Category: 3959-07-7

Han, Xin; Wang, Chao; Qin, Chong; Xiang, Weiguo; Fernandez-Salas, Ester; Yang, Chao-Yie; Wang, Mi; Zhao, Lijie; Xu, Tianfeng; Chinnaswamy, Krishnapriya; Delproposto, James; Stuckey, Jeanne; Wang, Shaomeng published the artcile< Discovery of ARD-69 as a highly potent proteolysis targeting chimera (PROTAC) degrader of androgen receptor (AR) for the treatment of prostate cancer>, Quality Control of 3959-07-7, the main research area is prostate neoplasm antitumor proteolysis targeting chimera androgen receptor.

We report herein the discovery of highly potent PROTAC degraders of androgen receptor (AR), as exemplified by IARD-69. I induces degradation of AR protein in AR-pos. prostate cancer cell lines in a dose- and time-dependent manner. I achieves DC50 values of 0.86, 0.76, and 10.4 nM in LNCaP, VCaP, and 22Rv1 AR+ prostate cancer cell lines, resp. I is capable of reducing the AR protein level by >95% in these prostate cancer cell lines and effectively suppressing AR-regulated gene expression. I potently inhibits cell growth in these AR-pos. prostate cancer cell lines and is >100 times more potent than AR antagonists. A single dose of I effectively reduces the level of AR protein in xenograft tumor tissue in mice. Further optimization of I may ultimately lead to a new therapy for AR+, castration-resistant prostate cancer.

Journal of Medicinal Chemistry published new progress about Androgen receptor antagonists. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Quality Control of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

An, Shuyi; Guo, Zhifen; Liu, Xin; Che, Yan; Xing, Hongzhu; Chen, Peng published the artcile< Visible-light-responsive lanthanide coordination polymers for highly efficient photocatalytic aerobic oxidation of amines and thiols>, Electric Literature of 3959-07-7, the main research area is coordination polymer lanthanide anthracene ethyne dibenzoate fluorobenzoate complex preparation; photochem oxidation catalyst lanthanide anthracene ethyne dibenzoate fluorobenzoate polymeric; crystal structure lanthanide anthracene ethyne dibenzoate fluorobenzoate polymeric complex.

Development of visible-light-induced photocatalytic reactions using mol. oxygen as the terminal oxidant is intriguing in view of the current environmental and energy issues. The authors report herein the synthesis and characterization of a series of novel photocatalysts of lanthanide coordination polymers (Ln-CPs) with desirable characters of wide-range visible-light adsorption and excellent chem. stability. They show excellent selectivity and yield for the aerobic oxidation of amines and thiols to produce imines and disulfide, resp. Mechanism studies including ESR and radical quenching indicate these Ln-CPs are highly efficient to activate mol. oxygen into highly reactive oxygen species of superoxide radical and singlet oxygen via photoinduced electron and energy transfer, resp. It is notable that the photocatalytic oxidation of thiols into disulfide have never been reported using a CP photocatalyst prior to this study. Meanwhile, the synthesized CPs exhibits superior photocatalytic performance to other reported ones for amine oxidation due to the synergy of singlet oxygen and superoxide radical species. The work provides an in-depth understanding of the photoinduced oxygen activation based on a CP photocatalyst to accomplish a visible-light-induced reaction, illustrating the great potential of photoactive CPs for green synthesis.

New Journal of Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Electric Literature of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bai, Xueying; Huang, Liliang; Qing, Bin; Zuo, Zhicheng; Feng, Huangdi published the artcile< Catalyst-Free Hydrogen Proton Transfer Reduction of Nitrobenzamides to Aminobenzamides with i-PrOH/KOH System>, Computed Properties of 3959-07-7, the main research area is aminobenzamide preparation chemoselective; nitrobenzamide hydrogen proton transfer reduction.

A reduction of nitrobenzenes via the combination of KOH and isopropanol was established for the general synthesis of aniline derivatives A metal catalyst isn’t required in this alternative reduction reaction, and a series of nitrobenzamide compounds RC6H4C(O)NHR1 (R = 2-NO2, 3-NO2, 4-NO2; R1 = 4-bromobenzyl, 2,6-diisopropylphenyl, 3-methoxybenzyl, etc.) were chemoselectively reduced into the corresponding aminobenzamides RC6H4C(O)NHR1 (R = 2-NH2, 3-NH2, 4-NH2) in good to excellent yields. This reaction is operationally simple, and proceeds under mild conditions.

Asian Journal of Organic Chemistry published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Computed Properties of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary