Category: 35065-86-2

Radical 1,4-Aryl Migration Enabled Remote Cross-Electrophile Coupling of 浼?Amino-灏?Bromo Acid Esters with Aryl Bromides was written by Tang, Shi;Xu, Zhen-Hua;Liu, Ting;Wang, Shuo-Wen;Yu, Jian;Liu, Jian;Hong, Yu;Chen, Shi-Lu;He, Jin;Li, Jin-Heng. And the article was included in Angewandte Chemie, International Edition in 2021.Synthetic Route of C8H7BrO2 This article mentions the following:

Here an unprecedented, efficient nickel-catalyzed radical relay was reported for the remote cross-electrophile coupling of 灏?bromo-浼?benzylamino acid esters with aryl bromides via 1,4-aryl migration/arylation cascades. 灏?Bromo-浼?benzylamino acid esters were considered as unique mol. scaffolds allowing for aryl migration reactions, which were conceptually novel variants for the radical Truce-Smiles rearrangement. This reaction enabled the formation of two new C(sp3)-C(sp2) bonds using a bench-stable Ni/bipyridine/Zn system featuring a broad substrate scope and excellent diastereoselectivity, which provided an effective platform for the remote aryl group migration and arylation of amino acid esters via redox-neutral C(sp3)-C(sp2) bond cleavage. Mechanistically, this cascade reaction was accomplished by combining two powerful catalytic cycles consisting of a cross-electrophile coupling and radical 1,4-aryl migration through the generation of C(sp3)-centered radical intermediates from the homolysis of C(sp3)-Br bonds and the switching of the transient alkyl radical into a robust 浼?aminoalkyl radical. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Synthetic Route of C8H7BrO2).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Synthetic Route of C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

QSPR modelling with the topological substructural molecular design approach: 灏?cyclodextrin complexation was written by Perez-Garrido, Alfonso;Helguera, Aliuska Morales;Cordeiro, M. Natalia D. S.;Escudero, Amalio Garrido. And the article was included in Journal of Pharmaceutical Sciences in 2009.Computed Properties of C8H7BrO2 This article mentions the following:

This study aims at developing a quant. structure-property relationship (QSPR) model for predicting complexation with 灏?cyclodextrins (灏?CD) based on a large variety of organic compounds Mol. descriptors were computed following the TOPol. Substructural Mol. DEsign (TOPS-MODE) approach and correlated with 灏?CD complex stability constants by linear multivariate data anal. This strategy afforded a final QSPR model that was able to explain around 86% of the variance in the exptl. activity, along with showing good internal cross-validation statistics, and also good predictivity on external data. Topol. substructural information influencing the complexation with 灏?CD was extracted from the QSPR model. This revealed that the major driving forces for complexation are hydrophobicity and van der Waals interactions. Therefore, the presence of hydrophobic groups (hydrocarbon chains, aryl groups, etc.) and voluminous species (Cl, Br, I, etc.) in the mols. renders easy their complexity with 灏?CDs. To our knowledge, this is the first time a correlation between TOPS-MODE descriptors and complexing abilities of 灏?CDs has been reported. 婕?2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:4557-4576, 2009. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Computed Properties of C8H7BrO2).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Computed Properties of C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hydrogen-bonded banana liquid crystals was written by Gimeno, Nelida;Ros, Maria Blanca;Serrano, Jose Luis;de la Fuente, Maria Rosario. And the article was included in Angewandte Chemie, International Edition in 2004.Electric Literature of C8H7BrO2 This article mentions the following:

H-bonded bent complexes of benzoic acids (H donor) and nonmesomorphic V-shaped 4′-stilbazoles (H acceptor) give rise to polar smectic C (SmCP) mesophases. The multifunctional character of these noncovalent materials is confirmed through their electrooptical, dielec., and luminescent responses. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Electric Literature of C8H7BrO2).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Electric Literature of C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On the Scope of Trimethylaluminum-Promoted 1,2-Additions of ArZnX Reagents to Aldehydes was written by Glynn, Daniel;Shannon, Jonathan;Woodward, Simon. And the article was included in Chemistry – A European Journal in 2010.Recommanded Product: 35065-86-2 This article mentions the following:

A practical asym. 1,2-addition of functionalized arylzinc halides to aromatic and aliphatic aldehydes is described by the use of aminoalc. catalysis in the presence of AlMe₃. The process is simple to carry out, uses only com. available reagents/ligands and provides moderate to good (80-96 % ee) enantioselectivities for a wide range of substrates. Either com. ArZnX reagents or those prepared in situ from low cost aryl bromides can be used. In the latter case electrophilic functional groups are tolerated (CO₂Et, CN). The reaction relies on rapid exchange between ArZnX and AlMe₃ to generate mixed organometallic species that lead to the formation of a key intermediate that is distinctly different from the classic “anti” transition states of Noyori. NMR monitoring and related experiments have been used to probe the validity of the proposed selective transition state. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Recommanded Product: 35065-86-2).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 35065-86-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A simple and mild acylation of alcohols, phenols, amines, and thiols with a reusable heteropoly acid catalyst (H₆P₂W₁₈O₆₂璺?4 H₂O) was written by Romanelli, Gustavo P.;Bennardi, Daniel O.;Autino, Juan C.;Baronetti, Graciela T.;Thomas, Horacio J.. And the article was included in E-Journal of Chemistry in 2008.Application In Synthesis of 3-Bromophenyl acetate This article mentions the following:

The acylation of alcs., phenols, thiols, and amines with varied substitution using acid anhydrides is efficiently catalyzed by Wells-Dawson heteropoly acid (H₆P₂W₁₈O₆₂璺?4 H₂O). Reactions proceed with very good to excellent yield in air at room temperature, using toluene as solvent (40 examples). The bulk catalyst was easily reused without appreciable loss of its activity. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Application In Synthesis of 3-Bromophenyl acetate).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Application In Synthesis of 3-Bromophenyl acetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Remarkably High Reactivity of Pd(OAc)₂/Pyridine Catalysts: Nondirected C-H Oxygenation of Arenes was written by Emmert, Marion H.;Cook, Amanda K.;Xie, Yushu J.;Sanford, Melanie S.. And the article was included in Angewandte Chemie, International Edition in 2011.Name: 3-Bromophenyl acetate This article mentions the following:

The rational optimization and general applicability of the catalytic system Pd(OAc)₂/pyridine is described (see scheme). The catalyst shows excellent reactivity in the C-H oxygenation of simple aromatic substrates. The Pd/pyridine ratio is critical as the use of one equivalent of pyridine per Pd center leads to dramatic enhancements in both reactivity and site selectivity in comparison to Pd(OAc)₂ alone. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Name: 3-Bromophenyl acetate).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Name: 3-Bromophenyl acetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fries reaction of m-halophenylacetate was written by Chen, F.-C.;Chang, K. T.. And the article was included in Taiwan Yaoxue Zazhi in 1952.Category: bromides-buliding-blocks This article mentions the following:

m-BrC₆H₄OAc (I) (10 g.) heated with 20 g. AlCl₃ (II), 2 hrs. at 80°, followed by steam distillation, gave 3 g. yellow crystals (III), m. 42-3°, and 0.4 g. yellow crystals (IV), m. 85-90°, from the distillate and the residue, resp. I (10 g.) treated with 18 g. II, 1 hr. at 45°, gave 1 g. IV. Assuming that the o-isomer predominates at elevated temperature, III and IV are apparently 4-bromo-2-hydroxy- and 2-bromo-4-hydroxyacetophenones, resp. III with BzH gave a chalcone (V), yellow needles, m. 115-16°; cyclization of V with H₃PO₄ gave a flavanone (VI), m. 77-8°; dehydrogenation of VI with N-bromosuccinimide gave a flavone, m. 162-3°. Heating 7 g. m-IC₆H₄OAc (VII) in 35 ml. PhNO₂ (VIII) with 20 g. II 4 hrs. at 90-5°, followed by steam distillation, gave 0.1 g. crystals (IX), m. 53-4°, and 0.1 g. crystals (X), m. 128-36°, from the distillate and the residue, resp. VII (5 g.) in 25 ml. VIII heated with 17 g. II 3 hrs. at 100-120° gave 0.15 g. IX. IX and X are apparently 2-hydroxy-4-iodo- and 4-hydroxy-2-iodoacetophenones, resp. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Category: bromides-buliding-blocks).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of 6,7-Dibromoflavone and Its Regioselective Diversification via Suzuki-Miyaura Reactions was written by Jordan, Sandor;Pajtas, David;Patonay, Tamas;Langer, Peter;Konya, Krisztina. And the article was included in Synthesis in 2017.Computed Properties of C8H7BrO2 This article mentions the following:

The first synthesis pathway to 6,7-dibromoflavone and its transformations to 7-aryl-6-bromo- and 6,7-diarylflavones by Suzuki-Miyaura reactions are presented. Due to the different electronic effects of bromo substituents, the first attack proceeded with good site selectivity at position 7. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Computed Properties of C8H7BrO2).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Computed Properties of C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A simple and mild acylation of alcohols, phenols, amines, and thiols with a reusable heteropoly acid catalyst (H₆P₂W₁₈O₆₂路24 H₂O) was written by Romanelli, Gustavo P.;Bennardi, Daniel O.;Autino, Juan C.;Baronetti, Graciela T.;Thomas, Horacio J.. And the article was included in E-Journal of Chemistry in 2008.Application In Synthesis of 3-Bromophenyl acetate This article mentions the following:

The acylation of alcs., phenols, thiols, and amines with varied substitution using acid anhydrides is efficiently catalyzed by Wells-Dawson heteropoly acid (H₆P₂W₁₈O₆₂路24 H₂O). Reactions proceed with very good to excellent yield in air at room temperature, using toluene as solvent (40 examples). The bulk catalyst was easily reused without appreciable loss of its activity. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Application In Synthesis of 3-Bromophenyl acetate).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Application In Synthesis of 3-Bromophenyl acetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hydrogen-bonded banana liquid crystals was written by Gimeno, Nelida;Ros, Maria Blanca;Serrano, Jose Luis;de la Fuente, Maria Rosario. And the article was included in Angewandte Chemie, International Edition in 2004.Electric Literature of C8H7BrO2 This article mentions the following:

H-bonded bent complexes of benzoic acids (H donor) and nonmesomorphic V-shaped 4′-stilbazoles (H acceptor) give rise to polar smectic C (SmCP) mesophases. The multifunctional character of these noncovalent materials is confirmed through their electrooptical, dielec., and luminescent responses. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Electric Literature of C8H7BrO2).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Electric Literature of C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary