Category: 3959-07-7

Anbardan, Soheil Zamani; Mokhtari, Javad; Yari, Ahmad; Bozcheloei, Abolfazl Hassani published the artcile< Direct synthesis of amides and imines by dehydrogenative homo or cross-coupling of amines and alcohols catalyzed by Cu-MOF>, Synthetic Route of 3959-07-7, the main research area is amine benzyl alc copper MOF catalyst dehydrogenative cross coupling; benzamide preparation green chem; benzyl amine copper MOF catalyst dehydrogenative homo coupling; benzylphenyl methanimine preparation green chem.

Oxidative dehydrogenative homo-coupling of amines to imines and cross-coupling of amines with alcs. to amides were achieved with high to moderate yields at room temperature in THF using Cu-MOF as an efficient and recyclable heterogeneous catalyst under mild conditions. Different primary benzyl amines and alcs. were utilized for the synthesis of a wide variety of amides and imines. The Cu-MOF catalyst was recycled and reused four times without loss of catalytic activity.

RSC Advances published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Synthetic Route of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Weibo; Li, Zhixinyi; Gao, Wei; Liu, Xiaoyu; Lv, You; Hao, Zesheng; Tang, Liangfu; Li, Kun; Zhao, Bin; Fan, Zhijin published the artcile< Design, Synthesis, and Evaluation of Novel Isothiazole-Purines as a Pyruvate Kinase-Based Fungicidal Lead Compound>, HPLC of Formula: 3959-07-7, the main research area is isothiazole purine preparation pyruvate kinase inhibitor fungicide phytopathogenic fungi; fungicidal activity; molecular docking; pyruvate kinase inhibitors.

Target identification is one of the most important bases for novel pesticide development; pyruvate kinase (PK) was discovered as a potent fungicide target in our previous studies. To continue the PK-based fungicide development, novel isothiazole-purine derivatives were rationally designed and synthesized. Bioassay results showed that compound 5ai displayed excellent in vitro activity against Rhizoctonia solani with an EC50 of 1.5μg/mL, which was superior to those of pos. controls diflumetorim with its EC50 of 19.8μg/mL and PK-based lead YZK-C22 with its EC50 of 4.2μg/mL. Compounds (I) (5.2μg/mL) and (II) (4.5μg/mL) displayed better activities against Gibberella zeae with their EC50s falling between 4.0 and 5.5μg/mL, while YZK-C22 showed an EC50 of 6.4μg/mL. In addition, (III) exhibited promising in vivo activity against Erysiphe graminis and Puccinia sorghi Schw. with 100% efficacy at 10μg/mL and 90% efficacy at 2μg/mL against P. sorghi Schw. Compound (IV) showed good PK inhibitory activity with an IC50 of 38.8μmol/L, and it was well docked into the active site of the target enzyme PK, which was slightly more active than YZK-C22 with its IC50 of 42.4μmol/L. Our studies discovered that isothiazole-purines were PK-based fungicidal leads deserving of further study.

Journal of Agricultural and Food Chemistry published new progress about Agrochemical fungicides. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, HPLC of Formula: 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bouz, Ghada; Bouz, Sarah; Jandourek, Ondrej; Konecna, Klara; Barta, Pavel; Vinsova, Jarmila; Dolezal, Martin; Zitko, Jan published the artcile< Synthesis, biological evaluation, and in silico modeling of N-substituted quinoxaline-2-carboxamides>, Application In Synthesis of 3959-07-7, the main research area is N substituted quinoxaline 2 carboxamides synthesis; Mycobacterium tuberculosis; antimycobacterial; cytotoxicity; molecular docking; pyrazinamide; quinoxaline; tuberculosis.

Despite the established treatment regimens, tuberculosis remains an alarming threat to public health according to WHO. Novel agents are needed to overcome the increasing rate of resistance and perhaps achieve eradication. As part of our long-term research on pyrazine derived compounds, we prepared a series of their ortho fused derivatives, N-phenyl- and N-benzyl quinoxaline-2-carboxamides, and evaluated their in vitro antimycobacterial activity. In vitro activity against Mycobacterium tuberculosis H37Ra (represented by min. inhibitory concentration, MIC) ranged between 3.91-500μg/mL, with most compounds having moderate to good activities (MIC < 15.625μg/mL). The majority of the active compounds belonged to the N-benzyl group. In addition to antimycobacterial activity assessment, final compounds were screened for their in vitro cytotoxicity. N-(naphthalen-1-ylmethyl)quinoxaline-2-carboxamide (compound 29) was identified as a potential antineoplastic agent with selective cytotoxicity against hepatic (HepG2), ovarian (SK-OV-3), and prostate (PC-3) cancer cells lines. Mol. docking showed that human DNA topoisomerase and vascular endothelial growth factor receptor could be potential targets for 29. Pharmaceuticals published new progress about Antimycobacterial agents. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application In Synthesis of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shi, Ji-Long; Hao, Huimin; Lang, Xianjun published the artcile< Phenol-TiO2 complex photocatalysis: visible light-driven selective oxidation of amines into imines in air>, Product Details of C7H8BrN, the main research area is phenol titania photocatalyst amine imine oxidation air.

Strong interfacial charge-transfer (ICT) has been observed between phenol and TiO2. It was demonstrated that a single Ph-O-Ti linkage could induce ICT transitions in the visible light region. By utilizing the surface complexation of phenol with TiO2, we, herein, present a new photocatalytic protocol for the selective oxidation of amines to imines in air. Our success depended on merging the phenol-TiO2 complex photocatalyst with (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO), so called cooperative photocatalysis, which improved stability of the surface-complexed phenol under the oxidative circumstance and promoted the selective conversion of amines. With 5 mol% of TEMPO as a co-catalyst and phenol-TiO2 complex (containing 0.8 mol% of phenol) as a photocatalyst, amines could be efficiently oxidized into imines with atm. O2 under blue light-emitting diode (LED) irradiation In addition, a mechanism is proposed to explain the visible-light photocatalytic performance of the present system.

Sustainable Energy & Fuels published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kumar, Sonu; Sarmah, Manash P.; Reddy, Yella; Bhatt, Ashish; Kant, Ravi published the artcile< A one-step synthesis of substituted benzo- and pyridine-fused 1H-imidazoles>, Synthetic Route of 3959-07-7, the main research area is aryl benzoimidazole preparation; fluoronitrobenzene amine cyclization microwave irradiation; imidazopyridine aryl preparation; amine nitrofluoropyrdine cyclization microwave irradiation.

A one-step microwave accelerated synthesis of substituted benzo- and pyridine-fused 1H-imidazoles were described. Mechanistically, the reaction proceeded by reacting substituted 2-fluoronitrobenzene and substituted arylamine through the formation of N-hydroxy intermediate, which at higher temperature cleaved to afford the desired product. This approach achieved reductions in reaction times, higher yields, cleaner reactions than the previously described synthetic processes.

Synthetic Communications published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Synthetic Route of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Fulin; Li, Xia; Dong, Xiaoyun; Hao, Huimin; Lang, Xianjun published the artcile< Thiazolo[5,4-d]thiazole-based covalent organic framework microspheres for blue light photocatalytic selective oxidation of amines with O2>, Safety of 4-Bromobenzylamine, the main research area is covalent organic framework microsphere photocatalysis.

Covalent organic frameworks (COFs) with photoactive units have attracted significant interest in visible light photocatalysis and can present a metal-free scenario for activating O2. As a typical photoactive unit, thiazolo[5,4-d]thiazole (TzTz) has rarely been added to COFs. However, circumventing the low reversibility of TzTz, it could be embedded into the building blocks beforehand, along with other bonds like β-ketoenamine in forming COFs. TzTz was embedded into 1,1′-biphenyl-4,4′-diamine (BD) using this approach to produce 4,4′-(TzTz-2,5-diyl)dianiline (DTz). Under organobase-modulated solvothermal conditions, combining 1,3,5-triformylphloroglucinol (Tp) with BD and DTz resulted in the production of β-ketoenamine-linked TpBD-COF and TpDTz-COF. Both TpDTz-COF and TpBD-COF are microspheres. TpDTz-COF possessed more adequate separation and charge migration than TpBD-COF. This resulted in superior performance for the blue light photocatalytic selective oxidation of benzylamine with O2. Furthermore, with O2 as the main oxidant, a wealth of benzylamines could be converted into imines over TpDTz-COF. Mechanistic investigations substantiate that oxidation of benzylamines obeys an electron transfer pathway, in which superoxide anion (O•-2) is the crucial reactive oxygen species. This study highlights the superiority of TzTz-embedded COFs in developing effective photocatalytic systems for organic transformations.

Chinese Journal of Catalysis published new progress about Covalent organic frameworks. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Safety of 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Smith, Philip J.; Jiang, Yubo; Tong, Zixuan; Pickford, Helena D.; Christensen, Kirsten E.; Nugent, Jeremy; Anderson, Edward A. published the artcile< Synthesis of Polysubstituted Fused Pyrroles by Gold-Catalyzed Cycloisomerization/1,2-Sulfonyl Migration of Yndiamides>, Safety of 4-Bromobenzylamine, the main research area is alkynylyndiamide gold catalyst regioselective cycloisomerization sulfonyl migration; tetrahydropyrrolopyrrole preparation.

Yndiamides (bis-N-substituted alkynes) are valuable precursors to azacycles. A cycloisomerization/1,2-sulfonyl migration of alkynyl-yndiamides to form tetrahydropyrrolopyrroles, unprecedented heterocyclic scaffolds that are relevant to medicinal chem were reported. This functional group tolerant transformation was achieved using Au(I) catalysis that proceeded at ambient temperature and a thermally promoted process. The utility of the products was demonstrated by a range of reactions to functionalize the fused pyrrole core.

Organic Letters published new progress about Alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Safety of 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Yuliang; Xu, Ze-Jun; Liu, Zhao-Peng; Lou, Hongxiang published the artcile< Visible-light-mediated de-aminative alkylation of N-arylamines with alkyl Katritzky salts>, Product Details of C7H8BrN, the main research area is alkyl tetrahydroisoquinoline preparation; tetrahydroisoquinoline Katritzky salt deaminative alkylation photochem; aryl alkyl aminoester preparation; Katritzky salt aryl aminoester deaminative alkylation photochem.

A visible-light-mediated de-aminative alkylation of N-arylamines was developed, providing direct access to α-amino C-H functionalization of N-arylamines from readily available Katritzky salts under mild conditions to get tetrahydroisoquinolines, e.g., I, and alkyl-N-aryl-aminoesters, e.g., II. In some cases, this operationally simple protocol could be performed in the absence of a photocatalyst. A wide range of substrates and functional groups were tolerated. The utility of this approach was highlighted by its application to the late-state modification of drug mols., natural products and peptides.

Organic Chemistry Frontiers published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sheng, Wenlong; Huang, Fengwei; Dong, Xiaoyun; Lang, Xianjun published the artcile< Solvent-controlled synthesis of Ti-based porphyrinic metal-organic frameworks for the selective photocatalytic oxidation of amines>, COA of Formula: C7H8BrN, the main research area is porphyrinic titanium MOF photocatalyst preparation aralkyl amine photooxidation; Amines; Metal–organic frameworks; Photocatalysis; Selective oxidation; Ti-oxo clusters.

The photocatalytic activity of metal-organic frameworks (MOFs) can be managed by the milieu of synthesis. Herein, N,N′-dimethylacetamide (DMA) and N,N′-diethylformamide (DEF) were employed as solvents for the synthesis of two Ti-based porphyrinic MOFs, namely Ti-PMOF-DMA and Ti-PMOF-DEF, from tetra-Bu orthotitanate and 4,4′,4′′,4′′′-(porphine-5,10,15,20-tetrayl)tetrakis(benzoic acid). Notably, both DMA and DEF were adsorbed onto the Ti-oxo clusters of the two MOFs to shape their properties. Ti-PMOF-DMA was observed with better optoelectronic response and charge transfer than Ti-PMOF-DEF. Moreover, Ti-PMOF-DMA owned a larger pore volume than Ti-PMOF-DEF, imparting more accessible sites to benzyl amines. Ti-PMOF-DMA exhibited better activity in selective photocatalytic aerobic oxidation of benzylamine than Ti-PMOF-DEF. Irradiated by red light-emitting diodes, outstanding results for selective conversion of benzyl amines to imines over Ti-PMOF-DMA were attained. Superoxide radical anion, generated by the electron transfer from porphyrin via Ti-oxo clusters to dioxygen, turned out to be the primary reactive oxygen species. There was generality towards aerobic oxidation of amines to imines and considerable stability for Ti-PMOF-DMA. This work provides a new perspective on the altering MOFs to enhance photocatalytic organic transformations.

Journal of Colloid and Interface Science published new progress about Adsorption. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, COA of Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kwon, Hyukmin; Kang, Seokwoo; Park, Sunwoo; Park, Sangshin; Oh, Seyoung; Kang, Yuna; Park, Jongwook published the artcile< New blue emitters including phenanthro[9,10-d]oxazole and bulky side group>, Name: 4-Bromobenzylamine, the main research area is phenanthro oxazole blue emitter photoluminescence.

The new blue organic emitter materials, 4′-(3-(phenanthro[9,10-d]oxazol-2-yl -)phenyl)-5′-phenyl-1[1,1′,:2′,1′′-tetraphenyl]-4-carbonitrile (m-PO-PPCN) and 4′-(4-(phenanthro[9,10-d]oxazol-2-yl-)phenyl)-5′-phenyl-1[1,1′,:2′,1′′-tetraphenyl]-4- carbonitrile (p-PO-PPCN) have been successfully synthesized and characterized. In the film state, the UV-visible (UV-Vis) absorption peaks of m-PO-PPCN and p-PO-PPCN were 402 and 413 nm, and the photoluminescence (PL) peaks were 408 and 457 nm. The photoluminescence quantum yield (PLQY) of the two materials was 38.4% and 54.9%. Organic light emitting diodes using m-PO-PPCN and p-PO-PPCN as the emitting layer (EML) showed that m-PO-PPCN had a current efficiency of 0.97 cd/A and an EQE of 1.25%, p-PO-PPCN exhibited current efficiency of 3.69 cd/A and an EQE of 3.46%.

Molecular Crystals and Liquid Crystals published new progress about Absorption. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Name: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary