Category: 393-36-2

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 393-36-2 as follows. Formula: C7H5BrF3N

3-[4-bromo-3-(trifluoromethyl)phenyl[[3-(trifluoromethyl)phenyl]methyl]amino]-1,1,1-trifluoro-2-propanol EX-625A) The alpha,alpha,alpha-trifluoro-m-tolualdehyde (3.63 g, 0.021 mol) was added neat to 4-bromo-3-trifluoromethylaniline (5.0 g, 0.021 mol). Dichloroethane (50 mL) was added followed by sodium triacetoxyborohydride (4.85 g, 0.023 mol) and acetic acid (1.42 g, 0.024 mol). The resulting mixture was stirred at room temperature for 18 h, then diluted with methylene chloride, quenched with sodium bicarbonate and extracted with methylene chloride. The organic layers were combined and dried over MgSO4 and concentrated to give 6.97 g of the desired 3-[4-bromo-3-(trifluoromethyl)-phenyl[[3-(trifluoromethyl)phenyl]methyl]amine product as a yellow oil, which was carried forward without purification. ESMS m/z=397 [M+H]+.

According to the analysis of related databases, 393-36-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sikorski, James A.; Durley, Richard C.; Mischke, Deborah A.; Reinhard, Emily J.; Fobian, Yvette M.; Tollefson, Michael B.; Wang, Lijuan; Grapperhaus, Margaret L.; Hickory, Brian S.; Massa, Mark A.; Norton, Monica B.; Vernier, William F.; Parnas, Barry L.; Promo, Michele A.; Hamme, Ashton T.; Spangler, Dale P.; Rueppel, Melvin L.; US2002/120011; (2002); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 393-36-2, name is 4-Bromo-3-(trifluoromethyl)aniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 393-36-2, Safety of 4-Bromo-3-(trifluoromethyl)aniline

(ii) 4-Cyano-3-(trifluoromethyl)aniline was prepared by the method of L. Friedman and H. Shechter (J. Org. Chem. 26, 2522, 1961)): A mixture of 5-amino-2-bromobenzotrifluoride (12.00 g, 50 mmol), CuCN (5.37 g, 60 mmol), and DMF (7.5 mL) was heated under reflux for 2 h. It was poured into 30% w/v NaCNaq (150 mL) and extracted with ether (75 mL). The ether layer was washed sequentially with 10% NaCNaq (100 mL), H2O (100 mL), and brine (100 mL), dried (Na2SO4) and evaporated to dryness to give the crude product (8.00 g). This was flash chromatographed on silica (700 g) using 20% ether in CH2Cl2 as the eluant to give the pure product as a light tan solid (7.03 g, 76%) suitable for further use. An analytical sample recrystallized from EtOH/H2O as off-white needles, mp 142-143C, NMR satisfactory, Anal. (C8H5F3N2) C,H,N,F.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AGOURON PHARMACEUTICALS, INC.; EP365763; (1990); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

393-36-2, Name is 4-Bromo-3-(trifluoromethyl)aniline, 393-36-2, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

Starting material laa;4-Bromo-N -ethyl-5-trifluoromethyl-benzene-l,2-diamineStep 1: N-(4-bromo-2-nitro-5-trifluoromethyl-phenyl)-acetamideFollowing the method of Ognyanov, V. L, et. al; /. Med. Chem.; 49(12); 3719(2006), under a nitrogen purge, 4-bromo-3-trifluoromethylaniline (7.2 g; 0.03 mol) was added to acetic anhydride (30 mL) in a 100 mL round-bottomed flask. After stirring for 16 h at room temperature, solvent was removed under reduced pressure to obtain a white solid, which was used as-is for the nitration step.

Statistics shows that 4-Bromo-3-(trifluoromethyl)aniline is playing an increasingly important role. we look forward to future research findings about 393-36-2.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/56150; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

393-36-2, These common heterocyclic compound, 393-36-2, name is 4-Bromo-3-(trifluoromethyl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-Bromo-3-(trifluoromethyl)aniline was converted into 4-bromo-3-(trifluoromethyl)phenyl isocyanate according to Method B1. According to Method C1a, 4-bromo-3-(trifluoromethyl)phenyl isocyanate was reacted with 4-(2-(N,N-dimethylcarbamoyl)-4-pyridyloxy)aniline to afford the urea. Entry 92: 4-Chloro-N-methylpyridinecarboxamide was synthesised as described in Method A2, Step 3b.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 393-36-2.

Reference:
Patent; Riedl, Bernd; Dumas, Jacques; Khire, Uday; Lowinger, Timothy B.; Scott, William J.; Smith, Roger A.; Wood, Jill E.; Monahan, Mary-Katherine; Natero, Reina; Renick, Joel; Sibley, Robert N.; US2001/11135; (2001); A1;; ; Patent; BAYER CORPORATION; US2003/181442; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

393-36-2, Name is 4-Bromo-3-(trifluoromethyl)aniline, 393-36-2, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

4-Bromo-3-(trifluoromethyl)aniline was converted to 4-bromo-3-(trifluoromethyl)phenyl isocyanate according to Method B1.

Statistics shows that 4-Bromo-3-(trifluoromethyl)aniline is playing an increasingly important role. we look forward to future research findings about 393-36-2.

Reference:
Patent; BAYER CORPORATION; US2003/144278; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary