Category: 403646-48-0

SDS of cas: 403646-48-0On November 30, 2001 ,《1,2-Didehydro-3- and -4-(trifluoromethoxy)benzene: the “”aryne”” route to 1- and 2-(trifluoromethoxy)naphthalenes》 appeared in European Journal of Organic Chemistry. The author of the article were Schlosser, Manfred; Castagnetti, E.. The article conveys some information:

Upon treatment of 1-bromo-2-(trifluoromethoxy)benzene with lithium diisopropylamide (LDA) at -100°C, 3-bromo-2-(trifluoromethoxy)phenyllithium is generated. It can be trapped as such, but isomerizes to afford 2-bromo-6-(trifluoromethoxy)phenyllithium when the temperature is raised to -75°C. The latter intermediate can be directly obtained from 1-bromo-3-(trifluoromethoxy)benzene. 1-Bromo-4-(trifluoromethoxy)benzene gives 5-bromo-2-(trifluoromethoxy)phenyllithium at -100°C, but at -75°C it slowly eliminates lithium bromide, thus setting free 1,2-dehydro-4-(trifluoromethoxy)benzene. In the same way, 1,2-dehydro-3-(trifluoromethoxy)benzene can be generated from 1-bromo-3-(trifluoromethoxy)benzene. Both arynes can be intercepted in situ with furan. The resulting [4+2] cycloadducts can be reduced with zinc powder, giving 1- and 2-(trifluoromethoxy)naphthalenes, they may be submitted to acid-catalyzed isomerization to produce trifluoromethoxy-1-naphthols, or they may be brominated to afford vic-dibromo derivatives Base-promoted dehydrobromination of the latter compounds produces 2- or 3-bromo-1,4-epoxy-1,4-dihydro-5- or -6-(trifluoromethoxy)naphthalenes, which undergo regioselective ring-opening in acidic media and halogen/metal exchange when treated with butyllithium. In the part of experimental materials, we found many familiar compounds, such as 2-Bromo-5-(trifluoromethoxy)benzoic acid(cas: 403646-48-0SDS of cas: 403646-48-0)

2-Bromo-5-(trifluoromethoxy)benzoic acid(cas: 403646-48-0) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis. SDS of cas: 403646-48-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of 2-Bromo-5-(trifluoromethoxy)benzoic acidOn October 15, 2022 ,《Development and profiling of mGlu7 NAMs with a range of saturable inhibition of agonist responses in vitro》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Reed, Carson W.; Rodriguez, Alice L.; Kalbfleisch, Jacob J.; Seto, Mabel; Jenkins, Matthew T.; Blobaum, Anna L.; Chang, Sichen; Lindsley, Craig W.; Niswender, Colleen M.. The article contains the following contents:

We describe here a series of metabotropic glutamate receptor 7 (mGlu7) neg. allosteric modulators (NAMs) with a saturable range of activity in inhibiting responses to an orthosteric agonist in two distinct in vitro pharmacol. assays. The range of inhibition among compounds in this scaffold provides highly structurally related ligands with differential degrees of receptor blockade that can be used to understand inhibitory efficacy profiles in native tissue or in vivo.2-Bromo-5-(trifluoromethoxy)benzoic acid(cas: 403646-48-0Safety of 2-Bromo-5-(trifluoromethoxy)benzoic acid) was used in this study.

2-Bromo-5-(trifluoromethoxy)benzoic acid(cas: 403646-48-0) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Safety of 2-Bromo-5-(trifluoromethoxy)benzoic acid Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

SDS of cas: 403646-48-0On May 15, 2019 ,《Surveying heterocycles as amide bioisosteres within a series of mGlu7 NAMs: Discovery of VU6019278》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Reed, Carson W.; Washecheck, Jordan P.; Quitlag, Marc C.; Jenkins, Matthew T.; Rodriguez, Alice L.; Engers, Darren W.; Blobaum, Anna L.; Jeffrey Conn, P.; Niswender, Colleen M.; Lindsley, Craig W.. The article conveys some information:

This letter describes a diversity-oriented library approach to rapidly assess diverse heterocycles as bioisosteric replacements for a metabolically labile amide moiety within a series of mGlu7 neg. allosteric modulators (NAMs). SAR rapidly honed in on either a 1,2,4- or 1,3,4-oxadizaole ring system as an effective bioisostere for the amide. Further optimization of the southern region of the mGlu7 NAM chemotype led to the discovery of VU6019278, a potent mGlu7 NAM (IC50 = 501 nM, 6.3% L-AP4 Min) with favorable plasma protein binding (rat fu = 0.10), low predicted hepatic clearance (rat CLhep = 27.7 mL/min/kg) and high CNS penetration (rat Kp = 4.9, Kp,uu = 0.65). In the part of experimental materials, we found many familiar compounds, such as 2-Bromo-5-(trifluoromethoxy)benzoic acid(cas: 403646-48-0SDS of cas: 403646-48-0)

2-Bromo-5-(trifluoromethoxy)benzoic acid(cas: 403646-48-0) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. SDS of cas: 403646-48-0 In contrast, terrestrial plants account only for a few bromine-containing compounds.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary