Category: 3344-70-5

Related Products of 3344-70-5, These common heterocyclic compound, 3344-70-5, name is 1,12-Dibromododecane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1.0 g of compound 3,2.63 g of 1,12-dibromododecane,0.43 g of potassium hydroxide and 0.16 g of tetrabutylammonium bromide,Was added to a mixture of 10 ml of dichloromethane and 6.5 ml of water,The mixture was stirred at room temperature under nitrogen for 24 hours,Washed twice with 30 ml of water,Washed once with 15 ml of saturated brine,The organic layer was separated,After adding anhydrous sodium sulfate to remove water,The solvent was removed on a rotary evaporator,(200: 300 mesh silica gel column chromatography elution (ethyl acetate / petroleum ether volume ratio of l: 30-l: 10),To give 1.19 g of the compound 4 as a pale yellow liquid,Yield 90percent.

Statistics shows that 1,12-Dibromododecane is playing an increasingly important role. we look forward to future research findings about 3344-70-5.

Reference:
Patent; Guilin University of Technology; Kong, Xiangfei; Dai, Shengping; Chang, Xiao; Zhang, Laiqi; Wang, Guixia; (10 pag.)CN106117220; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3344-70-5 as follows. Recommanded Product: 3344-70-5

General procedure: A dibromoalkane (1 equiv.) and sodium azide (3 equiv.) were dissolved in 4 : 1 DMF/H2O (15 mL). The mixture was irradiated in a CEM microwave reactor at 125oC (200 W, 200 psi) for 3 h. The reaction mixture was then cooled to room temperature, and 2-ethynylpyridine (2 equiv.), sodium ascorbate (0.5 equiv.), and CuSO4*5H2O (0.4 equiv.) were added to the reaction mixture. The mixture was stirred at room temperature for 12 h. The suspension was partitioned between aqueous 0.1M NH4OH/ethylenediaminetetraacetic acid (EDTA) (100 mL) and CH2Cl2 (100 mL), and the layers were separated. The organic phase was washed with water (100 mL) and brine (100 mL), dried over MgSO4, and the solvent was removed under reduced pressure to provide the ligands as off-white solids.

According to the analysis of related databases, 3344-70-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kumar, Sreedhar V.; Lo, Warrick K. C.; Brooks, Heather J. L.; Hanton, Lyall R.; Crowley, James D.; Australian Journal of Chemistry; vol. 69; 5; (2016); p. 489 – 498;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3344-70-5, name is 1,12-Dibromododecane, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C12H24Br2

Example 11 (n=12); (a) 1,1′-[(Dodecane-1,12-diyl)dioxy]bis[(11S,11aS)-10-(tert- butyloxycarbonyl)-8-methoxy-11- (tetrahydro-pyran-2-yloxy)- 1, 2, 3, 10, 11, 11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazpeine-5- one] (8j); 1,12-Dibromododecane (73.1 mg, 0.22 mmol, 0.5 equiv) was added to the mixture of monomer 7 (0. 2 g, 0.44 mmol, 1.0 equiv) potassium carbonate (0.98 mmol, 2. 2 equiv) and a catalytic amount of potassium iodide in dry DMF (30 mL), and the resulting mixture was heated to 90°C under a nitrogen atmosphere for 5 h. Removal of excess solvent under reduced pressure afforded a crude solid, which was subjected to flash column chromatography (SiO2, 50percent EtOAc- hexane) to afford the dimerized compound 8j (208 mg, 0.19 mmol, 87percent yield, mixture of diastereomers from THP protecting group) as a solid: [alpha]20D = +50° (c = 0.20, CHC13) ; 1H NMR (CDCl3, 400 MHz): No. 1.26-1. 68 (m, 84H, 14-H, 15-H, 16-H, 17-H, Boc, THP), 1.69-1. 89 (16H, 13-H, THP), 1.93-2. 20 (m, 16H, 1-H, 2-H), 3.44-3. 75 (m, 16H, 3-H, lla-H, THP), 3.83-4. 14 (m, 24H, 12-H, 7-OMe, THP), 5.02-5. 10 (m, 2H, THP), 5.12-5. 19 (m, 2H, THP), 5.69-5. 77 (d, 2H, 11-H), 5.79-5. 89 (d, 2H, 11-H), 6.50 (s, 2H, 9-H), 6.87 (s, 2H, 9-H), 7.19 (s, 2H, 6-H), 7.22 (s, 2H, 6-H) ;”C NMR (CDCl3, 400 MHz): 5 19.9, 20.4, 23.1, 23.2, 25.2, 25.3, 25.9, 28.1, 28.2, 28.9, 29.0, 29.1, 29.2, 29.3, 29.56, 29.58, 30.9, 31.2, 46.2, 55.9, 56.2, 60.0, 60.1, 63.3, 64.4, 69.12, 69.15, 80. 9,81. 2,88. 2,91. 2, 95.8, 100.2, 111.1, 111.5, 113.4, 114.0, 126.3, 129.6, 134. 1, 138.8, 147.8, 148.1, 151.5, 155.3, 167.4, 167.6 ; IR (neat): 2932, 1703,1643, 1604,1513, 1450,1392, 1327,1218, 1164, 1022cm~1 ; MS (FAB) m/z (relative intensity) 1085 ( + Na] +, 28), 1063 (M 100), 961 (17), 861 (13).

According to the analysis of related databases, 3344-70-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SPIROGEN LIMITED; WO2005/85259; (2005); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 3344-70-5, The chemical industry reduces the impact on the environment during synthesis 3344-70-5, name is 1,12-Dibromododecane, I believe this compound will play a more active role in future production and life.

EXAMPLE 30 N, N’-Dodecane-1, 12-diyl-bis-isoquinolinium Dibromide (bIQDDB). 1, 12-Dibromododecane (mmol) was added to a solution (30 mL) of isoquinoline, and the solution heated for 24 hours at 65 C. The resulting precipitate was filtered, and the product washed five times with dry diethyl ether. The resulting off-white solid was isolated.’H NMR (300 MHz, DMSO-D6) S 10.06 (1H, d, C1-H), 8.78 (1H, d, C3-H), 8.58 (1H, d, C8-H), 8.48 (1H, d, C4-H), 8. 35 (1H, d, C7-H), 8.25 (1H, t, C5-H), 8.07 (1H, t, C6-H), 4.70 (2H, t, C’1-CH2), 2.0 (2H, m, C’2-CH2), 1.75 (1H, m, C’3-CH2), 1.15-1. 40 (7H, m, C’3-6-CH2).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,12-Dibromododecane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION; WO2005/66129; (2005); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 3344-70-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3344-70-5, name is 1,12-Dibromododecane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a stirred solution of n-dibromoalkane (1 equiv.) in anhydrous THF (0.1M) under an argon atmosphere was added tert-BuOK (1.15 equiv.) in portionwise over 30 min. After being stirred under reflux for 16h, the reaction was cooled and subsequently quenched with water. The resulting mixture was then diluted with diethylether, and the layers were separated. The aqueous layer was extracted several times with diethylether, and the combined organic layers were washed with brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The resultant crude product was purified by flash column chromatography over silica gel using petroleum ether as eluent to afford the desired product.

The synthetic route of 1,12-Dibromododecane has been constantly updated, and we look forward to future research findings.

Reference:
Article; Saied, Essa M.; Le, Thuy Linh-Stella; Hornemann; Arenz, Christoph; Bioorganic and Medicinal Chemistry; vol. 26; 14; (2018); p. 4047 – 4057;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3344-70-5, name is 1,12-Dibromododecane, A new synthetic method of this compound is introduced below., Recommanded Product: 1,12-Dibromododecane

General procedure: Finelyground KOH (2.24 g, 40 mmol) was added to a solution of3,5-dimethylpyrazole (1.92 g, 20 mmol) in DMSO (10 ml).The suspension was thoroughly stirred for 30 min at 80°.Then a solution of 1,4-dibromobutane (2.16 g, 1.21 ml,10 mmol) in DMSO (10 ml) was added dropwise over30 min, while cooling the reaction mixture with water.After finishing the addition of dibrom derivative, stirringand heating at 80° were continued for additional 4 h, andthe reaction mixture was then poured into water (200 ml).The white precipitate that formed was filtered off, washedwith water, and dried.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Zatonskaya, Lina V.; Schepetkin, Igor A.; Petrenko, Tatiana V.; Ogorodnikov, Vladimir D.; Khlebnikov, Andrei I.; Potapov, Andrei S.; Chemistry of Heterocyclic Compounds; vol. 52; 6; (2016); p. 388 – 401; Khim. Geterotsikl. Soedin.; vol. 52; 6; (2016); p. 388 – 401,14;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3344-70-5, name is 1,12-Dibromododecane, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C12H24Br2

General procedure: The new inhibitors (3-22; Fig. 3) were prepared via standard synthetic strategy [24] and [25]. The solution of isoquinoline (1.6 g, 12.4 mmol) and corresponding alkylating agent (5.6 mmol) in DMF (10 ml) was stirred at 70 °C. The reaction mixture remained at the room temperature. It was portioned with acetone (50 ml) and cooled in refrigerator (5 °C) overnight. The crystalline or amorphous crude product was collected by filtration, washed with acetone (3 .x. 20 ml) and recrystallized from MeCN. NMR, ESI-MS and elemental analysis determined the entity and purity of all prepared compounds.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3344-70-5.

Reference:
Article; Musilek, Kamil; Komloova, Marketa; Holas, Ondrej; Hrabinova, Martina; Pohanka, Miroslav; Dohnal, Vlastimil; Nachon, Florian; Dolezal, Martin; Kuca, Kamil; European Journal of Medicinal Chemistry; vol. 46; 2; (2011); p. 811 – 818;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 3344-70-5,Some common heterocyclic compound, 3344-70-5, name is 1,12-Dibromododecane, molecular formula is C12H24Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a two-necked flask under argon, NaH (43.7 mmol) is put into suspension in anhydrous THF (100 ml). The reaction medium is cooled down in an ice bath and acetoethyl acetate is added dropwise (39.7 mmol). After stirring for 10 minutes at 0° C. n-BuLi is added dropwise (1.56 M; 43.7 mmol). Stirring is carried out for a further 10 minutes at ambient temperature before proceeding with alkylation.Dibromododecane (15.9 mmol) in solution in 20 ml of anhydrous THF is added dropwise to the previous solution. The reaction medium is allowed to return to ambient temperature and stirring is continued for 1 hour. Water is added followed by extraction with ether (3 times). The organic phase is washed with a saturated NaCl solution, dried over sodium sulphate, filtered and evaporated to dryness. The product is purified by chromatography on silica-gel eluting with AcOEt-Hexane (1-1). A white solid is obtained (Yield=65percent); M.p.=60° C.NMR 1H (200 MHz, CDCl3): d 4.16 (q, 4H, 2CH2), 3.41 (s, 4H, 2CH2), 2.50 (t, 4H, 2CH2), 1.56-121 (m, 30H).

The synthetic route of 3344-70-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CNRS; US6972343; (2005); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 3344-70-5, The chemical industry reduces the impact on the environment during synthesis 3344-70-5, name is 1,12-Dibromododecane, I believe this compound will play a more active role in future production and life.

General procedure: A suspension of lithium acetylide ethylenediamine complex (247 mg, 2.70 mmol) in dry DMSO (4 mL) was stirred for 10 min at room temperature under nitrogen. After the mixture was cooled to 8 °C, 1-bromo-7-hexadecyne (708 mg, 2.35 mmol) was added dropwise. The reaction mixture was stirred at rt overnight and cooled to 0 °C. Water (1 mL) was added very slowly. The suspension was stirred for 10 min at rt, then poured into water (60 mL), and extracted with hexane. The combined organic phases were dried (Na2SO4), filtered, evaporated to dryness under reduced pressure, and purified by chromatography (elution with hexane) to give Yield 66percent: 1H NMR delta 1.25 (12H, m, (CH2)6); 1.36 (4H, m, CH2C-C-C?C); 1.49 (4H, m, CH2C-C?C); 1.91 (1H, t, J = 2.6 Hz, C?CH); 2.16 (4H, td, J = 2.6 Hz, J = 7.2 Hz, CH2-C?C); 13C NMR delta 18.4 (C-3 and 14), 28.5 (C-4 and 13), 28.7 (C-5 and 12), 29.1 (C-6 and 11), 29.5 and 29.6 (C-8, 9, 10 and 11), 68.0 (C-1 and 16), 84.8 (C-2 and 15).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,12-Dibromododecane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Vilchze, Catherine; Leung, Lawrence W.; Bittman, Robert; Jacobs, William R.; Chemistry and Physics of Lipids; vol. 194; (2016); p. 125 – 138;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 3344-70-5, name is 1,12-Dibromododecane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C12H24Br2

General procedure: Alkane-1,X-bis(decyldimethylammonium) dibromides were obtained by quaternization reaction between appropriate dibromo-alkane (0.1 mol) and decyldimethylamine (0.2 mol). The reactions were conducted in acetonitrile at 60 °C for 24 h. Next, the solvents were removed by vacuum evaporator and the product of reaction was mixed with ethyl acetate. After adding the solvent, dibromide bis(ammonium) precipitated as white solid and was isolated by filtration. The end product was dried under a reduced pressure at 70 °C for 24 h.

The synthetic route of 1,12-Dibromododecane has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kaczmarek, Damian K.; Czerniak, Kamil; Klejdysz, Tomasz; Chemical Papers; vol. 72; 10; (2018); p. 2457 – 2466;,
Bromide – Wikipedia,
bromide – Wiktionary