Category: 337915-79-4

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 337915-79-4, name is 5-Bromo-N1-methylbenzene-1,2-diamine, A new synthetic method of this compound is introduced below., SDS of cas: 337915-79-4

Step C6-bromo- 1 -methyl- 1 H-benzimidazol-2-[00304] A solution of (2-amino-5-bromophenyl)methylamine (992 mg, 4.93 mmol) inMeOH (10 mL) was treated with cyanogen bromine (1045 mg, 9.87 mmol). The reaction mixture was maintained at room temperature for 1 h, then partitioned between EtOAc (100 mL), a sat. NaHC03 solution (100 mL) and water (20 mL). The organic layer was washed with a sat. NaCI solution, dried (Na2S04) and concentrated. The residue was triturated using CH2CI2 to obtain 6- bromo-1-methyl-1 H-benzimidazol-2-amine (952 mg, 4.21 mmol, 85 % yield) as a beige solid:.1H NMR (400 MHz, DMSO-cfe) delta ppm 3.48 (s, 3 H) 6.57 (s, 2 H) 7.04 (d, J=0.98 Hz, 2 H) 7.30 – 7.38 (m, 1 H) ES LC-MS m/z =226.1 (Br79, M+H)+; ES LC-MS m/z =228.1 (Br81, M+H)+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GLAXOSMITHKLINE LLC; BOTYANSZKI, Janos; DICKERSON, Scott Howard; LEIVERS, Martin Robert; LI, Xiaofei; MCFADYEN, Robert Blount; REDMAN, Aniko Maria; SHOTWELL, John Bradford; XUE, Jianjun; WO2012/174312; (2012); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 337915-79-4, name is 5-Bromo-N1-methylbenzene-1,2-diamine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 337915-79-4, name: 5-Bromo-N1-methylbenzene-1,2-diamine

To a solution of 42 mL of 6N HCI and 63 mL of water, 5-bromo-N1-methylbenzene- 1 ,2-diamine (9.1 g, 45.4 mmol) and glycolic acid (17.2 g, 227.2 mmol) was added sequentially. The mixture was heated to reflux for 2 hours. After cooling down to room temperature, the mixture was neutralized to PH 9 by ammonium hydroxide. Precipitate formed, filtered, rinsed by water and dried by vacuum to yield (6-bromo-1-methyl-1H- benzo[d]imidazol-2-yl)methanol (8.5 g). 400 MHz 1H NMR (CDCI3) delta 7.5 (d, 1 H), 7.46 (m, 1H), 7.35 (dd, 1 H), 4.92 (s, 2H), 4.74(b, 1 H), 3.8 (s, 3H); MS (M+1) 241 , 243

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-N1-methylbenzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2008/12623; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 337915-79-4, A common heterocyclic compound, 337915-79-4, name is 5-Bromo-N1-methylbenzene-1,2-diamine, molecular formula is C7H9BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate XI6-Bromo-1,2-dimethyl-1H-benzoimidazole A solution of 4-bromo-2-methylamino-aniline (1.10 g) in acetic acid (15 mL) was stirred at 130 C. for 2 h. After cooling to ambient temperature, the solution was concentrated under reduced pressure and the residue was taken up in ethyl acetate. The resulting solution was washed with 10% aqueous K2CO3 solution and brine and dried (MgSO4). The solvent was removed and the remainder was purified by chromatography on silica gel (CH2Cl2/MeOH/NH4OH 99:1:0.1->9:1:0.1) to give the title compound as a solid.Yield: 0.58 g (47% of theory); Mass spectrum (ESI+): m/z=225/227 (Br) [M+H]+.

The synthetic route of 337915-79-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VITAE PHARMACEUTICALS, INC.; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/108578; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary