Category: 35354-37-1

Adding a certain compound to certain chemical reactions, such as: 35354-37-1, name is 1-Bromo-5-methylhexane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35354-37-1, name: 1-Bromo-5-methylhexane

(a) Methyl 1-(5-methylhexyl)cyclopentanecarboxylate To a solution of methyl cyclopentanecarboxylate (300 mg, 2.3 mmol) in THF (20 ml) at -78° C. was added LHMDS (4.6 mL, 4.6 mmol) and stirred for 30 min, and followed by 1-bromo-5-methylhexane (626 mg, 3.5 mmol). The mixture was stirred from -78° C. to rt over 16 hr, before 30 ml of H2O was added and then was extracted with CH2Cl2 (2*30 mL). The combined extracts were washed with water, dried over MgSO4, filtered and concentrated, then purified using flash chromatography to give an oil (110 mg, 21percent). MS [M+H]+333.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Yang, Michael G.; Liu, Hong; US2002/61874; (2002); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 35354-37-1, name is 1-Bromo-5-methylhexane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: bromides-buliding-blocks

Example 145 (+-)-4-(3-Ethanesulfonylaminophenyl)-trans-3,4-dimethyl-N-(5-methylhexyl)piperidine To a stirred solution of (+-)4-(3-ethanesulfonylaminophenyl)-trans-3,4-dimethylpiperidine (Preparation 39, 120 mg, 0.4 mmol) in N,N-dimethylformamide (7 ml) was added sodium hydrogen carbonate (68 mg, 0.8 mmol) and 1-bromo-5-methylhexane (80 mg, 0.44 mmol). The stirred reaction mixture was heated to 100° C. for 16 h, then allowed to cool. Water (50 ml) was added and the mixture was extracted with diethyl ether (3*50 ml). The combined extracts were washed with brine (50 ml), dried (Na2SO4), filtered and concentrated in vacuo. The residue was purified by silica (5 g) column chromatography eluding initially with hexane, then hexane:ethyl acetate:0.880 ammonia (50:50:1) to give a yellow oil (15 mg). The residue was further purified by preparative HPLC on a Phenomenex Magellan.(TM). column, 15 cm*2.1 cm; flow 10.0 ml min-1; employing U.V. detection at 235 nm; eluant acetonitrile:0.1M aqueous ammonium acetate solution:methanol (25:35:40) to afford the title compound as its acetate salt as a yellow oil (10 mg, 6percent). NMR (CDCl3, selected data for the acetate salt): 0.8 (d, 3H), 1.8 (m, 1H), 2.4 (m, 1H), 2.85 (m, 1H), 3.1 (q, 2H), 7.05-7.3 (m, 4H). MS (APCI): M/Z [MH+] 395.2; C22H38N2O2S+H requires 395.3.

The synthetic route of 1-Bromo-5-methylhexane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Armer, Richard Edward; Dutton, Christopher James; Gethin, David Morris; Gibson, Stephen Paul; Smith, Julian Duncan; Tommasini, Ivan; US2003/78282; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 35354-37-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35354-37-1 as follows.

Example 148 (+-)-trans-3,4-Dimethyl-N-(5-methylhexyl)-4-(3-n-propanesulfonylaminophenyl)piperidine To a solution of (+-)-trans-3,4-dimethyl-4-(3-n-propanesulfonylaminophenyl)piperidine (Preparation 40, 220 mg, 0.71 mmol) and 1-bromo-5-methylhexane (140 mg, 0.78 mmol) in N,N-dimethylformamide (7 ml) was added sodium hydrogen carbonate (120 mg, 1.42 mmol) and the resultant mixture was heated overnight at 100° C. The reaction mixture was poured onto water (50 ml) and extracted with diethyl ether (3*50 ml). The combined extracts were washed with brine (50 ml), dried (MgSO4), filtered and concentrated in vacuo to give the crude product which was purified by silica (5 g) chromatography using a gradient solvent system eluding initially with hexane:0.880 ammonia (100:1) then ethyl acetate:hexane:0.880 ammonia (50:50:1) to afford the title compound as a pale yellow oil (77 mg, 27percent). NMR (CDCl3, selected data for the free base): 0.75 (d, 3H), 0.9 (d, 6H), 1.0 (t, 3H), 1.2 (t, 2H), 1.25 (m, 2H), 1.3 (s, 3H), 1.4-1.65 (m, 5H), 1.8 (m, 2H), 2.0 (m, 1H), 2.5 (q, 2H), 2.8 (m, 1H), 3.05 (m, 2H), 7.0-7.3 (m, 4H). MS (APCI): M/Z [MH+] 409.3; C23H40N2O2S+H requires 409.3.

According to the analysis of related databases, 35354-37-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Armer, Richard Edward; Dutton, Christopher James; Gethin, David Morris; Gibson, Stephen Paul; Smith, Julian Duncan; Tommasini, Ivan; US2003/78282; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 35354-37-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35354-37-1, name is 1-Bromo-5-methylhexane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 151 (+-)-trans-3,4-Dimethyl-N-(5-methylhexyl)-4-(3-(1-methyl-1H-imidazole-4-sulfonylamino)phenyl)piperidine To a solution of (+-)-trans-3,4-dimethyl-4-(3-(1-methyl-1H-imidazole-4-sulfonylamino)phenyl)piperidine (Preparation 41, 80 mg, 0.23 mmol) in N,N-dimethylformamide (3 ml) was added sodium hydrogen carbonate (21 mg, 0.25 mmol) and 1-bromo-5-methylhexane (43 mg, 0.24 mmol). The stirred reaction mixture was heated at 100° C. for 5 h, then concentrated in vacuo at 80° C. The residue was taken up in dichloromethane and purified by silica column chromatography, eluding with ethyl acetate:isopropanol (95:5) to give the title compound as a white solid (34 mg, 33 NMR (CDCl3, selected data for the free base): 0.6 (d, 3H), 0.85 (m, 6H), 1.25 (s, 3H), 3.6 (s, 3H), 7.0-7.25 (s, 5H), 7.45 (s, 1H). MS (thermospray): M/Z [MH+] 447.3; C24H38N4O2S+H requires 447.3.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-5-methylhexane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Armer, Richard Edward; Dutton, Christopher James; Gethin, David Morris; Gibson, Stephen Paul; Smith, Julian Duncan; Tommasini, Ivan; US2003/78282; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 35354-37-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35354-37-1 as follows.

Example 44 (+-)-4-(3-Methanesulfonylaminophenyl)-trans-3,4-dimethyl-N-(5-methylhexyl)piperidine To a stirred solution of (+-)-4-(3-methanesulfonylaminophenyl)-trans-3,4-dimethylpiperidine (Preparation 10, 25 mg, 0.088 mmol) in N,N-dimethylformamide (2 ml) was added sodium hydrogen carbonate (11 mg, 0.13 mmol) and 1-bromo-5-methylhexane (20 mg, 0.11 mmol). The reaction was heated to 90° C. for 24 h and then cooled to room temperature. The reaction mixture was diluted with water (40 ml) and extracted with diethyl ether (2*20 ml). The combined extracts were dried (MgSO4), filtered and concentrated in vacuo to give the crude product. This was purified by silica (5 g) column chromatography eluding with ethyl acetate:hexane (4:1) to give the title compound as a light brown gum (11 mg, 32percent). NMR (CDCl3, selected data for the free base): 0.75 (d, 3H), 0.8 (m, 6H), 1.2 (m, 3H), 2.55 (m, 2H), 3.0 (s, 3H), 7.0-7.4 (m, 4H). MS (thermospray): M/Z [MH+] 381.3; C21H36N2O2S+H requires 381.3.

According to the analysis of related databases, 35354-37-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Armer, Richard Edward; Dutton, Christopher James; Gethin, David Morris; Gibson, Stephen Paul; Smith, Julian Duncan; Tommasini, Ivan; US2003/78282; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 35354-37-1, name is 1-Bromo-5-methylhexane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35354-37-1, Safety of 1-Bromo-5-methylhexane

(a) Methyl 1-(5-methylhexyl)cyclopentanecarboxylate To a solution of methyl cyclopentanecarboxylate (300 mg, 2.3 mmol) in THF (20 ml) at -78¡ã C. was added LHMDS (4.6 mL, 4.6 mmol) and stirred for 30 min, and followed by 1-bromo-5-methylhexane (626 mg, 3.5 mmol). The mixture was stirred from -78¡ã C. to rt over 16 hr, before 30 ml of H2O was added and then was extracted with CH2Cl2 (2*30 mL). The combined extracts were washed with water, dried over MgSO4, filtered and concentrated, then purified using flash chromatography to give an oil (110 mg, 21percent). MS [M+H]+333.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Yang, Michael G.; Liu, Hong; US2002/61874; (2002); A1;,
Bromide – Wikipedia,
bromide – Wiktionary