Category: 405931-46-6

Jiang, Sheng-Peng; Dong, Xiao-Yang; Gu, Qiang-Shuai; Ye, Liu; Li, Zhong-Liang; Liu, Xin-Yuan published the artcile< Copper-Catalyzed Enantioconvergent Radical Suzuki-Miyaura C(sp3)-C(sp2) Cross-Coupling>, Application of C8H8BrF, the main research area is diarylalkane arylalkyne enantioselective preparation; copper catalyst enantioselective Suzuki Miyaura coupling benzylic propargyl bromide; acenaphthylenediolboronate enantioselective Suzuki Miyaura coupling benzylic propargyl bromide; radical mechanism copper catalyzed enantioselective Suzuki Miyaura coupling.

A copper-catalyzed enantioconvergent Suzuki-Miyaura C(sp3)-C(sp2) cross-coupling of various racemic alkyl halides with organoboronate esters has been established in high enantioselectivity. Critical to the success is the use of a chiral cinchona alkaloid-derived N,N,P-ligand for not only enhancing the reducing capability of copper catalyst to favor a stereoablative radical pathway over a stereospecific SN2-type process but also providing an ideal chiral environment to achieve the challenging enantiocontrol over the highly reactive radical species. The reaction has a broad scope with respect to both coupling partners, covering aryl- and heteroarylboronate esters, as well as benzyl-, heterobenzyl-, and propargyl bromides and chlorides with good functional group compatibility. Thus, it provides expedient access toward a range of useful enantioenriched skeletons featuring chiral tertiary benzylic stereocenters.

Journal of the American Chemical Society published new progress about Alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (aralkyl). 405931-46-6 belongs to class bromides-buliding-blocks, and the molecular formula is C8H8BrF, Application of C8H8BrF.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yan, Nicholas L.; Santos-Martins, Diogo; Nair, Reji; Chu, Alan; Wilson, Ian A.; Johnson, Kristen A.; Forli, Stefano; Morgan, Gareth J.; Petrassi, H. Michael; Kelly, Jeffery W. published the artcile< Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design>, Quality Control of 405931-46-6, the main research area is coumarin stabilizer amyloidogenic Ig light chain amyloidosis inhibitor.

In Ig light-chain (LC) amyloidosis, transient unfolding or unfolding and proteolysis enable aggregation of LC proteins, causing potentially fatal organ damage. A drug that kinetically stabilizes LCs could suppress aggregation; however, LC sequences are variable and have no natural ligands, hindering drug development efforts. We previously identified high-throughput screening hits that bind to a site at the interface between the two variable domains of the LC homodimer. We hypothesized that extending the stabilizers beyond this initially characterized binding site would improve affinity. Here, using protease sensitivity assays, we identified stabilizers that can be divided into four substructures. Some stabilizers exhibit nanomolar EC50 values, a 3000-fold enhancement over the screening hits. Crystal structures reveal a key π-π stacking interaction with a conserved tyrosine residue that was not utilized by the screening hits. These data provide a foundation for developing LC stabilizers with improved binding selectivity and enhanced physicochem. properties.

Journal of Medicinal Chemistry published new progress about Crystal structure. 405931-46-6 belongs to class bromides-buliding-blocks, and the molecular formula is C8H8BrF, Quality Control of 405931-46-6.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Galli, Marzia; Fletcher, Catherine J.; del Pozo, Marc; Goldup, Stephen M. published the artcile< Scalable anti-Markovnikov hydrobromination of aliphatic and aromatic olefins>, COA of Formula: C8H8BrF, the main research area is alkene hydrogen bromide regioselective hydrobromination; alkyl bromide preparation.

To improve access to a key synthetic intermediate a direct hydrobromination-Negishi route was targeted. Unsurprisingly, the anti-Markovnikov addition of HBr to estragole in the presence of AIBN proved successful. However, even in the absence of an added initiator, anti-Markovnikov addition was observed Re-examination of early reports revealed that selective Markovnikov addition, often simply termed “”normal”” addition, was not always observed with HBr unless air was excluded, leading to the rediscovery of a reproducible and scalable initiator-free protocol.

Organic & Biomolecular Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 405931-46-6 belongs to class bromides-buliding-blocks, and the molecular formula is C8H8BrF, COA of Formula: C8H8BrF.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Fenghua; Chen, Cheng; Yang, Kailin; Xu, Yang; Liu, Xiaomei; Gao, Fan; Liu, He; Chen, Xia; Zhao, Qi; Liu, Xiang; Cai, Yan; Yang, Haitao published the artcile< Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus>, HPLC of Formula: 405931-46-6, the main research area is preparation Michael acceptor peptidomimetic porcine epidemic diarrhea virus protease.

Porcine epidemic diarrhea virus (PEDV) causes high mortality in pigs. PEDV main protease (Mpro) plays an essential role in viral replication. We solved the structure of PEDV Mpro complexed with peptidomimetic inhibitor N3 carrying a Michael acceptor warhead, revealing at. level interactions. We further designed a series of 17 inhibitors with altered side groups. Inhibitors M2 and M17 demonstrated enhanced specificity against PEDV Mpro. These compounds have potential as future therapeutics to combat PEDV infection.

Journal of Medicinal Chemistry published new progress about Antiviral agents. 405931-46-6 belongs to class bromides-buliding-blocks, and the molecular formula is C8H8BrF, HPLC of Formula: 405931-46-6.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Binder, Jorg T.; Cordier, Christopher J.; Fu, Gregory C. published the artcile< Catalytic Enantioselective Cross-Couplings of Secondary Alkyl Electrophiles with Secondary Alkylmetal Nucleophiles: Negishi Reactions of Racemic Benzylic Bromides with Achiral Alkylzinc Reagents>, Reference of 405931-46-6, the main research area is secondary benzylic bromide cycloalkylzinc reagent nickel catalyzed Negishi coupling; chiral isoquinoline oxazoline ligand stereoselective Negishi coupling; acyclic alkylzinc reagent Negishi cross coupling isomerization.

The authors have developed a nickel-catalyzed method for the asym. cross-coupling of secondary electrophiles with secondary nucleophiles, specifically, stereoconvergent Negishi reactions of racemic benzylic bromides with achiral cycloalkylzinc reagents. In contrast to most previous studies of enantioselective Negishi cross-couplings, tridentate pybox ligands are ineffective in this process; however, a new, readily available bidentate isoquinoline-oxazoline ligand I furnishes excellent ee’s and good yields. Ent-I is also used to provide products of opposite configuration with excellent ee’s and good yields. The use of acyclic alkylzinc reagents as coupling partners led to the discovery of a highly unusual isomerization that generates a significant quantity of a branched cross-coupling product from an unbranched nucleophile.

Journal of the American Chemical Society published new progress about Aralkyl bromides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (secondary). 405931-46-6 belongs to class bromides-buliding-blocks, and the molecular formula is C8H8BrF, Reference of 405931-46-6.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Yajun; Jiang, Dandan; Fang, Zheng; Zhu, Ning; Sun, Naixian; He, Wei; Liu, Chengkou; Zhao, Lili; Guo, Kai published the artcile< Photomediated core modification of organic photoredox catalysts in radical addition: mechanism and applications>, Application of C8H8BrF, the main research area is bismethoxyphenyl dihydrophenazine bromoalkane photochem cross coupling; alkyl bisphenyl dihydrophenazine preparation.

Here, a new kind of core modification for dihydrophenazines, phenoxazines and phenothiazines was developed through this cross-coupling process. Mechanistic studies suggested that the radical species would be more likely to couple with OPC’ radical cations rather than the ground-state OPC. Core modification of OPCs could stabilize the radical ions in an oxidative quenching catalytic cycle. Significantly, core modifications of OPCs could lower the energy of light required for photoexcitation. Compared with their noncore-modified counterparts, all the core-modified dihydrophenazines and phenoxazines exhibited efficient performance in controlling O-ATRP for the synthesis of poly(Me methacrylate) with higher initiator efficiencies under the irradiation of simulated sunlight.

Chemical Science published new progress about Atom transfer radical polymerization. 405931-46-6 belongs to class bromides-buliding-blocks, and the molecular formula is C8H8BrF, Application of C8H8BrF.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary