Category: 402-43-7

These common heterocyclic compound, 402-43-7, name is 1-Bromo-4-(trifluoromethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 402-43-7

General procedure: A mixture of CuF2 (102 mg, 1.00 mmol), the aryl halide (500 mumol), 2-aminoethanol (74.9 muL, 1.25 mmol), and NaN3 (65.0 mg, 1.00 mmol) in DMA (1 mL) was stirred under an Ar atmosphere (balloon) at 95 C using a Chemistation personal organic synthesizer (EYELA, Tokyo). After complete consumption of the aryl halide was confirmed by TLC analyses or after 24 h (if the reaction was incomplete within 24 h), the mixture was diluted with EtOAc (10 mL) and then filtered through a Celite pad. The pad was successively washed with EtOAc (20 mL), H2O (25 mL), and concd aq ammonia solution (5 mL). After the two layers were separated, the aqueous layer was extracted with EtOAc (2×10 mL). The combined organic layers were washed with brine (20 mL), dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was purified by silica-gel column chromatography with n-hexane/EtOAc or n-pentane/Et2O as the eluent.

The synthetic route of 1-Bromo-4-(trifluoromethyl)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Maejima, Toshihide; Shimoda, Yutaka; Nozaki, Kei; Mori, Shigeki; Sawama, Yoshinari; Monguchi, Yasunari; Sajiki, Hironao; Tetrahedron; vol. 68; 6; (2012); p. 1712 – 1722;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 402-43-7, name is 1-Bromo-4-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., Formula: C7H4BrF3

General procedure: In a Schlenk tube, substrate (0.5 mmol), silane (0.6 mmol), base (1.5 mmol) and decane (71 mg, 0.5 mmol) as internal standard were added to 1 mL of preformed palladium nanoparticles (total amount of palladium 0.01 mmol) under argon. The reaction mixture was heated at 80 C and stirred for the indicated time (3-24 h), and then cooled down to room temperature. The organic products were extracted from glycerol with dichloromethane (5 * 3 mL). The obtained products were previously described in the literature and their identification was carried out by comparison of their GC-MS data, 1H and 13C NMR spectra with the reported data (see Table S1 in the Supporting Information).

According to the analysis of related databases, 402-43-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Reina, Antonio; Serrano-Maldonado, Alejandro; Teuma, Emmanuelle; Martin, Erika; Gomez, Montserrat; Catalysis Communications; vol. 104; (2018); p. 22 – 27;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 402-43-7, The chemical industry reduces the impact on the environment during synthesis 402-43-7, name is 1-Bromo-4-(trifluoromethyl)benzene, I believe this compound will play a more active role in future production and life.

A solution of l-bromo-4-(trifluoromethyl)benzene (1.1 g, 4.89 mmol, 1.00 eq), ethyl piperidine-4-carboxylate (770 mg, 4.90 mmol, 1.00 eq), NaOtBu (0.71 g, 1.50 eq), BINAP (0.31 g, 0.10 eq), and Pd2(dba)3 (450 mg, 0.49 mmol, 0.10 eq) in toluene (10 mL) was stirred for 16 h at 90 C. The resulting solution was extracted with 2×30 mL of EtOAc, and the combined organic layers were concentrated under vacuum. The residue was purified with silica gel chromatography using EtOAc/hexane (1/2) to afford 1 g (68%) of the title compound as an off-white solid. LC-MS: (ES, m/z): 302

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-(trifluoromethyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CENTAURUS THERAPEUTICS; ROMERO, Donna L.; MCCALL, John M.; BLITZER, Jeremy; (118 pag.)WO2018/112077; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 402-43-7, A common heterocyclic compound, 402-43-7, name is 1-Bromo-4-(trifluoromethyl)benzene, molecular formula is C7H4BrF3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

i-Butyl piperazine-l-carboxylate (1.52 g, 8.17 mmol, 2.00 equiv), l-bromo-4- (trifluoromethyl)benzene (1 g, 4.10 mmol, 1.00 equiv), BINAP (124 mg, 0.40 mmol, 0.10 equiv), Pd2(dba)3 (184 mg, 0.20 mmol, 0.05 equiv), NaOi-Bu (1.2 g, 12.50 mmol, 3.00 equiv), and toluene (15 mL) were combined in a 100-mL round- bottom flask, stirred overnight at 100C in an oil bath, and concentrated under vacuum. Purification by silica gel column with PE/EA (50:1) yielded 1.06 g (78%) of i-butyl 4-(4-(trifluoromethyl)phenyl)piperazine-l-carboxylate as a yellow solid.LC-MS (ES, m/z): 331 [M+H]+

The synthetic route of 402-43-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BIOENERGENIX; MCCALL, John, M.; MCKEARN, John; ROMERO, Donnal, L.; CLAIR, Michael; WO2011/28947; (2011); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 402-43-7, These common heterocyclic compound, 402-43-7, name is 1-Bromo-4-(trifluoromethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 9. Preparation of l-(4-trifluoromethyl-phenyl)-piperidiii-4-ol intermediate. A mixture of 4-hydroxypiperidine (100 mg; 0.99 mmol), 4-bromo benzotrifiuoride (0.167 mL, 1.19 mmol), tris(dibenzylideneacetone)dipalladium (37 mg; 0.04 mmol) and 2-(dicyclohexylphosphino)-2-methylbiphenyl (29 mg; 0.08 mmol) is thoroughly flushed with argon and tetrahydrofuran is added (1 mL). A molar solution of bis-(trimethylsilyl)-lithium amide in tetrahydrofuran (1.9 mL, 1.90 mmol) is added and the reaction mixture is heated at 65C. After 17 hours reaction time, aq. IM hydrochloric acid (7.5 mL) is added and the mixture is stirred for 15 minutes before neutralization by addition of aq. sat. sodium hydrogencarbonate. The mixture is extracted with ethyl acetate (2 x 10 mL). The combined organic layers are dried over sodium sulfate, filtered and evaporated under reduced pressure to yield crude l-(4-trifiuoromethyl-phenyl)-piperidin-4-ol.

Statistics shows that 1-Bromo-4-(trifluoromethyl)benzene is playing an increasingly important role. we look forward to future research findings about 402-43-7.

Reference:
Patent; INTERVET INTERNATIONAL B.V.; CHASSAING, Christophe Pierre Alain; MEYER, Thorsten; WO2010/115688; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 402-43-7, name is 1-Bromo-4-(trifluoromethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 402-43-7

General procedure: A mixture of CuF2 (102 mg, 1.00 mmol), the aryl halide (500 mumol), 2-aminoethanol (74.9 muL, 1.25 mmol), and NaN3 (65.0 mg, 1.00 mmol) in DMA (1 mL) was stirred under an Ar atmosphere (balloon) at 95 C using a Chemistation personal organic synthesizer (EYELA, Tokyo). After complete consumption of the aryl halide was confirmed by TLC analyses or after 24 h (if the reaction was incomplete within 24 h), the mixture was diluted with EtOAc (10 mL) and then filtered through a Celite pad. The pad was successively washed with EtOAc (20 mL), H2O (25 mL), and concd aq ammonia solution (5 mL). After the two layers were separated, the aqueous layer was extracted with EtOAc (2×10 mL). The combined organic layers were washed with brine (20 mL), dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was purified by silica-gel column chromatography with n-hexane/EtOAc or n-pentane/Et2O as the eluent.

The synthetic route of 1-Bromo-4-(trifluoromethyl)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Maejima, Toshihide; Shimoda, Yutaka; Nozaki, Kei; Mori, Shigeki; Sawama, Yoshinari; Monguchi, Yasunari; Sajiki, Hironao; Tetrahedron; vol. 68; 6; (2012); p. 1712 – 1722;,
Bromide – Wikipedia,
bromide – Wiktionary

402-43-7, name is 1-Bromo-4-(trifluoromethyl)benzene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1-Bromo-4-(trifluoromethyl)benzene

General procedure: The aryl halide (5.0 mmol), arylboronic acid (7.5 mmol), base (10.0 mmol), the calculated amount of thiourea, Pd and H2O (5 mL) were added to a flask containing a magnetic stir bar under air. The flask was sealed with a rubber septum and the contents were stirred at the specified temperature for the appropriate period of time. Upon completion, the reaction mixture was extracted using Et2O (3 10 mL). The solvent was removed on a rotary evaporator and the residue was purified by flash chromatography on silica gel to afford the desired product. The coupling products were characterized by 1H NMR and 13C NMR spectroscopy (see the Supporting Information). The identities of the products were confirmed by comparison with literature spectroscopic data.

The synthetic route of 402-43-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chen, Wei; Lu, Xiao-Yan; Xu, Bei-Hua; Yu, Wei-Guo; Zhou, Zi-Niu; Hu, Ying; Synthesis; vol. 50; 7; (2018); p. 1499 – 1510;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 402-43-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 402-43-7, name is 1-Bromo-4-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: der nitrogen atmosphere in a glovebox, a stir bar, an aryl halide (0.40 mmol, 1.0 equiv.), quinuclidine (0.60 mmol, 1.5 equiv., 66.7 mg), and 1 mL of DMAc solution containing dissolved NiBr2.3H2O (0.02 mmol, 0.05 equiv., 5.5 mg) was added to a 0.5 dram glass vial. The glass vial was then capped using a screw cap equipped with a PTFE/silicone septum and sealed with a strip of PARAFILM. The capped vial was then brought out of the glovebox and liquid amine (degassed, 0.60 mmol, 1.5 equiv.) was added via a HAMILTON syringe. Solid amines were weighed and added inside the glovebox. The capped glass vial containing the reaction mixture was then placed in a 3D-printed vial holder and subjected to 365 nm LED irradiation with fan cooling to maintain the vial at room temperature. After the time specified in the reaction schemes, the reaction mixture was washed with water, extracted with EtOAc or DCM and concentrated under vacuum. Purification of the crude product by flash chromatography on silica gel using the indicated solvent system afforded the desired product

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-4-(trifluoromethyl)benzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Colorado State University Research Foundation; Miyake, Garret; Lim, Chern-Hooi; Kudisch, Max; Liu, Bin; (41 pag.)US2019/345122; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary