Some common heterocyclic compound, 40422-70-6, name is 1-Bromo-3-(2-bromoethyl)benzene, molecular formula is C8H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H8Br2
Example 46 4-Bromo-2-(2-bromo-ethyl)-benzenesulfonyl chloride Chlorosulfonic acid (17 mL) was added dropwise to 1-bromo-3-(2-bromo-ethyl)-benzene (5 g, 19 mmol) at 0 C. The mixture was stirred at 0 C. for 1 h then an additional 3 h at rt. The mixture was poured into an ice-water slowly and extracted with methylene chloride, and the combined organic layers were evaporated under reduced pressure to give 4.3 g of crude 4-Bromo-2-(2-bromo-ethyl)-benzenesulfonyl chloride which was used directly for next reaction. MS (ESI) 342.9 (M-Cl+OH)-.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 40422-70-6, its application will become more common.
Reference:
Patent; Roche Palo Alto LLC; US2010/4231; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary