Category: 401-78-5

Wan, Lin-Xi; Miao, Shi-Xing; He, Zhen-Xiang; Li, Xiaohuan; Zhou, Xian-Li; Gao, Feng published the artcile< Pd-Catalyzed Direct Modification of an Anti-Alzheimer's Disease Drug: Synthesis and Biological Evaluation of α-Aryl Donepezil Analogues>, Related Products of 401-78-5, the main research area is benzylpiperidinylmethyl dimethoxy aryldihydroindenone preparation antialzheimer mol docking.

Palladium/BuAd2P catalyzed efficiently the direct α-arylation of ketone in the anti-Alzheimer’s disease drug donepezil I (Ar = H), leading to 15 aryldonepezil analogs I (Ar = 3-methylpyridin-2-yl (II), 4-chlorophenyl, naphth-1-yl, etc.) exhibiting high selective inhibition of acetylcholinesterase (AChE). The cell-based assays revealed that the 3-methylpridinyl analog (II) shows significantly lower toxicity compared to donepezil and remarkable neuroprotective activity against H2O2-induced damage in SH-SY5Y cells. Docking results of compound II also interpreted the possible mechanism of the selective inhibition between AChE and butyrylcholinesterase.

ACS Omega published new progress about Alzheimer disease. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Related Products of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Dejiang; Tang, Ting; Zhang, Zhao; Le, Liyuan; Xu, Zhi; Lu, Hao; Tong, Zhou; Zeng, Dishu; Wong, Wai-Yeung; Yin, Shuang-Feng; Ghaderi, Arash; Kambe, Nobuaki; Qiu, Renhua published the artcile< Nickel- and Palladium-Catalyzed Cross-Coupling of Stibines with Organic Halides: Site-Selective Sequential Reactions with Polyhalogenated Arenes>, Application In Synthesis of 401-78-5, the main research area is chloro fluorophenyl tetrahydrodibenzoazastibocine preparation arylation aryl halide; crystal structure chloro fluorophenyl tetrahydrodibenzoazastibocine; mol structure chloro fluorophenyl tetrahydrodibenzoazastibocine; biphenyl preparation; arylstibine preparation coupling reaction aryl halide palladium nickel catalyst.

Herein, the authors disclose a general and efficient method for the synthesis of Sb-aryl and Sb-alkyl stibines by the Ni-catalyzed cross-coupling of halostibines with organic halides. The synthesized Sb-aryl stibines couple with aryl halides to give biaryls efficiently via Pd catalysis. Sequential reactions of stibines with polyhalogenated arenes bearing active C-I/C-Br sites and inactive C-Cl sites successfully proceeded, giving a variety of complex mols. with good site selectivity. Drugs such as diflunisal and fenbufen, as well as a fenofibrate derivative, were synthesized on gram scales in good yields, together with the high recovery of chlorostibine. Also, catalytic mechanisms are proposed based on the results of control experiments

ACS Catalysis published new progress about Aryl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Application In Synthesis of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Slack, Eric D.; Colacot, Thomas J. published the artcile< Understanding the Activation of Air-Stable Ir(COD)(Phen)Cl Precatalyst for C-H Borylation of Aromatics and Heteroaromatics>, Synthetic Route of 401-78-5, the main research area is iridium complex catalyzed carbon hydrogen bond borylation aromatic heteroaromatic; borane aromatic heteroaromatic derivative preparation.

A newly developed robust catalyst [Ir(COD)(Phen)Cl] (A) was used for the C-H borylation of three dozen aromatics and heteroaromatics with excellent yield and selectivity. Activation of the catalyst was identified using catalytic amounts of H2O, alcs., etc., when B2pin2 was used in noncoordinating solvents, while for THF catalytic use of HBpin was required. The results were on par with the in situ based expensive system [Ir(OMe)(COD)]2/dtbbpy or Me4Phen.

Organic Letters published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Synthetic Route of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Schmidt, Olivia P.; Blackmond, Donna G. published the artcile< Temperature-Scanning Reaction Protocol Offers Insights into Activation Parameters in the Buchwald-Hartwig Pd-Catalyzed Amination of Aryl Halides>, HPLC of Formula: 401-78-5, the main research area is temperature scanning reaction protocol Buchwald Hartwig amination activation parameter.

A temperature-scanning reaction (TSR) protocol allows deconvolution of the driving forces of concentration and temperature in a single experiment, demonstrated here for the Buchwald-Hartwig amination reaction using different amine substrates that exhibit different rate-determining steps. An Eyring anal. reveals that the observed reactivity differences between 1-hexylamine and benzophenone hydrazone are related primarily to the different contributions of activation entropy in the two cases. This TSR protocol combined with other in situ kinetic methodologies including reaction progress kinetic anal. and variable time normalization anal. provides a rapid and comprehensive mechanistic picture of complex multistep catalytic reactions.

ACS Catalysis published new progress about Activation enthalpy. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, HPLC of Formula: 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Hao; Gao, Yuzhen; Zhou, Chunlin; Li, Gang published the artcile< Visible-Light-Driven Reductive Carboarylation of Styrenes with CO2 and Aryl Halides>, Formula: C7H4BrF3, the main research area is photochem regioselective reductive carboarylation styrene carbon dioxide aryl halide.

The first example of visible-light-driven reductive carboarylation of styrenes with CO2 and aryl halides in a regioselective manner has been achieved. A broad range of aryl iodides and bromides were compatible with this reaction. Moreover, pyridyl halides, alkyl halides, and even aryl chlorides were also viable with this method. These findings may stimulate the exploration of novel visible-light-driven Meerwein arylation-addition reactions with user-friendly aryl halides as the radical sources and the photocatalytic utilization of CO2. Thus, e.g., reaction of 1,1-diphenylethylene with PhI and CO2 under blue light in presence of [Ir(ppy)2(dtbbpy)]PF6 photocatalyst and hydrogen atom transfer catalyst DABCO with HCO2K as terminal reductant and K2CO3 as base in DMSO followed by methylation afforded I (82%, 78% isolated).

Journal of the American Chemical Society published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Formula: C7H4BrF3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Davies, David L.; Singh, Kuldip; Tamosiunaite, Neringa published the artcile< Steric effects on acetate-assisted cyclometallation of meta-substituted N-phenyl and N-benzyl imidazolium salts at [MCl2Cp*]2 (M = Ir, Rh)>, Recommanded Product: 3-Bromobenzotrifluoride, the main research area is aryl benzyl meta substituted imidazolium cyclometalation preparation half sandwich; iridium rhodium half sandwich cyclometalated aryl benzyl imidazolylidene preparation; crystal mol structure iridium rhodium cyclometalated aryl benzyl imidazolylidene.

Meta-Substituted aryl and benzyl imidazolium salts [3-MeIm-1-(3-RC6H4)][OTf] (H2L-Ar) and [3-MeIm-1-(CH2-3-RC6H4)][OTf] (H2L-CH2Ar) undergo acetate-assisted cyclometalation to provide mixtures of ortho and para substituted cyclometalated complexes [(L-C2,C2′)ClMCp*] and [(L-C2,C6′)ClMCp*], resp. (L = LAr, L-CH2Ar). The effect of the substituents on the isomer ratios is discussed; steric effects are more important in the 6-membered rings derived from the N-benzyl imidazolium salts than 5-membered rings from the N-Ph salts. Comparisons are made to steric effects with some other common directing groups.

Dalton Transactions published new progress about Carbene complexes, N-heterocyclic, transition metal complexes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (cyclometalated). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Recommanded Product: 3-Bromobenzotrifluoride.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hung, Vu Thai; Tran, Cong Chi; Yamamoto, Yuki; Kodama, Shintaro; Nomoto, Akihiro; Ogawa, Akiya published the artcile< Clarification on the Reactivity of Diaryl Diselenides toward Hexacyclohexyldilead under Light>, HPLC of Formula: 401-78-5, the main research area is aryl cyclohexyl selenide preparation; diaryl diselenide hexacyclohexyldilead light irradation; diaryl dichalcogenides; hexacyclohexyldilead; homolytic substitution; photoirradiation.

In this study, the reactivity of organochalcogen compounds toward a representative alkyl-lead bond compound under light was investigated in detail. Under light irradiation, the Cy-Pb bond of Cy6Pb2 (Cy = cyclohexyl) undergoes homolytic cleavage to generate a cyclohexyl radical (Cy·). This radical can be successfully captured by di-Ph diselenide, which exhibits excellent carbon-radical-capturing ability. In the case of (PhS)2 and (PhTe)2, the yields of the corresponding cyclohexyl sulfides and tellurides were lower than that of (PhSe)2. This probably occurred due to the low carbon-radical-capturing ability of (PhS)2 and the high photosensitivity of the cyclohexyl-tellurium bond.

Molecules published new progress about Diselenides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, HPLC of Formula: 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vogt, David B.; Seath, Ciaran P.; Wang, Hengbin; Jui, Nathan T. published the artcile< Selective C-F Functionalization of Unactivated Trifluoromethylarenes>, Reference of 401-78-5, the main research area is difluoroalkylarene preparation; trifluoromethylarene alkene photocatalytic alkylation.

Fluorinated organic mols. are pervasive within the pharmaceutical and agrochem. industries due to the range of structural and physicochem. properties that fluorine imparts. Currently, the most abundant methods for the synthesis of the aryl-CF2 functionality have relied on the deoxyfluorination of ketones and aldehydes using expensive and poorly atom economical reagents. Here, we report a general method for the synthesis of aryl-CF2R and aryl-CF2H compounds through activation of the corresponding trifluoromethyl arene precursors. This strategy is enabled by an endergonic electron transfer event that provides access to arene radical anions that lie outside of the catalyst reduction potential. Fragmentation of these reactive intermediates delivers difluorobenzylic radicals that can be intercepted by abundant alkene feedstocks or a hydrogen atom to provide a diverse array of difluoalkylaroms.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Reference of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ghorbani-Choghamarani, Arash; Mohammadi, Masoud; Taherinia, Zahra published the artcile< (ZrO)2Fe2O5 as an efficient and recoverable nanocatalyst in C-C bond formation>, Computed Properties of 401-78-5, the main research area is zirconium ferrite recoverable nanocatalyst carbon bond formation.

In this paper, the synthesis and characterization of zirconium ferrite ((ZrO)2Fe2O5) magnetic nanoparticles (MNPs) and their application as a catalyst in C-C cross-coupling reaction will be described. The structure of the catalyst was studied by Fourier transform IR spectroscopy (FT-IR), SEM, energy dispersive spectrometry (EDS), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), vibrating sample magnetometer (VSM) and ICP-OES anal. The resulting zirconium ferrite [(ZrO)2Fe2O5] was efficient for C-C coupling reactions, affording the desired products in good to excellent yields. Moreover, the catalyst could be easily recovered by magnetic separation and recycled for four times without significant loss of its catalytic activity.

Journal of the Iranian Chemical Society published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Computed Properties of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Trauner, Florian; Reiners, Felix; Apaloo-Messan, Kodjo-Edmond; Nissl, Benedikt; Shahbaz, Muhammad; Jiang, Dongfang; Aicher, Julian; Didier, Dorian published the artcile< Strain-release arylations for the bis-functionalization of azetidines>, Quality Control of 401-78-5, the main research area is azetidine preparation; organometallic compound azabicyclobutane arylation nucleophilic substitution Buchwald Hartwig coupling.

The addition of nucleophilic organometallic species onto in situ generated azabicyclobutanes enables the selective formation of 3-arylated azetidine intermediates through strain-release. Single pot strategies were further developed for the N-arylation of resulting azetidines, employing either SNAr reactions or Buchwald-Hartwig couplings.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Quality Control of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary