Category: 401-78-5

Wang, Tao; Wang, Yi-Ning; Wang, Rui; Zhang, Bo-Chao; Yang, Chi; Li, Yan-Lin; Wang, Xi-Sheng published the artcile< Enantioselective cyanation via radical-mediated C-C single bond cleavage for synthesis of chiral dinitriles>, Safety of 3-Bromobenzotrifluoride, the main research area is chiral dinitrile enantioselective preparation; cycloalkanone oxime ester enantioselective cyanation copper catalyst.

Herein, radical-mediated ring-opening and enantioselective cyanation of four- and five-membered cycloketone oxime esters was described to access chiral 1,5- and 1,6-dinitriles ArCHCN(CH2)nCN [R = Ph, 1-naphthyl, 2-naphthyl, etc.; n = 2, 3] with R-stereochem. Employment of dual photoredox/copper catalysis was essential for the asym. ring-opening cyanation of cyclopentanone oxime esters. Both reactions proceeded under mild conditions giving chiral dinitriles in high yields and enantioselectivity with low catalyst loading and broad substrate scope. The products dinitriles could be converted to valuable optically active diamides and diamines. Mechanistic studies indicate that the benzylic radical generated via C-C single bond cleavage was involved in the catalytic cycle.

Nature Communications published new progress about C-C bond cleavage. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Safety of 3-Bromobenzotrifluoride.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lu, Cong; Jing, Dong; Shen, Yanling; Luo, Jiajing; Zheng, Ke published the artcile< Redox-neutral access to 3,3'-disubstituted oxindoles via radical coupling reactions>, Recommanded Product: 3-Bromobenzotrifluoride, the main research area is arylpropanyl indolinone preparation; disubstituted oxindole redox active ester radical coupling.

In this paper, the results of using EDA complexes of in situ formed enolates with redox-active esters for radical-coupling reactions under mild conditions (metal-, photocatalyst-, and base-free) to afford (arylpropan-2-yl)indolin-2-ones I [R1 = H, Me, Boc; R2 = Me, Ph, 4-FC6H4, etc.; R3 = R4 = H, Me; R5 = Ph, 4-MeC6H4, 2-naphthyl, etc.] was reported. The leaving group from the substrate in these experiments was reused as a base in the reaction. This strategy could successfully be applied to a wide variety of primary, secondary, and tertiary alkyl radical precursors and oxindoles in radical-coupling reactions. The success of sunlight-driven transformation and gram-level synthesis via flow chem. delivered promising results for further application in industrial settings. Mechanistic investigation, including control experiments, and UV-vis spectroscopy provided insight into the mechanism.

Organic Chemistry Frontiers published new progress about Coupling reaction, homolytic. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Recommanded Product: 3-Bromobenzotrifluoride.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lutter, Ferdinand H.; Grokenberger, Lucie; Hofmayer, Maximilian S.; Knochel, Paul published the artcile< Cobalt-catalyzed acylation-reactions of (hetero)arylzinc pivalates with thiopyridyl ester derivatives>, Category: bromides-buliding-blocks, the main research area is thiopyridyl ester hetero arylzinc pivalate acylation catalyst; aryl ketone preparation.

A cobalt-catalyzed acylation reaction of various primary, secondary and tertiary alkyl, benzyl and (hetero)aryl S-pyridyl thioesters with (hetero)arylzinc pivalates was reported. The thioesters were prepared directly from the corresponding carboxylic acids under mild conditions, thus tolerating sensitive functional groups. Acylations of α-chiral S-pyridyl esters proceeded with very high stereoretention leaded to optically enriched α-chiral ketones.

Chemical Science published new progress about Acylation. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Blass, Benjamin E.; Chen, Peng-Jen; Taylor, Michelle; Griffin, Suzy A.; Gordon, John C.; Luedtke, Robert R. published the artcile< Synthesis and evaluation of cyclic diamino benzamide based D3 receptor ligands>, Product Details of C7H4BrF3, the main research area is cyclic diamino benzamide preparation D3 receptor pharmacokinetics.

Dopamine is a key neurotransmitter whose impact on pharmacol. processes is mediated by a family of dopamine receptors designated D1, D2, D3, D4 and D5. Various diseases and conditions such as schizophrenia, drug abuse, depression, restless leg syndrome, Parkinson′s disease (PD), and inflammatory diseases have been linked to aberrant D3 activity. Herein, we report a series of novel D3 ligands with improved solubility over our previous lead compound, MC25-41 (2).

Medicinal Chemistry Research published new progress about Brain. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Product Details of C7H4BrF3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bychek, Roman; Mykhailiuk, Pavel K. published the artcile< A Practical and Scalable Approach to Fluoro-Substituted Bicyclo[1.1.1]pentanes>, Recommanded Product: 3-Bromobenzotrifluoride, the main research area is fluoro substituted bicyclopentane preparation; Bicyclo[1.1.0]butane; Bicyclo[1.1.1]pentane; Bioisosteres; Fluorine.

A practical scalable approach to fluoro-substituted bicyclo[1.1.1]pentanes was developed. The physicochem. properties of the F-BCPs were studied, and the core was incorporated into the structure of the anti-inflammatory drug flurbiprofen in place of the fluorophenyl ring.

Angewandte Chemie, International Edition published new progress about Bicyclic compounds Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Recommanded Product: 3-Bromobenzotrifluoride.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shen, Xiao-Qin; Yan, Xiao-Wei; Zhang, Xing-Guo published the artcile< A palladium-catalyzed ring-expansion reaction of cyclobutanols with 2-haloanilines leading to benzazepines and quinolines>, Product Details of C7H4BrF3, the main research area is quinoline acyl preparation; benzazepine aryl preparation oxidative rearrangement; cyclobutanol haloaniline ring expansion palladium catalyst.

A general synthesis of 2-aryl benzazepines I (Ar = biphenyl-4-yl, 2-naphthyl, thiophen-2-yl, benzodioxol-5-yl, etc.; R = H, Ph, benzyloxymethyl; R1 = H, Me; R2 = H, Me, F, Cl, CF3, CO2Me; R1R2 = -CH=CH-CH=CH-; R3 = H, Me, MeO, Cl) has been developed through palladium-catalyzed ring-expansion reactions of cyclobutanols II with 2-haloanilines 2-X-4-R3-5-R2-6-R1C6HNH2. The further oxidative rearrangement reaction of benzazepines I provided an efficient synthesis of 2-acyl quinolines III. These transformations feature the efficient construction of six- and seven-membered N-containing heterocycles from easily obtained materials with excellent functional group tolerance.

Chemical Communications (Cambridge, United Kingdom) published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent) (halo-). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Product Details of C7H4BrF3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ghochikyan, Tariel V.; Vardanyan, Arpine S.; Samvelyan, Melanya A.; Galstyan, Armen S.; Langer, Peter published the artcile< Synthesis of cinnamyl substituted dihydrofuranones by the Heck cross-coupling reaction>, Application of C7H4BrF3, the main research area is cinnamyl substituted dihydrofuranone preparation; allyldihydrofuranone aryl bromide Heck palladium catalyst.

The Heck cross-coupling of 3-allyldihydrofuran-2(3H)-ones with aryl bromides afforded the corresponding 3-cinnamyl derivatives I [R = H, Me; R1 = H, CO2Et; Ar = Ph, 4-CO2MeC6H4, 3-F3CC6H4, etc.]. The structure of the products was confirmed by NMR spectroscopy, mass spectrometry and X-ray diffraction.

Mendeleev Communications published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Application of C7H4BrF3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mohammadi, Masoud; Ghorbani-Choghamarani, Arash published the artcile< L-Methionine-Pd complex supported on hercynite as a highly efficient and reusable nanocatalyst for C-C cross-coupling reactions>, Quality Control of 401-78-5, the main research area is hercynite magnetic nanocatalyst preparation green chem Suzuki Heck coupling.

A ”green” method was suggested for the synthesis of hercynite magnetic nanoparticles (MNPs) as a novel heterogeneous catalytic support to immobilize homogeneous complexes, L-Methionine-Pd was immobilized on the surface of hercynite MNPs by a simple, rapid, and convenient route. The structure and composition of the prepared Hercynite@L-Methionine-Pd MNPs were characterized by X-ray diffraction spectroscopy, energy-dispersive X-ray spectroscopy, inductively coupled plasma-optical emission spectrometry, SEM, X-ray mapping, thermogravimetric anal. and vibrating-sample magnetometry (VSM). Besides, they were applied as green nanocatalysts for Suzuki and Heck cross-coupling reactions. Hercynite@L-Methionine-Pd MNPs offer several advantages (simple synthetic method under green conditions, thermal and chem. stability during organic reactions, short reaction times, high yields of products, excellent selectivity and easy work-up procedure). Moreover, the recycled nanocatalyst was reused for at least five cycles with no significant loss of activity. The hot filtration test indicated heterogeneous catalysis for Suzuki and Heck cross-coupling reactions. This work is useful for the development and application of a magnetically recoverable Pd nanocatalyst on the basis of green-chem. principles.

New Journal of Chemistry published new progress about Biphenyls Role: SPN (Synthetic Preparation), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Quality Control of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jayasundara, Chathurika R. K.; Gil-Negrete, Jose M.; Montero Bastidas, Jose R.; Chhabra, Arzoo; Martinez, M. Montserrat; Perez Sestelo, Jose; Smith, Milton R. III; Maleczka, Robert E. Jr. published the artcile< Merging Iridium-Catalyzed C-H Borylations with Palladium-Catalyzed Cross-Couplings Using Triorganoindium Reagents>, Electric Literature of 401-78-5, the main research area is aryl halide iridium catalyzed borylation palladium cross coupling organoindium; borylated alkynyl heteroaryl arene preparation; organoindium palladium catalyzed cross coupling boryl arene.

A versatile and efficient method to prepare borylated arenes furnished with alkyl, alkenyl, alkynyl, aryl and heteroaryl functional groups is developed by merging Ir-catalyzed C-H borylations (CHB) with a chemoselective Pd-catalyzed cross-coupling of triorganoindium reagents (Sarandeses-Sestelo coupling) with aryl halides bearing a boronic ester substituent. Using triorganoindium cross-coupling reactions to introduce unsaturated moieties enables the synthesis of borylated arenes that would be difficult to access through the direct application of the CHB methodol. The sequential double catalyzed procedure can be also performed in one vessel.

Journal of Organic Chemistry published new progress about Aryl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Electric Literature of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ghorbani-Choghamarani, Arash; Taherinia, Zahra published the artcile< New revolution in biaryl synthesis: transition metal-free C-C bond formation promoted by the mixture of 2-mercaptoethanol/KOH/DMSO>, Computed Properties of 401-78-5, the main research area is biaryl preparation; phenylboronic acid aryl halide transition metal free Suzuki type.

Biaryls RR1 [R = C6H5; R1 = C6H5, 3-MeOC6H4, 4-O2NC6H4, etc.] were synthesized via transition metal-free C-C cross coupling reaction of aryl halides with phenylboronic acid that was believed to be a new revolution in Suzuki type reactions. Carbon-carbon bond formation could be promoted by a mixture of 2-mercaptoethanol/KOH/DMSO without the aid of any transition metals. It has been suggested that this reaction proceeded through radical species, hence the electron transfer route was suggested for operation during oxidation of 2-mercaptoethanol in DMSO.

ChemistrySelect published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Computed Properties of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary