Category: 3959-07-07 00:00:00

Xu, Biping; Su, Weiping published the artcile< A Tandem Dehydrogenation-Driven Cross-Coupling between Cyclohexanones and Primary Amines for Construction of Benzoxazoles>, Application of C7H8BrN, the main research area is substituted benzoxazole tandem dehydrogenation driven cross coupling; cyclohexanone primary amine; Aromatization; Heterocycles; Radical; Reaction Mechanisms; Synthetic Methods.

Herein, authors report a transition metal-free, operationally simple, general method for straightforward syntheses of 2-substituted benzoxazoles from readily available cyclohexanones and aliphatic primary amines by an imine α-oxygenation-initiated cascade reaction sequence. The key to achieving high selectivity and excellent functional-group tolerance is the use of TEMPO as a mild oxidant that selectively oxidizes the reaction intermediates through its multiple reactivity modes, thus facilitating the individual steps to proceed in succession. More than 70 substrate combinations are disclosed, demonstrating the reliability of this protocol to synthesize structurally diverse products, including marketed drugs, drug candidate, and natural products that are unattainable by the existing methods.

Angewandte Chemie, International Edition published new progress about Aralkyl amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Lang; Zhang, Jun published the artcile< KI/K2S2O8 Mediated Cascade C(sp3)-H/C(sp2)-H Thiolation for the Synthesis of Multi-Substituted Thiazoles>, Formula: C7H8BrN, the main research area is thiazole preparation fluorescence imaging.

Designing and synthesis of carbonyl-containing thiazoles are of great importance for related fields, hence, a simple and practical method was developed using com. xanthates, benzylamine, and readily available alkynones as substrates. The reaction was achieved using one-pot Michael addition and cascade iodine mediated C-H thiolation under mild conditions. This method features a broad substrate scope with high yield. Remarkably, the obtained carbonyl substituted thiazoles bearing electronic-donating substituents exhibit promising performance for aggregation-induced emission (AIE) and have been successfully used in biol. imaging.

European Journal of Organic Chemistry published new progress about Aggregation-induced emission. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tayama, Eiji; Kawai, Kohei published the artcile< Synthesis of tertiary alkyl fluorides and chlorides by site-selective nucleophilic ring-opening reaction of α-aryl azetidinium salts>, Electric Literature of 3959-07-7, the main research area is chloride alkyl fluoride preparation regioselective; aryl azetidinium salt nucleophilic ring opening.

Site-selective nucleophilic ring-opening reactions of 2-arylazetidine-2-carboxylic acid ester-derived tetraalkyl ammonium salts with tetrabutylammonium halides (Bu4NX) to give tertiary alkyl halides I [R = 5-Me, 5-MeO, 3-Br, 4-Br, 5-Br, 4-CF3, 5-CF3; R1 = NEt2, F, Cl; R2 = NEt2, F, Cl] were successfully demonstrated. For example, a nucleophilic ring-opening reaction of 2-(o-tolyl) derivative with 1.2 equiv of tetrabutylammonium fluoride (Bu4NF) in THF at 60°C preferentially proceeded at a more substituted carbon atom (2-position) compared to a less-substituted carbon atom (4-position) and afforded tert-Bu 4-(dimethylamino)-2-fluoro-2-(o-tolyl)butanoate in 71% yield as the corresponding tertiary alkyl fluoride. This result was applied to synthesize optically active organofluorine compounds starting from com. available (R)-1-phenylethylamine.

RSC Advances published new progress about Azetidines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (aryl). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Electric Literature of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xiao, Yuting; Tian, Guohui; Li, Wei; Xie, Ying; Jiang, Baojiang; Tian, Chungui; Zhao, Dongyuan; Fu, Honggang published the artcile< Molecule Self-Assembly Synthesis of Porous Few-Layer Carbon Nitride for Highly Efficient Photoredox Catalysis>, Name: 4-Bromobenzylamine, the main research area is self assembly porous carbon nitride efficient photoredox catalysis.

Polymeric C nitride (C3N4) has emerged as the most promising candidate for metal-free photocatalysts but is plagued by low activity due to the poor quantum efficiency and low sp. surface area. Exfoliation of bulk crystals into ultrathin nanosheets proved to be an effective and widely used strategy for enabling high photocatalytic performances; however, this process is complicated, time-consuming, and costly. Here, the authors report a simple bottom-up method to synthesize porous few-layer C3N4, which involves mol. self-assembly into layered precursors, alc. mols. intercalation, and subsequent thermal-induced exfoliation and polycondensation. The as-prepared few-layer C3N4 expose more active sites and greatly enhance the separation of charge carriers, thus exhibiting a 26-fold higher hydrogen evolution activity than bulk counterpart. Also, both the high activity and selectivity for the oxidative coupling of amines to imines can be obtained under visible light that surpass those of other metal-free photocatalysts so far.

Journal of the American Chemical Society published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Name: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gopalaiah, Kovuru; Choudhary, Renu published the artcile< Synthesis of Krohnke pyridines through iron-catalyzed oxidative condensation/double alkynylation/amination cascade strategy>, Category: bromides-buliding-blocks, the main research area is arylacetylene arylmethylamine iron regioselective tandem oxidative condensation alkynylation amination; triarylpyridine preparation.

An efficient protocol for the synthesis of sym. and unsym. 2,4,6-trisubstituted pyridines via oxidative cascade annulation of arylacetylenes with benzylamines was developed. The reaction proceeded smoothly by utilizing iron(II) triflate as a catalyst and mol. oxygen as an oxidant with broad substrate scope. Mechanistic studies revealed that the reaction may experience an oxidative condensation followed by double alkynylation and amination process.

Tetrahedron published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gao, Mingxia; Jia, Xiuquan; Ma, Jiping; Fan, Xiaomeng; Gao, Jin; Xu, Jie published the artcile< Self-regulated catalysis for the selective synthesis of primary amines from carbonyl compounds>, Safety of 4-Bromobenzylamine, the main research area is boron nitride support ruthenium nanoparticle preparation surface structure; aldehyde nitride support ruthenium catalyst reductive amination green chem; ketone nitride support ruthenium catalyst reductive amination green chem.

A facile control of the reaction selectivity in the layered boron nitride supported ruthenium catalyzed reductive amination reaction were reported. Specifically, locating ruthenium to the edge surface of layered boron nitride leaded to an increased hydrogenation activity owing to the enhanced interfacial electronic effects between ruthenium and the edge surface of boron nitride. This enabled self-accelerated reductive amination reactions which quant. synthesized structurally diverse primary amines by reductive amination of carbonyl compounds with two fold ammonia.

Green Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Safety of 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kawecki, Robert published the artcile< Synthesis of N-sulfenylimines from disulfides and primary methanamines>, Reference of 3959-07-7, the main research area is sulfenylimine preparation; aryl alkyldisulfide primary methanamine.

N-sulfenylimines (sulfenimines, thiooximes, N-alkylidenesulfenamides) were efficiently synthesized through the reaction of primary amines and disulfides with NBS or bromine. This reaction can be carried out in an open flask at room temperature without the need for any transition metal-containing additives. The use of thiols instead of disulfides gave similar results. A wide range of amines were reacted with aryl and alkyldisulfides, resulting in the formation of sulfenimines in a yield of 44-99%.

Journal of Organic Chemistry published new progress about Disulfides Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xia, Qing; Li, Yufei; Wang, Xinmin; Dai, Peng; Deng, Hongping; Zhang, Wei-Hua published the artcile< Visible Light-Driven α-Alkylation of N-Aryl tetrahydroisoquinolines Initiated by Electron Donor-Acceptor Complexes>, Related Products of 3959-07-7, the main research area is visible light alkylation aryltetrahydroisoquinoline electron donor acceptor complex.

The visible light-driven α-alkylation of N-aryl tetrahydroisoquinolines was initiated through electron donor-acceptor complex photochem. The reaction can proceed smoothly without the addition of any photocatalysts, transition-metal catalysts, or addnl. oxidants. The proposed mechanism was supported by various mechanistic studies, and the reactive open-shell alkyl radicals were generally produced from an alkylamine and underwent radical coupling for alkylating a wide range of N-aryl tetrahydroisoquinolines.

Organic Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Related Products of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Qin; Xu, Genrui; Li, Weiqiang; Wan, Juan; Liu, Teng; Huang, Chao published the artcile< Cu(I)-Catalyzed and Base-Promoted [5 + 2 + 1] Cascade Cyclization of 2-Nitrochalcones with Aliphatic Primary Amines to 5H-Pyrimido[5,4-b]indole Frameworks>, Safety of 4-Bromobenzylamine, the main research area is nitrochalcone primary amine copper catalyst tandem cycloaddition; pyrimidoindole preparation.

An unprecedented [5 + 2 + 1] cascade cyclization to the preparation of 5H-pyrimido[5,4-b]indole derivatives was disclosed. The novel protocol of 2-nitrochalcones reacted with aliphatic primary amines catalyzed by CuI and promoted by Cs2CO3, which underwent a critical intermediate 2,3-disubstituted indole, providing structurally diverse 5H-pyrimido[5,4-b]indoles in generally high yields (77-90%) and broad substrate scopes (34 examples).

Organic Letters published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Safety of 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xiong, Mingteng; Liang, Xiao; Zhou, Yifeng; Pan, Yuanjiang published the artcile< Synthesis of Polysubstituted Pyrroles through Electro-Oxidative Annulation of 1,3-Dicarbonyl Compounds and Primary Amines>, Product Details of C7H8BrN, the main research area is dialkyl aryl methyl dimethyl pyrrole dicarboxylate electrochem preparation; dicarbonyl compound primary amine electro oxidative annulation; alkyl aryl methylamino butenoate electro oxidative annulation.

Synthetic method of polysubstituted pyrroles I [R1 = H, 2-Me, 2-MeO, etc.; R2 = Me, Et; R3 = Me, Et, i-Pr] from easily available materials, 1,3-dicarbonyl compounds and primary amines, via electro-oxidative intermol. annulation was reported. Under similar conditions, enamines were also converted smoothly into desired products I, indicating that in situ formed enamines were crucial intermediates for the first transformation. Neither transition-metal salts nor harsh conditions were required to facilitate the dehydrocyclization process.

Journal of Organic Chemistry published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary