Category: 344-03-6

Synthetic Route of 344-03-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 344-03-6, name is 1,4-Dibromotetrafluorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

A procedure similar to that used for the synthesis of compound 5a was followed. 5.03 g (16.3 mmol) of 1,4-dibromotetrafluoro benzene, 0.3774 g (0.33 mmol) of Pd[P(C6H5)3]4, 42.5 mL of an aqueous Na2CO3 2 M solution, and 2 g (6.53 mmol) of 4-dodecyloxyphenylboronic acid. Two products were obtained as white crystals: T4F (yield 22.8%) and 5b (yield 40%). 5b: 1H NMR (CDCl3, delta = ppm) 0.88 (t, CH3, 3H, J = 6.9 Hz), 1.22-1.52 (m, CH2, 18 H), 1.8 (m, O-CH2-CH2, 2 H), 4.02 (t, O-CH2-CH2, 2H, J = 6.5 Hz), 7.0 (d, Ar, 2H, J = 8.8 Hz), 7.38 (d, Ar, 2H, J = 8.8 Hz).

The chemical industry reduces the impact on the environment during synthesis 1,4-Dibromotetrafluorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Article; Valdes-Pech, Moises Alberto; Larios-Lopez, Leticia; Rodriguez-Gonzalez, Rosa Julia; Felix-Serrano, Isaura; Trejo-Carbajal, Nayely; Navarro-Rodriguez, Damaso; Journal of Fluorine Chemistry; vol. 218; (2019); p. 42 – 50;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 344-03-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 344-03-6, name is 1,4-Dibromotetrafluorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

(A) Preparation of starting materials Synthesis of dimethylaminomethyl p-bromotetrafluorobenzene 10 g (32.5 mmoles) of 1,4-dibromotetrafluorobenzene are dissolved under argon in 100 ml of ether and 100 ml of tetrahydrofuran. The solution is cooled to -78¡ã C. and 21 ml of a 1.6 molar solution of butyllithium in hexane are added. After 15 minutes, 6.08 g (65 mmoles) of N,N-dimethylmethyleneimmonium chloride are added and the mixture is warmed to room temperature. After 11/2 hours the mixture is poured into water and extracted with ether. The ethereal extract is dried over MgSO4. The solvent is distilled off, affording as residue a white solid which is distilled at 100¡ã C. under a high vacuum. Yield: 7.8 g (84percent) of a colourless product which is solid at room temperature.

The chemical industry reduces the impact on the environment during synthesis 1,4-Dibromotetrafluorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Ciba-Geigy Corporation; US4590287; (1986); A;,
Bromide – Wikipedia,
bromide – Wiktionary

A common heterocyclic compound, 344-03-6, name is 1,4-Dibromotetrafluorobenzene, molecular formula is C6Br2F4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 344-03-6.

Synthesis of 3,3′,3″,3″‘-(3,6-dibromobenzene-1,2,4,5-tetrayl)tetrapyridine (1) To a stirred solution of 3-bromopyridine (1.0 g, 6.3 mmol) in anhydrous THF (30 mL) is dropwise added n-butyllithium (1.6M in hexane, 5.9 mL, 9.5 mmol) under nitrogen at -78¡ã C. After 1 h stirring, 1,4-dibromo-2,3,5,6-tetrafluorobenzene (0.43 g, 1.4 mmol) is added in a portion. Then, the reaction temperature is allowed to room temperature and stirs overnight. The reaction solution is quenched with water (200 mL), and the resulted mixture is extracted with chloroform. The combined organic layers are washed with brine, dried over anhydrous Na2SO4, filtered and concentrated. The mixture is purified on silica gel column chromatography using 5:1 (v/v) hexane/chloroform as eluent to give a white solid.

The synthetic route of 1,4-Dibromotetrafluorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kyulux, Inc.; Aguilera-Iparraguirre, Jorge; Gomez-Bombarelli, Rafael; Hirzel, Timothy D.; Cheng, Shuo-Hsien; Suzuki, Yoshitake; Yang, Yu Seok; (108 pag.)US2019/58130; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

344-03-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 344-03-6 as follows.

Unitine , 4 -bromotetrafluorobenzene, 0.11 muM 1 unitunitunito-cyanophenylboronic acid 0.1 muM 4 – 0 . 001molPd under a nitrogen atmosphere2(Dba)3Unitunitunits, 0.002 muM s-phos, 0 . 2molK3PO4The unitz reacted 300 ml 12h. 100 ml was found in a mixed solution consisting of unit_transformants ‘-type 100 C’-type ‘.’. Obtained M1

According to the analysis of related databases, 1,4-Dibromotetrafluorobenzene, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Tsinghua University; Duan Lian; Zhang Dongdong; Song Xiaozeng; Gao Wenzheng; Huang Xinxin; (33 pag.)CN110066227; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

A common heterocyclic compound, 344-03-6, name is 1,4-Dibromotetrafluorobenzene, molecular formula is C6Br2F4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 344-03-6.

A mixture of 5,5′-bis(tri-n-butylstannyl)-2,2′-dithiophene (4.62 g, 4.87 mmol), 1,4-dibromoperfluorobenzene (6.00 g, 19.48 mmol) and tetrakis(triphenylphosphine)palladium(0) (0.12 g, 0.10 mmol) in dry DMF (20 mL) was deareated twice with nitrogen. The reaction mixture was then heated at 85¡ã C. for 20 h during which time a precipitate formed. After cooling, the orange solid was collected and washed several times with hexane and ether to afford the crude product which was purified by gradient sublimation (2.14 g, 3.42 mmol, 70.2percent yield). M.p. 231¡ã C. 1H NMR (CDCl3) delta 7.60 (2H, d, 2J=4.1), 7.34 (2H, d); 19F NMR (CDCl3) delta -133.58 (4F), -138.56 (4F). Anal. Calcd for C20H4Br2F8S2: C, 38.72; H, 0.65; F, 24.51. Found: C, 38.75; H, 0.78; F, 24.29.

The synthetic route of 1,4-Dibromotetrafluorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Marks, Tobin J.; Facchetti, Antonio; US2008/293937; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary