil (6.37 g, 88 % purity, 92 % yield).

The synthetic route of 4117-09-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FIRMENICH SA; COULOMB, Julien; DEMOLE, Edouard; (29 pag.)WO2020/78892; (2020); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 4117-09-3, name is 7-Bromo-1-heptene, molecular formula is C7H13Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 7-Bromo-1-heptene

To a solution of methyl isobutyrate (2g; 19.60 mmol) in 25ml of THF at -78C was added lithium diisopropylamide (2.0M, 1.2 equiv; 11.77ml) dropwise. After 30 minutes, a solution of 7-bromo-1-heptene (1.2 equiv; 4.14g) in 5ml of THF was added slowly. The reaction was stirred at room temperature for 1-2 hours (until TLC showed completion), then it was diluted with ether and washed with 1M HCl, then water and finally brine. It was dried over sodium sulfate and purified on silica gel (5% ethyl acetate/hexane) to yield 3.25g (87%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4117-09-3, its application will become more common.

Reference:
Patent; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES; KEYES, Gregory; RAMSDEN, Christopher; (158 pag.)WO2019/10414; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 4117-09-3, The chemical industry reduces the impact on the environment during synthesis 4117-09-3, name is 7-Bromo-1-heptene, I believe this compound will play a more active role in future production and life.

To a mixture of 0.20 g of N-benzothiazol-6-yl-2-(2-fluoro-3-hydroxy- phenyl)acetamide, 0.25 g of 7-bromo-l-heptene and 3ml of DMF was added 0.46 g of cesium carbonate. The mixture was stirred at room temperature for 4 hours. Ice water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated saline solution, then, dried over magnesium sulfate and concentrated under reduced pressure. The resultant residue was subjected to silica gel column chromatography, and 0.16 g of N-benzothiazol-6-yl-2-(3 -(6-hepteny loxy)phenyl)acetamide (hereinafter, referred to as the present compound (17)) was obtained. The present compound (17)1H-NMR (CDCl3)delta: 1.45-1.52 (4H, m), 1.77-1.84 (2H, m), 2.05-2.13 (2H5 m), 3.75 (2H5 s), 3.97 (2H5 1, J = 6.5 Hz)5 4.93-5.03 (2H, m), 5.76-5.86 (IH5 m),6.87-6.95 (3H5 m), 7.18 (IH5 dd, J = 8.8, 2.0 Hz), 7.28-7.36 (2H, m), 7.99 (IH, d, J = 8.8 Hz)5 8.49 (IH, d, J = 2.0 Hz)5 8.90 (IH5 s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromo-1-heptene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; SAKAGUCHI, Hiroshi; WO2010/24422; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 4117-09-3, A common heterocyclic compound, 4117-09-3, name is 7-Bromo-1-heptene, molecular formula is C7H13Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Coupling of Alkyl Halides with t-BuMgCl; Procedure 1 (P1)An alkyl halide (1.0 mmol), decane (63 mg as an internal standard)and LiI (5.3 mg, 0.04 mmol) were added to a dry, nitrogen-flushedtest tube equipped with a rubber septum and a magnetic stir bar.THF (0.8 mL) was added and the solution was cooled to -78 C usinga dry ice/EtOH bath. t-BuMgCl (2a) (1.5 mL, 0.81 M in THF,1.2 mmol) was added slowly followed by isoprene (136.2 mg, 2.0mmol). To this mixture was added CoCl2 [2.6 mg, 0.02 mmol, as apowder or as a THF solution (0.5 mL, 0.04 M)]. (Note 1: CoCl2should be added after isoprene, otherwise the catalytic performancedecreases significantly). The cold bath was removed and the mixturewas warmed to r.t. (ca. over 10 min), and then heated for 5 h bysuspending the reaction vessel in an oil bath kept at 50 C. (Note 2:when the reaction mixture was heated at 30 C during this stage, unidentifiedside reactions occurred resulting in low yields of couplingproducts). The resulting mixture was cooled to 0 C in an ice bathand the reaction was quenched with aq HCl (5 mL, 1 M). The productwas extracted with Et2O (3 ¡Á 20 mL). The combined organiclayer dried over Na2SO4, concentrated and analyzed by gas chromatographyto determine the GC yield. The residue was purified by silicagel column chromatography or by GPC. According to P1, 7-bromohept-1-ene (4b) (177 mg, 1.0 mmol) andt-BuMgCl (2a) (0.81 M in THF, 1.2 mmol) were reacted under standardconditions.Yield: 86% (determined by GC using decane as an internal standard).

The synthetic route of 4117-09-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Iwasaki, Takanori; Takagawa, Hiroaki; Okamoto, Kanako; Singh, Surya Prakash; Kuniyasu, Hitoshi; Kambe, Nobuaki; Synthesis; vol. 46; 12; (2014); p. 1583 – 1592;,
Bromide – Wikipedia,
bromide – Wiktionary