402-49-3 Archives - Page 3 of 13 - Bromides-buliding-blocks

Zhang, Min team published research in Journal of Organic Chemistry in 2021 | 402-49-3

402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., Application of C8H6BrF3

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 402-49-3, formula is C8H6BrF3, The most pervasive is the naturally produced bromomethane. Application of C8H6BrF3

Zhang, Min;Lin, Jin-Hong;Xiao, Ji-Chang research published 《 HCF₂Se/HCF₂S Installation by Tandem Substitutions from Alkyl Bromides》, the research content is summarized as follows. Herein authors describe an efficient construction of HCF₂Se and HCF₂S groups by tandem substitutions between alkyl bromides and a reagent system consisting of MSeCN (or MSCN) and Ph₃P+CF₂H Br-. The tandem process occurs via the first nucleophilic substitution of alkyl bromides by -SeCN (or -SCN) and the subsequent nucleophilic difluoromethylation.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yuan, Yao team published research in Advanced Synthesis & Catalysis in 2021 | 402-49-3

Recommanded Product: 1-(Bromomethyl)-4-(trifluoromethyl)benzene, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Recommanded Product: 1-(Bromomethyl)-4-(trifluoromethyl)benzene.

Yuan, Yao;Zhang, Si-Yuan;Dong, Wu-Heng;Wu, Feng;Xie, Xiao-Min;Zhang, Zhao-Guo research published 《 Visible-Light-Induced Radical Cascade Cyclization of o-Diisocyanoarenes: Synthesis of Diethyl Benzo[a]phenazine-6,6(5H)-Dicarboxylate》, the research content is summarized as follows. A visible-light-induced radical cascade cyclization of ortho-diisocyanoarenes for the synthesis of di-Et benzo[a]phenazine-6,6(5H)-dicarboxylates has been developed. This process provides an efficient and convenient protocol for the construction of benzo[a]phenazine skeleton that widely present in biol. active mols. and pharmaceuticals. The reaction takes place under mild conditions and the products are obtained in moderate to excellent yields.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Xiaoxu team published research in Organometallics in 2022 | 402-49-3

Category: bromides-buliding-blocks, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

Yang, Xiaoxu;Ge, Shaozhong research published 《 Cobalt-Catalyzed 1,1,3-Triborylation of Terminal Alkynes》, the research content is summarized as follows. The authors have developed a Co-catalyzed regioselective 1,1,3-triborylation reaction of terminal alkynes with pinacolborane (HBpin) with a catalyst generated in situ from readily available and bench-stable Co(acac)₂ and xantphos. A variety of terminal alkynes undergo this triborylation reaction, affording the corresponding 1,1,3-triborylalkanes in good yields with high selectivity. The synthetic utility of this catalytic protocol was demonstrated by developing selective stepwise functionalization of 1,1,3-triborylalkane products. The results of mechanistic studies, such as conducting control experiments and D-labeling reactions, monitoring the reaction process, and identifying reaction intermediates, suggest that this 1,1,3-triborylation reaction proceeds through 1,3-diborylation of alken-1-ylboronates formed by Co-catalyzed hydroboration of terminal alkynes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Ren-Yin team published research in Organic Letters in 2022 | 402-49-3

Yang, Ren-Yin;Gao, Xinyan;Gong, Kehao;Wang, Juan;Zeng, Xiaojun;Wang, Mingwei;Han, Junbin;Xu, Bo research published 《 Synthesis of ArCF₂X and [¹⁸F]Ar-CF₃ via Cleavage of the Trifluoromethylsulfonyl Group》, the research content is summarized as follows. A versatile synthesis of ArCF₂X and [¹⁸F]Ar-CF₃ type compounds from readily available ArCF₂SO₂CF₃ has been developed. Diverse nucleophiles, including weak nucleophiles such as halides (¹⁸F^–, Cl^–, Br^–, and I^–), RSH, and ROH, could react with ArCF₂SO₂CF₃ efficiently to give the corresponding difluoromethylene products. The control experiments and the Hammett plot indicated that the reaction might proceed through a difluorocarbocation intermediate generated from the steric hindrance-assisted cleavage of the trifluoromethylsulfonyl group.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Ju-Song team published research in Angewandte Chemie, International Edition in 2022 | 402-49-3

Synthetic Route of 402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene, Synthetic Route of 402-49-3

Yang, Ju-Song;Lu, Ka;Li, Chen-Xiao;Zhao, Zu-Hang;Zhang, Xiao-Ming;Zhang, Fu-Min;Tu, Yong-Qiang research published 《 Chiral 1,2,3-Triazolium Salt Catalyzed Asymmetric Mono- and Dialkylation of 2,5-Diketopiperazines with the Construction of Tetrasubstituted Carbon Centers》, the research content is summarized as follows. Novel asym. mono- and dialkylation reactions of α-substituted 2,5-diketopiperazines catalyzed by new chiral spirocyclic-amide-derived triazolium organocatalysts was developed, resulting in a range of enantioenriched 2,5-diketopiperazine derivatives containing one or two tetrasubstituted carbon stereocenters. The reactions featured high yields (up to 98%) and excellent cis-diastereo- and enantioselectivities (up to >20:1 dr, >99% ee) and they provided a new asym. synthetic approach to important functionalized 2,5-diketopiperazine skeletons. Furthermore, a possible reaction mechanism was proposed based on both control experiments and extensive DFT calculations

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Yue team published research in Journal of Medicinal Chemistry in 2022 | 402-49-3

Application In Synthesis of 402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

Xu, Yue;Li, Hua;Xu, Shufen;Liu, Xian;Lin, Jingjing;Chen, Haiyan;Yuan, Zhenwei research published 《 Light-Triggered Fluorescence Self-Reporting Nitric Oxide Release from Coumarin Analogues for Accelerating Wound Healing and Synergistic Antimicrobial Applications》, the research content is summarized as follows. Nitric oxide (NO) has an important class of endogenous diat. mols. that play a key regulatory role in many physiol. and biochem. processes. However, the type of nitrosamine NO donor stimulated by light has many advantages compared to the conventional NO donors such as diazeniumdiolates and S-nitrosothiols compounds, including easy synthesis, good stability, and controllable release. In addition, NO release can be regulated by light induction with a built-in calibration mechanism fluorescence. Here, we report that the migration and proliferation of human umbilical vein vascular endothelial cells could be accelerated by the light-triggered NO donors, leading to the angiogenesis. Meanwhile, the screened NO donor 3a with Levofloxacin (Lev) showed synergistic effects to eradicate Methicillin-resistant Staphylococcus aureus (MRSA) biofilms in vitro and treat bacteria-infected wound in vivo.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Xi team published research in European Journal of Medicinal Chemistry in 2022 | 402-49-3

Xu, Xi;Chang, Xiujin;Huang, Jingxuan;Zhang, Di;Wang, Min;Jing, Tian;Zhuang, Yu;Kou, Junping;Qiu, Zhixia;Wang, Jubo;Li, Zhiyu;Bian, Jinlei research published 《 Discovery of novel glutaminase 1 allosteric inhibitor with 4-piperidinamine linker and aromatic heterocycles》, the research content is summarized as follows. Glutaminase 1 (GLS1) is overexpressed in multiple types of malignant tumors and is viewed as a promising target in cancer therapy. Thus, the discovery for small-mol. GLS1 inhibitors is urgent. Based on the authors’ previous study of compound I, a potent GLS1 allosteric inhibitor yet with a limited metabolic stability, a structure-based optimization was carried out, with a series of novel GLS1 allosteric inhibitors rationally designed, synthesized and biol. evaluated. Such endeavor has culminated in the identification of compound II, a promising GLS1 allosteric inhibitor with a 4-piperidinamine linker and aromatic heterocycles. Compound II displayed robust GLS1 binding affinity, superior liver microsome metabolic stability, and moderate anti-tumor activity (TGI: 47.5%) in HCT116 xenograft model with no considerable toxicity in vivo. The mechanism underlying the anti-proliferative effect of compound II on HCT116 cells was studied, revealing that the compound blocked the glutamine metabolism, induced the production of ROS, and triggered apoptosis. These findings merit further investigation of compound II as a targeted cancer therapeutic.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Zeng-Hua team published research in Angewandte Chemie, International Edition in 2021 | 402-49-3

Wu, Zeng-Hua;Cheng, An-Qi;Yuan, Meng;Zhao, Ya-Xuan;Yang, Huai-Lan;Wei, Li-Hua;Wang, Huai-Yu;Wang, Tao;Zhang, Zunting;Duan, Wei-Liang research published 《 Cobalt-Catalysed Asymmetric Addition and Alkylation of Secondary Phosphine Oxides for the Synthesis of P-Stereogenic Compounds》, the research content is summarized as follows. Secondary pyridyl arylphosphine oxides undergo addition to activated double bonds and nucleophilic substitution with benzyl halides catalyzed by cobalt(II) complexes with chiral pincer isoindole-bis(oxazoline) ligands yielding P-chiral phosphine oxides ArPyP(O)R (Py = 2-pyridyl), which were converted into aryl and alkyl derivatives ArR¹P(O)R by reaction with Grignard reagents R¹MgX with minor loss of enantiopurity. The catalytic asym. synthesis of P-chiral phosphorus compounds is an important way to construct P-chiral ligands. Herein, we report a new strategy that adopts the pyridinyl moiety as the coordinating group in the cobalt-catalyzed asym. nucleophilic addition/alkylation of secondary phosphine oxides. A series of tertiary phosphine oxides were generated with up to 99% yield and 99.5% ee, and with broad functional-group tolerance. Mechanistic studies reveal that (R)-secondary phosphine oxides preferentially interact with the cobalt catalysts to produce P-stereogenic compounds

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Bin team published research in Nature Communications in 2021 | 402-49-3

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Category: bromides-buliding-blocks.

Wu, Bin;Wang, Jianing;Liu, Xingchen;Zhu, Rong research published 《 Bicyclo[2.2.0]hexene derivatives as a proaromatic platform for group transfer and chemical sensing》, the research content is summarized as follows. Here the design, preparation, synthetic utility, and sensing application of a class of proarom. structures, namely bicyclo[2.2.0]hexene (BCHs) derivatives I [R = allyl, i-Pr, Bn, etc.] was reported. Building on a valence isomerism concept, they featured modular and easy synthesis as well as high thermal stability, and could be oxidatively activated under mild conditions. New alkyl transfer reactions using BCHs as a radical donor were developed to showcase the utility of their proaromaticity. Moreover, the redox-triggered valence isomerization of a quinoline-derived BCH led to colorimetric and fluorescent responses toward vapors of electrophilic reagents in solution and solid phase, resp. This optical response was showed to involved a 1,3-cyclohexadiene structure that possesses an intramol. charge transfer excited state with interesting aggregation induced emission (AIE) character. Thus, the potential of BCHs was demonstrated as a versatile platform for the development of new reagents and functional materials.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Dunqi team published research in ACS Catalysis in 2022 | 402-49-3

Wu, Dunqi;Fan, Wenzheng;Wu, Lianqian;Chen, Pinhong;Liu, Guosheng research published 《 Copper-Catalyzed Enantioselective Radical Chlorination of Alkenes》, the research content is summarized as follows. In this report, authors reviewed a copper-catalyzed asym. atom transfer radical addition (ATRA) reaction, which remains a great challenge since the discovery of racemic ATRA in the 1940s. This enantioselective radical chlorination of acrylamides was developed, where three reagents, including Togni-I and TMSCl, PhICF₃Cl, and CX₃SO₂Cl, were employed as the radical sources and chlorine source, affording a series of chlorinated carbon-centered quaternary compounds in good yields with excellent enantioselectivity. Notably, the well-designed bulky chiral ligand plays a key role in the successful enantioselective radical chlorination process.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary