Category: 3395-91-3

Tan, Fei; Pu, Maoping; He, Jun; Li, Jinzhao; Yang, Jian; Dong, Shunxi; Liu, Xiaohua; Wu, Yun-Dong; Feng, Xiaoming published an article in 2021. The article was titled 《Catalytic Asymmetric Homologation of Ketones with α-Alkyl α-Diazo Esters》, and you may find the article in Journal of the American Chemical Society.Application of 3395-91-3 The information in the text is summarized as follows:

The homologation of ketones with diazo compounds was a useful strategy to synthesize one-carbon chain-extended acyclic such as PhC(O)CMeCO2MeR [R = allyl, Bn, CH2(2-naphthyl), etc.] or ring-expanded cyclic ketones e.g., I. However, the asym. homologation of acyclic ketones with α-diazo esters remains a challenge due to the lower reactivity and complicated selectivity. Herein, the enantioselective catalytic homologation of acetophenone and related derivatives with α-alkyl α-diazo esters was reported utilizing a chiral scandium(III) N,N’-dioxide as the Lewis acid catalyst. This reaction supplies a highly chemo-, regio-, and enantioselective pathway for the synthesis of optically active β-keto esters with an all-carbon quaternary center through highly selective alkyl-group migration of the ketones. Moreover, the ring expansion of cyclic ketones was accomplished under slightly modified conditions, affording a series of enantioenriched cyclic β-keto esters. D. functional theory calculations was carried out to elucidate the reaction pathway and possible working models that could explain the observed regio- and enantioselectivity. The experimental process involved the reaction of Methyl 3-bromopropanoate(cas: 3395-91-3Application of 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Application of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Ruhland, Klaus; Horny, Robert; Wanzel, Andrea; Reisach, Sebastian; Nizamutdinova, Alina; Kirchhain, Holger; Rehfuss, Ulrich; van Wuellen, Leo; Fischer, Andreas; Scheliga, Felix; Huebner, Tobias published an article in Journal of Applied Polymer Science. The title of the article was 《Investigation of the chemical changes during the thermal treatment of acrylonitrile -co- methyl acrylate-polymer (polyacrylonitrile-precursor) focusing on the fate of the methyl acrylate moiety》.Category: bromides-buliding-blocks The author mentioned the following in the article:

Seventeen samples of acrylonitrile (AN)-co-Me acrylate (MA)-polymer (MA content 0-11 mol%) are examined Several selective isotopic labelings are employed (d1-MA, d2-MA, 13CO-MA, CD3-MA, d1-AN, d2-AN, and 15N-AN). The thermal treatment under inert atm. is investigated to gain insight into the chem. transformation mechanisms concerning the MA sub-unit. The volatiles are determined by means of evolved gas anal. (EGA) (Fourier transform IR [FTIR] and GC/MS). Methanol is found for the first time as one decisive volatile stemming from the MA sub-unit, next to water and carbon dioxide. In addition, methylamines are proven to be formed by reaction of ammonia with the MA sub-unit, while a similar reaction of hydrogen cyanide (HCN) yielding in acetonitrile could be ruled out. Several volatile compounds could even be quantified. The non-volatile polymeric material is characterized by means of simultaneous thermal anal. (differential scanning calorimetry, thermogravimetric anal.), in-situ-FTIR spectroscopy and sophisticated solid-state NMR methods. Selected defined model compounds are synthesized and analyzed for comparison. Detailed reaction mechanisms for the thermal transformation are concluded from the results, pointing in particular to the importance of ammonia for all processes as stoichiometric and/or catalytic reagent. In the experiment, the researchers used many compounds, for example, Methyl 3-bromopropanoate(cas: 3395-91-3Category: bromides-buliding-blocks)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of C4H7BrO2In 2021 ,《Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase》 was published in Journal of Medicinal Chemistry. The article was written by Markert, Christian; Thoma, Gebhard; Srinivas, Honnappa; Bollbuck, Birgit; Luond, Rainer M.; Miltz, Wolfgang; Walchli, Rudolf; Wolf, Romain; Hinrichs, Jurgen; Bergsdorf, Christian; Azzaoui, Kamal; Penno, Carlos A.; Klein, Kai; Wack, Nathalie; Jager, Petra; Hasler, Franziska; Beerli, Christian; Loetscher, Pius; Dawson, Janet; Wieczorek, Grazyna; Numao, Shin; Littlewood-Evans, Amanda; Rohn, Till A.. The article contains the following contents:

The cytosolic metalloenzyme leukotriene A4 hydrolase (LTA4H) is the final and rate-limiting enzyme in the biosynthesis of pro-inflammatory leukotriene B4 (LTB4). Preclin. studies have validated this enzyme as an attractive drug target in chronic inflammatory diseases. Despite several attempts, no LTA4H inhibitor has reached the market, yet. Herein, we disclose the discovery and preclin. profile of LYS006 (I), a highly potent and selective LTA4H inhibitor. A focused fragment screen identified hits that could be cocrystd. with LTA4H and inspired a fragment merging. Further optimization led to chiral amino acids and ultimately to LYS006, a picomolar LTA4H inhibitor with exquisite whole blood potency and long-lasting pharmacodynamic effects. Due to its high selectivity and its ability to fully suppress LTB4 generation at low exposures in vivo, LYS006 has the potential for a best-in-class LTA4H inhibitor and is currently investigated in phase II clin. trials in inflammatory acne, hidradenitis suppurativa, ulcerative colitis, and NASH. After reading the article, we found that the author used Methyl 3-bromopropanoate(cas: 3395-91-3Electric Literature of C4H7BrO2)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Electric Literature of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Zhu, Ru-Yi; Saint-Denis, Tyler G.; Shao, Ying; He, Jian; Sieber, Joshua D.; Senanayake, Chris H.; Yu, Jin-Quan published 《Ligand-Enabled Pd(II)-Catalyzed Bromination and Iodination of C(sp3)-H Bonds》.Journal of the American Chemical Society published the findings.Application In Synthesis of Methyl 3-bromopropanoate The information in the text is summarized as follows:

We herein report the palladium(II)-catalyzed bromination and iodination of a variety of α-hydrogen-containing carboxylic acid and amino acid-derived amides. These reactions are exclusively enabled by quinoline-type ligands. The halogenated products obtained in this reaction are highly versatile and rapidly undergo further diversification. Further, we report the first example of a free carboxylic acid-directed Pd(II)-catalyzed C(sp3)-H bromination, enabled by quinoline ligands. The experimental process involved the reaction of Methyl 3-bromopropanoate(cas: 3395-91-3Application In Synthesis of Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Application In Synthesis of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines》 was published in European Journal of Medicinal Chemistry in 2020. These research results belong to Zhang, Xuan; He, Yonghan; Zhang, Peiyi; Budamagunta, Vivekananda; Lv, Dongwen; Thummuri, Dinesh; Yang, Yang; Pei, Jing; Yuan, Yaxia; Zhou, Daohong; Zheng, Guangrong. Quality Control of Methyl 3-bromopropanoate The article mentions the following:

Targeting BCL-XL via PROTACs is a promising strategy in reducing BCL-XL inhibition associated platelet toxicity. Recently, we reported potent BCL-XL PROTAC degraders that recruit VHL or CRBN E3 ligase. However, low protein expression or mutation of the responsible E3 ligase has been known to result in decreased protein degradation efficiency of the corresponding PROTACs. To overcome these mechanisms of resistance, PROTACs based on recruiting alternative E3 ligases could be generated. Thus, we designed and synthesized a series of PROTACs that recruit IAP E3 ligases for BCL-XL degradation Among those PROTACs, compound 8a(I) efficiently degrades BCL-XL in malignant T-cell lymphoma cell line MyLa 1929 while CRBN-based PROTACs that have high potency in other cancer cell lines show compromised potency, likely due to the low CRBN expression. Moreover, compared with the parent compound ABT-263, PROTAC 8a shows comparable cell killing effects in MyLa 1929 cells whereas the on-target platelet toxicity is significantly reduced. Our findings expand the anti-tumor spectra of BCL-XL degraders and further highlight the importance of selecting suitable E3 members to achieve effective cellular activity. In addition to this study using Methyl 3-bromopropanoate, there are many other studies that have used Methyl 3-bromopropanoate(cas: 3395-91-3Quality Control of Methyl 3-bromopropanoate) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Quality Control of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Long, Keith; Vaughn, Zoe; McDaniels, Michael David; Joyasawal, Sipak; Przepiorski, Aneta; Parasky, Emily; Sander, Veronika; Close, David; Johnston, Paul A.; Davidson, Alan J.; de Caestecker, Mark; Hukriede, Neil A.; Huryn, Donna M. published an article in ACS Pharmacology & Translational Science. The title of the article was 《Validation of HDAC8 Inhibitors as Drug Discovery Starting Points to Treat Acute Kidney Injury》.Name: Methyl 3-bromopropanoate The author mentioned the following in the article:

Acute kidney injury (AKI), a sudden loss of kidney function, is a common and serious condition for which there are no approved specific therapies. While there are multiple approaches to treat the underlying causes of AKI, no targets have been clin. validated. Here, we assessed a series of potent, selective competitive inhibitors of histone deacetylase 8 (HDAC8), a promising therapeutic target in an AKI setting. Using biochem. assays, zebrafish AKI phenotypic assays, and human kidney organoid assays, we show that selective HDAC8 inhibitors can lead to efficacy in increasingly stringent models. One of these, PCI-34051, was efficacious in a rodent model of AKI, further supporting the potential for HDAC8 inhibitors and, in particular, this scaffold as a therapeutic approach to AKI. In the experiment, the researchers used many compounds, for example, Methyl 3-bromopropanoate(cas: 3395-91-3Name: Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Name: Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Samvelyan, M. A.; Ghochikyan, T. V.; Grigoryan, S. V.; Tamazyan, R. A.; Aivazyan, A. G. published 《Alkylation of 1,2,4-triazole-3-thiols with haloalkanoic acid esters》.Russian Journal of Organic Chemistry published the findings.Formula: C4H7BrO2 The information in the text is summarized as follows:

Alkylation of 4,5-disubstituted 4H-1,2,4-triazole-3-thiols I [R = C6H5, (CH2)2OH, pyridin-3-yl, etc; R1 = C6H5, CH2=CHCH2] with Me chloroformate and Et chloroacetate chemoselectively afforded the corresponding S-alkyl derivatives, II (n = 0, 1; X = Et, Me), whereas the alkylation of 5-benzyl-4-phenyl-4H-1,2,4-triazole-3-thiol with methyl-3-bromopropanoate gave an inseparable mixture of Me 3-[(5-benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]propanoate and Me 3-(3-benzyl-4-phenyl-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-1-yl)propanoate products. Hydrazinolysis of S-(5-benzyl-4-phenyl-4H-1,2,4-triazol-3-yl) Me carbonothioate involved anomalous cleavage with formation of the initial 4,5-disubstituted 1,2,4-triazole I (R = benzyl; R1 = phenyl) and Me hydrazinecarboxylate. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-bromopropanoate(cas: 3395-91-3Formula: C4H7BrO2)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Brullo, Chiara; Ricciarelli, Roberta; Prickaerts, Jos; Arancio, Ottavio; Massa, Matteo; Rotolo, Chiara; Romussi, Alessia; Rebosio, Claudia; Marengo, Barbara; Pronzato, Maria Adelaide; van Hagen, Britt T. J.; van Goethem, Nick P.; D’Ursi, Pasqualina; Orro, Alessandro; Milanesi, Luciano; Guariento, Sara; Cichero, Elena; Fossa, Paola; Fedele, Ernesto; Bruno, Olga published 《New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment》.European Journal of Medicinal Chemistry published the findings.Category: bromides-buliding-blocks The information in the text is summarized as follows:

Phosphodiesterase type 4D (PDE4D) has been indicated as a promising target for treating neurodegenerative pathologies such as Alzheimer’s Disease (AD). By preventing cAMP hydrolysis, PDE4 inhibitors (PDE4Is) increase the cAMP response element-binding protein (CREB) phosphorylation, synaptic plasticity and long-term memory formation. Pharmacol. and behavioral studies on the authors’ hit GEBR-7b demonstrated that selective PDE4DIs could improve memory without causing emesis and sedation. The hit development led to new mol. series, herein reported, characterized by a catechol structure bonded to five member heterocycles. Mol. modeling studies highlighted the pivotal role of a polar alkyl chain in conferring selective enzyme interaction. Compound 1-{3-[3-(cyclopentyloxy)-4-methoxyphenyl]-1H-pyrazol-1-yl}-3-morpholin-4-ylpropan-2-oldihydrochloride (8a) showed PDE4D3 selective inhibition and was able to increase intracellular cAMP levels in neuronal cells, as well as in the hippocampus of freely moving rats. Furthermore, 8a was able to readily cross the blood-brain barrier and enhanced memory performance in mice without causing any emetic-like behavior. These data support the view that PDE4D is an adequate mol. target to restore memory deficits in different neuropathologies, including AD, and also indicate compound 8a as a promising candidate for further preclin. development. After reading the article, we found that the author used Methyl 3-bromopropanoate(cas: 3395-91-3Category: bromides-buliding-blocks)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Lamiable-Oulaidi, Farah; Harijan, Rajesh K.; Shaffer, Karl J.; Crump, Douglas R.; Sun, Yan; Du, Quan; Gulab, Shivali A.; Khan, Ashna A.; Luxenburger, Andreas; Woolhouse, Anthony D.; Sidoli, Simone; Tyler, Peter C.; Schramm, Vern L. published an article in Journal of Medicinal Chemistry. The title of the article was 《Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1》.Safety of Methyl 3-bromopropanoate The author mentioned the following in the article:

Hypermethylation of CpG regions by human DNA methyltransferase 1 (DNMT1) silences tumor-suppression genes, and inhibition of DNMT1 can reactivate silenced genes. The 5-azacytidines are approved inhibitors of DNMT1, but their mutagenic mechanism limits their utility. A synthon approach from the analogs of S-adenosylhomocysteine, methionine, and deoxycytidine recapitulated the chem. features of the DNMT1 transition state in the synthesis of 16 chem. stable transition-state mimics. Inhibitors causing both full and partial inhibition of purified DNMT1 were characterized. The inhibitors show modest selectivity for DNMT1 vs. DNMT3b. Active-site docking predicts inhibitor interactions with S-adenosyl-L-methionine and deoxycytidine regions of the catalytic site, validated by direct binding anal. Inhibitor action with purified DNMT1 is not reflected in cultured cells. A partial inhibitor activated cellular DNA methylation, and a full inhibitor had no effect on cellular DNA methylation. These compounds provide chem. access to a new family of noncovalent DNMT chem. scaffolds for use in DNA methyltransferases. In the experimental materials used by the author, we found Methyl 3-bromopropanoate(cas: 3395-91-3Safety of Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Safety of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Discovery of novel aminopiperidinyl amide CXCR4 modulators through virtual screening and rational drug design》 was published in European Journal of Medicinal Chemistry in 2020. These research results belong to Oum, Yoon Hyeun; Kell, Steven A.; Yoon, Younghyoun; Liang, Zhongxing; Burger, Pieter; Shim, Hyunsuk. Recommanded Product: Methyl 3-bromopropanoate The article mentions the following:

The C-X-C chemokine receptor type 4 (CXCR4) is a potential therapeutic target for HIV infection, metastatic cancer, and inflammatory autoimmune diseases. In this study, we screened the ZINC chem. database for novel CXCR4 modulators through a series of in silico guided processes. After evaluating the screened compounds for their binding affinities to CXCR4 and inhibitory activities against the chemoattractant CXCL12, we identified a hit compound (ZINC 72372983) showing 100 nM affinity and 69% chemotaxis inhibition at the same concentration (100 nM). To increase the potency of our hit compound, we explored the protein-ligand interactions at an at. level using mol. dynamics simulation which enabled us to design and synthesize a novel compound (Z7R) with nanomolar affinity (IC50 = 1.25 nM) and improved chemotaxis inhibition (78.5%). Z7R displays promising anti-inflammatory activity (50%) in a mouse edema model by blocking CXCR4-expressed leukocytes, being supported by our immunohistochem. study. In the experiment, the researchers used many compounds, for example, Methyl 3-bromopropanoate(cas: 3395-91-3Recommanded Product: Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary