Category: 33884-43-4

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 33884-43-4, name is 2-(2-Bromoethyl)-1,3-dioxane, A new synthetic method of this compound is introduced below., SDS of cas: 33884-43-4

Sodium hydroxide (3.46g, 1.3 eq) was taken up in water (2OmL) and stirred for about 30 minutes. Then 3-tert-butyl phenol (10.0 g, 66.6 mmol) was added and the resulting mixture was stirred at room temperature for 30 minutes. Next, 2-(2-bromoethyl)-[l,3] dioxane (9.9 mL, 1.1 eq) was added ant the resulting mixture was heated at reflux for 40 hours. The reaction mixture was cooled to room temperature and then added ethyl acetate (150 mL) and with stirring acetic acid was added to pH = 4, followed by dilution with water (100 mL) and ethyl acetate (150 mL). After partitioning, the layers were separated and then washed the organic layer with water (3X 10OmL) and the ethyl acetate layers were dried over magnesium sulfate, filtered and concentrated to give the title compound as a colorless oil (16.9Ig).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; DEWDNEY, Nolan James; HAWLEY, Ronald Charles; KONDRU, Rama K.; LAI, Yingjie; LOU, Yan; WO2010/122038; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33884-43-4, name is 2-(2-Bromoethyl)-1,3-dioxane, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 33884-43-4

Synthesis Example 9 Synthesis of 3-(1,3-Dioxan-2-yl)-1-(5-norbornen-2-yl)-1-propanol (Monomer 9) A Grignard reagent was customarily prepared from 36.2 g of 2-(2-bromoethyl)-1,3-dioxane in 200 ml of dry tetrahydrofuran. Then 19.5 g of 5-norbornene-2-carbaldehyde was added dropwise over 30 minutes to the Grignard reagent at 20 C. Stirring was continued for 30 minutes whereupon the reaction solution was added to a saturated aqueous solution of ammonium chloride to stop reaction. After diethyl ether extraction, the organic layer was successively washed with water, saturated sodium bicarbonate water and saturated sodium chloride water, dried over anhydrous sodium sulfate, and concentrated in vacuum. It was further purified by vacuum distillation, obtaining 36.2 g of 3-(1,3-dioxan-2-yl)-1-(5-norbornen-2-yl)-1-propanol (boiling point 125 C./27 Pa, yield 95%). IR (thin film): nu=3440 (br.), 3056, 2962, 2860, 2731, 2657, 1570, 1448, 1404, 1377, 1336, 1284, 1240, 1146, 1093, 1047, 997, 926, 721 cm-1; 1H-NMR (300 MHz in CDCl3): delta=0.45-2.35 (12H, m), 2.55-3.50 (3H, m), 3.65-3.80 (2H, m), 4.05-4.15 (2H, m), 4.40-4.60 (1H, m), 5.80-6.20 (2H, m).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 33884-43-4.

Reference:
Patent; Shin-Etsu Chemical Co., Ltd.; US6515149; (2003); B2;,
Bromide – Wikipedia,
bromide – Wiktionary