Category: 3959-07-07 00:00:00

Cheng, Xiuyan; Zhang, Jianling; Sha, Yufei; Xu, Mingzhao; Duan, Ran; Su, Zhuizhui; Li, Jialiang; Wang, Yanyue; Hu, Jingyang; Guan, Bo; Han, Buxing published the artcile< Periodically nanoporous hydrogen-bonded organic frameworks for high performance photocatalysis>, Formula: C7H8BrN, the main research area is hydrogen bonded organic framework photocatalysis oxidative coupling reaction.

The development of highly catalytic hydrogen-bonded organic frameworks (HOFs) is of great importance, but remains challenging. Herein, we demonstrate the fabrication of a periodically nanoporous HOF for high performance photocatalysis. Compared with the conventional microporous HOFs, the nanoporous HOF architecture has a larger number of free carboxyl groups on the surface and presents greatly improved photoelectrochem. properties. It exhibits high catalytic activity for the photo-oxidative coupling of amines under mild conditions such as air atm. and room temperature and without any co-catalysts, sacrificial reagents or photosensitizers. The relationship between the structure, properties and catalytic performance of the nanoporous HOF was studied by exptl. and theor. investigations. It shows that such a HOF structure facilitates reactant adsorption and O2 dissociation, thus promoting the oxidative coupling reaction. This work provides a new way for improving the catalytic performance of a single HOF.

Nanoscale published new progress about Activation energy. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Yajie; Sun, Dan; Du, Lizhi; Jiao, Yuzhen; Han, Wei; Tian, Guohui published the artcile< Sandwich-Structured Hybrid of NiCo Nanoparticles-Embedded Carbon Nanotubes Grafted on C3N4 Nanosheets for Efficient Photodehydrogenative Coupling Reactions>, Formula: C7H8BrN, the main research area is nickel cobalt carbon nanotube benzylamine green photodehydrogenation catalyst; NiCo nanoparticles; nitrogen-deficient C3N4; nitrogen-doped carbon nanotubes; photodehydrogenative coupling; sandwich structure.

Exploring cheap and efficient hybrid catalysts offers exciting opportunities for enhancing the performance of photocatalysts in the green organic synthesis field. Herein, a facile and effective approach is designed for the synthesis of a sandwich-structured hybrid in which NiCo bimetallic nanoparticles are embedded in the tip of nitrogen-doped carbon nanotubes (N-CNTs) grafted on both sides of a nitrogen deficient C3N4 (Nv-C3N4) nanosheet for photodehydrogenative coupling reactions. Such a brand-new type of sandwich-structured hybrid comprises Nv-C3N4 nanosheets and surrounding N-CNTs embedded with NiCo nanoparticles at their tips. Remarkably, the resultant hybrid exhibits integrated functionalities, abundant active sites, enhanced visible light absorption, and excellent interfacial charge transfer ability. As a result, the optimized NiCo@N-CNTs@Nv-C3N4 photocatalyst shows significantly improved photodehydrogenative coupling performance of amines to imines compared to the control single-metal-based catalysts (Ni@N-CNTs@Nv-C3N4 and Co@N-CNTs@Nv-C3N4). The mechanistic investigation through exptl. and computational study demonstrates that, compared with single-metal-based hybrids, the NiCo bimetallic hybrid exhibits stronger amine adsorption and weaker photogenerated hydrogen atom adsorption, thus promoting the dehydrogenative activation of primary amines and fast generation of imines. This work presents a promising insight for designing and preparing efficient photocatalysts to trigger organic synthesis in high yields.

ACS Applied Materials & Interfaces published new progress about Carbon nanotubes. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tu, Yalin; Sun, Yameng; Qiao, Shuang; Luo, Yao; Liu, Panpan; Jiang, Zhong-Xing; Hu, Yumin; Wang, Zifeng; Huang, Peng; Wen, Shijun published the artcile< Design, Synthesis, and Evaluation of VHL-Based EZH2 Degraders to Enhance Therapeutic Activity against Lymphoma>, Product Details of C7H8BrN, the main research area is lymphoma EZH2 inhibitors degraders VHL CRBN YM181 YM281 antitumor.

Traditional EZH2 inhibitors are developed to suppress the enzymic methylation activity, and they may have therapeutic limitations due to the nonenzymic functions of EZH2 in cancer development. Here, we report proteolysis-target chimera (PROTAC)-based EZH2 degraders to target the whole EZH2 in lymphoma. Two series of EZH2 degraders were designed and synthesized to hijack E3 ligase systems containing either von Hippel-Lindau (VHL) or cereblon (CRBN), and some VHL-based compounds were able to mediate EZH2 degradation Two best degraders, YM181 (I) and YM281 (II), induced robust cell viability inhibition in diffuse large B-cell lymphoma (DLBCL) and other subtypes of lymphomas, outperforming a clin. used EZH2 inhibitor EPZ6438 (tazemetostat) that was only effective against DLBCL. The EZH2 degraders displayed promising antitumor activities in lymphoma xenografts and patient-derived primary lymphoma cells. Our study demonstrates that EZH2 degraders have better therapeutic activity than EZH2 inhibitors, which may provide a potential anticancer strategy to treat lymphoma.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Yang; Cheng, Xiuyan; Li, Ze; Jin, Yigang; Sun, Yimeng; Zou, Ye; Liu, Liyao; Duan, Ran; Zhang, Jianling; Xu, Wei published the artcile< Two highly crystalline coordination polymers with two-dimensional PbS networks for photocatalytic synthesis of imines>, Name: 4-Bromobenzylamine, the main research area is hydroxybenzenethiolate benzenedithiolate lead sulfide coordination polymer preparation crystal structure; crystal mol structure hydroxybenzenethiolate benzenedithiolate lead coordination polymer; photocatalysis imine hydroxybenzenethiolate benzenedithiolate lead coordination polymer.

Two highly crystalline coordination polymers (CPs), namely, Pb-HBT and Pb-BDT, were synthesized from the reaction of Pb(II) ions with 4-hydroxybenzenethiol (HBT) and 1,4-benzenedithiol (BDT). Both of these CPs display similar layer structures of alternately stacked two-dimensional PbS networks and benzene units according to their crystal structures solved based on high resolution powder x-ray diffraction data. They exhibit high photocatalytic activities for the oxidation reactions of amines to imines under mild conditions, i.e., in air and at room temperature under sacrificial reagent-, co-catalyst- and redox mediator-free conditions.

Catalysis Science & Technology published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Name: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dong, Xiaoyun; Hao, Huimin; Wang, Ningning; Yuan, Hong; Lang, Xianjun published the artcile< Cadmium sulfide/titanate hybrid green light photocatalysis for selective aerobic oxidative homocoupling of amines>, Application In Synthesis of 3959-07-7, the main research area is cadmium sulfide green light photocatalysis amines aerobic oxidative homocoupling; CdS/titanate hybrid; Green light; Homocoupling of amines; Selective oxidation; Semiconductor photocatalysis.

Semiconductor photocatalysis can carry out selective chem. transformations under ambient conditions, mitigating the associated environmental consequences. However, a single semiconductor photocatalyst usually cannot perform the transformations satisfactorily from the aspects of light-absorption, efficiency, and selectivity, etc. To address these challenges, cadmium sulfide (CdS)/titanate hybrid was fabricated by simultaneously growing titanate and CdS and had been comprehensively characterized. The optimized CdS/titanate hybrid can power the highly selective oxidative homocoupling of amines under the irradiation of green light-emitting diodes (LEDs). Specifically, CdS with a narrow bandgap captures green light; the conduction band of titanate activates mol. oxygen (O2). The valence band of CdS could ensure the selective oxidative homocoupling of amines in methanol (CH3OH). The hybridization between CdS and titanate accounts for the expeditious oxidative homocoupling of amines into imines and the improved stability. Reactive oxygen species (ROS) quenching experiments and in situ ESR (EPR) tests suggest that superoxide anion (O·-2) and benzylamine radical are intermediates en route to imines. This work highlights the viability of hybridization of dual semiconductor nanostructures in implementing visible light-powered selective conversions.

Journal of Colloid and Interface Science published new progress about Absorption spectra. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application In Synthesis of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jiang, Jun; Liu, Xiangying; Luo, Rongchang published the artcile< Donor-Acceptor Type Conjugated Microporous Polymer as a Metal-Free Photocatalyst for Visible-Light-Driven Aerobic Oxidative Coupling of Amines>, Formula: C7H8BrN, the main research area is donor acceptor conjugated microporous polyamine photocatalyst aerobic oxidative coupling; visible light polyamine photocatalyst aerobic oxidative coupling.

Developing cheap, highly efficient, metal-free heterogeneous photocatalysts remain a great challenge in photoredox reactions. Herein, we utilize a typical Suzuki coupling of low-cost triphenylamine derivative and 9,10-dibromoanthracene to synthesis a donor-acceptor type conjugated microporous polymer (denoted as PAA-CMP). As expected, heterogeneous PAA-CMP exhibits excellent photocatalytic performance, good functional group tolerance and satisfying recyclability in metal-free aerobic oxidative coupling of amines to imines driven by visible light, which is due to its absolute energy level positions and good physicochem. stability. More excitingly, PAA-CMP can enable the gram-scale air-oxidized photocatalytic conversion under natural sunlight irradiation, yielding the desired imine product with an isolated yield of 65% for 48 h. The current work provides a great application prospect for CMPs in low-cost and large-scale organic industrial production in the future. The prepared donor-acceptor (D-A) type conjugated microporous polymer (PAA-CMP) as a metal-free and heterogeneous photocatalyst enable the gram-scale air-oxidized photocatalytic conversion of benzylamine into N-benzylidenebenzylamine under natural sunlight irradiation, yielding the desired imine product with an isolated yield of 65%.

Catalysis Letters published new progress about Light. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Yuexin; Zhou, Jun; Ma, Xiaoming; Li, Xia; Lang, Xianjun published the artcile< Cooperative Photocatalysis with 4-Amino-TEMPO for Selective Aerobic Oxidation of Amines over TiO2 Nanotubes>, Computed Properties of 3959-07-7, the main research area is titania nanotube semiconductor catalyst; 4-amino-TEMPO; Sodium 6,7-dihydroxynaphthalene-2-sulfonate; Surface complexes; TiO2 nanotubes; Visible light photocatalysis.

Attaching π-conjugated mols. onto TiO2 can form surface complexes that could capture visible light. However, to make these TiO2 surface complexes durable, integrating 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) or its analogs as a redox mediator with photocatalysis is the key to constructing selective chem. transformations. Herein, sodium 6,7-dihydroxynaphthalene-2-sulfonate (DHNS) was obtained by extending the π-conjugated system of catechol by adding a benzene ring and a substituent sodium sulfonate (-SO3-Na+). The DHNS-TiO2 showed the best photocatalytic activity towards the blue light-induced selective aerobic oxidation of benzylamine. Compared to TEMPO, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO) could rise above 70% in conversion of benzylamine over the DHNS-TiO2 photocatalyst. Eventually, a wide range of amines could be selectively oxidized into imines with atm. O2 by cooperative photocatalysis of DHNS-TiO2 with 4-amino-TEMPO. Notably, superoxide (O2•-) is crucial in coupling the photocatalytic cycle of DHNS-TiO2 and the redox cycle of 4-amino-TEMPO. This work underscores the design of surface ligands for semiconductors and the selection of a redox mediator in visible light photocatalysis for selective chem. transformations.

Chemistry – An Asian Journal published new progress about ESR (electron spin resonance). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Computed Properties of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Peng, Ting; He, Yujiao; Wang, Tao; Yu, Jialing; Ma, Xiaofang; Zhou, Zongyuan; Sheng, Yuwen; Li, Lingyu; Peng, Huipan; Li, Sheng; Zou, Jiawei; Yuan, Yi; Zhao, Yongyun; Shi, Hailong; Li, Fu; Liu, Wanli; Hu, Kaifeng; Lu, Xiaoxia; Zhang, Guolin; Wang, Fei published the artcile< Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis>, Reference of 3959-07-7, the main research area is hepatocellular carcinoma miRNA biogenesis TRBP SAR proliferation cancer therapy.

MicroRNAs (miRNAs) are key players in human hepatocellular carcinoma (HCC) tumorigenesis. Therefore, small mols. targeting components of miRNA biogenesis may provide new therapeutic means for HCC treatment. By a high-throughput screening and structural simplification, we identified a small mol., CIB-3b (I), which suppresses the growth and metastasis of HCC in vitro and in vivo by modulating expression profiles of miRNAome and proteome in HCC cells. Mechanistically, CIB-3b phys. binds to transactivation response (TAR) RNA-binding protein 2 (TRBP) and disrupts the TRBP-Dicer interaction, thereby altering the activity of Dicer and mature miRNA production Structure-activity relationship study via the synthesis of 45 CIB-3b derivatives showed that some compounds exhibited a similar inhibitory effect on miRNA biogenesis to CIB-3b. These results support TRBP as a potential therapeutic target in HCC and warrant further development of CIB-3b along with its analogs as a novel therapeutic strategy for the treatment of HCC.

Journal of Medicinal Chemistry published new progress about A-kinase anchor protein 10 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fu, Yiwei; Shi, Haoyu; Lei, Shengshu; Shi, Lei; Li, Hao published the artcile< Cu catalyzed [4 + 2] cycloaddition for the synthesis of highly substituted 3-fluoropyridines>, SDS of cas: 3959-07-7, the main research area is fluoro aryl nicotinoyl preparation; trifluoro aryl ethanimine acryloyloxazolidinone cycloaddition aromatization catalyst copper; propenoylimidazolidinone trifluoro aryl ethanimine cycloaddition aromatization catalyst copper.

A copper catalyzed annulation-aromatization of benzyl trifluoromethyl ketimines with 3-acryloyloxazolidin-2-ones for the synthesis of 3-fluoropyridines I [R = H, 3-Cl, 3-Me, etc.; R1 = H, 4-Cl, 4-MeO, etc.; R2 = 2-oxopyrrolidin-1-yl, 2-oxooxazolidin-3-yl, 2-oxo-3-phenyl-imidazolidin-1-yl, etc.] through double C-F bond cleavages had been developed. In this approach, the annulation occurred between the in situ formed dienes from trifluoromethyl ketimines via the first C-F bond cleavage and 3-acryloyloxazolidin-2-ones. Then the aromatization afforded 3-fluoropyridines I in moderate yields through the second C-F bond cleavage. The 3-fluoropyridine products I [R = R1 = H; R2 = 2-oxooxazolidin-3-yl] could be further hydrolyzed to multi-substituted 3-pyridinecarboxylic acids.

Organic & Biomolecular Chemistry published new progress about [4+2] Cycloaddition reaction. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, SDS of cas: 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xia, Mengxin; Moussa, Ziad; Judeh, Zaher M. A. published the artcile< Acetic Acid-Catalyzed Selective Synthesis of N-Substituted 2-Amino-3-Cyanopyrroles via a Three-Component Reaction Between Carbohydrates, Primary Amines and Malononitrile>, Product Details of C7H8BrN, the main research area is carbohydrate amine malononitrile acetic acid catalyst cascade cyclization; acetoxyaminocyanopyrrole preparation.

Direct conversion of unprotected carbohydrates to N-heterocycles was challenging and highly desirable. A simple three-component synthesis of N-substituted 2-amino-3-cyanopyrrole key framework was developed from the reaction between unprotected carbohydrates, malononitrile and primary amines. The reaction proceeded under mild reaction conditions (AcOH catalyst, EtOH, 60 °C, 2 h), tolerated a wide substrate scope, worked smoothly on a 4 g scale and gave the pyrroles in up to 86% yield. The pyrroles were also converted into functional intermediates to demonstrated their versatility. NMR and LC-MS experiments supported a proposed cascade reaction mechanism. The approach demonstrated a robust upcycling process for the challenging synthesis of highly functionalized N-heterocyclic compounds from unprotected carbohydrates.

Asian Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary