Synthetic Route of 332-42-3, These common heterocyclic compound, 332-42-3, name is 1-Fluoro-4-(2-bromoethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of 5-(1H-pyrazol-3-yl)-thiophene-2-carbonitrile [300mg, 1.72mmol, Reference Example 3 (b) ], potassium carbonate [(500MG,] 3. [6MMOL)] and [N, N-] [DIMETHYLFORMAMIDE] (4ml) was added 1- (2-bromoethyl)-4-fluoro-benzene (566mg, 3.4mmol). The resulting mixture was heated to [80C] and stirred overnight. The reaction mixture was then quenched in water and extracted with diethyl ether. The organic layer was dried (MgSO4), concentrated, and then subjected to flash column chromatography using a mixture of cyclohexane and ethyl acetate [(8] : 2, v/v) as eluent, to provide [5-{1-[2-(4-] [FLUORO-PHENYL !-ETHYL]-1 H-PVRAZOL-3-YL}-THIOPHENE-2-CARBONITRILE.]
The synthetic route of 332-42-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARGENTA DISCOVERY LIMITED; WO2004/13130; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary