Category: 3395-91-3

In 2018,Tanini, Damiano; Tiberi, Caterina; Gellini, Cristina; Salvi, Pier Remigio; Capperucci, Antonella published 《A Straightforward Access to Stable β-Functionalized Alkyl Selenols》.Advanced Synthesis & Catalysis published the findings.Recommanded Product: 3395-91-3 The information in the text is summarized as follows:

Treatment of epoxides with bis(trimethylsilyl)-selenide under strictly controlled conditions allowed to isolate β-hydroxy selenols which evidence an unexpected stability, taking into account their known propensity to afford diselenides. Also thiiranes and aziridines lead to functionalized selenols bearing a thiol and a N-Ts- or N-Boc-protected amino moiety on β-position. These selenols were stable enough to react with different electrophiles. Ab-initio DF calculations on two suitable model systems, Pr selenol and β-hydroxy derivative, allow to ascribe the observed low tendency to oxidation to noncovalent interactions between the selenol moiety and the -OH group.Methyl 3-bromopropanoate(cas: 3395-91-3Recommanded Product: 3395-91-3) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Yuqi; Zhao, Meng; Fang, Jing; Ye, Shuyue; Wang, Anna; Zhao, Yan; Cui, Chaoxiang; He, Lei; Shi, Haibin published an article in 2021. The article was titled 《Smart On-Site Immobilizable Near-Infrared II Fluorescent Nanoprobes for Ultra-Long-Term Imaging-Guided Tumor Surgery and Photothermal Therapy》, and you may find the article in ACS Applied Materials & Interfaces.Recommanded Product: Methyl 3-bromopropanoate The information in the text is summarized as follows:

Accurate diagnosis and efficient treatment of tumors are highly significant in battling cancer. Near-IR II (NIR-II) fluorescence imaging shows big promise for deep tumor visualization in living systems due to high temporal and spatial resolution and deep tissue penetration capability, whereas the development of efficient NIR-II probes for tumor theranostics still faces a huge challenge. Herein, we have designed and constructed intelligent mPEG5000-PCL3000-encapsulated NIR-II nanoprobe ZM1068-NPs that showed great chem. stability and excellent biocompatibility. With the merits of the strong fluorescence in the NIR-II region and prominent optical-thermal conversion efficiency, this probe was successfully used for NIR-II imaging-guided surgery and photothermal therapy of breast carcinoma in living mice. More notably, it was for the first time found that ZM1068 dyes could be covalently on-site-immobilized within tumors through the thiol-chlor nucleophilic substitution reaction, resulting in improved tumor accumulation and retention time. We thus envision that this probe may provide an attractive means for precise cancer diagnosis and treatment. The experimental process involved the reaction of Methyl 3-bromopropanoate(cas: 3395-91-3Recommanded Product: Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Recommanded Product: Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C4H7BrO2In 2016 ,《Bacterial versus human sphingosine-1-phosphate lyase (S1PL) in the design of potential S1PL inhibitors》 was published in Bioorganic & Medicinal Chemistry. The article was written by Sanllehi, Pol; Abad, Jose-Luis; Casas, Josefina; Bujons, Jordi; Delgado, Antonio. The article contains the following contents:

A series of potential active-site sphingosine-1-phosphate lyase (S1PL) inhibitors have been designed from scaffolds 1 and 2, arising from virtual screening using the X-ray structures of the bacterial (StS1PL) and the human (hS1PL) enzymes. Both enzymes are very similar at the active site, as confirmed by the similar exptl. kinetic constants shown by the fluorogenic substrate RBM13 in both cases. However, the docking scoring functions used probably overestimated the weight of electrostatic interactions between the ligands and key active-site residues in the protein environment, which may account for the modest activity found for the designed inhibitors. In addition, the possibility that the inhibitors do not reach the enzyme active site should not be overlooked. Finally, since both enzymes show remarkable structural differences at the access channel and in the proximity to the active site cavity, caution should be taken when designing inhibitors acting around that area, as evidenced by the much lower activity found in StS1PL for the potent hS1PL inhibitor D. In the experiment, the researchers used Methyl 3-bromopropanoate(cas: 3395-91-3Synthetic Route of C4H7BrO2)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Synthetic Route of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 3395-91-3In 2018 ,《Metal-Free Thiolation of Imidazopyridines with Functionalized Haloalkanes Using Elemental Sulfur》 was published in Advanced Synthesis & Catalysis. The article was written by Zhang, Jun-Rong; Zhan, Ling-Zhi; Wei, Liang; Ning, Yun-Yun; Zhong, Xiao-Lin; Lai, Jing-Xiong; Xu, Li; Tang, Ri-Yuan. The article contains the following contents:

The assembly of two functional mols. via a sulfur linking atom allowed an access to a diverse array of thioether-containing compounds I [R = Et, CH2CN, n-Bu, etc., R1 = Ph, 4-MeC6H4, 4-FC6H4, etc., R2 = H, Me, F]. This method disclosed a metal-free thiolation of imidazopyridines with a variety of functionalized haloalkanes using elemental sulfur to gave thiolated imidazopyridines I. In addition to this study using Methyl 3-bromopropanoate, there are many other studies that have used Methyl 3-bromopropanoate(cas: 3395-91-3Application of 3395-91-3) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Journal of Organic Chemistry included an article by Frayne, Stephen H.; Northrop, Brian H.. Reference of Methyl 3-bromopropanoate. The article was titled 《Evaluating Nucleophile Byproduct Formation during Phosphine- and Amine-Promoted Thiol-Methyl Acrylate Reactions》. The information in the text is summarized as follows:

The commonly accepted mechanism of nucleophile-initiated thiol-acrylate reactions requires the formation of undesired nucleophile byproducts. A systematic evaluation of the formation of such nucleophile byproducts has been carried out to understand the relationships between byproduct formation and nucleophile structure, stoichiometry, solvent, and reaction type. Three common nucleophiles for thiol-Michael reactions were investigated: dimethylphenylphosphine (DMPP), diethylamine (DEA), and hexylamine (HA). The formation of phosphonium ester and aza-Michael byproducts upon initiating a representative thiol-acrylate reaction between 1-hexanethiol and Me acrylate at a range of initiator loading (0.01-10.0 equiv) and in different solvents (neat, DMSO, THF, and CHCl3) was determined by 1H NMR spectroscopy. The influence of reaction type was investigated by expanding from small mol. reactions to end group thiol-acrylate functionalization of PEG-diacrylate polymers and through investigations of polymer-polymer coupling reactions. Results indicate that the propensity of forming nucleophile byproducts varies with nucleophile type, solvent, and reaction type. Interestingly, for all but polymer-polymer ligation reactions, nucleophile byproduct formation is largely unobserved for nitrogen-centered nucleophiles DEA and HA and essentially nonexistent for the phorphorous-centered nucleophile DMPP. A rationale for the differences in nucleophile byproduct formation for DMPP, DEA, and HA is proposed and supported by exptl. and computational anal. After reading the article, we found that the author used Methyl 3-bromopropanoate(cas: 3395-91-3Reference of Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Reference of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Al-Horaibi, Sultan A.; Gaikwad, S. T.; Rajbhoj, Anjali S. published 《Synthesis, characterizations, and comparative study of electro-optical properties of indole-based squaraine sensitizers as efficiency to enhancing dye-sensitized solar cells》.Advanced Materials Letters published the findings.SDS of cas: 3395-91-3 The information in the text is summarized as follows:

Squaraine dyes (SQ) have acquired sufficiently great attention as dye-sensitized solar cell (DSSCs) materials. In the present study, we have synthesized and characterized of two novel sym. sensitizers dyes for dye-sensitized solar cells which contain electron withdrawing (-COOH) group with long alkyl ester chain (SQ1) and another without encoring group (SQ2). We have investigated the structural, electronic, photo-electrochem., and charge transport properties of two SQ1& SQ2 indole-based squaraine dyes. The ground state geometry has been computed by applying d. functional theory (DFT). The excitation energy and the oscillator strength were calculated by using time-dependent (DFT-TD) at DFT/B3LYP/ 6-31G** level of theory. We have focused and study on the frontier MOs (HOMO and LUMO), electron injection (ΔGinject), light harvesting efficiency (LHE), open-circuit voltage (Voc), relative electron injection (ΔGrinject), and short-circuit c.d. (Jsc). The effect of-COOH as (acceptor) and -OCH3 (donor) groups on SQ1 and SQ2 were investigated. The factors affecting, ΔGinject, LHE, Voc and Jsc revealed that SQ1 would be more favorable to enhance the performance of DSSCs. The theor. calculations and absorbance results show that the electron d. of LUMO of SQ1 is delocalized in the whole chromophore, leading to strong electronic coupling between SQ1 and TiO2 surface. So, the SQ1 sensitized solar cells exhibit better photovoltaic performance.Methyl 3-bromopropanoate(cas: 3395-91-3SDS of cas: 3395-91-3) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.SDS of cas: 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,European Journal of Medicinal Chemistry included an article by Zhu, Yan; Sun, Nannan; Yu, Mingcheng; Guo, Huimin; Xie, Qiong; Wang, Yonghui. Recommanded Product: 3395-91-3. The article was titled 《Discovery of aryl-substituted indole and indoline derivatives as RORγt agonists》. The information in the text is summarized as follows:

A series of aryl-substituted indole and indoline derivatives were discovered as novel RORγt agonists by a scaffold-based hybridization of the reported RORγt agonists 1 and 2. SAR studies on the core structures, the RHS hydrophilic side chains and the LHS hydrophobic aryl groups of a hybrid compound 3 led to the identification of potent RORγt agonists with improved drug-like properties. Compound 14 represented a high potency lead with an EC50 of 20.8 ± 1.5 nM, the (S)-enantiomer (EC50 = 16.1 ± 4.5 nM) of which was 17 times more potent than the (R) counterpart (EC50 = 286 ± 30.4 nM) in RORγ dual FRET assay. The cell-based GAL4 reporter gene assay also suggested 14 as the most active compound which exhibited an EC50 of 247 ± 33.1 nM and a maximum activation percentage of 133%. Moreover, 14 showed high metabolic stability (t1/2 = 113 min) in mouse liver microsome and had improved aqueous solubility at pH 7.4 compared to the parent compounds Furthermore, 14 was found to be orally bioavailable and demonstrated excellent in vivo pharmacokinetics in mice. Present studies indicate that 14 deserves further investigation in tumor animal models as a potential candidate of RORγt agonist for cancer immunotherapy. In the experimental materials used by the author, we found Methyl 3-bromopropanoate(cas: 3395-91-3Recommanded Product: 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Functionalized helical β-peptoids》 were Wellhofer, Isabelle; Frydenvang, Karla; Kotesova, Simona; Christiansen, Andreas M.; Laursen, Jonas S.; Olsen, Christian A.. And the article was published in Journal of Organic Chemistry in 2019. Computed Properties of C4H7BrO2 The author mentioned the following in the article:

Peptidomimetic foldamers adopting well-defined three-dimensional structures while being stable toward proteolysis are of interest in biomedical research, chem. biol., and biomimetic materials science. Despite their backbone flexibility, β-peptoids containing N-(S)-1-(1-naphthyl)ethyl (Ns1npe) side chains can fold into unique triangular prism-shaped helixes. We report herein the successful introduction of amino groups onto robustly folded β-peptoid helixes by construction and incorporation of novel chiral building blocks. This is the first example of an X-ray crystal structure of a linear β-peptoid containing more than one type of side chain. We thus present a unique foldamer design comprising a robustly folded core with functionalized side chains protruding perpendicular to the helical axis to provide a highly predictable display of functional groups. This work paves the way for development of β-peptoid foldamers with a desired function, such as catalytic properties or as scaffolds enabling polyvalent display. The experimental process involved the reaction of Methyl 3-bromopropanoate(cas: 3395-91-3Computed Properties of C4H7BrO2)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Computed Properties of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Gao, Dong; Zeng, Juan; Wang, Xiaodong; Liu, Yu; Li, Wang; Hu, Yunlong; Gao, Ningning; Diao, Yuwen; Wang, Zhulin; Jiang, Wenqi; Chen, Jinhua; Jin, Guangyi published 《Conjugation of weak ligands with weak antigens to activate TLR-7: A step toward better vaccine adjuvants》.European Journal of Medicinal Chemistry published the findings.Computed Properties of C4H7BrO2 The information in the text is summarized as follows:

To study the structure-activity relationship (SAR) of Toll-like receptor 7 (TLR-7) agonists based on 8-oxoadenines, a novel subset of C9-substituted 8-hydroxy-2-(2-methoxyethoxy)-adenines and their antigen conjugates were synthesized. In vitro, the ability of cytokines (IL-12p70 and IFN-γ) induction of ligands with alkyl acid at C9-position were very weak compared with benzoic acid counter parts. Unexpectedly, its antigen conjugates that conjugated with proteins or peptides with weak immunogenicity, showed enhanced activity of cytokines induction. After administered systemically in mice in vivo, all conjugates induced prolonged increase in pro-inflammatory cytokines and antigen-specific IgG levels in serum compared with free compounds Results from mol. dynamics (MD) simulations further confirmed the conclusion and provided the details of interaction to explain the phenomenon of experiment In conclusion, we discovered that TLR-7 could be activated via some conjugates of weak ligand and weak antigen, which could be safer adjuvant candidates for vaccines in the future. The experimental process involved the reaction of Methyl 3-bromopropanoate(cas: 3395-91-3Computed Properties of C4H7BrO2)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Computed Properties of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Edwards, Jacob T.; Merchant, Rohan R.; McClymont, Kyle S.; Knouse, Kyle W.; Qin, Tian; Malins, Lara R.; Vokits, Benjamin; Shaw, Scott A.; Bao, Deng-Hui; Wei, Fu-Liang; Zhou, Ting; Eastgate, Martin D.; Baran, Phil S. published 《Decarboxylative alkenylation》.Nature (London, United Kingdom) published the findings.Recommanded Product: Methyl 3-bromopropanoate The information in the text is summarized as follows:

Olefin chem., through pericyclic reactions, polymerizations, oxidations, or reductions, has an essential role in the manipulation of organic matter. Despite its importance, olefin synthesis still relies largely on chem. introduced more than three decades ago, with metathesis being the most recent addition Here we describe a simple method of accessing olefins with any substitution pattern or geometry from one of the most ubiquitous and variegated building blocks of chem.: alkyl carboxylic acids. The activating principles used in amide-bond synthesis can therefore be used, with nickel- or iron-based catalysis, to extract carbon dioxide from a carboxylic acid and economically replace it with an organozinc-derived olefin on a molar scale. We prepare more than 60 olefins across a range of substrate classes, and the ability to simplify retrosynthetic anal. is exemplified with the preparation of 16 different natural products across 10 different families. The results came from multiple reactions, including the reaction of Methyl 3-bromopropanoate(cas: 3395-91-3Recommanded Product: Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary