Category: 4101-68-2

Synthetic Route of 4101-68-2, These common heterocyclic compound, 4101-68-2, name is 1,10-Dibromodecan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under nitrogen atmosphere, compound 7 (1.23 g, 1.65 mmol), 1,10-dibromodecane (2.97 g, 9.9 mmol), potassium hydroxide (0.43 g, 6.6 mmol), tetrabutylammonium bromide , 0.495 mmol) was added to dichloromethane (10 ml) and water (6.5 ml), and the mixture was stirred at room temperature for 24 hours. The mixture was allowed to stand for several minutes. The aqueous layer and the organic layer were separated, and methanol (30 ml) was added to the organic layer. The precipitate was filtered and purified by silica gel column chromatography (eluent ethyl acetate / petroleum ether, volume ratio 1: 30-1: 20) to give a colorless solid (1.41 g) in 89% yield.

The synthetic route of 4101-68-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guilin University of Technology; Kong, Xiangfei; Wang, Guixia; Xia, Liting; Su, Jian; Zhang, Haifeng; (19 pag.)CN105541616; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 4101-68-2,Some common heterocyclic compound, 4101-68-2, name is 1,10-Dibromodecan, molecular formula is C10H20Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1.23 g of compound 3, 2.97 g of 1,10-dibromodecane, 0.43 g of potassium hydroxide and 0.16 gTetrabutylammonium bromide was added to 10 ml of methylene chloride and 6.5 ml of water, and the mixture was stirred at room temperature for 24 hours under a nitrogen atmosphere.Washed twice with 30 ml of water, washed with 15 ml of saturated brine, the organic layer was separated,After drying with anhydrous sodium sulfate, the solvent was removed by rotary evaporator,Purification with 200-300 mesh silica gel column chromatography (eluent is ethyl acetate / petroleum ether, volume ratio of 1: 30-1:20) to give 1.41 g of compound 4 as a colorless solid in 89% yield

The synthetic route of 4101-68-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guilin University of Technology; Kong, Xiangfei; Dai, Shengping; Zhang, Laiqi; Liao, Peihai; Wang, Guixia; (10 pag.)CN106117225; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4101-68-2, name is 1,10-Dibromodecan belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 1,10-Dibromodecan

Compound 3 (713 mg, 0.5 mmol) was dissolved in anhydrous toluene (5 mL). 1,10-Dibromodecane (450 mg, 1.5 mmol), a catalytic amount of tetrabutylammonium hydrogen sulfate (TBAHS) (0.05 mmol), and KOH (1.5 mmol) were added into this solution subsequently. This reaction mixture was stirred at room temperature under N2 gas overnight and then concentrated under reduced pressure. The residue was purified by flash chromatography (elution with a gradient of hexanes/ethyl acetate from 10:1 to 4:1) to give the desired product as a white solid. Yield: 666 mg (81%). 1H NMR (300 MHz, chloroform-d) delta 5.23 (d, J = 3.1 Hz, 1H, anomeric H), 5.19 – 5.13 (m, 1H, anomeric H), 4.33 – 4.22 (m, 1H), 4.18 (d, J = 10.2 Hz, 1H), 4.09 (d, J = 5.8 Hz, 1H), 3.87 – 3.10 (m, 17H), 2.48 (d, J = 11.4 Hz, 1H), 2.07 – 1.96 (m, 1H), 1.92 – 1.80 (m, 2H), 1.57 – 1.50 (m, 1H), 1.48 – 1.40 (m, 45H), 1.39 – 1.18 (m, 14H), 1.12 – 1.00 (m, 1H), 0.99 – 0.82 (m, 36H), 0.22 – -0.03 (m, 24H). 13C NMR (75 MHz, chloroform-d) delta 155.63, 155.55, 154.85, 154.77, 154.59, 97.87 (anomeric C), 96.54 (anomeric C), 85.78, 79.95, 79.63, 79.39, 79.24, 79.11, 77.45, 75.31, 73.37, 72.69, 71.56, 68.07, 66.88, 63.16, 63.13, 57.32, 50.57, 48.97, 48.38, 41.73, 36.66, 35.97, 35.90, 35.68, 33.99, 33.80, 32.88, 30.66, 30.43, 29.98, 29.72, 29.70, 29.65, 29.56, 29.47, 29.38, 28.80, 28.66, 28.53, 28.42, 28.20, 26.15, 26.02, 26.01, 25.80, 24.70, 23.45, 18.51, 18.35, 18.12, 17.93, -3.39, -3.77, -4.18, -4.86, -4.92, -5.06, -5.14, -5.20. MS (ESI) m/e calcd for C77H152BrN5O19Si4Na [M+Na]+: 1667.3, found: 1667.4.

The synthetic route of 4101-68-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yang, Xuan; Ammeter, Derek; Idowu, Temilolu; Domalaon, Ronald; Brizuela, Marc; Okunnu, Oreofe; Bi, Liting; Guerrero, Yanelis Acebo; Zhanel, George G.; Kumar, Ayush; Schweizer, Frank; European Journal of Medicinal Chemistry; vol. 175; (2019); p. 187 – 200;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 4101-68-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4101-68-2, name is 1,10-Dibromodecan belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

1,10-Bisazidodecane NaN3 (1.30 g, 20.0 mmol) was suspended in a solution of 1,10-dibromodecane (2.42 g, 10.0 mmol) in dry dimethylformamide (15 mL). After stirring for 12 h at 60 C. water (15 mL) was added and the mixture was extracted with diethyl ether (3*100 mL). The organic layer was washed with water (3*50 mL), dried over Na2SO4 and evaporated. The crude product was purified by chromatography on silica gel (0%?20% ethyl acetate in cyclohexane). Yield: 6.82 mmol, 68% yellowish oil. 1H: [300 MHz, CDCl3] delta=1.30-1.54 (m, 12H), 1.51-1.68 (m, 4H), 3.26-3.35 (m, 4H) ppm. HRMS: [C10H20N6] m/z cal. [M+H]+=225.1822 m/z found [M+H]+=225.1821.

The synthetic route of 1,10-Dibromodecan has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Arenz, Christoph; Davies, Brian Patrick; Neubacher, Saskia; Klemm, Claudine Mercedes; US2009/92980; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4101-68-2, name is 1,10-Dibromodecan, A new synthetic method of this compound is introduced below., Recommanded Product: 4101-68-2

Under nitrogen atmosphere, 1.23 g of compound 3, 2.97 g of 1,10-dibromodecane, 0.43 g of potassium hydroxide and 0.16 g Tetrabutylammonium bromide was added to a mixture of 10 ml of methylene chloride and 6.5 ml of water. After stirring at room temperature for 24 hours,Ml of water, washed once with 15 ml of saturated brine, the organic layer was separated, and dried over anhydrous sodium sulfate to remove water After which the solvent was removed on a rotary evaporator and purified using 200-300 mesh silica gel column chromatography (eluent ethyl acetate / petroleum ether volume 1: 30-1: 20) to give 1.41 g of the compound 4 as a colorless solid in a yield of 89%

The synthetic route of 4101-68-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guilin University of Technology; Kong, Xiangfei; Dai, Shengping; Yang, Liu; Liao, Peihai; Wang, Guixia; (8 pag.)CN106117227; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary