Category: 3395-91-3

In 2016,Morera, Ludovica; Roatsch, Martin; Fuerst, Michael C. D.; Hoffmann, Inga; Senger, Johanna; Hau, Mirjam; Franz, Henriette; Schuele, Roland; Heinrich, Markus R.; Jung, Manfred published 《4-Biphenylalanine- and 3-Phenyltyrosine-Derived Hydroxamic Acids as Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A》.ChemMedChem published the findings.Formula: C4H7BrO2 The information in the text is summarized as follows:

Overexpression of the histone lysine demethylase KDM4A, which regulates H3K9 and H3K36 methylation states, has been related to the pathol. of several human cancers. We found that a previously reported hydroxamate-based histone deacetylase (HDAC) inhibitor (SW55) was also able to weakly inhibit this demethylase with an IC50 value of 25.4 μm. Herein we report the synthesis and biochem. evaluations, with two orthogonal in vitro assays, of a series of derivatives of this lead structure. With extensive chem. modifications on the lead structure, also by exploiting the versatility of the radical arylation with aryldiazonium salts, we were able to increase the potency of the derivatives against KDM4A to the low-micromolar range and, more importantly, to obtain demethylase selectivity with respect to HDACs. Cell-permeable derivatives clearly showed a demethylase-inhibition-dependent antiproliferative effect against HL-60 human promyelocytic leukemia cells. In the experiment, the researchers used Methyl 3-bromopropanoate(cas: 3395-91-3Formula: C4H7BrO2)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 3395-91-3In 2020 ,《Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer’s disease: Design, synthesis, and biological evaluation》 was published in Bioorganic Chemistry. The article was written by Xu, Ana; He, Feng; Zhang, Xiangna; Li, Xiaoyang; Ran, Yingying; Wei, Chao; James Chou, C.; Zhang, Rui; Wu, Jingde. The article contains the following contents:

In order to develop multitarget-directed ligands as potential treatments for Alzheimer’s disease, twenty-eight new tacrine-hydroxamate derivatives were designed, synthesized, and biol. evaluated. As expected, most of the compounds exhibited inhibitory activities against cholinesterases (ChEs) and histone deacetylase (HDACs). Among the tested compounds, I showed not only potent and selective inhibition on AChE at sub-nanomolar potency (AChEIC50 = 0.12 nM, BChEIC50 = 361.52 nM) but also potent inhibition on HDAC (IC50 = 0.23 nM). Moreover, I exhibited inhibitory activity on Aβ1-42 self-aggregation as well as disaggregation activity on pre-formed Aβ fibrils. Furthermore, I exhibited antioxidant activity and metal chelating properties. Further mechanistic studies demonstrated that I is a pan-inhibitor of HDACs and a mixed-type inhibitor for AChE. It was shown that I is a BBB penetrant by online prediction. Taken together, the results indicate that I can serve as a lead compound to develop promising candidate analogs as AD therapeutics. In the experiment, the researchers used Methyl 3-bromopropanoate(cas: 3395-91-3Application of 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Saleh, Maysaa M.; Laughton, Charles A.; Bradshaw, Tracey D.; Moody, Christopher J. published 《Correction: Development of a series of bis-triazoles as G-quadruplex ligands [Erratum to document cited in CA170:314024]》.RSC Advances published the findings.Reference of Methyl 3-bromopropanoate The information in the text is summarized as follows:

The country of affiliation c was shown incorrectly in the original article; the correction is provided here. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-bromopropanoate(cas: 3395-91-3Reference of Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Reference of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Barysevich, Maryia V.; Aniskevich, Yauhen M.; Hurski, Alaksiej L. published an article in 2021. The article was titled 《Electrochemical Synthesis of 2-Bromoethyl and 2-Iodoethyl Ketones from Cyclopropanols》, and you may find the article in Synlett.Name: Methyl 3-bromopropanoate The information in the text is summarized as follows:

A simple electrochem. protocol for the preparation of 2-bromoethyl- and 2-iodoethyl ketones from cyclopropanols and magnesium halides were developed. The reaction proceeded with exclusive regioselectivity and without epimerization of the α-stereocenter in the products. The synthesized diastereomerically pure 2-bromoethyl ketones underwent smooth copper and nickel-catalyzed alkylation, alkenylation, and arylations reactions. In the experimental materials used by the author, we found Methyl 3-bromopropanoate(cas: 3395-91-3Name: Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Name: Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pantelic, Nebojsa D.; Bozic, Bojan; Zmejkovski, Bojana B.; Banjac, Nebojsa R.; Dojcinovic, Biljana; Wessjohann, Ludger A.; Kaluderovic, Goran N. published an article in 2021. The article was titled 《In vitro evaluation of antiproliferative properties of novel organotin(IV) carboxylate compounds with propanoic acid derivatives on a panel of human cancer cell lines》, and you may find the article in Molecules.Name: Methyl 3-bromopropanoate The information in the text is summarized as follows:

The synthesis of novel triphenyltin(IV) compounds, Ph3SnLn (n = 1-3), with oxaprozin (3-(4,5-diphenyloxazol-2-yl)propanoic acid), HL1, and the new propanoic acid derivatives 3-(4,5-bis(4-methoxylphenyl)oxazol-2-yl)propanoic acid, HL2, and 3-(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)propanoic acid, HL3, has been performed. The ligands represent com. drugs or their derivatives and the tin complexes have been characterized by standard anal. methods. The in vitro antiproliferative activity of both ligands and organotin(IV) compounds has been evaluated on the following tumor cell lines: human prostate cancer (PC-3), human colorectal adenocarcinoma (HT-29), breast cancer (MCF-7), and hepatocellular cancer (HepG2), as well as on normal mouse embryonic fibroblast cells (NIH3T3) with the aid of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-12 diphenyltetrazolium bromide) and CV (crystal violet) assays. Contrary to the inactive ligand precursors, all organotin(IV) carboxylates showed very good activity with IC50 values ranging from 0.100 to 0.758 μM. According to the CV assay (IC50 = 0.218 ± 0.025 μM), complex Ph3SnL1 demonstrated the highest cytotoxicity against the caspase 3 deficient MCF-7 cell line. Inductively coupled plasma mass spectrometry (ICP-MS) anal. indicated a two-fold lower concentration of tin in MCF-7 cells in comparison to platinum. To investigate the mechanism of action of the compound Ph3SnL1 on MCF-7 cells, morphol., autophagy and cell cycle anal., as well as the activation of caspase and ROS/RNS and NO production, has been performed. Results suggest that Ph3SnL1 induces caspase-independent apoptosis in MCF-7 cells.Methyl 3-bromopropanoate(cas: 3395-91-3Name: Methyl 3-bromopropanoate) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Name: Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Serkov, I. V.; Proshin, A. N.; Ustinov, A. K.; Bachurin, S. O. published 《Nitroxyethylamides of carbazolecarboxylic acids》.Doklady Chemistry published the findings.Quality Control of Methyl 3-bromopropanoate The information in the text is summarized as follows:

A method of synthesis of carbazole-derived hybrid compounds containing nitroxy group as an NO-producing fragment was developed, the compounds were of interest as a base for designing potential remedies for the treatment of neurodegenerative diseases. In the experimental materials used by the author, we found Methyl 3-bromopropanoate(cas: 3395-91-3Quality Control of Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Quality Control of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Yamada, Takeshi; Miki, Shouta; Ul’Husna, Anisa; Michikawa, Akiko; Nakatani, Kazuhiko published 《Synthesis of Naphthyridine Carbamate Dimer (NCD) Derivatives Modified with Alkanethiol and Binding Properties of G-G Mismatch DNA》.Organic Letters published the findings.Product Details of 3395-91-3 The information in the text is summarized as follows:

Bis(naphthyridinecarbamates) of (mercaptoalkyl)dipropanolamines were prepared as thiol-containing DNA-binding compounds selective for G-G mismatches; in the presence of the G-G mismatch, the compounds undergo dimerization to form DNA complexes of the corresponding disulfides. The disulfide dimers of the naphthyridinecarbamates of (mercaptoalkyl)dipropanolamines produced 1:1 complexes with the dsDNA 5′-TCAACGGTTGA-3′:3′-AGTTGGCAACT-5′ with improved thermal stability and with higher pos. cooperativities than the corresponding thiols. The dimerization of bis(naphthyridinecarbamate) of a (mercaptoalkyl)dipropanolamine was selectively accelerated in the presence of CGG repeat DNA but not on CAG repeat DNA. In the experiment, the researchers used Methyl 3-bromopropanoate(cas: 3395-91-3Product Details of 3395-91-3)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Product Details of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A Click-Chemistry-Based Enrichable Crosslinker for Structural and Protein Interaction Analysis by Mass Spectrometry》 was published in ChemBioChem in 2020. These research results belong to Stadlmeier, Michael; Runtsch, Leander Simon; Streshnev, Filipp; Wuehr, Martin; Carell, Thomas. Safety of Methyl 3-bromopropanoate The article mentions the following:

Mass spectrometry is the method of choice for the characterization of proteomes. Most proteins operate in protein complexes, in which their close association modulates their function. However, with standard MS anal., information on protein-protein interactions is lost and no structural information is retained. To gain structural and interactome data, new crosslinking reagents are needed that freeze inter- and intramol. interactions. Herein, the development of a new reagent, which has several features that enable highly sensitive crosslinking MS, is reported. The reagent enables enrichment of crosslinked peptides from the majority of background peptides to facilitate efficient detection of low-abundant crosslinked peptides. Due to the special cleavable properties, the reagent can be used for MS2 and potentially for MS3 experiments Thus, the new crosslinking reagent, in combination with high-end MS, should enable sensitive anal. of interactomes, which will help researchers to obtain important insights into cellular states in health and diseases. In addition to this study using Methyl 3-bromopropanoate, there are many other studies that have used Methyl 3-bromopropanoate(cas: 3395-91-3Safety of Methyl 3-bromopropanoate) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Safety of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis of 4-Vinyl-1H-1,2,3-triazoles on Solid Supports via Polystyrene-Bound But-3-ynyl Selenide》 was written by Ming, Peng; Liu, Xiao-Ling; Wei, Mei-Hong; Sheng, Shou-Ri. Quality Control of Methyl 3-bromopropanoateThis research focused onvinyltriazole preparation solid polystyrene bound butynyl selenide. The article conveys some information:

A facile method for solid-phase organic synthesis of 1-substituted-4-vinyl-1,2,3-triazoles from polystyrene-supported but-3-ynyl selenide was developed. This sequential [3+2] cycloaddition and oxidation-elimination reactions could be carried out under mild reaction conditions with straightforward operation and good yield and purity of the products, and broad scope of substrates, and could be applied in this reaction system in generation of a small library of title compounds In the experimental materials used by the author, we found Methyl 3-bromopropanoate(cas: 3395-91-3Quality Control of Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Asturiol, D.; Casati, S.; Worth, A. published 《Consensus of classification trees for skin sensitization hazard prediction》.Toxicology In Vitro published the findings.Safety of Methyl 3-bromopropanoate The information in the text is summarized as follows:

Since March 2013, it is no longer possible to market in the European Union (EU) cosmetics containing new ingredients tested on animals. Although several in silico alternatives are available and achievements have been made in the development and regulatory adoption of skin sensitization non-animal tests, there is not yet a generally accepted approach for skin sensitization assessment that would fully substitute the need for animal testing. The aim of this work was to build a defined approach (i.e. a predictive model based on readouts from various information sources that uses a fixed procedure for generating a prediction) for skin sensitization hazard prediction (sensitizer/non-sensitizer) using Local Lymph Node Assay (LLNA) results as reference classifications. To derive the model, we built a dataset with high quality data from in chemico (DPRA) and in vitro (KeratinoSens and h-CLAT) methods, and it was complemented with predictions from several software packages. The modeling exercise showed that skin sensitization hazard was better predicted by classification trees based on in silico predictions. The defined approach consists of a consensus of two classification trees that are based on descriptors that account for protein reactivity and structural features. The model showed an accuracy of 0.93, sensitivity of 0.98, and specificity of 0.85 for 269 chems. In addition, the defined approach provides a measure of confidence associated to the prediction. In the experiment, the researchers used many compounds, for example, Methyl 3-bromopropanoate(cas: 3395-91-3Safety of Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Safety of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary