Category: 3959-07-07 00:00:00

He, Junhui; Dong, Jianyu; Su, Lebin; Wu, Shaofeng; Liu, Lixin; Yin, Shuang-Feng; Zhou, Yongbo published the artcile< Selective Oxidative Cleavage of 3-Methylindoles with Primary Amines Affording Quinazolinones>, Related Products of 3959-07-7, the main research area is quinazolinone preparation; methylindole primary amine selective oxidative cleavage tetrabutylammonium iodide catalyst.

A selective functionalization of C-C=C bonds toward N-C=O bonds is realized by an n-Bu4NI-catalyzed reaction of 3-methylindoles I (R1 = 7-Me, 5-MeO, 5-F, etc.) and 3-methyl-1H-pyrrolo[2,3-c]pyridine with primary amines R2NH2 (R2 = Bu, benzyl, cyclopropyl, thiophen-2-yl, etc.) using TBHP as the unique oxidant. The systematic process involves oxygenation, nitrogenation, ring-opening, and recyclization, affording a broad range of quinazolinones II (R3 = 8-Me, 6-MeO, 6-Br, etc.) and 3-benzylpyrido[3,4-d]pyrimidin-4(3H)-one in good to excellent yields.

Organic Letters published new progress about C-C bond cleavage (C=C). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Related Products of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Peng, Lingteng; Hu, Zhifang; Zhao, Yanting; Peng, Lifen; Xu, Zhi; Yin, Shuang-Feng; Tang, Zilong; Qiu, Renhua; Kambe, Nobuaki published the artcile< One-pot synthesis of phosphorylnaphth[2,1-d]oxazoles and products as P,N-ligands in C-N and C-C formation>, Application of C7H8BrN, the main research area is carbon nitrogen bond formation palladium catalyst nickel phosphinylnaphthoxazole; crystal structure mol phosphinylnaphthoxazole methoxy phenyl preparation; phosphorylnaphthoxazole preparation coupling catalyst nitrogen carbon bond formation.

Phosphinylnaphtho[2,1-d]oxazoles were synthesized successfully through one-pot phosphonation of naphthoquinone with diaryl(alkyl)phosphine oxides and Cu-catalyzed oxidative condensation with imines, followed by methylation and reduction Upon applying 4-phosphinylnaphtho[2,1-d]oxazole as a P,N-chelating ligand, Pd-catalyzed C-N formation of amines or nitrobenzene as well as Ni-catalyzed C-C formation and the synthesis of quinoline proceeded successfully. The reaction was facilely scaled up to give a N-benzylaniline in a gram scale synthesis. This research provided a facile and convenient protocol to synthesize phosphinylnaphtho[2,1-d]oxazoles, which could be applied as an efficient P,N-ligand in transition-metal-catalyzed C-N and C-C formation to produce the desired products in high yields with wide functional group tolerance under small catalyst loading, solvent-free conditions in many reactions.

Organic & Biomolecular Chemistry published new progress about Amines Role: SPN (Synthetic Preparation), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Honnanayakanavar, Jyoti M.; Nanubolu, Jagadeesh Babu; Suresh, Surisetti published the artcile< Tandem copper catalyzed regioselective N-arylation-amidation: synthesis of angularly fused dihydroimidazoquinazolinones and the anticancer agent TIC10/ONC201>, Computed Properties of 3959-07-7, the main research area is fused tricyclic dihydroimidazoquinazolinone preparation regioselective; aminoimidazoline carboxylic acid arylation amidation cyclocondensation copper catalyst.

Herein, a copper-catalyzed tandem reaction of 2-aminoimidazolines I (R = n-Bu, Ph, furan-2-ylmethyl, pyridin-4-ylmethyl, etc.) and ortho-halo(hetero)aryl carboxylic acids R1C(O)OH (R1 = 2-bromophenyl, 2-bromo-4,5-difluorophenyl, 2-bromopyridin-3-yl, 4-chloropyridin-3-yl, etc.) that causes the regioselective formation of angularly fused tricyclic 1,2-dihydroimidazo[1,2-a]quinazolin-5(4H)-one derivs II (R2 = H, OMe, F; R3 = H, OMe, Cl, Br, F, NO2; R4 = H, F), III and IV was presented. The reaction involved in the construction of the core six-membered pyrimidone moiety proceeded via regioselective N-arylation-condensation. The presented protocol has been successfully applied to accomplish the total synthesis of TIC10/ONC201 V, which is an active angular isomer acting as a tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL): a sought after anticancer clin. agent.

Organic & Biomolecular Chemistry published new progress about Amidation (regioselective). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Computed Properties of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hao, Qianqian; Jia, Xiuquan; Ma, Jiping; Gao, Mingxia; Fan, Xiaomeng; Gao, Jin; Xu, Jie published the artcile< Aprotic Amine-modified Manganese Dioxide Catalysts for Selectivity-tunable Oxidation of Amines>, Application In Synthesis of 3959-07-7, the main research area is manganese dioxide catalyst preparation surface area; arylamine heterogeneous catalyst oxidation; arylidenearylamine preparation; amines oxidation; aprotic modifier; imines; manganese dioxide; selectivity-tunable catalysis.

Herein, showed successful control of redox-acid catalysis of metal oxides with aprotic tertiary amine modifiers. Robust modification of manganese dioxide catalysts with N,N-dialkylcyclohexylamine selectively blocks the Lewis acid sites, with their redox activity mostly unaffected. Enables the efficient synthesis of imines in high to excellent selectivity via aerobic oxidation of structurally diverse aryl amines.

Chemistry – An Asian Journal published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application In Synthesis of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Qian, Peng; Zhou, Zhenghong; Hu, Kangfei; Wang, Jiawei; Li, Zhibin; Zha, Zhenggen; Wang, Zhiyong published the artcile< Electrocatalytic Three-Component Reaction: Synthesis of Cyanide-Functionalization Imidazo-Fused N-Heterocycles>, Application In Synthesis of 3959-07-7, the main research area is quinaldine alkylamine trimethylsilyl cyanide electrochem three component cyclization green; cyanide functionalized imidazoquinoline preparation.

An electrochem. three-component cyclization was developed under metal-free conditions, which provides a novel and facile approach for the construction of cyanide-functionalization imidazo-fused N-heterocycles. A variety of cyanide-functionalization imidazo-fused N-heterocycles can be obtained from easily available Me N-heteroaromatics, primary alkylamines, and trimethylsilyl cyanide with good to excellent yields. The reaction features a broad scope of substrates, scalability, and mild conditions.

Organic Letters published new progress about Cyclic voltammetry. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application In Synthesis of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liang, Liang; Luo, Dong; Zuo, Tao; Zhou, Xiao-Ping; Li, Dan published the artcile< Control over the synthesis of homovalent and mixed-valence cubic cobalt-imidazolate cages>, COA of Formula: C7H8BrN, the main research area is cobalt Schiff imidazolecarboxaldehyde benzylamine complex preparation isothermal magnetization; crystal structure cobalt Schiff imidazolecarboxaldehyde benzylamine complex.

Cubic cobalt-imidazolate cages were successfully synthesized via subcomponent self-assembly in different solvents under solvothermal conditions. The homovalent CoII and mixed-valence CoIII,II-imidazolate cages are assembled with control over the mixed solvent ratio of N,N-diethylformamide/ethanol, resp.

Chemical Communications (Cambridge, United Kingdom) published new progress about Crystal structure. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, COA of Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Xixi; Wang, Yanxin; Li, Bo; Liu, Bing; Wang, Wei; Xiang, Nian; Zhang, Zehui published the artcile< Catalytic dehydrogenation of amines to imines and the in-situ reduction of sulfoxides into sulfides>, Related Products of 3959-07-7, the main research area is nickel nitrogen doped carbon catalytic dehydrogenation amine sulfoxide.

The catalytic acceptorless dehydrogenation of primary amines into imines and H2 represents one of the most important organic transformations, and the in-situ utilization of the generated H2 for chem. reduction reactions has never been reported in previous research. Herein, nitrogen-doped carbon supported nickel catalysts (abbreviated as Ni/NC-T, where T represents the pyrolysis temperature) were facilely prepared by the simple pyrolysis process, and the Ni/NC-600 catalyst demonstrated excellent catalytic performance towards the tandem reaction of the dehydrogenation of primary amines into imines and the subsequent hydrodeoxygenation of sulfoxides into sulfides using the in-situ released H2, affording high to quant. yields. The developed methods demonstrated some advantages such as the use of heterogeneous non-noble metal catalysts with low cost and high stability, and the in-situ utilization of generated H2 with high atom efficiency.

Journal of Catalysis published new progress about Adsorption (isotherm). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Related Products of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lyu, Shaoshuai; Hao, Huimin; Li, Xia; Lang, Xianjun published the artcile< Cooperative TiO2 photocatalysis with TEMPO and N-hydroxysuccinimide for blue light-driven selective aerobic oxidation of amines>, Safety of 4-Bromobenzylamine, the main research area is TEMPO hydroxysuccinimide photocatalysis aerobic oxidation; Amine/imine transformation; Cooperative photocatalysis; Reaction channel; Semiconductor; Visible light.

TiO2 has been the focus of attention in semiconductor photocatalysis for several decades because it can potentially settle the grand energy and environmental issues with earth-abundant elements of Ti and O. However, because of its wide band gap, TiO2 can only collect UV light, hindering its practical applications under the illumination of sunlight. In view of this, an interesting phenomenon of light-driven adsorption of amines onto TiO2 to form a visible light-absorbing complex was adapted to assemble smart photocatalysis. The endurance of this complex was eminently refurbished by blue light-driven continuous adsorption of amines. This in turn promoted a vital selective chem. transformation, blue light-driven selective oxidation of amines into imines with atm. dioxygen (O2). More importantly, the inclusion of TEMPO and N-hydroxysuccinimide (NHS) into the smart photocatalytic system could cooperatively expedite the blue light-driven selective aerobic oxidation of amines into imines through dual independent reaction channels, resembling that of enzymic catalysis. This work underscores the importance of manoeuvring multiple reaction channels by cooperative photocatalysis during selective chem. transformations.

Chemosphere published new progress about Adsorption. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Safety of 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Jia; Bao, Wenhao; Tang, Zhaocheng; Guo, Baodang; Zhang, Shiwei; Liu, Haili; Huang, Shuping; Zhang, Yan; Rao, Yijian published the artcile< Cercosporin-bioinspired selective photooxidation reactions under mild conditions>, SDS of cas: 3959-07-7, the main research area is benzylic derivative oxygen cercosporin light photooxidation; carbonyl preparation; amine oxygen cercosporin light photooxidation; aldehyde preparation; sulfide oxygen cercosporin light photooxidation; sulfoxide preparation.

The development of an efficient system for selective oxidation of organic compounds to generate more valuable compounds with mol. oxygen is a significant challenge in industrial chem. Bioinspired by the ability of naturally occurring perylenequinonoid pigments (PQPs) to generate reactive oxygen species (ROS) upon photoirradiation, here we report that cercosporin, one of the perylenequinonoid pigments, can function as a cost-effective and environmentally friendly photocatalyst for a wide range of selective oxidations, including benzylic C-H bonds to carbonyls, amines to aldehydes, and sulfides to sulfoxides. All of the representative reactions proceeded smoothly with high efficiency under mild conditions. Owing to the use of inexpensive metal-free visible light-driven photocatalyst produced from microbial fermentation with cheap glucose as the starting material and the ease of handling, we expect that this developed method will be particularly attractive for many more applications in synthetic transformation.

Green Chemistry published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, SDS of cas: 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gopalaiah, Kovuru; Tiwari, Ankit published the artcile< Synthesis of (E)-3-Alkylideneindolin-2-ones by an Iron-Catalyzed Aerobic Oxidative Condensation of Csp3-H Bonds of Oxindoles and Benzylamines>, Application In Synthesis of 3959-07-7, the main research area is alkylideneindolinone preparation iron catalyst oxidative condensation oxindole benzylamine.

A novel synthetic route for the construction of (E)-3-alkylideneindolin-2-ones through iron-catalyzed aerobic oxidative condensation of oxindoles with benzylamines was developed. This oxidative reaction involves a sequence of C-H activation, amine self-condensation, nucleophilic addition, and C-C double bond formation. The synthetic importance of this protocol was demonstrated by preparing tyrosine kinase inhibitors, anticonvulsant and antitumor agents, and other valuable 3-alkylideneindolin-2-one derivatives Key intermediates were isolated and a plausible mechanistic pathway for the reaction is discussed.

European Journal of Organic Chemistry published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application In Synthesis of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary