Category: 3893-18-3

Li, Xiang; Huang, Wei; Liu, Yan-Qing; Kang, Jing-Wen; Xia, Dan; He, Gu; Peng, Cheng; Han, Bo published the artcile< Control of Activation Mode To Achieve Diastereodivergence in Asymmetric Syntheses of Chiral Spiropiperidinone Derivatives>, Category: bromides-buliding-blocks, the main research area is crystal mol structure furanyl tosyl azaspiro decanedione; azaspiro decanedione preparation; spiropiperidinone preparation stereoselective Michael hemiaminalization cascade aldehyde cyclic ketoamide; stereoselective Michael hemiaminalization cascade unsaturated aldehyde cyclic ketoamide; HOMO LUMO activation stereoselective Michael hemiaminalization cascade aldehyde ketoamide.

An efficient organocatalytic cascade reaction has been developed involving a Michael-hemiaminalization relay for the asym. synthesis of spiropiperidinone derivatives bearing adjacent quaternary and tertiary chiral centers via LUMO or HOMO activation. Importantly, this methodol. demonstrates that applying distinct activation modes to different substrates in the same reaction can diverge diastereoselectivity. To our knowledge, this is also one of the few published cases of primary amine catalytic [3+3] cycloaddition reactions involving α-branched β-ketoamides.

Journal of Organic Chemistry published new progress about Amides, oxo Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yadav, Rahul; Darakshan; Bhaumick, Prabhas; Choudhury, Lokman H.; Parvin, Tasneem published the artcile< Synthesis of Pentacyclic Pyran Fused Pyrazolo Benzo[h]quinolines by Multicomponent Reaction and Their Photophysical Studies>, SDS of cas: 3893-18-3, the main research area is pentacyclic pyranpyrazolobenzoquinoline preparation photophys study; aldehyde hydroxy naphthoquinone aminopyrazole one pot three component reaction.

A one-pot method for the synthesis of pentacyclic pyran fused pyrazolo benzo[h]quinolines I (R1 = Ph, 4-chlorophenyl, anthracen-9-yl, etc.; R2 = Me, Ph, 4-methylphenyl, 4-chlorophenyl; R3 = Me, Ph, 4-methylphenyl) in acetic acid medium from the three-component reaction of 2-hydroxy-1,4-naphthoquinone, α, β-unsaturated aldehydes and 5-aminopyrazoles under the reflux conditions has been described. In this reaction, four new bonds (2 C-C, 1 C-N and 1 C-O) and two new rings (pyridine and pyran) were formed in one-pot. The novel products contain four bioactive moieties such as pyran, pyridine, pyrazole and α-naphthol. The salient features of this method are: one-pot process, short reaction time, easier purification, no need of column chromatog. and good yields of the products I. All the products I were characterized by IR, NMR and HRMS. Most of the synthesized compounds I were found highly fluorescent. Therefore, their photophys. properties were studied by UV-Visible and Fluorescence spectroscopy. Their quantum yields which were calculated and found in the range 0.243-0.424 in CHCl3 solution (c = 10-5 M) have been reported. Compound I (R1 = phenyl; R2 = phenyl; R3 = methyl) showed the highest quantum yield of 0.424.

ChemistrySelect published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, SDS of cas: 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fouque, Amelie; Delalande, Olivier; Jean, Mickael; Castellano, Remy; Josselin, Emmanuelle; Malleter, Marine; Shoji, Kenji F.; Hung, Mac Dinh; Rampanarivo, Hariniaina; Collette, Yves; van de Weghe, Pierre; Legembre, Patrick published the artcile< Correction to A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells [Erratum to document cited in CA163:325630]>, Category: bromides-buliding-blocks, the main research area is covalent mTOR inhibitor DHM25 antitumor breast cancer erratum.

The plots for T47-D cells in Figure 2A are incorrect; the corrected figure is provided here.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Peng; Wang, Xiao; Chen, Feng; Zhang, Zheng-Bing; Chen, Chao; Peng, Lin; Wang, Li-Xin published the artcile< Organocatalytic Enantioselective Michael/Cyclization Domino Reaction between 3-Amideoxindoles and α,β-Unsaturated Aldehydes: One-Pot Preparation of Chiral Spirocyclic Oxindole-γ-lactams>, Reference of 3893-18-3, the main research area is enantioselective Michael cyclization amideoxindole unsaturated aldehyde; spirocyclic oxindole lactam preparation.

The first organocatalytic enantioselective Michael/cyclization domino reaction between 3-amideoxindoles and α,β-unsaturated aldehydes is described. After sequential oxidation with pyridinium chlorochromate, a direct and one-pot preparation of highly sterically hindered spirocyclic oxindole-γ-lactams was achieved in 51-81% yields with 75-97% ee and ≤80/20 dr.

Journal of Organic Chemistry published new progress about Crystal structure. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Reference of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Qinglin; Liu, Qian; Chen, Yurong; Li, Yinle; Su, Hui; Liu, Qinghua; Li, Guangqin published the artcile< Ir nanoclusters confined within hollow MIL-101(Fe) for selective hydrogenation of α,β-unsaturated aldehyde>, Formula: C9H7BrO, the main research area is MIL 101 Fe support iridium nanocatalyst preparation surface area; alkenyl aldehyde iridium catalyst selective hydrogenation; unsaturated alchol preparation.

Although the selective hydrogenation of α,β-unsaturated aldehyde to unsaturated alc. (UOL) is an extremely important transformation, it is still a great challenge to achieve high selectivity to UOL due to thermodn. favoring of the C=C hydrogenation over the C=O hydrogenation. Herein, iridium nanoclusters (Ir NCs) confined within hollow MIL-101(Fe) expresses satisfied reaction activity (93.9%) and high selectivity (96.2%) for the hydrogenation of cinnamaldehyde (CAL) to cinnamyl alc. (COL) under 1 bar H2 atmosphere and room temp were reported. The unique hollow structure of MIL-101(Fe) benefited for the fast transport of reactant, ensuring the comparable reaction activity and better recyclability of Ir@MIL-101(Fe) than the counterparts which Ir NCs were on the surface of MIL-101(Fe). Furthermore, the XPS data indicatds the electropos. Ir NCs, owing to the electron transfer from Ir to MIL-101(Fe), can interact with oxygen lone pairs and Fourier transform IR spectrum showed the Lewis acid sites in MIL-101(Fe) can strongly interact with C=O bond, which contributed to a high selectivity for COL. This work suggested the considerable potential of synergetic effect between hollow MOFs and metal nanoclusters for selective hydrogenation reactions.

Chinese Chemical Letters published new progress about Alcohols, unsaturated Role: SPN (Synthetic Preparation), PREP (Preparation). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Formula: C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hayashi, Yujiro; Toyoshima, Maya; Gotoh, Hiroaki; Ishikawa, Hayato published the artcile< Diphenylprolinol Silyl Ether Catalysis in an Asymmetric Formal Carbo [3 + 3] Cycloaddition Reaction via a Domino Michael/Knoevenagel Condensation>, Application of C9H7BrO, the main research area is diphenylprolinol silyl ether catalyst unsaturated aldehyde oxopentanedioate stereoselective cycloaddition; Michael reaction Knoevenagel condensation diphenylprolinol silyl ether catalyst; cyclohexenone stereoselective preparation.

Diphenylprolinol silyl ether I (R1 = H, R2 = H, TMS, TBS; R1 = CF3, R2 = TMS) was found to catalyze the formal carbo [3 + 3] cycloaddition reaction through the domino reaction via the Michael reaction, followed by Knoevenagel condensation of the α,β-unsaturated aldehyde and di-Me 3-oxopentanedioate, affording substituted cyclohexenone derivatives, e.g. II, with excellent enantioselectivity.

Organic Letters published new progress about Cycloaddition reaction (asym. formal [3+3]). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application of C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Peng, Fu; Zhao, Qian; Huang, Wei; Liu, Shuai-Jiang; Zhong, Ya-Jun; Mao, Qing; Zhang, Nan; He, Gu; Han, Bo published the artcile< Amine-catalyzed and functional group-controlled chemo- and regioselective synthesis of multi-functionalized CF3-benzene via a metal-free process>, Application of C9H7BrO, the main research area is arylpropenal fluoroalkyl cyanobutenoate amine tandem Rauhut Currier reaction; fluoroalkyl biaryl ester preparation chemoselective regioselective green chem; trifluoromethyl oxopentenoate arylpropenal amine tandem Michael reaction; formyl trifluoromethyl terphenyl ester preparation regioselective chemoselective green chem; phenyl butenoate cinnamaldehyde amine chemoselective regioselective Rauhut Currier reaction; diphenyl ester preparation green chem.

A new strategy for the preparation of CF3-containing multi-substituted benzene compounds via an amine-catalyzed reaction under metal-free and air-tolerant conditions was developed. This green reaction provided a functional group-controlled synthetic strategy and the polysubstituted benzene derivatives were obtained in moderate to good yields. Using a tri-substituted alkene containing a cyano group as the starting material, CF3-functionalized benzene compounds with four adjacent substituents were formed via a Rauhut-Currier (RC) reaction-triggered [3 + 3] cascade. When the cyano group was replaced with a benzoyl group, Michael-initialized [4 + 2] aromatization occurred, producing the corresponding CF3-benzene with five contiguous substituent groups. The reaction also features numerous advantages, including excellent chemo- and regioselectivity, extensive substrate scope and environmentally friendly conditions. A simple conversion of an aldehyde into a terminal alkyne was also achieved and the utility of this environmentally compatible method and the one-pot reaction was demonstrated by synthesizing a CF3-functionalized benzene-zidovudine hybrid.

Green Chemistry published new progress about [3+3] Cycloaddition reaction. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application of C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Suresh, Pavithira; Thamotharan, Subbiah; Ganesan, Subramaniapillai Selva published the artcile< Driving NHC organocatalysis on water through hydrophobic hydration for the synthesis of diverse heterocycles and carbocycles>, HPLC of Formula: 3893-18-3, the main research area is heterocycle spirocyclic preparation heterocyclic carbene catalyst water solvent; carbocycle preparation heterocyclic carbene catalyst water solvent.

Unprecedented acceleration in the rate of the N-heterocyclic carbene (NHC) organocatalysis was observed while performing the reaction in water medium with NaCl as an additive during the synthesis of diverse spirooxindole-γ-butyrolactone derivatives, e.g., I. The seminal role of the hydrophobic hydration effect for the acceleration of the reaction was further proven by performing the reaction with antihydrophobic additive LiClO4 and using denser D2O solvent.

Catalysis Communications published new progress about Cycloalkenes Role: SPN (Synthetic Preparation), PREP (Preparation) (cyclopentenes). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, HPLC of Formula: 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fu, Zhenqian; Sun, Hui; Chen, Shaojin; Tiwari, Bhoopendra; Li, Guohui; Robin Chi, Yonggui published the artcile< Controlled β-protonation and [4+2] cycloaddition of enals and chalcones via N-heterocyclic carbene/acid catalysis: toward substrate independent reaction control>, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde, the main research area is enol lactone preparation enal chalcone cycloaddition NHC catalyst.

A substrate-independent selective generation of enolates over homoenolate equivalent in NHC-catalyzed reactions of enals and chalcones is disclosed. Acid co-catalysts play vital roles in control of the reaction pathways, allowing for individual access to diverse products from identical substrates.

Chemical Communications (Cambridge, United Kingdom) published new progress about [4+2] Cycloaddition reaction. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tang, Shibing; He, Jinmei; Sun, Yongquan; He, Liuer; She, Xuegong published the artcile< Efficient and Regioselective One-Pot Synthesis of 3-Substituted and 3,5-Disubstituted Isoxazoles>, Electric Literature of 3893-18-3, the main research area is isoxazole regioselective preparation; hydroxyl toluenesulfonamide unsaturated aldehyde ketone conjugate addition cyclization.

A series of 3-substituted and 3,5-disubstituted isoxazoles have been efficiently synthesized in moderate to excellent yields by the reaction of N-hydroxyl-4-toluenesulfonamide with α,β-unsaturated aldehydes/ketones. This novel strategy is associated with readily available starting materials, mild conditions, high regioselectivity, and wide scope.

Organic Letters published new progress about Conjugate addition reaction. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Electric Literature of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary