Category: 3893-18-3

Luo, Xiaoyan; Zhou, Zhiqiang; Li, Xin; Liang, Xinmiao; Ye, Jinxing published the artcile< Enantioselective organocatalytic phospha-Michael reaction of α,β-unsaturated aldehydes>, Reference of 3893-18-3, the main research area is enantioselective organocatalytic phospha Michael alpha beta unsaturated aldehyde; diaryl phosphine oxide phospha Michael alpha beta unsaturated aldehyde; diphenyl trimethylsilyloxy pyrrolidine catalyzed phospha Michael unsaturated aldehyde; crystal mol structure bromophenyl diphenylphosphoryl propanol.

The enantioselective organocatalytic phospha-Michael reaction of α,β-unsaturated aldehydes with diaryl phosphine oxides is explored for the first time using (S)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine as a catalyst. It afforded 1,4-addition adducts in good to excellent yields with up to 99% ee.

RSC Advances published new progress about Addition reaction (1,4-addition reaction). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Reference of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jiang, Kun; Tiwari, Bhoopendra; Chi, Yonggui Robin published the artcile< Access to Spirocyclic Oxindoles via N-Heterocyclic Carbene-Catalyzed Reactions of Enals and Oxindole-Derived α,β-Unsaturated Imines>, Reference of 3893-18-3, the main research area is unsaturated imine enal NHC stereoselective spirocyclization catalyst; beta lactam fused spirocyclic oxindole stereoselective preparation.

A diastereoselective access to β-lactam fused spirocyclic oxindoles, e.g., I and II, and related compounds bearing all carbon spiro centers is described. This N-heterocyclic carbene-catalyzed process employed challenging β,β-disubstituted α,β-unsaturated imines to react with enals.

Organic Letters published new progress about Diastereoselective synthesis. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Reference of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Afewerki, Samson; Breistein, Palle; Pirttila, Kristian; Deiana, Luca; Dziedzic, Pawel; Ibrahem, Ismail; Cordova, Armando published the artcile< Catalytic Enantioselective β-Alkylation of α,β-Unsaturated Aldehydes by Combination of Transition-Metal- and Aminocatalysis: Total Synthesis of Bisabolane Sesquiterpenes>, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde, the main research area is bisabolane sesquiterpene curcumene tumerone dehydrocurcumene enantioselective synthesis; unsaturated aldehyde asym beta alkylation.

The first example of enantioselective β-alkylation of α,β-unsaturated aldehydes by combination of aminocatalysis and transition-metal catalysis is reported. The catalyzed asym. 1,4-addition gave the corresponding β-alkyl aldehydes with up to 98:2 e.r. Thus, simple bench stable chiral amines can be used as catalyst in combination with a copper salt without the use of a glove box to achieve catalytic asym. addition of dialkylzinc reagents to enals with high enantioselectivity. The novel co-catalytic reaction was utilized as the key step for the expeditious total synthesis of bisabolane sesquiterpenes, e.g. I.

Chemistry – A European Journal published new progress about 1,4-Addition reaction. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

White, Nicholas A.; Rovis, Tomislav published the artcile< Oxidatively Initiated NHC-Catalyzed Enantioselective Synthesis of 3,4-Disubstituted Cyclopentanones from Enals>, Formula: C9H7BrO, the main research area is NHC catalyst oxidative enantioselective cyclization aryl enal; cyclopentanone stereoselective preparation.

An unprecedented N-heterocyclic carbene (NHC)-catalyzed annulation of enals to form 3,4-disubstituted cyclopentanones, e.g. I, has been discovered. Aryl enals undergo dimerization in the presence of a single-electron oxidant to form C2 sym. cyclopentanones. A cross-reaction has also been developed, allowing for the synthesis of differentially substituted cyclopentanones. Mechanistically, the reaction is thought to proceed through radical intermediates, further establishing the synthetic utility of this class of reactivity.

Journal of the American Chemical Society published new progress about Enantioselective synthesis. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Formula: C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Geng, Zhi-Cong; Zhang, Shao-Yun; Li, Nai-Kai; Li, Ning; Chen, Jian; Li, Hai-Yan; Wang, Xing-Wang published the artcile< Organocatalytic Diversity-Oriented Asymmetric Synthesis of Tricyclic Chroman Derivatives>, Application In Synthesis of 3893-18-3, the main research area is diphenylprolinol trimethylsilyl ether catalyst Michael aldol Diels Alder reaction; hydroxyaryloxobutenoate enal aldol Diels Alder reaction; organocatalytic diversity oriented asym synthesis tricyclic chroman derivative.

The tandem oxo-Michael-IED/HDA (inverse-electron-demand hetero-Diels-Alder) and oxo-Michael-IED/HDA-Michael-Aldol condensation transformations between (E)-2-hydroxyaryl-2-oxobut-3-enoate derivatives with enals have been developed in the presence of (S)-diphenylprolinol trimethylsilyl ether as an organocatalyst. Two types of tricyclic chroman derivatives, e.g. I and II, were, resp., obtained, by adjusting the reactant ratio and reaction temperature, in good yields (up to 96%) with excellent enantioselectivities (up to >99%) and good diastereoselectivities (up to >30/1). It should be noted that the divergent chiral chroman derivatives were obtained by successive reaction of (E)-2-hydroxyaryl-2-oxobut-3-enoate derivatives with two different enal substrates in highly catalytic results.

Journal of Organic Chemistry published new progress about Aldol condensation. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application In Synthesis of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hattori, Tomohiro; Takakura, Ryoya; Ichikawa, Tomohiro; Sawama, Yoshinari; Monguchi, Yasunari; Sajiki, Hironao published the artcile< Switching the Cleavage Sites in Palladium on Carbon-Catalyzed Carbon-Carbon Bond Disconnection>, Electric Literature of 3893-18-3, the main research area is palladium catalysis regioselective carbon bond cleavage cinnamaldehyde; styrene benzaldehyde derivative preparation.

We have demonstrated a palladium on carbon-catalyzed approach to regioselectively alter the cleavage sites of the C-C bonds of cinnamaldehyde derivatives by a slight change in the reaction conditions in isopropanol under an O2 atmosphere. Styrene derivatives could be selectively formed by the addition of Na2CO3 in association with the dissociation of carbon monoxide, while benzaldehyde derivatives were generated by the addition of CuCl and morpholine instead of Na2CO3.

Journal of Organic Chemistry published new progress about Aryl aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Electric Literature of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Chengcheng; Wang, Yang; Wang, Guanyang; Huang, Chusen; Jia, Nengqin published the artcile< A new mitochondria-targeting fluorescent probe for ratiometric detection of H2O2 in live cells>, Category: bromides-buliding-blocks, the main research area is mitochondria fluorescent probe hydrogen peroxide live cell; Hydrogen peroxide; Live cell imaging; Mitochondria; Quantitative detection; Ratiometric fluorescent probe.

With this research the authors presented a ratiometric and mitochondria-target fluorescent probe (Mito-HT) (I) for detection of H2O2 both in vitro and in live cells. Mito-HT was constructed by direct conjugation of aryl boronate to fluorophore with three synthetic steps. The borate group is cleaved from Mito-HT in the presence of H2O2, resulting in the exposure of the hydroxyl group of the electron donating group. Then the ICT mechanism was turned on, and the fluorescence emission of Mito-HT at 493 nm was red shifted to 562 nm, thereby achieving radiometric detection of H2O2. Mito-HT exhibited a highly selectivity towards H2O2, and this interaction can be completed within 40 min. Mito-HT could be used for quant. detection of H2O2 (0-200μM) through ratiometric fluorescence signal readout. And limit of detection (LOD) is ∼0.33μM. The relatively high stability and medium fluorescence quantum yield of Mito-HT (0.39) and Mito-HT-OH (0.43) enable clear mitochondria localization and dual-channel fluorescence imaging of H2O2 in live cells with confocal microscopy.

Analytica Chimica Acta published new progress about Fluorescence imaging. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kim, Yeseul; Kim, Sanghun; Cho, Kiu-Hyung; Lee, Jin-Hyung; Lee, Jintae published the artcile< Antibiofilm Activities of Cinnamaldehyde Analogs against Uropathogenic Escherichia coli and Staphylococcus aureus>, Product Details of C9H7BrO, the main research area is Escherichia coli Staphylococcus aureus cinnamaldehyde uropathogenic antibiofilm activity; Staphylococcus aureus; antibiofilm; cinnamaldehyde; uropathogenic Escherichia coli.

Bacterial biofilm formation is a major cause of drug resistance and bacterial persistence; thus, controlling pathogenic biofilms is an important component of strategies targeting infectious bacterial diseases. Cinnamaldehyde (CNMA) has broad-spectrum antimicrobial and antibiofilm activities. In this study, we investigated the antibiofilm effects of ten CNMA derivatives and trans-CNMA against Gram-neg. uropathogenic Escherichia coli (UPEC) and Gram-pos. Staphylococcus aureus. Among the CNMA analogs tested, 4-nitrocinnamaldehyde (4-nitroCNMA) showed antibacterial and antibiofilm activities against UPEC and S. aureus with min. inhibitory concentrations (MICs) for cell growth of 100 mug/mL, which were much more active than those of trans-CNMA. 4-NitroCNMA inhibited UPEC swimming motility, and both trans-CNMA and 4-nitroCNMA reduced extracellular polymeric substance production by UPEC. Furthermore, 4-nitroCNMA inhibited the formation of mixed UPEC/S. aureus biofilms. Collectively, our observations indicate that trans-CNMA and 4-nitroCNMA potently inhibit biofilm formation by UPEC and S. aureus. We suggest efforts be made to determine the therapeutic scope of CNMA analogs, as our results suggest CNMA derivatives have potential therapeutic use for biofilm-associated diseases.

International Journal of Molecular Sciences published new progress about Antibiofilm agents. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Product Details of C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Noole, Artur; Malkov, Andrei V.; Kanger, Tonis published the artcile< Asymmetric organocatalytic synthesis of spiro-cyclopropaneoxindoles>, Related Products of 3893-18-3, the main research area is spiro cyclopropaneoxindole enantioselective preparation; dicarbonyl compound alkylidene oxindole cascade enantioselective reaction organocatalyst.

Straightforward cascade reactions for the synthesis of spiro-cyclopropaneoxindoles are described. The target compounds are obtained in high yields and in good enantio- and diastereoselectivities via hydrogen bonding or iminium catalysis.

Synthesis published new progress about Enantioselective synthesis. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Related Products of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary