Category: 3395-91-3

《Structure-activity relationships and biological evaluation of 7-substituted harmine analogs for human β-cell proliferation》 was written by Kumar, Kunal; Wang, Peng; Swartz, Ethan A.; Khamrui, Susmita; Secor, Cody; Lazarus, Michael B.; Sanchez, Roberto; Stewart, Andrew F.; DeVita, Robert J.. Product Details of 3395-91-3 And the article was included in Molecules in 2020. The article conveys some information:

Recently, we have shown that harmine induces β-cell proliferation both in vitro and in vivo, mediated via the DYRK1A-NFAT pathway. We explore structure-activity relationships of the 7-position of harmine for both DYRK1A kinase inhibition and β-cell proliferation based on our related previous structure-activity relationship studies of harmine in the context of diabetes and β-cell specific targeting strategies. Thirty three harmine analogs of the 7-position substituent were synthesized and evaluated for biol. activity. Two novel inhibitors were identified which showed DYRK1A inhibition and human β-cell proliferation capability. The DYRK1A inhibitor, compound 3-(7-oxy-1-methyl-9-H-b-carbolin)propionic acid Me ester, induced β-cell proliferation half that of harmine at three times higher concentration From these studies we can draw the inference that 7-position modification is limited for further harmine optimization focused on β-cell proliferation and cell-specific targeting approach for diabetes therapeutics. In addition to this study using Methyl 3-bromopropanoate, there are many other studies that have used Methyl 3-bromopropanoate(cas: 3395-91-3Product Details of 3395-91-3) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Product Details of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Efforts towards Rh(II)-catalyzed N-alkoxyazomethine ylide generation: Disparate reactivities of O-tethered α-diazo keto and -β-ketoester oximes》 was published in Tetrahedron in 2020. These research results belong to Chen, Doris; Jones, Elizabeth V.; Rocke, Benjamin N.; Flick, Andrew C.; Wright, Stephen W.; Trujillo, John I.; France, Stefan. COA of Formula: C4H7BrO2 The article mentions the following:

Herein, dirhodium-catalyzed intramol. N-alkoxyazomethine ylide generation from α-diazo keto and -β-ketoester oximes and the disparate reactivities observed was described. After reading the article, we found that the author used Methyl 3-bromopropanoate(cas: 3395-91-3COA of Formula: C4H7BrO2)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.COA of Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《SNP discrimination by tolane-modified peptide nucleic acids: application for the detection of drug resistance in pathogens》 was written by Takagi, Kenji; Hayashi, Tenko; Sawada, Shinjiro; Okazaki, Miku; Hori, Sakiko; Ogata, Katsuya; Kato, Nobuo; Ebara, Yasuhito; Kaihatsu, Kunihiro. Name: Methyl 3-bromopropanoateThis research focused onzanamivir oseltamivir antiviral agent PNA drug resistance SNP influenza; drug resistance; influenza virus; peptide nucleic acid; single nucleotide polymorphism; tolane. The article conveys some information:

During the treatment of viral or bacterial infections, it is important to evaluate any resistance to the therapeutic agents used. An amino acid substitution arising from a single base mutation in a particular gene often causes drug resistance in pathogens. Therefore, mol. tools that discriminate a single base mismatch in the target sequence are required for achieving therapeutic success. Here, we synthesized peptide nucleic acids (PNAs) derivatized with tolane via an amide linkage at the N-terminus and succeeded in improving the sequence specificity, even with a mismatched base pair located near the terminal region of the duplex. We assessed the sequence specificities of the tolane-PNAs for single-strand DNA and RNA by UV-melting temperature anal., thermodn. anal., an in silico conformational search, and a gel mobility shift assay. As a result, all of the PNA-tolane derivatives stabilized duplex formation to the matched target sequence without inducing mismatch target binding. Among the different PNA-tolane derivatives, PNA that was modified with a naphthyl-type tolane could efficiently discriminate a mismatched base pair and be utilized for the detection of resistance to neuraminidase inhibitors of the influenza A/H1N1 virus. Therefore, our mol. tool can be used to discriminate single nucleotide polymorphisms that are related to drug resistance in pathogens. After reading the article, we found that the author used Methyl 3-bromopropanoate(cas: 3395-91-3Name: Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhao, Lei; Meng, Xiao; Zou, Yifeng; Zhao, Junsong; Wang, Lili; Zhang, Lanlan; Wang, Chao published their research in Organic Letters in 2021. The article was titled 《Directed Nickel-Catalyzed Diastereoselective Reductive Difunctionalization of Alkenyl Amines》.Reference of Methyl 3-bromopropanoate The article contains the following contents:

We report herein an intermol. syn-arylalkylation and alkenylalkylation of alkenyl amines with two different organohalides (iodides and bromides) using Ni(II) catalyst. The cleavable bidentate quinolinamide was utilized after extensive directing group screening to enable olefin difunctionalization with high levels of regio-, chemo-, and diastereocontrol. This general and practical protocol was compatible with α- or β-substituted terminal alkenes and internal alkenes, providing rapid access to branched aliphatic amines bearing two skipped and vicinal stereocenters with high diastereoselectivities that would otherwise be difficult to synthesize. After reading the article, we found that the author used Methyl 3-bromopropanoate(cas: 3395-91-3Reference of Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Reference of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of Methyl 3-bromopropanoateIn 2022 ,《Inhibiting Erastin-Induced Ferroptotic Cell Death by Purine-Based Chelators》 appeared in ChemBioChem. The author of the article were Joshi, Saurabh; Agarwal, Saloni; Panjla, Apurva; Valiyaveettil, Suresh; Ganesh, Subramaniam; Verma, Sandeep. The article conveys some information:

Ferroptosis is a cell death event caused by increased lipid peroxidation leading to iron-dependent oxidative stress and is associated with a wide variety of diseases. In recent years, ferroptosis inhibition has emerged as a novel strategy to target different pathologies. Here, we report the synthesis of two purine derivatives, 1 and 2, for iron chelation strategy and evaluate their potency to inhibit erastin-induced ferroptosis. Both compounds showed efficient iron chelation in solution as well as in cellular environment. The crystal structure of the purine derivatives with iron demonstrated a 2 : 1 (ligand to metal center) stoichiometry for iron and purine derivative complexation. The synthesized compounds also decrease the reactive oxygen species concentration in cell cultures. Compound 2 showed better potency towards the prevention of ferroptotic cell death as compared to com. available iron chelator in the erastin-induced ferroptosis cell culture model. Such purine analogs are potential functional scaffolds for the development of target mols. for ferroptosis inhibition. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-bromopropanoate(cas: 3395-91-3Safety of Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Kundu, Subrata; Nagapradeep, N.; Mohapatra, Balaram; Biswas, Sourav; Verma, Sandeep; Chandrasekhar, Vadapalli published 《Organostannoxane-supported nucleobase arrays: synthesis and supramolecular structures of polymeric and molecular organotin complexes containing guanine, uracil and 2-aminopurine》.CrystEngComm published the findings.Name: Methyl 3-bromopropanoate The information in the text is summarized as follows:

The reaction of L1H {L1H = 3-(N9-guaninyl)propionic acid} with Me3SnCl or (n-Bu3Sn)2O afforded the 1D coordination polymers, [Me3Sn(L1)]n (1) and [n-Bu3Sn(L1)]n (2) resp. A reaction between L2H {L2H = 3-(N7-guaninyl)propionic acid} with Me3SnCl also afforded a 1D coordination polymer, [Me3Sn(L2)]n (3). A similar reaction between L3H [uracil-6-carboxylic acid] with (Ph3Sn)2O in a 2 : 1 ratio afforded a dimer [(n-Bu3SnL3)2·H2O] (4). A mononuclear compound [Me3Sn(L4)·H2O] (5) was obtained in a 1 : 1 reaction of 3-{N9-(2-aminopurinyl)}propanoic acid (L4H) with Me3SnCl. Complexes 1-5 show rich supramol. structures in the solid state as a result of several intermol. interactions. Thus, in the one-dimensional coordination polymer 3, triple hydrogen bonding (GG), between inter-chain guanine units has been observed Similarly a homo orotate quartet has been observed in 4 as a result of intermol. interactions. In the experiment, the researchers used Methyl 3-bromopropanoate(cas: 3395-91-3Name: Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Name: Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Chemical Science included an article by Ding, Feng; Chen, Zhao; Kim, Won Young; Sharma, Amit; Li, Chonglu; Ouyang, Qingying; Zhu, Hua; Yang, Guangfu; Sun, Yao; Kim, Jong Seung. Application In Synthesis of Methyl 3-bromopropanoate. The article was titled 《A nano-cocktail of an NIR-II emissive fluorophore and organoplatinum(II) metallacycle for efficient cancer imaging and therapy》. The information in the text is summarized as follows:

The scarcity of efficient imaging technologies for precise cancer treatment greatly drives the development of new nanotheranostic based platforms that enable both diagnostic and therapeutic functions, together in a single formulation. Owing to the complicated physiol. microenvironment, nanosystems designed with the possibility of noninvasive real-time monitoring of therapeutic progression in the second near-IR channel (NIR-II, 1000-1700 nm) could substantially improve the current cancer therapies. Herein, we design a novel NIR-II theranostic nanoprobe, PSY (size ∼110 nm), by incorporating organoplatinum(II) metallacycles P1 and an organic NIR-II mol. dye, SY1030, into the FDA-approved polymer Pluronic F127. Preliminary in vitro and in vivo studies suggest that PSY is capable of being internalized into glioma U87MG-cells with no significant internalization in non-cancerous tissues. In addition, it shows excellent photostability and minimal background for real-time monitoring the process of therapy in the NIR-II region. Furthermore, in U87MG xenografts and orthotopic breast tumor, PSY demonstrat significantly improved anticancer efficacy compared to a clin. approved Pt(II)-based anticancer drug, cisplatin. The engineered nano-cocktail PSY offers a simple strategy for delivering the organoplatinum(II) macrocycle P1 and NIR-II fluorophore SY1030 as a cocktail of diagnostic and therapeutic functions and highlights its promising capacity for future cancer treatment. In addition to this study using Methyl 3-bromopropanoate, there are many other studies that have used Methyl 3-bromopropanoate(cas: 3395-91-3Application In Synthesis of Methyl 3-bromopropanoate) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Application In Synthesis of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Kundu, Subrata; Nagapradeep, N.; Mohapatra, Balaram; Biswas, Sourav; Verma, Sandeep; Chandrasekhar, Vadapalli published 《Organostannoxane-supported nucleobase arrays: synthesis and supramolecular structures of polymeric and molecular organotin complexes containing guanine, uracil and 2-aminopurine》.CrystEngComm published the findings.Name: Methyl 3-bromopropanoate The information in the text is summarized as follows:

The reaction of L1H {L1H = 3-(N9-guaninyl)propionic acid} with Me3SnCl or (n-Bu3Sn)2O afforded the 1D coordination polymers, [Me3Sn(L1)]n (1) and [n-Bu3Sn(L1)]n (2) resp. A reaction between L2H {L2H = 3-(N7-guaninyl)propionic acid} with Me3SnCl also afforded a 1D coordination polymer, [Me3Sn(L2)]n (3). A similar reaction between L3H [uracil-6-carboxylic acid] with (Ph3Sn)2O in a 2 : 1 ratio afforded a dimer [(n-Bu3SnL3)2·H2O] (4). A mononuclear compound [Me3Sn(L4)·H2O] (5) was obtained in a 1 : 1 reaction of 3-{N9-(2-aminopurinyl)}propanoic acid (L4H) with Me3SnCl. Complexes 1-5 show rich supramol. structures in the solid state as a result of several intermol. interactions. Thus, in the one-dimensional coordination polymer 3, triple hydrogen bonding (GG), between inter-chain guanine units has been observed Similarly a homo orotate quartet has been observed in 4 as a result of intermol. interactions. In the experiment, the researchers used Methyl 3-bromopropanoate(cas: 3395-91-3Name: Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Name: Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Chemical Science included an article by Ding, Feng; Chen, Zhao; Kim, Won Young; Sharma, Amit; Li, Chonglu; Ouyang, Qingying; Zhu, Hua; Yang, Guangfu; Sun, Yao; Kim, Jong Seung. Application In Synthesis of Methyl 3-bromopropanoate. The article was titled 《A nano-cocktail of an NIR-II emissive fluorophore and organoplatinum(II) metallacycle for efficient cancer imaging and therapy》. The information in the text is summarized as follows:

The scarcity of efficient imaging technologies for precise cancer treatment greatly drives the development of new nanotheranostic based platforms that enable both diagnostic and therapeutic functions, together in a single formulation. Owing to the complicated physiol. microenvironment, nanosystems designed with the possibility of noninvasive real-time monitoring of therapeutic progression in the second near-IR channel (NIR-II, 1000-1700 nm) could substantially improve the current cancer therapies. Herein, we design a novel NIR-II theranostic nanoprobe, PSY (size ∼110 nm), by incorporating organoplatinum(II) metallacycles P1 and an organic NIR-II mol. dye, SY1030, into the FDA-approved polymer Pluronic F127. Preliminary in vitro and in vivo studies suggest that PSY is capable of being internalized into glioma U87MG-cells with no significant internalization in non-cancerous tissues. In addition, it shows excellent photostability and minimal background for real-time monitoring the process of therapy in the NIR-II region. Furthermore, in U87MG xenografts and orthotopic breast tumor, PSY demonstrat significantly improved anticancer efficacy compared to a clin. approved Pt(II)-based anticancer drug, cisplatin. The engineered nano-cocktail PSY offers a simple strategy for delivering the organoplatinum(II) macrocycle P1 and NIR-II fluorophore SY1030 as a cocktail of diagnostic and therapeutic functions and highlights its promising capacity for future cancer treatment. In addition to this study using Methyl 3-bromopropanoate, there are many other studies that have used Methyl 3-bromopropanoate(cas: 3395-91-3Application In Synthesis of Methyl 3-bromopropanoate) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Application In Synthesis of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Development of novel amides as noncovalent inhibitors of immunoproteasomes》 were Ettari, Roberta; Cerchia, Carmen; Maiorana, Santina; Guccione, Manuela; Novellino, Ettore; Bitto, Alessandra; Grasso, Silvana; Lavecchia, Antonio; Zappala, Maria. And the article was published in ChemMedChem in 2019. SDS of cas: 3395-91-3 The author mentioned the following in the article:

The development of immunoproteasome-selective inhibitors is a promising strategy for treating hematol. malignancies, autoimmune and inflammatory diseases. In this context, we report the design, synthesis, and biol. evaluation of a new series of amide derivatives as immunoproteasome inhibitors. Notably, the designed compounds act as noncovalent inhibitors, which might be a promising therapeutic option because of the lack of drawbacks and side effects associated with irreversible inhibition. Among the synthesized compounds, we identified a panel of active inhibitors with Ki values in the low micromolar or sub-micromolar ranges toward the β5i and/or β1i subunits of immunoproteasomes. One of the active compounds was shown to be the most potent and selective inhibitor with a Ki value of 21 nM against the single β1i subunit. Docking studies allowed us to determine the mode of binding of the mols. in the catalytic site of immunoproteasome subunits.Methyl 3-bromopropanoate(cas: 3395-91-3SDS of cas: 3395-91-3) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.SDS of cas: 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary