Category: 3395-91-3

Noureldin, Nada A.; Richards, Jennifer; Kothayer, Hend; Baraka, Mohammed M.; Eladl, Sobhy M.; Wootton, Mandy; Simons, Claire published their research in BMC Chemistry in 2021. The article was titled 《Design, computational studies, synthesis and in vitro antimicrobial evaluation of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues》.HPLC of Formula: 3395-91-3 The article contains the following contents:

Two series of benzimidazole based thio-oxadiazole and thio-thiadiazole analogs were designed and synthesized as novel antimicrobial drugs through inhibition of phenylalanyl-tRNA synthetase (PheRS), which is a promising antimicrobial target. Compounds were designed to mimic the structural features of phenylalanyl adenylate (Phe-AMP) the PheRS natural substrate. A 3D conformational alignment for the designed compounds and the PheRS natural substrate revealed a high level of conformational similarity, and a mol. docking study indicated the ability of the designed compounds to occupy both Phe-AMP binding pockets. A mol. dynamics (MD) simulation comparative study was performed to understand the binding interactions with PheRS from different bacterial microorganisms. The synthetic pathway of the designed compounds proceeded in five steps starting from benzimidazole. The fourteen synthesized compounds 5a-d, 6a-c, 8a-d and 9a-c were purified, fully characterised and obtained in high yield. In vitro antimicrobial evaluation against five bacterial strains showed a moderate activity of compound 8b with MIC value of 32 μg/mL against S. aureus, while all the synthesized compounds showed weak activity against both E. faecalis and P. aeruginosa (MIC 128 μg/mL). Compound 8b provides a lead compound for further structural development to obtain high affinity PheRS inhibitors. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-bromopropanoate(cas: 3395-91-3HPLC of Formula: 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.HPLC of Formula: 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Zhifang; Li, Zuojie; Du, Tao; Chen, Yan; Wang, Qingpeng; Li, Guoshuai; Liu, Min; Zhang, Ning; Li, Dacheng; Han, Jun published an article in 2021. The article was titled 《Design, synthesis and biological evaluation of dihydro-2-quinolone platinum(IV) hybrids as antitumor agents displaying mitochondria injury and DNA damage mechanism》, and you may find the article in Dalton Transactions.Related Products of 3395-91-3 The information in the text is summarized as follows:

The design of novel platinum(IV) complexes with mitochondria injury competence, besides the DNA damage mechanism, is a promising way to develop new platinum drugs. Herein, dihydro-2-quinolone (DHQLO) as a mitocan was incorporated into the platinum(IV) system for the first time to prepare a new series of DHQLO platinum(IV) compounds Complex 1b could effectively inhibit the proliferation of tumor cells in vitro and in vivo. It accumulated at higher levels in both whole cells and DNA, and easily underwent intercellular reduction to release platinum(II) and DHQLO moieties. The released platinum(II) complex caused serious DNA damage by covalent conjunction with the DNA duplex, and remarkably increased the expression of the γ-H2AX protein. Moreover, 1b also caused serious mitochondria injury to induce mitochondrial membrane depolarization and increase ROS generation. Such actions upon DNA and mitochondria activate the p53 apoptotic pathway synergetically in tumor cells by upregulating the protein p53 and apoptotic proteins caspase9 and caspase3, which efficiently promoted the apoptotic death of tumor cells. Compound 1b with such synergic mechanism exhibited great potential in reversing cisplatin resistance and improving antitumor efficacies. After reading the article, we found that the author used Methyl 3-bromopropanoate(cas: 3395-91-3Related Products of 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Related Products of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 3395-91-3In 2022 ,《Construction of tetralin and chromane cores by the Lewis acid promoted ring-opening cyclization of cyclopropyl methanesulfonates》 was published in Tetrahedron Letters. The article was written by Novikau, Ilya; Leushukou, Andrei; Tsiuryn, Mikita; Hurski, Alaksiej. The article contains the following contents:

Rearrangement of cyclopropyl methanesulfonates to allylic carbocations was employed for the construction of tetralin and chromate bicyclic cores. Authors found that this transformation proceeds efficiently and rapidly at room temperature in the presence of dimethylaluminum triflate serving as a non-nucleophilic Lewis acid. The reaction begins with the cyclopropanol ring-opening and follows by the Friedel-Crafts cyclization of the resulting cationic intermediate with a pendant aromatic ring. In the experimental materials used by the author, we found Methyl 3-bromopropanoate(cas: 3395-91-3Application of 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 3395-91-3In 2020 ,《Byproducts formed During Thiol-Acrylate Reactions Promoted by Nucleophilic Aprotic Amines: Persistent or Reactive?》 was published in ChemPlusChem. The article was written by Drogkaris, Vasileios; Northrop, Brian H.. The article contains the following contents:

The nucleophile-initiated mechanism of thiol-Michael reactions naturally leads to the formation of undesired nucleophile byproducts. Three aza-Michael compounds representing nucleophile byproducts of thiol-acrylate reactions initiated by 4-dimethylaminopyridine (DMAP), 1-methylimidazole (MIM), and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) have been synthesized and their reactivity in the presence of thiolate has been investigated. Spectroscopic anal. shows that each nucleophile byproduct reacts with thiolate to produce a desired thiol-acrylate product along with liberated aprotic amines DMAP, MIM, or DBU, thus demonstrating that these byproducts are reactive rather than persistent. D. functional theor. computations support exptl. observations and predict that a β-elimination mechanism is favored for converting each nucleophile byproduct into a desired thiol-acrylate product, though an SN2 process can be competitive (i. e. within <2.5 kcal/mol) in less polar solvents. The results came from multiple reactions, including the reaction of Methyl 3-bromopropanoate(cas: 3395-91-3HPLC of Formula: 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.HPLC of Formula: 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Reductive sp3-sp2 Coupling Reactions Enable Late-Stage Modification of Pharmaceuticals》 was published in Organic Letters in 2020. These research results belong to Mennie, Katrina M.; Vara, Brandon A.; Levi, Samuel M.. HPLC of Formula: 3395-91-3 The article mentions the following:

Late-stage derivatization of pharmaceutically relevant scaffolds relies on the availability of highly functional-group tolerant reactions. Reactions that increase the sp3 character of mols. enable the pursuit of more selective and well-tolerated pharmaceuticals. Herein, we report the use of sp3-sp2 cross-electrophile reductive couplings to modify a generic ATP-competitive kinase inhibitor with a broad range of primary and secondary alkyl halide coupling partners. After reading the article, we found that the author used Methyl 3-bromopropanoate(cas: 3395-91-3HPLC of Formula: 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.HPLC of Formula: 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Hartman, Tomas; Konecny, Jan; Mazanek, Vlastimil; Sturala, Jiri; Sofer, Zdenek published an article in Inorganic Chemistry. The title of the article was 《A Decade of Germananes: Four Approaches to Their Functionalization》.Name: Methyl 3-bromopropanoate The author mentioned the following in the article:

Since the 1st synthesis of germanane (GeH) reported in 2013, two-dimensional Ge-based materials were intensively studied. Over the past decade, several methodologies for the functionalization of germanane were introduced. The 1st approach used exfoliation of Zintl phase CaGe2 with alkyl halides. Liu’s solvothermal method was used for the synthesis of Me germanane. Another methodol. used Ge-H activation with Na naphthalenide and its subsequent alkylation. All of these methods provide functionalized germananes; thus, a comparison of these methods is needed. Such a comparison of current synthetic approaches towards alkyl germananes is reported, and addnl., a new method for Ge-H activation using a NaK equimolar alloy is presented as a 4th approach. For this purpose, eight alkyl reagents were chosen representing reactive benzyl bromides as well as linear esters and nitriles because they contain easily trackable functional groups. The materials were characterized using FTIR spectroscopy, Raman spectroscopy, XPS, and TGA, and the data were compared. The comparison of all methods revealed not only some drawbacks for each method but also their advantages. The method using Na naphthalenide provided the lowest degree of surface coverage, whereas the solvothermal method seemed to provide materials with the highest degree of functionalization; unfortunately, the functionalization was also accompanied by a high degree of surface oxidation, i.e., (Ge-OH/Ge = O) formation. The highest degree of surface coverage accompanied by the lowest degree of surface oxidation was achieved employing Goldberger’s phase transfer direct exfoliation of CaGe2 as well as Ge-H activation using the NaK alloy with subsequent alkylation. The results came from multiple reactions, including the reaction of Methyl 3-bromopropanoate(cas: 3395-91-3Name: Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Name: Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Category: bromides-buliding-blocksIn 2021 ,《Design and synthesis of novel tacrine-dipicolylamine dimers that are multiple-target-directed ligands with potential to treat Alzheimer′s disease》 was published in Bioorganic Chemistry. The article was written by Zhang, Panpan; Wang, Ze; Mou, Chenye; Zou, Jiamei; Xie, Yanfei; Liu, Zhiwen; Benjamin Naman, C.; Mao, Yuechun; Wei, Jiaxin; Huang, Xinghan; Dong, Jiahui; Yang, Mengxiang; Wang, Ning; Jin, Haixiao; Liu, Fufeng; Lin, Dongdong; Liu, Hao; Zhou, Fei; He, Shan; Zhang, Bin; Cui, Wei. The article contains the following contents:

Alzheimer′s disease (AD) is a prevalent neurodegenerative disorder that has multiple causes. Therefore, multiple-target-directed ligands (MTDLs), which act on multiple targets, have been developed as a novel strategy for AD therapy. In this study, novel drug candidates were designed and synthesized by the covalent linkings of tacrine, a previously used anti-AD acetylcholinesterase (AChE) inhibitor, and dipicolylamine, an β-amyloid (Aβ) aggregation inhibitor. Most tacrine-dipicolylamine dimers potently inhibited AChE and Aβ1-42 aggregation in vitro, and 13a exhibited nanomolar level inhibition. Mol. docking anal. suggested that 13a could interact with the catalytic active sites and the peripheral anion site of AChE, and bind to Aβ1-42 pentamers. Moreover, 13a effectively attenuated Aβ1-42 oligomers-induced cognitive dysfunction in mice by activating the cAMP-response element binding protein/brain-derived neurotrophic factor signaling pathway, decreasing tau phosphorylation, preventing synaptic toxicity, and inhibiting neuroinflammation. The safety profile of 13a in mice was demonstrated by acute toxicity experiments All these results suggested that novel tacrine-dipicolylamine dimers, especially 13a, have multi-target neuroprotective and cognitive-enhancing potentials, and therefore might be developed as MTDLs to combat AD.Methyl 3-bromopropanoate(cas: 3395-91-3Category: bromides-buliding-blocks) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Mawad, Damia; Artzy-Schnirman, Arbel; Tonkin, Joanne; Ramos, Jose; Inal, Sahika; Mahat, Muzamir M.; Darwish, Nadim; Zwi-Dantsis, Limor; Malliaras, George G.; Gooding, J. Justin; Lauto, Antonio; Stevens, Molly M. published 《Electroconductive Hydrogel Based on Functional Poly(Ethylenedioxy Thiophene)》.Chemistry of Materials published the findings.Product Details of 3395-91-3 The information in the text is summarized as follows:

Poly(ethylene dioxythiophene) with functional pendant groups bearing double bonds is synthesized and employed for the fabrication of electroactive hydrogels with advantageous characteristics; covalently crosslinked porous 3D scaffolds with notable swelling ratio, appropriate mech. properties, electroactive in physiol. conditions, and suitable for pro-liferation and differentiation of C2C12 cells. This is a new approach for the fabrication of conductive engineered constructs. The results came from multiple reactions, including the reaction of Methyl 3-bromopropanoate(cas: 3395-91-3Product Details of 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Product Details of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Discovery of triazole-based uracil derivatives bearing amide moieties as novel dipeptidyl peptidase-IV inhibitors》 was written by Deng, Xiaoyan; Han, Li; Zhou, Jinpei; Zhang, Huibin; Li, Qing. SDS of cas: 3395-91-3This research focused ontriazole amide uracil preparation dipeptidyl peptidase IV inhibitor antidiabetic; Amide; DPP-4 inhibitor; T2DM; Triazole; Uracil derivatives. The article conveys some information:

Dipeptidyl peptidase-IV (DPP-4) is a validated target for T2DM treatment. The authors previously reported a novel series of triazole-based uracil derivatives bearing aliphatic carboxylic acids with potent DPP-4 inhibitory activities in vitro, but these compounds showed poor hypoglycemic effects in vivo. Herein the authors further optimized the triazole moiety by amidation of the carboxylic acid to improve in vivo activities. Two series of compounds 3a-f and 4a-g were designed and synthesized. By screening in DPP-4, compound 4c ((R)-2-(4-((4-(3-aminopiperidin-1-yl)-3-(but-2-yn-1-yl)-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)methyl)-1H-1,2,3-triazol-1-yl)-N,N-dimethylacetamide hydrochloride) was identified as a potent DPP-4 inhibitor with the IC50 value of 28.62 nM. Docking study revealed compound 4c has a favorable binding mode and interpreted the SAR of these analogs. DPP-8 and DPP-9 tests indicated compound 4c had excellent selectivity over DPP-8 and DPP-9. Further in vivo evaluations revealed that compound 4c showed more potent hypoglycemic activity than its corresponding carboxylic acid in ICR mice and dose-dependently reduced glucose levels in type 2 diabetic C57BL/6 mice. The overall results have shown that compound 4c could be a promising lead for further development of novel DPP-4 agents treating T2DM. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-bromopropanoate(cas: 3395-91-3SDS of cas: 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.SDS of cas: 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Li, Qing; Han, Li; Zhang, Bin; Zhou, Jinpei; Zhang, Huibin published 《Synthesis and biological evaluation of triazole based uracil derivatives as novel DPP-4 inhibitors》.Organic & Biomolecular Chemistry published the findings.COA of Formula: C4H7BrO2 The information in the text is summarized as follows:

A series of triazole based uracil derivatives I (R1 = H, 2-F, 2-Me-5-Cl, 4-OMe, etc.) and II [R2 = 2-EtO2CC6H4, 3-HO2CC6H4, CH2CO2H, CH2CO2Et, CH(CH3)CO2H, etc.] were designed and synthesized as novel DPP-4 inhibitors. Compound I (R1 = H) was identified as a lead compound for SAR studies focused on the structural modification at the S2′ subsite of DPP-4. The novel analogs I (R1 = 2-F, 3-F, 4-F, 2,4-F2) were obtained by modifying the substituents at the Ph group and compounds II by introducing the carbonyl group. On screening in DPP-4, compounds II [R2 = (CH2)2CO2H, (CH2)2CO2Me, CH2CH:CHCO2H] showed a significant improvement in DPP-4 inhibitory activities compared to compound I (R1 = H) and showed comparable activities to the marketed DPP-4 inhibitor, alogliptin. Docking studies revealed new favorable binding modes of designed compounds in the S2′ subsite and proved that structural modifications in the S2′ subsite were an effective option to increase the inhibition of DPP-4. In vitro DPP-8 and DPP-9 tests indicated that all compounds showed excellent selectivity against DPP-8 and DPP-9. Further in vivo evaluation showed that compound II [R2 = (CH2)2CO2Me] could significantly improve oral glucose tolerance in ICR mice and dose-dependently reduced glucose levels in type 2 diabetic C57BL/6 mice. These data suggest that compound II (R2 = (CH2)2CO2Me) could be a promising DPP-4 inhibitor for future treatment of T2DM. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-bromopropanoate(cas: 3395-91-3COA of Formula: C4H7BrO2)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.COA of Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary