Related Products of 4102-60-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4102-60-7 name is 18-Bromo-6,9-octadecadiene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Intermediate 127b: (6Z,9Z)-18-iodooctadeca-6,9-diene To a solution of intermediate 127a (14.0 g, 42.659 mmol) in acetone (150 mL) in a RBF charged with a magnetic stir bar under N2 was added sodium iodide (12.7 g, 85.3 mmol). The reaction was heated to reflux (55 C) for 2 hours, after which it was cooled to room temperature and the solids were filtered off. The solvent was evaporated and the remaining solids were removed by dissolution in H20 (100 mL) and extraction with DCM (2 x 200 mL). The combined organic layers were dried over Na2S04 and evaporated to dryness to afford the desired product as a crude pale brown liquid (15.5 g, 97%). This material was used in the next step without further purification. TLC: Rf = 0.6 (100% pentane), PMA active.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 18-Bromo-6,9-octadecadiene, and friends who are interested can also refer to it.
Reference:
Patent; NOVARTIS AG; BRITO, Luis; CHEN, Delai; GAMBER, Gabriel Grant; GEALL, Andrew; LOVE, Kevin; ZABAWA, Thomas; ZECRI, Frederic; WO2015/95346; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary