Category: 3893-18-3

Sun, Wangsheng; Zhu, Gongming; Hong, Liang; Wang, Rui published the artcile< The Marriage of Organocatalysis with Metal Catalysis: Access to Multisubstituted Chiral 2,5-Dihydropyrroles by Cascade Iminium/Enamine-Metal Cooperative Catalysis [Erratum to document cited in CA156:362840]>, Product Details of C9H7BrO, the main research area is erratum enantioselective aza Michael carbocyclization reaction unsaturated aldehyde tosylpropargylamine; organo metal cooperative catalyst enantioselective synthesis erratum; pyrrole aryl dihydro enantioselective synthesis erratum.

On page 13962, Reference 14 contained an incorrect CCDC number; the corrected number is given.

Chemistry – A European Journal published new progress about Amines, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Product Details of C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Xiang-Yu; Zhao, Kun; Liu, Qiang; Zhi, Ying; Ward, James; Rissanen, Kari; Enders, Dieter published the artcile< N-heterocyclic carbene-catalyzed 1,6-addition of homoenolate equivalent intermediates: asymmetric synthesis of nonspirocyclic quaternary oxindoles>, Related Products of 3893-18-3, the main research area is nonspirocyclic diarylmethyl isoxazolyl oxindole ester preparation stereoselective; quinone methide cinnamaldehyde isatin isoxazole cycloaddition heterocyclic carbene catalyst.

Although there is a growing interest in developing asym. 1,6-addition reactions of carbon nucleophiles to Michael acceptors, the corresponding 1,6-addition of homoenolates remains an unsolved problem. Currently, the N-heterocyclic carbene (NHC)-catalyzed cycloadditions of homoenolate equivalent intermediates have achieved widespread success. However, considerable limitations still exist for the linear reactions with electron-deficient alkenes, which are limited to 1,4-Michael acceptors. This report presents the first NHC-catalyzed asym. homoenolate addition of enals to 1,6-Michael acceptors. The strategy leads to the challenging nonspirocyclic 3,3-disubstituted oxindoles with two adjacent stereocenters, a quaternary and a trisubstituted one, in good yields and high stereoselectivities with a wide variety of substrates.

CCS Chemistry published new progress about Cycloaddition reaction catalysts. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Related Products of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Mei-Mei; Huang, Hui; Tian, Wanrong; Pu, Yiru; Zhang, Chaozheng; Yang, Jirui; Ren, Qing; Tao, Feiyan; Deng, Yun; Lu, Jun published the artcile< Construction of multi-substituted pyrazoles via potassium carbonate-mediated [3 + 2] cycloaddition of in-situ generated nitrile imines with cinnamic aldehydes>, Category: bromides-buliding-blocks, the main research area is methanecarbohydrazonoyl chloride cinnamaldehyde potassium carbonate mediator regioselective cycloaddition; phenyl pyrazole preparation.

A highly efficient potassium carbonate-mediated [3 + 2] cycloaddition reaction of hydrazonoyl chlorides with cinnamic aldehydes to furnish multi-substituted pyrazoles under nontoxic and mild conditions was developed. A plausible stepwise cycloaddition reaction mechanism was proposed. This protocol featured broad substrate coverage, good functional group tolerance, wide scalability, and operational simplicity, as well as conveniently constructed pyrazole scaffolds.

RSC Advances published new progress about [3+2] Cycloaddition reaction (regioselective). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ghosh, Arghya; Barik, Soumen; Biju, Akkattu T. published the artcile< NHC-Catalyzed [3 + 3] Annulation of Thioamides and Modified Enals for the Enantioselective Synthesis of Functionalized Thiazinones>, SDS of cas: 3893-18-3, the main research area is thiazinone preparation enantioselective; thioamide bromoenal thia Michael addition intramol cyclization.

N-Heterocyclic carbene (NHC)-catalyzed [3 + 3] annulation of thioamides with modified enals allowing the enantioselective synthesis of functionalized 1,3-thiazin-4-ones is reported. The NHC generated from the chiral triazolium salt was optimal and the reaction is initiated by the thia-Michael addition to catalytically generated α,β-unsaturated acylazolium intermediates derived from 2-bromoenals, followed by intramol. cyclization. This operationally simple procedure offers a straightforward and rapid access to target compounds in moderate to good yields and enantiomeric ratio values.

Organic Letters published new progress about Cyclization catalysts, stereoselective ([3 + 3]). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, SDS of cas: 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Xiaowei; Li, Yuxiu; Liu, Ruihua; Wang, Zemin; Li, Xiangqian; Shi, Dayong published the artcile< AcOH-mediated aerobic oxidative synthesis of 2-thioalkylbenzothiazoles via a three-component reaction>, Application In Synthesis of 3893-18-3, the main research area is aminothiophenol propenal thiophenol acetic acid mediator three component reaction; phenylulfanylalkyl benzothiazole regioselective preparation green chem.

An AcOH-mediated three-component reaction of 2-aminothiophenols, α,β-unsaturated aldehydes, and thiophenols to prepare high value-added 2-(thioalkyl)benzothiazoles, e.g., I, was developed. The reaction was conducted under metal-free conditions, where oxygen served as the terminal oxidant. In addition, this strategy was tolerant of different functional groups, providing efficient access to a variety of functionalized benzothiazole derivatives in moderate to good yields. This reaction has complete regioselectivity and provides a powerful method for building complex mols.

Tetrahedron Letters published new progress about Benzothiazoles Role: SPN (Synthetic Preparation), PREP (Preparation). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application In Synthesis of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xie, Haibo; Zhu, Jiangtao; Chen, Zixian; Li, Shan; Wu, Yongming published the artcile< Synthesis of 3-trifluoromethyl-1,4-dihydropyridazines by the PTSA-catalyzed reaction of α,β-unsaturated aldehydes with (E)-1-phenyl-2-(2,2,2-trifluoroethylidene)>, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde, the main research area is fluoromethyl hydropyridazine preparation PTSA catalyzed condensation unsaturated aldehyde phenylfluoroethylidene.

A facile and efficient method for the synthesis 3-trifluoromethyl-1,4-dihydropyridazine from a variety of readily available α,β-unsaturated aldehyde and (E)-1-phenyl-2-(2,2,2-trifluoroethylidene)hydrazine was developed. The reaction proceeded under mild conditions and gave the expected 1,4-dihydropyridazine products in moderate to high yields.

Synlett published new progress about Condensation reaction. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fernandez, Maitane; Uria, Uxue; Vicario, Jose L.; Reyes, Efraim; Carrillo, Luisa published the artcile< Enantioselective Conjugate Addition of Donor-Acceptor Hydrazones to α,β-Unsaturated Aldehydes through Formal Diaza-Ene Reaction: Access to 1,4-Dicarbonyl Compounds>, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde, the main research area is donor acceptor hydrazone enal conjugate addition formal diaza ene; conjugate addition adduct hydride shift oxidation; carboxylic acid gamma hydrazono stereoselective organocatalytic preparation; dicarbonyl stereoselective preparation.

Donor-acceptor monosubstituted hydrazones participate as suitable reagents able to undergo an enantioselective formal diaza-ene reaction with α,β-unsaturated aldehydes under chiral secondary amine catalysis. This constitutes a new approach for the enantioselective conjugate addition of hydrazones to enals under metal-free conditions and leads to the formation of γ-hydrazono carboxylic acids after oxidation/[1,3]-H shift. The methodol. is also useful for the synthesis of enantioenriched β-substituted α-keto-1,5-diesters by using the hydrazone moiety as a masked carbonyl group.

Journal of the American Chemical Society published new progress about Aliphatic acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (γ-hydrazono). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rios, Ramon; Ibrahem, Ismail; Vesely, Jan; Sunden, Henrik; Cordova, Armando published the artcile< Organocatalytic asymmetric 5-hydroxypyrrolidine synthesis: a highly enantioselective route to 3-substituted proline derivatives>, Related Products of 3893-18-3, the main research area is hydroxypyrrolidine proline substituted asym synthesis; acylaminomalonate organocatalytic tandem reaction unsaturated aldehyde.

The highly enantioselective organocatalytic tandem reaction between 2-acylaminomalonates and α,β-unsaturated aldehydes is presented. The reaction is a direct entry to 5-hydroxypyrrolidines and 3-substituted proline derivatives, which are furnished in high yields and 90-99% ee.

Tetrahedron Letters published new progress about Acylation. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Related Products of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Doyle, Amanda A.; Kramer, Tobias; Kavanagh, Kevin; Stephens, John C. published the artcile< Cinnamaldehydes: Synthesis, antibacterial evaluation, and the effect of molecular structure on antibacterial activity>, Computed Properties of 3893-18-3, the main research area is cinnamaldehyde synthesis mol structure antibacterial activity.

trans-Cinnamaldehyde is a major component of Cinnamomum cassia and has been reported to give rise to antimicrobial properties in cinnamon spice. In order to better understand the relationship between the structure of trans-cinnamaldehyde and its antimicrobial role, fifteen structurally different trans-cinnamaldehyde derivatives were selected for study based on their predicted electrophilicities. Both synthesized and com. trans-cinnamaldehyde derivatives were evaluated for their antibacterial activity, with modest mM activity levels found against both E. coli and S. aureus. An initial mechanism of action study, suggesting that the electrophilicity of the trans-cinnamaldehydes affects the antibacterial activity, was conducted as well as an exploration of their ability to alter bacterial cell wall integrity. In addition, in vivo toxicity levels were determined using the larvae of the greater wax moth, Galleria mellonella, with all derivatives tested showing low toxicity.

Results in Chemistry published new progress about Antibacterial agents. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Computed Properties of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liang, Zhi-Qin; Gao, Zhong-Hua; Jia, Wen-Qiang; Ye, Song published the artcile< Bifunctional N-Heterocyclic Carbene Catalyzed [3+4] Annulation of Enals and Aurones>, HPLC of Formula: 3893-18-3, the main research area is benzofuran lactone fused preparation diastereoselective enantioselective; aurone enal annulation bifunctional heterocyclic carbene catalyst; N-heterocyclic carbenes; annulation; kinetic control; lactones; organocatalysis.

Bifunctional N-heterocyclic carbenes with a free hydroxy group were demonstrated as efficient catalysts for the [3+4] annulation of enals RHC:CHCHO (R = 4-H3CCO6H4, 2-ClC6H4, furan-2-yl, CH2CH2CH3, etc.) with aurones I [Ar = C6H5, naphthalen-1-yl, furan-2-yl, styryl, etc.] to give the corresponding benzofuran-fused ε-lactones II in good yields with good diastereoselectivities and excellent enantioselectivities. The control experiments reveals that the [3+4] cycloadducts are kinetically favored and could be transformed to the thermodynamically favored [3+2] cycloadducts with a non-bifunctional NHC catalyst.

Chemistry – A European Journal published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, HPLC of Formula: 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary