Category: 33786-90-2

Related Products of 33786-90-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33786-90-2, name is 5-Bromobenzene-1,3-diamine, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a mixture of 5-substituted-2,4-dichloropyrimidines 1a-j (1.00g, 5.52mmol) and benzene-1, 3-diamines 2a-j (0.59g, 5.52mmol) was dissolved in n-butanol (10mL) and DIPEA (1.42g, 11.04mmol) was added and the reaction mixture was stirred at room temperature. The reaction was continued until complete consumption of starting material, monitored by TLC, for 2?8h. The solvent was removed under reduced pressure and the residue was dissolved in EtOAc. Organic layer was washed with water, dried over Na2SO4 and evaporated to dryness. The residue was purified by flash column chromatography (SiO2, Hexanes/EtOAc) to afford the compounds 3a-j.

The chemical industry reduces the impact on the environment during synthesis 5-Bromobenzene-1,3-diamine. I believe this compound will play a more active role in future production and life.

Reference:
Article; Addepalli, Yesu; Yang, Xiaohong; Zhou, Minghui; Reddy, D. Prabhakar; Zhang, Shao-Lin; Wang, Zhen; He, Yun; European Journal of Medicinal Chemistry; vol. 151; (2018); p. 214 – 225;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 33786-90-2,Some common heterocyclic compound, 33786-90-2, name is 5-Bromobenzene-1,3-diamine, molecular formula is C6H7BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A round bottom flask was charged 5-bromo-1 ,3-diaminobenzene (3.7 g, 19.8 mmol) and suspended in water (20 ml_). Di-ferf-butyl dicarbonate (9.50 g, 43.56 mmol) was added causing heating and effervescence. The reaction mixture was further diluted with water (80 ml_) then heated at 70 ¡ãC for 5 h. On cooling to room temperature, water (100 ml_) was added, the precipitate collected by filtration and thoroughly washed with water. The solid residue was extracted into dichloromethane (100 ml_), dried over magnesium sulphate, filtered and concentrated to dryness to give the title compound as a pale yellow solid (7.4 g, 96percent). LCMS [M+Na]+ = 411.0.

The synthetic route of 33786-90-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VECTUS BIOSYSTEMS LIMITED; DUGGAN, Karen Annette; (120 pag.)WO2018/18091; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary