Category: 402-43-7

In 2019,Chem included an article by Deng, Ruixian; Xi, Junwei; Li, Qigang; Gu, Zhenhua. Application In Synthesis of 1-Bromo-4-(trifluoromethyl)benzene. The article was titled 《Enantioselective Carbon-Carbon Bond Cleavage for Biaryl Atropisomers Synthesis》. The information in the text is summarized as follows:

Development of new synthetic strategies for enantioselective carbon-carbon and carbon-heteroatom bond formation is one of the pillars of modern organic chem. Whereas significant advances have been achieved in center chirality construction, catalytically asym. construction of axial chirality is still under development. Moreover, axially chiral mols. constructed through carbon-carbon and carbon-heteroatom bond cleavage are extremely limited. Authors report an asym. synthesis of biaryl atropisomers I (R = OCF3, Ph, CO2tBu, etc.; R2 = Ph, 3-MeC6H4, 4-ClC6H4, etc.; Ar3 = Ph, p-Tol, 2-thienyl, etc.) via palladium-catalyzed chemoselective carbon-carbon cleavage of 9-aryl-9H-fluoren-9-ols. The reaction demonstrated broad substrate scope and produced the atropisomers in high yields and enantioselectivity. The ring-opening reactivity was considerably accelerated by the torsional strain created by the steric repulsion between two ortho-substituents of the biaryl skeleton in the substrates. The high enantiocontrol hinges on the evolvement of a new TADDOL-based phosphoramidite as ligand. These findings set up a new platform for the development of novel synthetic methods via asym. carbon-carbon cleavage. The experimental process involved the reaction of 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Application In Synthesis of 1-Bromo-4-(trifluoromethyl)benzene)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool. Application In Synthesis of 1-Bromo-4-(trifluoromethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Direct C-H Arylation of Aldehydes by Merging Photocatalyzed Hydrogen Atom Transfer with Palladium Catalysis》 was published in ACS Catalysis in 2020. These research results belong to Wang, Lu; Wang, Ting; Cheng, Gui-Juan; Li, Xiaobao; Wei, Jun-Jie; Guo, Bin; Zheng, Caijuan; Chen, Guangying; Ran, Chongzhao; Zheng, Chao. Application of 402-43-7 The article mentions the following:

Herein, we report that merging palladium catalysis with hydrogen atom transfer (HAT) photocatalysis enabled direct arylations and alkenylations of aldehyde C-H bonds, facilitating visible light-catalyzed construction of a variety of ketones. Tetrabutylammonium decatungstate and anthraquinone were found to act as synergistic HAT photocatalysts. D. functional theory calculations suggested a Pd0-PdII-PdIII-PdI-Pd0 pathway and revealed that regeneration of the Pd0 catalyst and the photocatalyst occurs simultaneously in the presence of KHCO3. This regeneration features a low energy barrier, promoting efficient coupling of the palladium catalytic cycle with the photocatalytic cycle. The work reported herein suggests great promise for further applications of HAT photocatalysis in palladium-catalyzed cross-coupling and C-H functionalization reactions to be successful. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Application of 402-43-7)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Application of 402-43-7 The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Zheqi; Wu, Dong; Ding, Chao; Yin, Guoyin published their research in CCS Chemistry in 2021. The article was titled 《Modular synthesis of diarylalkanes by nickel-catalyzed 1,1-diarylation of unactivated terminal alkenes》.Product Details of 402-43-7 The article contains the following contents:

A nickel-catalyzed 1,1-diarylation of electronically unbiased alkenes was developed, providing straightforward access to diarylalkanes from readily available materials. Importantly, both the efficiency and the regioselectivity of this transformation were ensured by reaction conditions, rather than the coordinating group of substrates. It was also demonstrated that under balloon pressure, ethylene and propylene was also be utilized as substrates. Preliminary mechanistic experiments suggested that this transformation involves a Ni(0)/Ni(II) catalytic cycle rather than a Ni(I)/Ni(III) cycle. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Product Details of 402-43-7)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Product Details of 402-43-7 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

COA of Formula: C7H4BrF3In 2020 ,《Synthesis and Characterization of N,N-Dimethylformamide-Protected Palladium Nanoparticles and Their Use in the Suzuki-Miyaura Cross-Coupling Reaction》 appeared in ACS Omega. The author of the article were Ishida, Junya; Nakatsuji, Masato; Nagata, Tatsuki; Kawasaki, Hideya; Suzuki, Takeyuki; Obora, Yasushi. The article conveys some information:

The synthesis of new N,N-dimethylformamide (DMF)-protected palladium nanoparticles (Pd NPs-OAc) employing Pd(OAc)2 (= Pd(OCOCH3)2) as the NP precursor was reported. Pd NPs-OAc were comprehensively characterized by transmission electron microscopy, FT-IR, NMR and XPS to determine the Pd NP size distribution and the coordination state of DMF. Pd NPs-OAc were compared with Pd NPs-Cl, using PdCl2 as the NP precursor. The Suzuki-Miyaura cross-coupling reaction proceeded efficiently in the presence of Pd NPs-OAc and a high catalytic activity was observed with a turnover number of up to 1.5 x 105. Furthermore, the Pd NP-OAc catalysts could be recycled at least five times. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7COA of Formula: C7H4BrF3)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. COA of Formula: C7H4BrF3 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Organic Letters included an article by Si, Xiaojia; Zhang, Lumin; Hashmi, A. Stephen K.. Recommanded Product: 402-43-7. The article was titled 《Benzaldehyde- and Nickel-Catalyzed Photoredox C(sp3)-H Alkylation/Arylation with Amides and Thioethers》. The information in the text is summarized as follows:

Herein a synergistic combination of a nickel catalyst and benzaldehyde for the use of amides and thioethers in C(sp3)-H alkylation and arylation reactions employing simple aryl or alkyl halides is reported. This method provides a simple and cheap strategy for the direct functionalization of amides and thioethers. Readily available starting materials, mild reaction conditions, a good functional-group tolerance, and a broad substrate scope make this methodol. attractive and practical for pharmaceutical and synthetic chem. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Recommanded Product: 402-43-7)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Recommanded Product: 402-43-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Arylsilylation of Electron-Deficient Alkenes via Cooperative Photoredox and Nickel Catalysis》 was published in ACS Catalysis in 2020. These research results belong to Zhang, Zhikun; Hu, Xile. Quality Control of 1-Bromo-4-(trifluoromethyl)benzene The article mentions the following:

Carbosilylation of alkenes can be an efficient approach to the synthesis of organosilicon compounds However, few general methods of carbosilylation are known. Here, we introduce a strategy for arylsilylation of electron-deficient terminal alkenes by combining photoredox-catalyzed silyl radical generation, innate reactivity of silyl radical with alkene, and Ni-catalyzed aryl-alkyl cross-coupling. This cooperative photoredox and nickel catalysis operates under mild conditions. It employs readily available alkenes, aryl bromides, and silane as reagents, and it produces useful synthetic building blocks in a modular manner. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Quality Control of 1-Bromo-4-(trifluoromethyl)benzene)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. Quality Control of 1-Bromo-4-(trifluoromethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Solar-driven tandem photoredox nickel-catalysed cross-coupling using modified carbon nitride》 was published in Chemical Science in 2020. These research results belong to Qin, Yangzhong; Martindale, Benjamin C. M.; Sun, Rui; Rieth, Adam J.; Nocera, Daniel G.. Reference of 1-Bromo-4-(trifluoromethyl)benzene The article mentions the following:

Nickel-catalyzed aryl amination and etherification were driven with sunlight using a surface-modified carbon nitride to extend the absorption of the photocatalyst into a wide range of the visible region. In contrast to traditional homogeneous photochem. methodologies, the lower cost and higher recyclability of the metal-free photocatalyst, along with the use of readily available sunlight, provide an efficient and sustainable approach to promote nickel-catalyzed cross-couplings. In the experimental materials used by the author, we found 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Reference of 1-Bromo-4-(trifluoromethyl)benzene)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Reference of 1-Bromo-4-(trifluoromethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《A laser driven flow chemistry platform for scaling photochemical reactions with visible light》 were Harper, Kaid C.; Moschetta, Eric G.; Bordawekar, Shailendra V.; Wittenberger, Steven J.. And the article was published in ACS Central Science in 2019. Synthetic Route of C7H4BrF3 The author mentioned the following in the article:

Visible-light-promoted organic reactions can offer increased reactivity and selectivity via unique reaction pathways to address a multitude of practical synthetic problems, yet few practical solutions exist to employ these reactions for multikilogram production We have developed a simple and versatile continuous stirred tank reactor (CSTR) equipped with a high-intensity laser to drive photochem. reactions at unprecedented rates in continuous flow, achieving kg/day throughput using a 100 mL reactor. Our approach to flow reactor design uses the Beer-Lambert law as a guideline to optimize catalyst concentration and reactor depth for maximum throughput. This laser CSTR platform coupled with the rationale for design can be applied to a breadth of photochem. reactions. The experimental process involved the reaction of 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Synthetic Route of C7H4BrF3)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Synthetic Route of C7H4BrF3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Pd/C as Heterogeneous Catalyst for the Direct Arylation of (Poly)fluorobenzenes》 were Mao, Shuxin; Shi, Xinzhe; Soule, Jean-Francois; Doucet, Henri. And the article was published in Chemistry – A European Journal in 2019. Synthetic Route of C7H4BrF3 The author mentioned the following in the article:

The potential of the heterogeneous catalyst 10 % Pd/C in the direct arylation of (poly)fluorobenzene derivatives with aryl bromides has been investigated. In general, high yields of biaryl derivatives were obtained by using tri-, tetra-, and pentafluorobenzenes, whereas mono- and difluorobenzenes exhibited poor reactivity. The regioselectivities of the arylation reactions were similar to those observed with homogeneous palladium catalysts. Both electron-withdrawing and -donating substituents, such as nitrile, nitro, acetyl, ester, trifluoromethyl, tert-Bu, methoxy, or Me, on the aryl bromide were tolerated. Unexpectedly, tetrafluoro-substituted [1,1′-biphenyl]-4-ols were obtained from pentafluorobenzene at 150° due to a formal regioselective hydroxylation, whereas at lower temperatures the expected pentafluorobiphenyls were obtained. However, no C-F bond cleavage was observed with the other polyfluorobenzene derivatives These arylation reactions were carried out with only 1 mol % Pd/C as the catalyst and KOAc as an inexpensive base. Therefore, this protocol represents a very attractive access to (poly)fluoro-substituted biphenyls in terms of cost, simplicity, and sustainable chem. because the Pd/C catalyst can be easily removed at the end of the reaction, there is no contamination with phosphine ligand residues, and the major side-product of the reaction is KOAc.HBr. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Synthetic Route of C7H4BrF3)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Synthetic Route of C7H4BrF3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Nickel-Catalyzed Cross-Electrophile Reductive Couplings of Neopentyl Bromides with Aryl Bromides》 was written by Biswas, Soumik; Qu, Bo; Desrosiers, Jean-Nicolas; Choi, Younggi; Haddad, Nizar; Yee, Nathan K.; Song, Jinghua J.; Senanayake, Chris H.. Name: 1-Bromo-4-(trifluoromethyl)benzene And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

5-Cyanoimidazole was identified as an inexpensive ligand for nickel-catalyzed cross-electrophile couplings by screening a diverse set of pharmaceutical compound library. A strategic screening approach led to the discovery of this novel ligand, which was successfully applied in the preparation of various alkylated arene products with good to high yields. Furthermore, the properties of this ligand allowed expanding the scope of reductive couplings to challenging substrates, such as sterically hindered neopentyl halides, which are known to generate motifs that are prevalent in biol. active mols. The results came from multiple reactions, including the reaction of 1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7Name: 1-Bromo-4-(trifluoromethyl)benzene)

1-Bromo-4-(trifluoromethyl)benzene(cas: 402-43-7) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Name: 1-Bromo-4-(trifluoromethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary