Category: 40787-48-2

Application of 40787-48-2,Some common heterocyclic compound, 40787-48-2, name is 1,4-Dibromo-2,5-diethylbenzene, molecular formula is C10H12Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In the glove box the mixture of 1 ,4-dibromo-2,5-diethylbenzene (7.1 1 g, 24.35mmol), 4-chloro-2-methylphenylboronic acid (8.3g,48.70mmol), Aliquat 336 (0.5g), and Pd(PPh3) (1 .4g, 1 .21 mmol, 0.05eq), and Na2CO3 (12.9g, 121 .7mmol) in degassed toluene (200mL) was prepared. Outside dry box, the degassed water (65ml_) was added to the former mixture under nitrogen, and then the resultant mixture was stirred at 88C overnight under nitrogen. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were dried over anhydrous MgSO4. Filtration, concentration of the filtrate, and then the silica column chromatography (hexane) provided the desired product, 18, (6.7g, 72% yield) as a white solid.

The synthetic route of 40787-48-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; PARK, Kyung-Ho; RADU, Nora, Sabina; JOHANSSON, Gary, A.; FENNIMORE, Adam; DELANEY, William, J.; LECLOUX, Daniel, David; WO2011/159872; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 40787-48-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 40787-48-2 as follows.

Finally, the final product d was obtained by Suzuki coupling reaction: 9 mmol of 9-benzoquinone-10 borate was obtained.1.5 mmol of 1,4-dibromo-2,5-diethylbenzene, 0.36 mmol of tetrakis(triphenylphosphine)palladium, 60 mL of toluene,15 mL of ethanol, 333 mmol of K2CO, (formed as a solution with 15 mL of water), and added to the reaction flask.The system was then evacuated under reflux of nitrogen at 110 C for 24 hours.After completion of the reaction, the methanol was subjected to hot-washing suction filtration, toluene to recrystallization, and sublimation to obtain the final product d, yield 42%.

According to the analysis of related databases, 40787-48-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shaanxi Normal University; Hu Jianyong; Zhang Jiali; (19 pag.)CN108383693; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary