Category: 4101-68-2

Some common heterocyclic compound, 4101-68-2, name is 1,10-Dibromodecan, molecular formula is C10H20Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 4101-68-2

Tempo 1 (0.01 mol) was added to a three-neck flask containing 100 ml dry benzene that is maintained at nitrogen atmosphere. To the flask, sodium hydride (0.015 mol) was added and kept refluxed for 24 hrs. The flask was cooled in ice bath and added 1,10- dibromodecane (0.02 mol) in one portion. The refluxing was then resumed for another 72 hrs. The contents of the flask was cooled in ice bath and added 25ml water and transferred to a separatory funnel. The red upper benzene layer was separated , dried over anhydrous magnesium sulfate and solvent removed by rotory evaporation to get a red oil. The oil was purified by column chromatography on silica gel 60. The material was added to the column and eluted first with about 150 ml hexane that removed the excess of dibromodecane. The desired bromodecanoyl ether of Tempol was eluted with a mixture of hexane and ether(90:10). The red eluate was collected and was found to be pure on thin layer chromatography plates developed using the same solvent mixture. The yield was 0.008 mol (80%).The bromoether of Tempol 0.008 mol and triphenyl phosphine (0,01 mol) were taken in a flask and added 20ml of n-propanol. The contents of the flask was kept refluxed under nitrogen for 72 hrs. The flask was cooled and the solvent was removed by rotory evaporation. The residue was dissolved in 10 ml dichloromethane and added to 100 ml ether with stirring. The precipitated product was collected by decantation of the solvent. The residual semisolid was then purified on silica gel 60 column eluting first with dichloromethane and the desired product was ehited with a mixture of dichloromethane and methanol (90:10). Homogeneous fractions combined and solvent removed to get a red-brown semisolid with a yield of 65%. Purity was ascertained by LC-MS (mass =573.4) .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4101-68-2, its application will become more common.

Reference:
Patent; COLBY PHARMACEUTICAL COMPANY; MEDICAL COLLEGE OF WISCONSIN, INC.; WO2008/109740; (2008); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4101-68-2, name is 1,10-Dibromodecan, A new synthetic method of this compound is introduced below., Quality Control of 1,10-Dibromodecan

Tempol (0.01 mol) was added to a three-neck flask containing 100 ml dry benzene that is maintained at nitrogen atmosphere. To the flask, sodium hydride (0.015 mol) was added and kept refluxed for 24 hrs. The flask was cooled in ice bath and added 1,10-dibromodecane (0.02 mol) in one portion. The refluxing was then resumed for another 72 hrs. The contents of the flask was cooled in ice bath and added 25 ml water and transferred to a separatory funnel. The red upper benzene layer was separated , dried over anhydrous magnesium sulfate and solvent removed by rotory evaporation to get a red oil. The oil was purified by column chromatography on silica gel 60. The material was added to the column and eluted first with about 150 ml hexane that removed the excess of dibromodecane. The desired bromodecanoyl ether of Tempol was eluted with a mixture of hexane and ether (90:10). The red eluate was collected and was found to be pure on thin layer chromatography plates developed using the same solvent mixture. The yield was 0.008 mol (80%).

The synthetic route of 4101-68-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; COLBY PHARMACEUTICAL COMPANY; MEDICAL COLLEGE OF WISCONSIN, INC.; US2011/59922; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4101-68-2, name is 1,10-Dibromodecan, A new synthetic method of this compound is introduced below., Computed Properties of C10H20Br2

General procedure: For example, to a solution of 7-hydroxycoumarin (5.0 g, 31.0 mmol) in acetone (60.0 mL) was added anhydrous K2CO3 (6.9 g, 50.0 mmol) and triethylamine (1.0 mL) at room temperature. After stirring at room temperature for 30 min, 1, 2-dibromoethane (12.6 g, 62.0 mmol) was added to the reaction mixture, and the whole was refluxed at 60C for 24 h. Then the reaction mixture was filtered, and the filtrate was evaporated under reduced pressure. The residue was treated with water (200.0 mL) and extracted with dichloromethane (4×200.0 mL). The organic layer was combined, dried with anhydrous Na2SO4, and concentrated under reduced pressure. The crude product was purified via silica gel column chromatography with mixed petroleum ether and ethyl acetate (5:1, v/v) as eluent, and resulted in a white solid.

The synthetic route of 4101-68-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hu, Yang; Chen, Weichao; Shen, Yufeng; Zhu, Bin; Wang, Gao-Xue; Bioorganic and Medicinal Chemistry Letters; vol. 29; 14; (2019); p. 1749 – 1755;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 4101-68-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4101-68-2, name is 1,10-Dibromodecan, This compound has unique chemical properties. The synthetic route is as follows.

To a stirred suspension of salicyaldehyde (2 mL, 20 mmol) and potassiumcarbonate (5.52 g, 40 mmol) in DMF (100 mL) was added 1,10-dibromodecane (10.8mL, 48 mmol). The mixture was stirred at 80 C for 3 h, and the solvent was evaporated under reducedpressure. The resulting residue was triturated with ether (1000 mL), and theorganic phase was washed with dilute sodium hydroxide solution, water, brine,and dried over sodium sulfate. After evaporation of the solvent, the residuewas purified by column chromatography (petroleum/ethyl acetate, 20:1), toafford compound 2 (2.45 g, 36%) as an oil. 1H NMR(300 M,CDCl3): d 1.31-1.46 (m, 12 H), 1.82-1.87 (p, 4 H), 3.41 (t, J =6.90 Hz, 2 H), 4.07 (t, J = 6.30 Hz, 2 H), 6.99 (m, 2 H), 7.52 (m, 1 H), 7.81(m, 1 H), 10.50 (s, 1 H). MS (EI) (m/e): 340 (M-H+). Anal. Calcd forC17H25BrO2: C, 59.83%; H, 7.38%; O, 9.38%.Found: C, 59.32%; H, 7.98%.

The chemical industry reduces the impact on the environment during synthesis 1,10-Dibromodecan. I believe this compound will play a more active role in future production and life.

Reference:
Article; Liu, Hui; Li, Zhan-Ting; Chinese Chemical Letters; vol. 25; 5; (2014); p. 659 – 662;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4101-68-2, name is 1,10-Dibromodecan, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4101-68-2

To a 500 rnL rmmd-bottom flask was added L l 0-dibromodecane 223a (24. 2 g, 80.655 mmol, 3.00 equiv.), acetone (1.50 mL), 2-potassio-2,3-dihydro-lH-isoindole-1 ,3-dione 223b(5 g, 26.99 mmol, 1.00 equiv.), and potassium carbonate (l 1.2 g, 81.04 mmoL 3.00 equiv.).TI1e resulting mixture v.·as stirred at 60C for 16h and concentrated. The residue was purifiedby silica gel column chromatography eluting with ethyl acetate/petroleum ether (l. 10) to give2-(10-bromodecyl)-2,3-dihydro-lH-isoindole-1,3-dione 223c (8.5g, 86~6) as a white solid.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4101-68-2.

Reference:
Patent; ARDELYX, INC.; CHAO, Jianhua; JAIN, Rakesh; HU, Lily; LEWIS, Jason Gustaf; BARIBAULT, Helene; CALDWELL, Jeremy; (582 pag.)WO2018/39386; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4101-68-2 as follows. name: 1,10-Dibromodecan

2.2.4 9-(10-bromodecyl)-9H-carbazole (4) Under argon atmosphere, carbazole (1.67 g, 0.01 mol), anhydrous potassium carbonate (2.77 g, 0.02 mol), and 1,10-dibromodecane (6.00 g, 0.02 mol) in 40 mL of anhydrous acetonitrile were refluxed at 95 C for 36 h. After cooling to room temperature, insoluble substance was filtered, and the solvent was removed under reduced pressure. The crude product was purified by column chromatography on silica gel with petroleum to get 9-(10-bromodecyl)-9H-carbazole as white crystals (1.66 g, Yield 43%). 1H NMR (500 MHz, CDCl3, delta): 8.08 (d, J = 7.7 Hz, 2H, Ar-H), 7.43 (t, J = 7.8 Hz, 2H, Ar-H), 7.35 (d, J = 8.1 Hz, 2H, Ar-H), 7.20 (t, J = 7.5 Hz, 2H, Ar-H), 4.21 (t, J = 7.3 Hz, 2H, CH2), 3.33 (t, J = 6.8 Hz, 2H, CH2Br), 1.79 (m, 4H, CH2), 1.33-0.91 (m, 12H, CH2). FT-IR (cm-1, KBr): 2930, 2850 (s; CH), 1632, 1619, 1593 (m; Ar). Anal. Calcd. For C22H28BrN: C, 68.39; H, 7.30; N, 3.63; Found: C, 68.47; H, 7.25; N, 3.56.

According to the analysis of related databases, 4101-68-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Huang, Jin; Wang, Weina; Gu, Jiangjiang; Li, Weizhi; Zhang, Qiuhong; Ding, Yin; Xi, Kai; Zheng, Youxuan; Jia, Xudong; Polymer; vol. 55; 26; (2014); p. 6696 – 6707;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 4101-68-2,Some common heterocyclic compound, 4101-68-2, name is 1,10-Dibromodecan, molecular formula is C10H20Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of phthalimide potassium salt (5.57 g, 30 mmol) and K2CO3 (15.00 g, 100 mmol) in CH3CN (100 mL) was added1,10-dibromodecane (49.94 g, 185 mmol), then the mixture was refluxed for 11 hours. The obtained mixture was filtered and CH3CN was removed by a rotary evaporator. The crude product was purified by column chromatography (SiO2, PE/EA = 6 : 1) to give a whitesolid (10.19 g, 93 %).

The synthetic route of 4101-68-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Mengjun; Du, Xusheng; Tian, Huasheng; Jia, Qiong; Deng, Rong; Cui, Yahan; Wang, Chunyu; Meguellati, Kamel; Chinese Chemical Letters; vol. 30; 2; (2019); p. 345 – 348;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 4101-68-2, name is 1,10-Dibromodecan, molecular formula is C10H20Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 4101-68-2

Tempo 1 (0.01 mol) was added to a three-neck flask containing 100 ml dry benzene that is maintained at nitrogen atmosphere. To the flask, sodium hydride (0.015 mol) was added and kept refluxed for 24 hrs. The flask was cooled in ice bath and added 1,10- dibromodecane (0.02 mol) in one portion. The refluxing was then resumed for another 72 hrs. The contents of the flask was cooled in ice bath and added 25ml water and transferred to a separatory funnel. The red upper benzene layer was separated , dried over anhydrous magnesium sulfate and solvent removed by rotory evaporation to get a red oil. The oil was purified by column chromatography on silica gel 60. The material was added to the column and eluted first with about 150 ml hexane that removed the excess of dibromodecane. The desired bromodecanoyl ether of Tempol was eluted with a mixture of hexane and ether(90:10). The red eluate was collected and was found to be pure on thin layer chromatography plates developed using the same solvent mixture. The yield was 0.008 mol (80%).The bromoether of Tempol 0.008 mol and triphenyl phosphine (0,01 mol) were taken in a flask and added 20ml of n-propanol. The contents of the flask was kept refluxed under nitrogen for 72 hrs. The flask was cooled and the solvent was removed by rotory evaporation. The residue was dissolved in 10 ml dichloromethane and added to 100 ml ether with stirring. The precipitated product was collected by decantation of the solvent. The residual semisolid was then purified on silica gel 60 column eluting first with dichloromethane and the desired product was ehited with a mixture of dichloromethane and methanol (90:10). Homogeneous fractions combined and solvent removed to get a red-brown semisolid with a yield of 65%. Purity was ascertained by LC-MS (mass =573.4) .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4101-68-2, its application will become more common.

Reference:
Patent; COLBY PHARMACEUTICAL COMPANY; MEDICAL COLLEGE OF WISCONSIN, INC.; WO2008/109740; (2008); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4101-68-2, name is 1,10-Dibromodecan, A new synthetic method of this compound is introduced below., Application In Synthesis of 1,10-Dibromodecan

Tempol (0.01 mol) was added to a three-neck flask containing 100 ml dry benzene that is maintained at nitrogen atmosphere. To the flask, sodium hydride (0.015 mol) was added and kept refluxed for 24 hrs. The flask was cooled in ice bath and added 1,10-dibromodecane (0.02 mol) in one portion. The refluxing was then resumed for another 72 hrs. The contents of the flask was cooled in ice bath and added 25 ml water and transferred to a separatory funnel. The red upper benzene layer was separated , dried over anhydrous magnesium sulfate and solvent removed by rotory evaporation to get a red oil. The oil was purified by column chromatography on silica gel 60. The material was added to the column and eluted first with about 150 ml hexane that removed the excess of dibromodecane. The desired bromodecanoyl ether of Tempol was eluted with a mixture of hexane and ether (90:10). The red eluate was collected and was found to be pure on thin layer chromatography plates developed using the same solvent mixture. The yield was 0.008 mol (80%).

The synthetic route of 4101-68-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; COLBY PHARMACEUTICAL COMPANY; MEDICAL COLLEGE OF WISCONSIN, INC.; US2011/59922; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 4101-68-2, The chemical industry reduces the impact on the environment during synthesis 4101-68-2, name is 1,10-Dibromodecan, I believe this compound will play a more active role in future production and life.

General procedure: The bromide or iodide salts of 1,n-bis(isoquinolinium)alkane dications (n = 2, 4, 5, 6, 8, 9, 10 and 12) and alpha,alpha’-bis(isoquinolinium)-p-xylene dibromide were prepared using modifications of a method outlined by Kuca et al.. A mixture of the appropriate 1,n-bis(isoquinolinium)alkane dibromide or diiodide (1.0 mmol) or alpha,alpha’-dibromo-p-xylene (1.0 mmol) and isoquinoline (9.0 mmol) in DMF was heated at 70 C for 1-4 days. The addition of diethyl ether to the cooled solution resulted in a light brown precipitate, which was filtered and washed with diethyl ether.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,10-Dibromodecan, other downstream synthetic routes, hurry up and to see.

Reference:
Conference Paper; Kwok, Julian C.; Macartney, Donal H.; Supramolecular Chemistry; vol. 26; 3-4; (2014); p. 182 – 191;,
Bromide – Wikipedia,
bromide – Wiktionary