Category: 34699-28-0

Adding a certain compound to certain chemical reactions, such as: 34699-28-0, name is 1-(4-Bromophenyl)-1,2,2-triphenylethylene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 34699-28-0, HPLC of Formula: C26H19Br

2, 250ml three-necked flask was evacuated and filled with N2 three times, 10mmol of Compound 1-1 was added, 120ml of water after drying and discharged air tetrahydrofuran,Under conditions of -78 C, 12 mmol n-butyllithium was slowly added and stirred for 3 hours Slowly into 21mmol trimethyl borate, return to room temperature, stirred for 12 hours, 10ml hydrochloric acid was added to terminate the reaction, the organic phase Extract with CH2Cl2, extract the organic layer three times with saturated brine, dry the combined organic phases over anhydrous Na2SO4, spin-off Organic solvents, column chromatography gave the product 1-2 as a white solid. Yield: 81.6%

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Jiangxi Science and Technology Normal University; Pu Shouzhi; Chen Zhao; Liu Gang; Zhao Fei; (11 pag.)CN107082753; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 34699-28-0,Some common heterocyclic compound, 34699-28-0, name is 1-(4-Bromophenyl)-1,2,2-triphenylethylene, molecular formula is C26H19Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Into a 250 mL two-necked round-bottom flask under nitrogen was slowly added n-butyllithium (1.6 M in hexane, 7.5 mL, 12 mmol) and a THF solution (80 mL) of 1-(4-bromophenyl)-1,2,2-triphenylethene (3) (4.11 g, 10 mmol) at -78C. After stirring for 3 h, 2.4 mL of trimethylborate (20 mmol) was added into the reaction mixture. The mixture was warmed to room temperature and the reaction was terminated by adding hydrochloric acid (2 M, 10 mL) after 12 h. The mixture was then poured into water and extracted with dichloromethane. The organic layer was washed with water and dried over magnesium sulfate. After filtration and solvent evaporation, the residue was purified by silica-gel column chromatography using n-hexane/ethyl acetate as eluent. White solid of 4-(1,2,2-Triphenylvinyl)phenylboronic acid (4) was obtained in 70% yield (2.6 g). 1H NMR (300 MHz, CDCl3), delta (TMS, ppm): 7.88 (d, 2H, J=8.1 Hz), 7.13-7.00 (m, 17H), 4.49 (s, 1H). 13C NMR (75 MHz, CDCl3), delta (TMS, ppm): 148.9, 144.2, 144.1, 144.09, 142.4, 141.4, 135.6, 133.5, 132.0, 131.6, 128.4, 128.3, 127.4, 127.2. HRMS (TOF): m/e 376.2030 (M+, calcd 376.1635).

The synthetic route of 34699-28-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY; TANG, Benzhong; HONG, Yuning; LEUNG, Wai Tung; US2013/59392; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 34699-28-0, name is 1-(4-Bromophenyl)-1,2,2-triphenylethylene, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 34699-28-0

A mixture of 1-(4-bromophenyl)-1,2,2-triphenylethylene (4.0 g,9.8 mmol), bis(pinacolato)diboron (3.7 g, 14.6 mmol), CH3COOK (4.8 g, 48.8 mmol) and 1,1′-bis(diphenylphosphino)ferrocenepalladium dichloride (214 mg, 0.3 mmol) in 1,4-dioxane (100 mL) was refluxed for 24 h under nitrogen. After cooling to room temperature, the mixture was poured into water and extracted with CH2Cl2 (3 20 mL). The organic phase was collected and washed with water (3 x 20 mL) and dried with anhydrous Na2SO4. Thesolvent was removed under vacuum, and then the residue was purified by column chromatography with petroleum ether (PE)/CH2Cl2 (4:1) as an eluent to give compound 3 (3.6 g, yield: 79%) as a green solid. 1H NMR (400 MHz, CDCl3), delta: 7.54 (d, J = 8.0 Hz, 2H),7.09-7.01 (m, 17H), 1.32 (s, 12H).

According to the analysis of related databases, 34699-28-0, the application of this compound in the production field has become more and more popular.

Reference:
Conference Paper; Wang, Yafei; Liu, Wanhui; Qu, Zuoming; Tan, Hua; Liu, Yu; Xie, Guohua; Zhu, Weiguo; Dyes and Pigments; vol. 143; (2017); p. 173 – 182;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 34699-28-0, name is 1-(4-Bromophenyl)-1,2,2-triphenylethylene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 34699-28-0, name: 1-(4-Bromophenyl)-1,2,2-triphenylethylene

General procedure: In a 250 mL single-necked flask,Followed by addition of tetramethylene bromide 4 or 6 (1 eq)Diclofenac borate (1 eq or 2 eq),KOAc (4eq or 8eq),PdCl2 (dppf) 2 ¡¤ CH2Cl2 (0.03 eq or 0.06 eq),Treated with 1,4-dioxane,Under nitrogen protection, heated to 80 reaction 24hCooled to room temperature, 1,4-dioxane was removed by distillation,And then extracted with CH2Cl2The solution was washed with water and dried over anhydrous magnesium sulfate.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Changzhou University; Wang Yafei; Liao Yuanwei; Zhu Weiguo; (14 pag.)CN106565595; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 34699-28-0, name is 1-(4-Bromophenyl)-1,2,2-triphenylethylene, A new synthetic method of this compound is introduced below., 34699-28-0

theTetraphenylethylene bromide (4.11g,10.0mmol) and 4-Formylphenylboronic acid(1.49g,10.0mmol)added into three necked flask, then added 60m of toluene , 15ml of 2M K2CO3aqueous solution, Tetrabutyl ammonium bromide (TBAB)(0.64g,2.0mmol), after passing the Argon for 40 min, a amount ofcatalyst Pd (PPh3)4 added , oil bath was heated to 85 Cfor 24 h. The reaction was terminated, extraction was carried out with water,afterorganic phase was dried over anhydrous sodium sulfate and dried in vacuo on arotary evaporator to give the crude product. The product was purified by silicagel column chromatography; the eluent was a mixed solvent of dichloromethaneand n-hexane with volume ratio of 10:1 and 1:1. Pure product as a beige solid,3.3 g (yield 76%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Sun Yat-sen University; Ma, ChunPing; Chi, ZhenGuo; Zhou, Xie; Zhang, Yi; Liu, SiWei; Xu, JiaRui; (14 pag.)CN103804318; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary